Multifaceted functions of Siva-1: more than an Indian God of Destruction.

Abstract:

:Siva-1, as a p53-inducible gene, has been shown to induce extensive apoptosis in a number of different cell lines. Recent evidence suggests that Siva-1 functions as a part of the auto-regulatory feedback loop that restrains p53 through facilitating Mdm2-mediated p53 degradation. Also, Siva-1 plays an important role in suppressing tumor metastasis. Here we review the current understanding of Siva-1-mediated apoptotic signaling pathway. We also add comments on the p53-Siva-1 feedback loop, the novel function of Siva-1 in suppressing tumor metastasis, and their potential implications.

journal_name

Protein Cell

journal_title

Protein & cell

authors

Mei Y,Wu M

doi

10.1007/s13238-012-2018-5

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

117-22

issue

2

eissn

1674-800X

issn

1674-8018

journal_volume

3

pub_type

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