Core pluripotency factors promote glycolysis of human embryonic stem cells by activating GLUT1 enhancer.

abstract：:FcγRIIB, the only inhibitory IgG Fc receptor, functions to suppress the hyper-activation of immune cells. Numerous studies have illustrated its inhibitory function through the ITIM motif in the cytoplasmic tail of FcγRIIB. However, later studies revealed that in addition to the ITIM, the transmembrane (TM) domain of F...

journal_title：Protein & cell

authors： Wang J,Li Z,Xu L,Yang H,Liu W

更新日期：2018-12-01 00:00:00

abstract：:The importance of NAC (named as NAM, ATAF1, 2, and CUC2) proteins in plant development, transcription regulation and regulatory pathways involving protein-protein interactions has been increasingly recognized. We report here the high resolution crystal structure of SNAC1 (stress-responsive NAC) NAC domain at 2.5 Å. Al...

journal_title：Protein & cell

authors： Chen Q,Wang Q,Xiong L,Lou Z

更新日期：2011-01-01 00:00:00

abstract：:Oral mucositis, a severe oral ulceration, is a common toxic effect of radio- or chemoradio-therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatment. Among cancer patients, at least 40% and up to 70%, of individuals treated with standard chemotherapy regimens or upper-body rad...

journal_title：Protein & cell

authors： Bian L,Han G,Zhao CW,Garl PJ,Wang XJ

更新日期：2015-03-01 00:00:00

abstract：:A chimeric protein called Wallerian degeneration slow (Wld(S)) was first discovered in a spontaneous mutant strain of mice that exhibited delayed Wallerian degeneration. This provides a useful tool in elucidating the mechanisms of axon degeneration. Over-expression of Wld(S) attenuates the axon degeneration that is as...

journal_title：Protein & cell

authors： Feng Y,Yan T,He Z,Zhai Q

更新日期：2010-03-01 00:00:00

abstract：:Dehydration is one of the key steps in the biosynthesis of mycolic acids and is vital to the growth of Mycobacterium tuberculosis (Mtb). Consequently, stalling dehydration cures tuberculosis (TB). Clinically used anti-TB drugs like thiacetazone (TAC) and isoxyl (ISO) as well as flavonoids inhibit the enzyme activity o...

journal_title：Protein & cell

authors： Dong Y,Qiu X,Shaw N,Xu Y,Sun Y,Li X,Li J,Rao Z

更新日期：2015-07-01 00:00:00

abstract：:CUE domain-containing 2 (CUEDC2) is a protein involved in the regulation of the cell cycle, inflammation, and tumorigenesis and is highly expressed in many types of tumors. CUEDC2 is phosphorylated by Cdk1 during mitosis and promotes the release of anaphase-promoting complex or cyclosome (APC/C) from checkpoint inhibi...

journal_title：Protein & cell

authors： Man J,Zhang X

更新日期：2011-09-01 00:00:00

abstract：:Macroautophagy is an evolutionarily conserved intracellular degradation system used by life ranging from yeasts to mammals. The core autophagic machinery is composed of ATG (autophagy-related) protein constituents. One particular member of the ATG protein family, Atg7, has been the focus of recent research. Atg7 acts ...

journal_title：Protein & cell

authors： Xiong J

更新日期：2015-10-01 00:00:00

abstract：:Mutations in the fused in sarcoma/translocated in liposarcoma (FUS/TLS) gene have been associated with amyotrophic lateral sclerosis (ALS). FUS-positive neuropathology is reported in a range of neurodegenerative diseases, including ALS and fronto-temporal lobar degeneration with ubiquitin-positive pathology (FTLDU). T...

journal_title：Protein & cell

authors： Fushimi K,Long C,Jayaram N,Chen X,Li L,Wu JY

更新日期：2011-02-01 00:00:00

abstract：:Alzheimer's disease (AD) pathogenesis is characterized by senile plaques in the brain and evidence of oxidative damage. Oxidative stress may precede plaque formation in AD; however, the link between oxidative damage and plaque formation remains unknown. Presenilins are transmembrane proteins in which mutations lead to...

journal_title：Protein & cell

authors： Wangler MF,Reiter LT,Zimm G,Trimble-Morgan J,Wu J,Bier E

更新日期：2011-07-01 00:00:00

abstract：:Therapeutic monoclonal antibodies are among the most effective biotherapeutics to date. An important aspect of antibodies is their ability to bind antigen while at the same time recruit immune effector functions. The majority of approved recombinant monoclonal antibody therapies are of the human IgG1 subclass, which c...

journal_title：Protein & cell

authors： Wang X,Mathieu M,Brezski RJ

更新日期：2018-01-01 00:00:00

abstract：:T-cell receptor (TCR)-engineered T cells are a novel option for adoptive cell therapy used for the treatment of several advanced forms of cancer. Work using TCR-engineered T cells began more than two decades ago, with numerous preclinical studies showing that such cells could mediate tumor lysis and eradication. The s...

journal_title：Protein & cell

authors： Ping Y,Liu C,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：:The inherent evolvability of promiscuous enzymes endows them with great potential to be artificially evolved for novel functions. Previously, we succeeded in transforming a promiscuous acylaminoacyl peptidase (apAAP) from the hyperthermophilic archaeon Aeropyrum pernix K1 into a specific carboxylesterase by making a s...

journal_title：Protein & cell

authors： Liu C,Yang G,Wu L,Tian G,Zhang Z,Feng Y

更新日期：2011-06-01 00:00:00

abstract：:Studies on chronic myeloid leukemia (CML) have served as a paradigm for cancer research and therapy. These studies involve the identification of the first cancer-associated chromosomal abnormality and the subsequent development of tyrosine kinase inhibitors (TKIs) that inhibit BCR-ABL kinase activity in CML. It become...

journal_title：Protein & cell

authors： Zhang H,Li S

更新日期：2013-03-01 00:00:00

abstract：:Polycomb Group Proteins (PcG) are a family of epigenetic regulators responsible for the repression of an array of genes important in development and cell fate specification. PcG proteins complex to form two types of epigenetic regulators: Polycomb Repressive Complex 1 and 2 (PRC1 and PRC2). Although the mechanisms reg...

journal_title：Protein & cell

authors： Jones A,Wang H

更新日期：2010-12-01 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal or X-linked recessive disorder characterized by chromosomal instability, bone marrow failure, cancer susceptibility, and a profound sensitivity to agents that produce DNA interstrand cross-link (ICL). To date, 15 genes have been identified that, when mutated, result in FA or an FA-l...

journal_title：Protein & cell

authors： Su X,Huang J

更新日期：2011-09-01 00:00:00

abstract：:In recent years, human cancer genome projects provide unprecedented opportunities for the discovery of cancer genes and signaling pathways that contribute to tumor development. While numerous gene mutations can be identified from each cancer genome, what these mutations mean for cancer is a challenging question to add...

journal_title：Protein & cell

authors： Yu T,Bachman J,Lai ZC

更新日期：2015-01-01 00:00:00

abstract：:Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious k...

journal_title：Protein & cell

authors： Liang P,Xu Y,Zhang X,Ding C,Huang R,Zhang Z,Lv J,Xie X,Chen Y,Li Y,Sun Y,Bai Y,Songyang Z,Ma W,Zhou C,Huang J

更新日期：2015-05-01 00:00:00

abstract：:Osteosarcoma is the most common primary sarcoma of bone, and it is a leading cause of cancer death among adolescents and young adults. However, the molecular mechanism underlying osteosarcoma carcinogenesis remains poorly understood. Recently, cyclin-dependent kinase 6 (CDK6) was identified as an important oncogene. W...

journal_title：Protein & cell

authors： Zhu K,Liu L,Zhang J,Wang Y,Liang H,Fan G,Jiang Z,Zhang CY,Chen X,Zhou G

更新日期：2016-06-01 00:00:00

abstract：:With the smooth move towards the coming expected clinical reports of anticancer pharmaceutical molecules targeting telomeres and telomerase, and also with the exciting success in the extension of lifespan by regulating telomerase activity without increased onset of oncogenesis in laboratory mouse models (Garcia-Cao et...

journal_title：Protein & cell

authors： Lu Y,Wei B,Zhang T,Chen Z,Ye J

更新日期：2013-08-01 00:00:00

abstract：:Sterol-regulatory element binding proteins (SREBPs) are the key transcriptional regulators of lipid metabolism. The activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi, where it is sequentially cleaved by site-1 protease (S1P) and site-2 protease and releases a...

journal_title：Protein & cell

authors： Xiao J,Xiong Y,Yang LT,Wang JQ,Zhou ZM,Dong LW,Shi XJ,Zhao X,Luo J,Song BL

更新日期：2020-07-14 00:00:00

abstract：:S-Nitros(yl)ation is a ubiquitous redox-based post-translational modification of protein cysteine thiols by nitric oxide or its derivatives, which transduces the bioactivity of nitric oxide (NO) by regulation of protein conformation, activity, stability, localization and protein-protein interactions. These years, more...

journal_title：Protein & cell

authors： Zhang X,Huang B,Zhang L,Zhang Y,Zhao Y,Guo X,Qiao X,Chen C

更新日期：2012-12-01 00:00:00

abstract：:Arrestins are soluble relatively small 44-46 kDa proteins that specifically bind hundreds of active phosphorylated GPCRs and dozens of non-receptor partners. There are binding partners that demonstrate preference for each of the known arrestin conformations: free, receptor-bound, and microtubule-bound. Recent evidence...

journal_title：Protein & cell

authors： Gurevich VV,Gurevich EV,Uversky VN

更新日期：2018-12-01 00:00:00

abstract：:Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent pro...

journal_title：Protein & cell

authors： Zhan Y,Wu L

更新日期：2012-07-01 00:00:00

abstract：:New anti-tubercular drugs and drug targets are urgently needed to reduce the time for treatment and also to identify agents that will be effective against Mycobacterium tuberculosis persisting intracellularly. Mycobacteria have a unique cell wall. Deletion of the gene for arylamine N-acetyltransferase (NAT) decreases ...

journal_title：Protein & cell

authors： Westwood IM,Bhakta S,Russell AJ,Fullam E,Anderton MC,Kawamura A,Mulvaney AW,Vickers RJ,Bhowruth V,Besra GS,Lalvani A,Davies SG,Sim E

更新日期：2010-01-01 00:00:00

abstract：:Human pluripotent stem cells (hPSCs) are an important system to study early human development, model human diseases, and develop cell replacement therapies. However, genetic manipulation of hPSCs is challenging and a method to simultaneously activate multiple genomic sites in a controllable manner is sorely needed. He...

journal_title：Protein & cell

authors： Guo J,Ma D,Huang R,Ming J,Ye M,Kee K,Xie Z,Na J

更新日期：2017-05-01 00:00:00

abstract：:SARS coronavirus (SARS-CoV) develops an antagonistic mechanism by which to evade the antiviral activities of interferon (IFN). Previous studies suggested that SARS-CoV papain-like protease (PLpro) inhibits activation of the IRF3 pathway, which would normally elicit a robust IFN response, but the mechanism(s) used by S...

journal_title：Protein & cell

authors： Chen X,Yang X,Zheng Y,Yang Y,Xing Y,Chen Z

更新日期：2014-05-01 00:00:00

abstract：:Coronaviruses are the causative agent of respiratory and enteric diseases in animals and humans. One example is SARS, which caused a worldwide health threat in 2003. In coronaviruses, the structural protein N (nucleocapsid protein) associates with the viral RNA to form the filamentous nucleocapsid and plays a crucial ...

journal_title：Protein & cell

authors： Ma Y,Tong X,Xu X,Li X,Lou Z,Rao Z

更新日期：2010-07-01 00:00:00

abstract：:While the majority of all human cancers counteract telomere shortening by expressing telomerase, ~15% of all cancers maintain telomere length by a telomerase-independent mechanism known as alternative lengthening of telomeres (ALT). Here, we show that high load of intrinsic DNA damage is present in ALT cancer cells, l...

journal_title：Protein & cell

authors： Ge Y,Wu S,Zhang Z,Li X,Li F,Yan S,Liu H,Huang J,Zhao Y

更新日期：2019-11-01 00:00:00

abstract：:The induced pluripotent stem cells (iPSCs), derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without any immune rejectio...

journal_title：Protein & cell

authors： Cao J,Li X,Lu X,Zhang C,Yu H,Zhao T

更新日期：2014-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a leading cause of liver disease worldwide. Although several HCV protease/polymerase inhibitors were recently approved by U.S. FDA, the combination of antivirals targeting multiple processes of HCV lifecycle would optimize anti-HCV therapy and against potential drug-resistance. Viral entry i...

journal_title：Protein & cell

authors： Cao L,Chen J,Wang Y,Yang Y,Qing J,Rao Z,Chen X,Lou Z

更新日期：2019-03-01 00:00:00