Immune plexins and semaphorins: old proteins, new immune functions.

abstract：:The induced pluripotent stem cells (iPSCs), derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without any immune rejectio...

journal_title：Protein & cell

authors： Cao J,Li X,Lu X,Zhang C,Yu H,Zhao T

更新日期：2014-01-01 00:00:00

abstract：:The sigma-1 receptor is a molecular chaperone protein highly enriched in the brain. Recent studies linked it to many diseases, such as drug addition, Alzheimer's disease, stroke, depression, and even cancer. Sigma-1 receptor is enriched in lipid rafts, which are membrane microdomains essential in signaling processes. ...

journal_title：Protein & cell

authors： Li J,Liu B,Gao X,Ma Z,CaoSong T,Mei YA,Zheng Y

更新日期：2012-02-01 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal or X-linked recessive disorder characterized by chromosomal instability, bone marrow failure, cancer susceptibility, and a profound sensitivity to agents that produce DNA interstrand cross-link (ICL). To date, 15 genes have been identified that, when mutated, result in FA or an FA-l...

journal_title：Protein & cell

authors： Su X,Huang J

更新日期：2011-09-01 00:00:00

abstract：:The inherent evolvability of promiscuous enzymes endows them with great potential to be artificially evolved for novel functions. Previously, we succeeded in transforming a promiscuous acylaminoacyl peptidase (apAAP) from the hyperthermophilic archaeon Aeropyrum pernix K1 into a specific carboxylesterase by making a s...

journal_title：Protein & cell

authors： Liu C,Yang G,Wu L,Tian G,Zhang Z,Feng Y

更新日期：2011-06-01 00:00:00

abstract：:Polycomb Group Proteins (PcG) are a family of epigenetic regulators responsible for the repression of an array of genes important in development and cell fate specification. PcG proteins complex to form two types of epigenetic regulators: Polycomb Repressive Complex 1 and 2 (PRC1 and PRC2). Although the mechanisms reg...

journal_title：Protein & cell

authors： Jones A,Wang H

更新日期：2010-12-01 00:00:00

abstract：:In the original publication the PDB numbers were not cited. ...

journal_title：Protein & cell

authors： Yu J,Zhang B,Zhang Y,Xu CQ,Zhuo W,Ge J,Li J,Gao N,Li Y,Yang M

更新日期：2019-07-01 00:00:00

abstract：:Human pluripotent stem cells (hPSCs) are an important system to study early human development, model human diseases, and develop cell replacement therapies. However, genetic manipulation of hPSCs is challenging and a method to simultaneously activate multiple genomic sites in a controllable manner is sorely needed. He...

journal_title：Protein & cell

authors： Guo J,Ma D,Huang R,Ming J,Ye M,Kee K,Xie Z,Na J

更新日期：2017-05-01 00:00:00

abstract：:Hearing impairment (HI) affects 1/1000 children and over 2% of the aged population. We have previously reported that mutations in the gene encoding gap junction protein connexin-31 (C×31) are associated with HI. The pathological mechanism of the disease mutations remains unknown. Here, we show that expression of C×31 ...

journal_title：Protein & cell

authors： Xia K,Ma H,Xiong H,Pan Q,Huang L,Wang D,Zhang Z

更新日期：2010-10-01 00:00:00

abstract：:Coronaviruses are the causative agent of respiratory and enteric diseases in animals and humans. One example is SARS, which caused a worldwide health threat in 2003. In coronaviruses, the structural protein N (nucleocapsid protein) associates with the viral RNA to form the filamentous nucleocapsid and plays a crucial ...

journal_title：Protein & cell

authors： Ma Y,Tong X,Xu X,Li X,Lou Z,Rao Z

更新日期：2010-07-01 00:00:00

abstract：:CUE domain-containing 2 (CUEDC2) is a protein involved in the regulation of the cell cycle, inflammation, and tumorigenesis and is highly expressed in many types of tumors. CUEDC2 is phosphorylated by Cdk1 during mitosis and promotes the release of anaphase-promoting complex or cyclosome (APC/C) from checkpoint inhibi...

journal_title：Protein & cell

authors： Man J,Zhang X

更新日期：2011-09-01 00:00:00

abstract：:The fungus Trichophyton schoenleinii (T. schoenleinii) is the causative agent of Trichophytosis and Tinea favosa of the scalp in certain regions of Eurasia and Africa. Human innate immune system plays an important role in combating with various pathogens including fungi. The inflammasome is one of the most critical ar...

journal_title：Protein & cell

authors： Li H,Wu S,Mao L,Lei G,Zhang L,Lu A,An L,Yang G,Abliz P,Meng G

更新日期：2013-07-01 00:00:00

abstract：:The Escherichia coli fadR protein product, a paradigm/prototypical FadR regulator, positively regulates fabA and fabB, the two critical genes for unsaturated fatty acid (UFA) biosynthesis. However the scenario in the other Ɣ-proteobacteria, such as Shewanella with the marine origin, is unusual in that Rodionov and cow...

journal_title：Protein & cell

authors： Zhang H,Zheng B,Gao R,Feng Y

更新日期：2015-09-01 00:00:00

abstract：:The self-renewal and multipotent potentials in neural stem cells (NSCs) maintain the normal physiological functions of central nervous system (CNS). The abnormal differentiation of NSCs would lead to CNS disorders. However, the mechanisms of how NSCs differentiate into astrocytes, oligodendrocytes (OLs) and neurons ar...

journal_title：Protein & cell

authors： Wang K,Wang H,Wang J,Xie Y,Chen J,Yan H,Liu Z,Wen T

更新日期：2012-03-01 00:00:00

abstract：:We recently found that growth factor receptor-bound (Grb) protein 14 is a novel physiological modulator of photoreceptor specific cyclic nucleotide-gated channel alpha subunit (CNGA1). Grb14 promotes the CNG channel closure through its Ras-associating (RA) domain. In the current study we show that this RA domain-media...

journal_title：Protein & cell

authors： Gupta VK,Rajala A,Rodgers KK,Rajala RV

更新日期：2011-11-01 00:00:00

abstract：:Therapeutic monoclonal antibodies are among the most effective biotherapeutics to date. An important aspect of antibodies is their ability to bind antigen while at the same time recruit immune effector functions. The majority of approved recombinant monoclonal antibody therapies are of the human IgG1 subclass, which c...

journal_title：Protein & cell

authors： Wang X,Mathieu M,Brezski RJ

更新日期：2018-01-01 00:00:00

abstract：:Histone deacetylase 6 (HDAC6), a predominantly cytoplasmic protein deacetylase, participates in a wide range of cellular processes through its deacetylase activity. However, the diverse functions of HDAC6 cannot be fully elucidated with its known substrates. In an attempt to explore the substrate diversity of HDAC6, w...

journal_title：Protein & cell

authors： Zhang L,Liu S,Liu N,Zhang Y,Liu M,Li D,Seto E,Yao TP,Shui W,Zhou J

更新日期：2015-01-01 00:00:00

abstract：:Leukocyte immunoglobulin-like receptors (LILRs), also called CD85s, ILTs, or LIRs, are important mediators of immune activation and tolerance that contain tandem immunoglobulin (Ig)-like folds. There are 11 (in addition to two pseudogenes) LILRs in total, two with two Ig-like domains (D1D2) and the remaining nine with...

journal_title：Protein & cell

authors： Nam G,Shi Y,Ryu M,Wang Q,Song H,Liu J,Yan J,Qi J,Gao GF

更新日期：2013-10-01 00:00:00

abstract：:This study was designed to evaluate ERK5 expression in lung cancer and malignant melanoma progression and to ascertain the involvement of ERK5 signaling in lung cancer and melanoma. We show that ERK5 expression is abundant in human lung cancer samples, and elevated ERK5 expression in lung cancer was linked to the acqu...

journal_title：Protein & cell

authors： Jiang W,Cai F,Xu H,Lu Y,Chen J,Liu J,Cao N,Zhang X,Chen X,Huang Q,Zhuang H,Hua ZC

更新日期：2020-11-01 00:00:00

abstract：:In recent years, human cancer genome projects provide unprecedented opportunities for the discovery of cancer genes and signaling pathways that contribute to tumor development. While numerous gene mutations can be identified from each cancer genome, what these mutations mean for cancer is a challenging question to add...

journal_title：Protein & cell

authors： Yu T,Bachman J,Lai ZC

更新日期：2015-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a leading cause of liver disease worldwide. Although several HCV protease/polymerase inhibitors were recently approved by U.S. FDA, the combination of antivirals targeting multiple processes of HCV lifecycle would optimize anti-HCV therapy and against potential drug-resistance. Viral entry i...

journal_title：Protein & cell

authors： Cao L,Chen J,Wang Y,Yang Y,Qing J,Rao Z,Chen X,Lou Z

更新日期：2019-03-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulation of glucose transporter 1 (GLUT1, SLC2A1), a key glycolytic gene to maintain pluripotency. By combining the g...

journal_title：Protein & cell

authors： Yu L,Ji KY,Zhang J,Xu Y,Ying Y,Mai T,Xu S,Zhang QB,Yao KT,Xu Y

更新日期：2019-09-01 00:00:00

abstract：:While the majority of all human cancers counteract telomere shortening by expressing telomerase, ~15% of all cancers maintain telomere length by a telomerase-independent mechanism known as alternative lengthening of telomeres (ALT). Here, we show that high load of intrinsic DNA damage is present in ALT cancer cells, l...

journal_title：Protein & cell

authors： Ge Y,Wu S,Zhang Z,Li X,Li F,Yan S,Liu H,Huang J,Zhao Y

更新日期：2019-11-01 00:00:00

abstract：:Ultraviolet-B (UV-B) is a relatively minor component of sunlight, but can induce stress-related physiological processes or UV-B-specific photomorphogenic responses in plants. In the last decade, significant progress has been made in understanding the UV-B photomorphogenic pathway, including identification of the key c...

journal_title：Protein & cell

authors： Li J,Yang L,Jin D,Nezames CD,Terzaghi W,Deng XW

更新日期：2013-07-01 00:00:00

abstract：:Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide, such as the on-going outbreak of the novel coronavirus SARS-CoV-2. Herein, we identified two potent inhibitors of human DHODH, S312 and S416, with favorable drug-likeness and pharmacokinetic profiles, which all showed broad-spec...

journal_title：Protein & cell

authors： Xiong R,Zhang L,Li S,Sun Y,Ding M,Wang Y,Zhao Y,Wu Y,Shang W,Jiang X,Shan J,Shen Z,Tong Y,Xu L,Chen Y,Liu Y,Zou G,Lavillete D,Zhao Z,Wang R,Zhu L,Xiao G,Lan K,Li H,Xu K

更新日期：2020-10-01 00:00:00

abstract：:Complement proteins in blood recognize charged particles. The anionic phospholipid (aPL) cardiolipin binds both complement proteins C1q and factor H. C1q is an activator of the complement classical pathway, while factor H is an inhibitor of the alternative pathway. To examine opposing effects of C1q and factor H on co...

journal_title：Protein & cell

authors： Tan LA,Yu B,Sim FC,Kishore U,Sim RB

更新日期：2010-11-01 00:00:00

abstract：:Microbial lipopeptides play an important role in apoptosis induction of tumor cells. However, there is little knowledge about the relationship between apoptosis induction and membrane fatty acids. The present study focused on the effects of lipopeptides produced by Bacillus subtilis HSO121 on Bcap-37 cell lines. 3-(4,...

journal_title：Protein & cell

authors： Liu X,Tao X,Zou A,Yang S,Zhang L,Mu B

更新日期：2010-06-01 00:00:00

abstract：:Oral mucositis, a severe oral ulceration, is a common toxic effect of radio- or chemoradio-therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatment. Among cancer patients, at least 40% and up to 70%, of individuals treated with standard chemotherapy regimens or upper-body rad...

journal_title：Protein & cell

authors： Bian L,Han G,Zhao CW,Garl PJ,Wang XJ

更新日期：2015-03-01 00:00:00

abstract：:Diabetes mellitus has become one of the most common chronic diseases, thereby posing a major challenge to global health. Characterized by high levels of blood glucose (hyperglycemia), diabetes usually results from a loss of insulin-producing β-cells in the pancreas, leading to a deficiency of insulin (type 1 diabetes)...

journal_title：Protein & cell

authors： Kumar M,Nath S,Prasad HK,Sharma GD,Li Y

更新日期：2012-10-01 00:00:00

abstract：:Mutations in the fused in sarcoma/translocated in liposarcoma (FUS/TLS) gene have been associated with amyotrophic lateral sclerosis (ALS). FUS-positive neuropathology is reported in a range of neurodegenerative diseases, including ALS and fronto-temporal lobar degeneration with ubiquitin-positive pathology (FTLDU). T...

journal_title：Protein & cell

authors： Fushimi K,Long C,Jayaram N,Chen X,Li L,Wu JY

更新日期：2011-02-01 00:00:00

abstract：:Treatment of latent tuberculosis infection remains an important goal of global TB eradication. To this end, targets that are essential for intracellular survival of Mycobacterium tuberculosis are particularly attractive. Arylamine N-acetyltransferase (NAT) represents such a target as it is, along with the enzymes enco...

journal_title：Protein & cell

authors： Abuhammad AM,Lowe ED,Fullam E,Noble M,Garman EF,Sim E

更新日期：2010-04-01 00:00:00