Abstract:
:This study was designed to evaluate ERK5 expression in lung cancer and malignant melanoma progression and to ascertain the involvement of ERK5 signaling in lung cancer and melanoma. We show that ERK5 expression is abundant in human lung cancer samples, and elevated ERK5 expression in lung cancer was linked to the acquisition of increased metastatic and invasive potential. Importantly, we observed a significant correlation between ERK5 activity and FAK expression and its phosphorylation at the Ser910 site. Mechanistically, ERK5 increased the expression of the transcription factor USF1, which could transcriptionally upregulate FAK expression, resulting in FAK signaling activation to promote cell migration. We also provided evidence that the phosphorylation of FAK at Ser910 was due to ERK5 but not ERK1/2, and we then suggested a role for Ser910 in the control of cell motility. In addition, ERK5 had targets in addition to FAK that regulate epithelial-to-mesenchymal transition and cell motility in cancer cells. Taken together, our findings uncover a cancer metastasis-promoting role for ERK5 and provide the rationale for targeting ERK5 as a potential therapeutic approach.
journal_name
Protein Celljournal_title
Protein & cellauthors
Jiang W,Cai F,Xu H,Lu Y,Chen J,Liu J,Cao N,Zhang X,Chen X,Huang Q,Zhuang H,Hua ZCdoi
10.1007/s13238-020-00701-1subject
Has Abstractpub_date
2020-11-01 00:00:00pages
825-845issue
11eissn
1674-800Xissn
1674-8018pii
10.1007/s13238-020-00701-1journal_volume
11pub_type
杂志文章相关文献
Protein & Cell文献大全abstract::Human pluripotent stem cells (hPSCs) are an important system to study early human development, model human diseases, and develop cell replacement therapies. However, genetic manipulation of hPSCs is challenging and a method to simultaneously activate multiple genomic sites in a controllable manner is sorely needed. He...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-016-0360-8
更新日期:2017-05-01 00:00:00
abstract::Dendritic cells (DCs) comprise two functionally distinct subsets: plasmacytoid DCs (pDCs) and myeloid DCs (mDCs). pDCs are specialized in rapid and massive secretion of type I interferon (IFN-I) in response to nucleic acids through Toll like receptor (TLR)-7 or TLR-9. In this report, we characterized a CD56(+) DC popu...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-015-0140-x
更新日期:2015-04-01 00:00:00
abstract::The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly supervised, providing a fundamental mechanism of host defense. Pathogeni...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-016-0320-3
更新日期:2016-11-01 00:00:00
abstract::MTUS1 (microtubule-associated tumor suppressor 1) has been identified that can function as a tumor suppressor gene in many malignant tumors. However, the function and mechanisms underlying the regulation of MTUS1 are unclear. In the present study, we reported that miR-19a and miR-19b (miR-19a/b) promote proliferation ...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-017-0393-7
更新日期:2017-06-01 00:00:00
abstract::In the original publication the PDB numbers were not cited. ...
journal_title:Protein & cell
pub_type: 已发布勘误
doi:10.1007/s13238-019-0619-y
更新日期:2019-07-01 00:00:00
abstract::Blastocyst complementation by pluripotent stem cell (PSC) injection is believed to be the most promising method to generate xenogeneic organs. However, ethical issues prevent the study of human chimeras in the late embryonic stage of development. Primate embryonic stem cells (ESCs), which have similar pluripotency to ...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-019-00676-8
更新日期:2020-02-01 00:00:00
abstract::Polycomb Group Proteins (PcG) are a family of epigenetic regulators responsible for the repression of an array of genes important in development and cell fate specification. PcG proteins complex to form two types of epigenetic regulators: Polycomb Repressive Complex 1 and 2 (PRC1 and PRC2). Although the mechanisms reg...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-010-0142-7
更新日期:2010-12-01 00:00:00
abstract::Alzheimer's disease (AD) pathogenesis is characterized by senile plaques in the brain and evidence of oxidative damage. Oxidative stress may precede plaque formation in AD; however, the link between oxidative damage and plaque formation remains unknown. Presenilins are transmembrane proteins in which mutations lead to...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-011-1073-7
更新日期:2011-07-01 00:00:00
abstract::Microbial lipopeptides play an important role in apoptosis induction of tumor cells. However, there is little knowledge about the relationship between apoptosis induction and membrane fatty acids. The present study focused on the effects of lipopeptides produced by Bacillus subtilis HSO121 on Bcap-37 cell lines. 3-(4,...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-010-0072-4
更新日期:2010-06-01 00:00:00
abstract::Dementia is a comprehensive category of brain diseases that is great enough to affect a person's daily functioning. The most common type of dementia is Alzheimer's disease, which makes most of cases. New researches indicate that gastrointestinal tract microbiota are directly linked to dementia pathogenesis through tri...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-016-0338-6
更新日期:2017-02-01 00:00:00
abstract::CUE domain-containing 2 (CUEDC2) is a protein involved in the regulation of the cell cycle, inflammation, and tumorigenesis and is highly expressed in many types of tumors. CUEDC2 is phosphorylated by Cdk1 during mitosis and promotes the release of anaphase-promoting complex or cyclosome (APC/C) from checkpoint inhibi...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-011-1089-z
更新日期:2011-09-01 00:00:00
abstract::The self-renewal and multipotent potentials in neural stem cells (NSCs) maintain the normal physiological functions of central nervous system (CNS). The abnormal differentiation of NSCs would lead to CNS disorders. However, the mechanisms of how NSCs differentiate into astrocytes, oligodendrocytes (OLs) and neurons ar...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-012-0014-4
更新日期:2012-03-01 00:00:00
abstract::FcγRIIB, the only inhibitory IgG Fc receptor, functions to suppress the hyper-activation of immune cells. Numerous studies have illustrated its inhibitory function through the ITIM motif in the cytoplasmic tail of FcγRIIB. However, later studies revealed that in addition to the ITIM, the transmembrane (TM) domain of F...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-018-0509-8
更新日期:2018-12-01 00:00:00
abstract::Histone deacetylase 6 (HDAC6), a predominantly cytoplasmic protein deacetylase, participates in a wide range of cellular processes through its deacetylase activity. However, the diverse functions of HDAC6 cannot be fully elucidated with its known substrates. In an attempt to explore the substrate diversity of HDAC6, w...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-014-0102-8
更新日期:2015-01-01 00:00:00
abstract::Progranulin (PGRN) is a growth factor implicated in various pathophysiological processes, including wound healing, inflammation, tumorigenesis, and neurodegeneration. It was previously reported that PGRN binds to tumor necrosis factor receptors (TNFR) and has therapeutic effects in inflammatory arthritis (Tang et. al,...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-015-0213-x
更新日期:2015-11-01 00:00:00
abstract::Human monocyte is an important cell type which is involved in various complex human diseases. To better understand the biology of human monocytes and facilitate further studies, we developed the first comprehensive proteome knowledge base specifically for human monocytes by integrating both in vivo and in vitro datase...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-016-0342-x
更新日期:2017-02-01 00:00:00
abstract::Siva-1, as a p53-inducible gene, has been shown to induce extensive apoptosis in a number of different cell lines. Recent evidence suggests that Siva-1 functions as a part of the auto-regulatory feedback loop that restrains p53 through facilitating Mdm2-mediated p53 degradation. Also, Siva-1 plays an important role in...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-012-2018-5
更新日期:2012-02-01 00:00:00
abstract::Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulation of glucose transporter 1 (GLUT1, SLC2A1), a key glycolytic gene to maintain pluripotency. By combining the g...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-019-0637-9
更新日期:2019-09-01 00:00:00
abstract::The inherent evolvability of promiscuous enzymes endows them with great potential to be artificially evolved for novel functions. Previously, we succeeded in transforming a promiscuous acylaminoacyl peptidase (apAAP) from the hyperthermophilic archaeon Aeropyrum pernix K1 into a specific carboxylesterase by making a s...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-011-1057-7
更新日期:2011-06-01 00:00:00
abstract::Diabetes mellitus has become one of the most common chronic diseases, thereby posing a major challenge to global health. Characterized by high levels of blood glucose (hyperglycemia), diabetes usually results from a loss of insulin-producing β-cells in the pancreas, leading to a deficiency of insulin (type 1 diabetes)...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-012-2055-0
更新日期:2012-10-01 00:00:00
abstract::The importance of NAC (named as NAM, ATAF1, 2, and CUC2) proteins in plant development, transcription regulation and regulatory pathways involving protein-protein interactions has been increasingly recognized. We report here the high resolution crystal structure of SNAC1 (stress-responsive NAC) NAC domain at 2.5 Å. Al...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-011-1010-9
更新日期:2011-01-01 00:00:00
abstract::Treatment of latent tuberculosis infection remains an important goal of global TB eradication. To this end, targets that are essential for intracellular survival of Mycobacterium tuberculosis are particularly attractive. Arylamine N-acetyltransferase (NAT) represents such a target as it is, along with the enzymes enco...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-010-0037-7
更新日期:2010-04-01 00:00:00
abstract::A chimeric protein called Wallerian degeneration slow (Wld(S)) was first discovered in a spontaneous mutant strain of mice that exhibited delayed Wallerian degeneration. This provides a useful tool in elucidating the mechanisms of axon degeneration. Over-expression of Wld(S) attenuates the axon degeneration that is as...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-010-0021-2
更新日期:2010-03-01 00:00:00
abstract::In recent years, human cancer genome projects provide unprecedented opportunities for the discovery of cancer genes and signaling pathways that contribute to tumor development. While numerous gene mutations can be identified from each cancer genome, what these mutations mean for cancer is a challenging question to add...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-014-0122-4
更新日期:2015-01-01 00:00:00
abstract::The induced pluripotent stem cells (iPSCs), derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without any immune rejectio...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-013-0003-2
更新日期:2014-01-01 00:00:00
abstract::Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on the epigenetic bio-markers to predict aging rate with high accuracy. This progress enlightens us in many aspect...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-013-3913-0
更新日期:2013-10-01 00:00:00
abstract::Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent pro...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-012-0042-0
更新日期:2012-07-01 00:00:00
abstract::The nervous system is one of the most complicated organ systems in invertebrates and vertebrates. Down syndrome cell adhesion molecule (DSCAM) of the immunoglobulin (Ig) superfamily is expressed widely in the nervous system during embryonic development. Previous studies in Drosophila suggest that Dscam plays important...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-011-1072-8
更新日期:2011-08-01 00:00:00
abstract::Therapeutic monoclonal antibodies are among the most effective biotherapeutics to date. An important aspect of antibodies is their ability to bind antigen while at the same time recruit immune effector functions. The majority of approved recombinant monoclonal antibody therapies are of the human IgG1 subclass, which c...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-017-0473-8
更新日期:2018-01-01 00:00:00
abstract::The sigma-1 receptor is a molecular chaperone protein highly enriched in the brain. Recent studies linked it to many diseases, such as drug addition, Alzheimer's disease, stroke, depression, and even cancer. Sigma-1 receptor is enriched in lipid rafts, which are membrane microdomains essential in signaling processes. ...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-012-2006-9
更新日期:2012-02-01 00:00:00