Mechanism involved in the modulation of photoreceptor-specific cyclic nucleotidegated channel by the tyrosine kinase adapter protein Grb14.

abstract：:Macroautophagy is an evolutionarily conserved intracellular degradation system used by life ranging from yeasts to mammals. The core autophagic machinery is composed of ATG (autophagy-related) protein constituents. One particular member of the ATG protein family, Atg7, has been the focus of recent research. Atg7 acts ...

journal_title：Protein & cell

authors： Xiong J

更新日期：2015-10-01 00:00:00

abstract：:The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly supervised, providing a fundamental mechanism of host defense. Pathogeni...

journal_title：Protein & cell

authors： Xia P,Wang S,Gao P,Gao G,Fan Z

更新日期：2016-11-01 00:00:00

abstract：:With the smooth move towards the coming expected clinical reports of anticancer pharmaceutical molecules targeting telomeres and telomerase, and also with the exciting success in the extension of lifespan by regulating telomerase activity without increased onset of oncogenesis in laboratory mouse models (Garcia-Cao et...

journal_title：Protein & cell

authors： Lu Y,Wei B,Zhang T,Chen Z,Ye J

更新日期：2013-08-01 00:00:00

abstract：:SARS coronavirus (SARS-CoV) develops an antagonistic mechanism by which to evade the antiviral activities of interferon (IFN). Previous studies suggested that SARS-CoV papain-like protease (PLpro) inhibits activation of the IRF3 pathway, which would normally elicit a robust IFN response, but the mechanism(s) used by S...

journal_title：Protein & cell

authors： Chen X,Yang X,Zheng Y,Yang Y,Xing Y,Chen Z

更新日期：2014-05-01 00:00:00

abstract：:Retinoic acid-inducible gene I (RIG-I) is an important pattern recognition receptor that detects viral RNA and triggers the production of type-I interferons through the downstream adaptor MAVS (also called IPS-1, CARDIF, or VISA). A series of structural studies have elaborated some of the mechanisms of dsRNA recogniti...

journal_title：Protein & cell

authors： Feng M,Ding Z,Xu L,Kong L,Wang W,Jiao S,Shi Z,Greene MI,Cong Y,Zhou Z

更新日期：2013-02-01 00:00:00

abstract：:The Escherichia coli fadR protein product, a paradigm/prototypical FadR regulator, positively regulates fabA and fabB, the two critical genes for unsaturated fatty acid (UFA) biosynthesis. However the scenario in the other Ɣ-proteobacteria, such as Shewanella with the marine origin, is unusual in that Rodionov and cow...

journal_title：Protein & cell

authors： Zhang H,Zheng B,Gao R,Feng Y

更新日期：2015-09-01 00:00:00

abstract：:Progranulin (PGRN) is a growth factor implicated in various pathophysiological processes, including wound healing, inflammation, tumorigenesis, and neurodegeneration. It was previously reported that PGRN binds to tumor necrosis factor receptors (TNFR) and has therapeutic effects in inflammatory arthritis (Tang et. al,...

journal_title：Protein & cell

authors： Wang BC,Liu H,Talwar A,Jian J

更新日期：2015-11-01 00:00:00

abstract：:The nervous system is one of the most complicated organ systems in invertebrates and vertebrates. Down syndrome cell adhesion molecule (DSCAM) of the immunoglobulin (Ig) superfamily is expressed widely in the nervous system during embryonic development. Previous studies in Drosophila suggest that Dscam plays important...

journal_title：Protein & cell

authors： Xu Y,Ye H,Shen Y,Xu Q,Zhu L,Liu J,Wu JY

更新日期：2011-08-01 00:00:00

abstract：:FcγRIIB, the only inhibitory IgG Fc receptor, functions to suppress the hyper-activation of immune cells. Numerous studies have illustrated its inhibitory function through the ITIM motif in the cytoplasmic tail of FcγRIIB. However, later studies revealed that in addition to the ITIM, the transmembrane (TM) domain of F...

journal_title：Protein & cell

authors： Wang J,Li Z,Xu L,Yang H,Liu W

更新日期：2018-12-01 00:00:00

abstract：:Ultraviolet-B (UV-B) is a relatively minor component of sunlight, but can induce stress-related physiological processes or UV-B-specific photomorphogenic responses in plants. In the last decade, significant progress has been made in understanding the UV-B photomorphogenic pathway, including identification of the key c...

journal_title：Protein & cell

authors： Li J,Yang L,Jin D,Nezames CD,Terzaghi W,Deng XW

更新日期：2013-07-01 00:00:00

abstract：:Thymic epithelial cells (TECs) are one of the most important components in thymic microenvironment supporting thymocyte development and maturation. TECs, composed of cortical and medullary TECs, are derived from a common bipotent progenitor, mediating thymocyte positive and negative selections. Multiple levels of sign...

journal_title：Protein & cell

authors： Sun L,Luo H,Li H,Zhao Y

更新日期：2013-05-01 00:00:00

abstract：:The human Shwachman-Diamond syndrome (SDS) is an autosomal recessive disease caused by mutations in a highly conserved ribosome assembly factor SBDS. The functional role of SBDS is to cooperate with another assembly factor, elongation factor 1-like (Efl1), to promote the release of eukaryotic initiation factor 6 (eIF6...

journal_title：Protein & cell

authors： Ma C,Yan K,Tan D,Li N,Zhang Y,Yuan Y,Li Z,Dong MQ,Lei J,Gao N

更新日期：2016-03-01 00:00:00

abstract：:Gene mutation (e.g. substitution, insertion and deletion) and related phenotype information are important biomedical knowledge. Many biomedical databases (e.g. OMIM) incorporate such data. However, few studies have examined the quality of this data. In the current study, we examined the quality of protein single-point...

journal_title：Protein & cell

authors： Li Z,Ying B,Liu X,Zhang X,Yu H

更新日期：2012-03-01 00:00:00

abstract：:Sometimes crystals cannot diffract X-rays beyond 3.0 Å resolution due to the intrinsic flexibility associated with the protein. Low resolution diffraction data not only pose a challenge to structure determination, but also hamper interpretation of mechanistic details. Crystals of a 25.6 kDa non-Pfam, hypothetical prot...

journal_title：Protein & cell

authors： Su J,Li Y,Shaw N,Zhou W,Zhang M,Xu H,Wang BC,Liu ZJ

更新日期：2010-05-01 00:00:00

abstract：:Oral mucositis, a severe oral ulceration, is a common toxic effect of radio- or chemoradio-therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatment. Among cancer patients, at least 40% and up to 70%, of individuals treated with standard chemotherapy regimens or upper-body rad...

journal_title：Protein & cell

authors： Bian L,Han G,Zhao CW,Garl PJ,Wang XJ

更新日期：2015-03-01 00:00:00

abstract：:The self-renewal and multipotent potentials in neural stem cells (NSCs) maintain the normal physiological functions of central nervous system (CNS). The abnormal differentiation of NSCs would lead to CNS disorders. However, the mechanisms of how NSCs differentiate into astrocytes, oligodendrocytes (OLs) and neurons ar...

journal_title：Protein & cell

authors： Wang K,Wang H,Wang J,Xie Y,Chen J,Yan H,Liu Z,Wen T

更新日期：2012-03-01 00:00:00

abstract：:Plexins and semaphorins are a large family of proteins that are involved in cell movement and response. The importance of plexins and semaphorins has been emphasized by their discovery in many organ systems including the nervous (Nkyimbeng-Takwi and Chapoval, 2011; McCormick and Leipzig, 2012; Yaron and Sprinzak, 2012...

journal_title：Protein & cell

authors： Roney K,Holl E,Ting J

更新日期：2013-01-01 00:00:00

abstract：:The cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in host defense by sensing cytosolic DNA derived from microbial pathogens or mis-located cellular DNA. Upon DNA binding, cGAS utilizes GTP and ATP as substrates to synthesize cGAMP, leading to MITA-mediated innate immune response. In this study, we ident...

journal_title：Protein & cell

authors： Li M,Shu HB

更新日期：2020-08-01 00:00:00

abstract：:Treatment of latent tuberculosis infection remains an important goal of global TB eradication. To this end, targets that are essential for intracellular survival of Mycobacterium tuberculosis are particularly attractive. Arylamine N-acetyltransferase (NAT) represents such a target as it is, along with the enzymes enco...

journal_title：Protein & cell

authors： Abuhammad AM,Lowe ED,Fullam E,Noble M,Garman EF,Sim E

更新日期：2010-04-01 00:00:00

abstract：:T-cell receptor (TCR)-engineered T cells are a novel option for adoptive cell therapy used for the treatment of several advanced forms of cancer. Work using TCR-engineered T cells began more than two decades ago, with numerous preclinical studies showing that such cells could mediate tumor lysis and eradication. The s...

journal_title：Protein & cell

authors： Ping Y,Liu C,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal or X-linked recessive disorder characterized by chromosomal instability, bone marrow failure, cancer susceptibility, and a profound sensitivity to agents that produce DNA interstrand cross-link (ICL). To date, 15 genes have been identified that, when mutated, result in FA or an FA-l...

journal_title：Protein & cell

authors： Su X,Huang J

更新日期：2011-09-01 00:00:00

abstract：:Leukocyte immunoglobulin-like receptors (LILRs), also called CD85s, ILTs, or LIRs, are important mediators of immune activation and tolerance that contain tandem immunoglobulin (Ig)-like folds. There are 11 (in addition to two pseudogenes) LILRs in total, two with two Ig-like domains (D1D2) and the remaining nine with...

journal_title：Protein & cell

authors： Nam G,Shi Y,Ryu M,Wang Q,Song H,Liu J,Yan J,Qi J,Gao GF

更新日期：2013-10-01 00:00:00

abstract：:MTUS1 (microtubule-associated tumor suppressor 1) has been identified that can function as a tumor suppressor gene in many malignant tumors. However, the function and mechanisms underlying the regulation of MTUS1 are unclear. In the present study, we reported that miR-19a and miR-19b (miR-19a/b) promote proliferation ...

journal_title：Protein & cell

authors： Gu Y,Liu S,Zhang X,Chen G,Liang H,Yu M,Liao Z,Zhou Y,Zhang CY,Wang T,Wang C,Zhang J,Chen X

更新日期：2017-06-01 00:00:00

abstract：:Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent pro...

journal_title：Protein & cell

authors： Zhan Y,Wu L

更新日期：2012-07-01 00:00:00

abstract：:The sigma-1 receptor is a molecular chaperone protein highly enriched in the brain. Recent studies linked it to many diseases, such as drug addition, Alzheimer's disease, stroke, depression, and even cancer. Sigma-1 receptor is enriched in lipid rafts, which are membrane microdomains essential in signaling processes. ...

journal_title：Protein & cell

authors： Li J,Liu B,Gao X,Ma Z,CaoSong T,Mei YA,Zheng Y

更新日期：2012-02-01 00:00:00

abstract：:The inherent evolvability of promiscuous enzymes endows them with great potential to be artificially evolved for novel functions. Previously, we succeeded in transforming a promiscuous acylaminoacyl peptidase (apAAP) from the hyperthermophilic archaeon Aeropyrum pernix K1 into a specific carboxylesterase by making a s...

journal_title：Protein & cell

authors： Liu C,Yang G,Wu L,Tian G,Zhang Z,Feng Y

更新日期：2011-06-01 00:00:00

abstract：:Siva-1, as a p53-inducible gene, has been shown to induce extensive apoptosis in a number of different cell lines. Recent evidence suggests that Siva-1 functions as a part of the auto-regulatory feedback loop that restrains p53 through facilitating Mdm2-mediated p53 degradation. Also, Siva-1 plays an important role in...

journal_title：Protein & cell

authors： Mei Y,Wu M

更新日期：2012-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a leading cause of liver disease worldwide. Although several HCV protease/polymerase inhibitors were recently approved by U.S. FDA, the combination of antivirals targeting multiple processes of HCV lifecycle would optimize anti-HCV therapy and against potential drug-resistance. Viral entry i...

journal_title：Protein & cell

authors： Cao L,Chen J,Wang Y,Yang Y,Qing J,Rao Z,Chen X,Lou Z

更新日期：2019-03-01 00:00:00

abstract：:Cockayne syndrome (CS) is a rare autosomal recessive inherited disorder characterized by a variety of clinical features, including increased sensitivity to sunlight, progressive neurological abnormalities, and the appearance of premature aging. However, the pathogenesis of CS remains unclear due to the limitations of ...

journal_title：Protein & cell

authors： Wang S,Min Z,Ji Q,Geng L,Su Y,Liu Z,Hu H,Wang L,Zhang W,Suzuiki K,Huang Y,Zhang P,Tang TS,Qu J,Yu Y,Liu GH,Qiao J

更新日期：2020-01-01 00:00:00

abstract：:Arrestins are soluble relatively small 44-46 kDa proteins that specifically bind hundreds of active phosphorylated GPCRs and dozens of non-receptor partners. There are binding partners that demonstrate preference for each of the known arrestin conformations: free, receptor-bound, and microtubule-bound. Recent evidence...

journal_title：Protein & cell

authors： Gurevich VV,Gurevich EV,Uversky VN

更新日期：2018-12-01 00:00:00