Atg7 in development and disease: panacea or Pandora's Box?

Abstract:

:Macroautophagy is an evolutionarily conserved intracellular degradation system used by life ranging from yeasts to mammals. The core autophagic machinery is composed of ATG (autophagy-related) protein constituents. One particular member of the ATG protein family, Atg7, has been the focus of recent research. Atg7 acts as an E1-like activating enzyme facilitating both microtubule-associated protein light chain 3 (LC3)-phosphatidylethanolamine and ATG12 conjugation. Thus, Atg7 stands at the hub of these two ubiquitin-like systems involving LC3 and Atg12 in autophagic vesicle expansion. In this review, I focus on the pleiotropic function of Atg7 in development, maintenance of health, and alternations of such control in disease.

journal_name

Protein Cell

journal_title

Protein & cell

authors

Xiong J

doi

10.1007/s13238-015-0195-8

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

722-34

issue

10

eissn

1674-800X

issn

1674-8018

pii

10.1007/s13238-015-0195-8

journal_volume

6

pub_type

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