Abstract:
:Siva-1, as a p53-inducible gene, has been shown to induce extensive apoptosis in a number of different cell lines. Recent evidence suggests that Siva-1 functions as a part of the auto-regulatory feedback loop that restrains p53 through facilitating Mdm2-mediated p53 degradation. Also, Siva-1 plays an important role in suppressing tumor metastasis. Here we review the current understanding of Siva-1-mediated apoptotic signaling pathway. We also add comments on the p53-Siva-1 feedback loop, the novel function of Siva-1 in suppressing tumor metastasis, and their potential implications.
journal_name
Protein Celljournal_title
Protein & cellauthors
Mei Y,Wu Mdoi
10.1007/s13238-012-2018-5subject
Has Abstractpub_date
2012-02-01 00:00:00pages
117-22issue
2eissn
1674-800Xissn
1674-8018journal_volume
3pub_type
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