Functional regulation of monocyte-derived dendritic cells by microRNAs.

abstract：:MicroRNAs (miRNAs) are a class of noncoding RNAs that regulates target gene expression at posttranscriptional level, leading to further biological functions. We have demonstrated that microvesicles (MVs) can deliver miRNAs into target cells as a novel way of intercellular communication. It is reported that in central ...

journal_title：Protein & cell

authors： Mao S,Sun Q,Xiao H,Zhang C,Li L

更新日期：2015-07-01 00:00:00

abstract：:Therapeutic monoclonal antibodies are among the most effective biotherapeutics to date. An important aspect of antibodies is their ability to bind antigen while at the same time recruit immune effector functions. The majority of approved recombinant monoclonal antibody therapies are of the human IgG1 subclass, which c...

journal_title：Protein & cell

authors： Wang X,Mathieu M,Brezski RJ

更新日期：2018-01-01 00:00:00

abstract：:The fruit fly, Drosophila melanogaster, is able to discriminate visual landmarks and form visual long-term memory in a flight simulator. Studies focused on the molecular mechanism of long-term memory have shown that memory formation requires mRNA transcription and protein synthesis. However, little is known about the ...

journal_title：Protein & cell

authors： Jiang H,Hou Q,Gong Z,Liu L

更新日期：2011-03-01 00:00:00

abstract：:Coronaviruses are the causative agent of respiratory and enteric diseases in animals and humans. One example is SARS, which caused a worldwide health threat in 2003. In coronaviruses, the structural protein N (nucleocapsid protein) associates with the viral RNA to form the filamentous nucleocapsid and plays a crucial ...

journal_title：Protein & cell

authors： Ma Y,Tong X,Xu X,Li X,Lou Z,Rao Z

更新日期：2010-07-01 00:00:00

abstract：:The importance of NAC (named as NAM, ATAF1, 2, and CUC2) proteins in plant development, transcription regulation and regulatory pathways involving protein-protein interactions has been increasingly recognized. We report here the high resolution crystal structure of SNAC1 (stress-responsive NAC) NAC domain at 2.5 Å. Al...

journal_title：Protein & cell

authors： Chen Q,Wang Q,Xiong L,Lou Z

更新日期：2011-01-01 00:00:00

abstract：:New anti-tubercular drugs and drug targets are urgently needed to reduce the time for treatment and also to identify agents that will be effective against Mycobacterium tuberculosis persisting intracellularly. Mycobacteria have a unique cell wall. Deletion of the gene for arylamine N-acetyltransferase (NAT) decreases ...

journal_title：Protein & cell

authors： Westwood IM,Bhakta S,Russell AJ,Fullam E,Anderton MC,Kawamura A,Mulvaney AW,Vickers RJ,Bhowruth V,Besra GS,Lalvani A,Davies SG,Sim E

更新日期：2010-01-01 00:00:00

abstract：:The human Shwachman-Diamond syndrome (SDS) is an autosomal recessive disease caused by mutations in a highly conserved ribosome assembly factor SBDS. The functional role of SBDS is to cooperate with another assembly factor, elongation factor 1-like (Efl1), to promote the release of eukaryotic initiation factor 6 (eIF6...

journal_title：Protein & cell

authors： Ma C,Yan K,Tan D,Li N,Zhang Y,Yuan Y,Li Z,Dong MQ,Lei J,Gao N

更新日期：2016-03-01 00:00:00

abstract：:Oral mucositis, a severe oral ulceration, is a common toxic effect of radio- or chemoradio-therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatment. Among cancer patients, at least 40% and up to 70%, of individuals treated with standard chemotherapy regimens or upper-body rad...

journal_title：Protein & cell

authors： Bian L,Han G,Zhao CW,Garl PJ,Wang XJ

更新日期：2015-03-01 00:00:00

abstract：:In recent years, human cancer genome projects provide unprecedented opportunities for the discovery of cancer genes and signaling pathways that contribute to tumor development. While numerous gene mutations can be identified from each cancer genome, what these mutations mean for cancer is a challenging question to add...

journal_title：Protein & cell

authors： Yu T,Bachman J,Lai ZC

更新日期：2015-01-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulation of glucose transporter 1 (GLUT1, SLC2A1), a key glycolytic gene to maintain pluripotency. By combining the g...

journal_title：Protein & cell

authors： Yu L,Ji KY,Zhang J,Xu Y,Ying Y,Mai T,Xu S,Zhang QB,Yao KT,Xu Y

更新日期：2019-09-01 00:00:00

abstract：:The liver is the largest internal organ in mammals, and is important for the maintenance of normal physiological functions of other tissues and organs. Hepatitis, cirrhosis, liver cancer and other chronic liver diseases are serious threats to human health, and these problems are compounded by a scarcity of liver donor...

journal_title：Protein & cell

authors： Chen X,Zeng F

更新日期：2011-03-01 00:00:00

abstract：:Hearing impairment (HI) affects 1/1000 children and over 2% of the aged population. We have previously reported that mutations in the gene encoding gap junction protein connexin-31 (C×31) are associated with HI. The pathological mechanism of the disease mutations remains unknown. Here, we show that expression of C×31 ...

journal_title：Protein & cell

authors： Xia K,Ma H,Xiong H,Pan Q,Huang L,Wang D,Zhang Z

更新日期：2010-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most frequent human malignancies worldwide with very poor prognosis. It is generally accepted that the progression of HCC is a long-term process with accumulation of multiple genetic and epigenetic alterations, which further lead to the activation of critical oncogenes or i...

journal_title：Protein & cell

authors： Liu M,Jiang L,Guan XY

更新日期：2014-09-01 00:00:00

abstract：:Vision formation is classically based on projections from retinal ganglion cells (RGC) to the lateral geniculate nucleus (LGN) and the primary visual cortex (V1). Neurons in the mouse V1 are tuned to light stimuli. Although the cellular information of the retina and the LGN has been widely studied, the transcriptome p...

journal_title：Protein & cell

authors： Liu J,Wang M,Sun L,Pan NC,Zhang C,Zhang J,Zuo Z,He S,Wu Q,Wang X

更新日期：2020-06-01 00:00:00

abstract：:S-Nitros(yl)ation is a ubiquitous redox-based post-translational modification of protein cysteine thiols by nitric oxide or its derivatives, which transduces the bioactivity of nitric oxide (NO) by regulation of protein conformation, activity, stability, localization and protein-protein interactions. These years, more...

journal_title：Protein & cell

authors： Zhang X,Huang B,Zhang L,Zhang Y,Zhao Y,Guo X,Qiao X,Chen C

更新日期：2012-12-01 00:00:00

abstract：:Cockayne syndrome (CS) is a rare autosomal recessive inherited disorder characterized by a variety of clinical features, including increased sensitivity to sunlight, progressive neurological abnormalities, and the appearance of premature aging. However, the pathogenesis of CS remains unclear due to the limitations of ...

journal_title：Protein & cell

authors： Wang S,Min Z,Ji Q,Geng L,Su Y,Liu Z,Hu H,Wang L,Zhang W,Suzuiki K,Huang Y,Zhang P,Tang TS,Qu J,Yu Y,Liu GH,Qiao J

更新日期：2020-01-01 00:00:00

abstract：:With the smooth move towards the coming expected clinical reports of anticancer pharmaceutical molecules targeting telomeres and telomerase, and also with the exciting success in the extension of lifespan by regulating telomerase activity without increased onset of oncogenesis in laboratory mouse models (Garcia-Cao et...

journal_title：Protein & cell

authors： Lu Y,Wei B,Zhang T,Chen Z,Ye J

更新日期：2013-08-01 00:00:00

abstract：:Studies on chronic myeloid leukemia (CML) have served as a paradigm for cancer research and therapy. These studies involve the identification of the first cancer-associated chromosomal abnormality and the subsequent development of tyrosine kinase inhibitors (TKIs) that inhibit BCR-ABL kinase activity in CML. It become...

journal_title：Protein & cell

authors： Zhang H,Li S

更新日期：2013-03-01 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal or X-linked recessive disorder characterized by chromosomal instability, bone marrow failure, cancer susceptibility, and a profound sensitivity to agents that produce DNA interstrand cross-link (ICL). To date, 15 genes have been identified that, when mutated, result in FA or an FA-l...

journal_title：Protein & cell

authors： Su X,Huang J

更新日期：2011-09-01 00:00:00

abstract：:Histone deacetylase 6 (HDAC6), a predominantly cytoplasmic protein deacetylase, participates in a wide range of cellular processes through its deacetylase activity. However, the diverse functions of HDAC6 cannot be fully elucidated with its known substrates. In an attempt to explore the substrate diversity of HDAC6, w...

journal_title：Protein & cell

authors： Zhang L,Liu S,Liu N,Zhang Y,Liu M,Li D,Seto E,Yao TP,Shui W,Zhou J

更新日期：2015-01-01 00:00:00

abstract：:While human induced pluripotent stem cells (hiPSCs) have promising applications in regenerative medicine, most of the hiPSC lines available today are not suitable for clinical applications due to contamination with nonhuman materials, such as sialic acid, and potential pathogens from animal-product-containing cell cul...

journal_title：Protein & cell

authors： Wang Q,Mou X,Cao H,Meng Q,Ma Y,Han P,Jiang J,Zhang H,Ma Y

更新日期：2012-01-01 00:00:00

abstract：:Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious k...

journal_title：Protein & cell

authors： Liang P,Xu Y,Zhang X,Ding C,Huang R,Zhang Z,Lv J,Xie X,Chen Y,Li Y,Sun Y,Bai Y,Songyang Z,Ma W,Zhou C,Huang J

更新日期：2015-05-01 00:00:00

abstract：:Leukocyte immunoglobulin-like receptors (LILRs), also called CD85s, ILTs, or LIRs, are important mediators of immune activation and tolerance that contain tandem immunoglobulin (Ig)-like folds. There are 11 (in addition to two pseudogenes) LILRs in total, two with two Ig-like domains (D1D2) and the remaining nine with...

journal_title：Protein & cell

authors： Nam G,Shi Y,Ryu M,Wang Q,Song H,Liu J,Yan J,Qi J,Gao GF

更新日期：2013-10-01 00:00:00

abstract：:The sigma-1 receptor is a molecular chaperone protein highly enriched in the brain. Recent studies linked it to many diseases, such as drug addition, Alzheimer's disease, stroke, depression, and even cancer. Sigma-1 receptor is enriched in lipid rafts, which are membrane microdomains essential in signaling processes. ...

journal_title：Protein & cell

authors： Li J,Liu B,Gao X,Ma Z,CaoSong T,Mei YA,Zheng Y

更新日期：2012-02-01 00:00:00

abstract：:Alzheimer's disease (AD) pathogenesis is characterized by senile plaques in the brain and evidence of oxidative damage. Oxidative stress may precede plaque formation in AD; however, the link between oxidative damage and plaque formation remains unknown. Presenilins are transmembrane proteins in which mutations lead to...

journal_title：Protein & cell

authors： Wangler MF,Reiter LT,Zimm G,Trimble-Morgan J,Wu J,Bier E

更新日期：2011-07-01 00:00:00

abstract：:Blastocyst complementation by pluripotent stem cell (PSC) injection is believed to be the most promising method to generate xenogeneic organs. However, ethical issues prevent the study of human chimeras in the late embryonic stage of development. Primate embryonic stem cells (ESCs), which have similar pluripotency to ...

journal_title：Protein & cell

authors： Fu R,Yu D,Ren J,Li C,Wang J,Feng G,Wang X,Wan H,Li T,Wang L,Zhang Y,Hai T,Li W,Zhou Q

更新日期：2020-02-01 00:00:00

abstract：:The fungus Trichophyton schoenleinii (T. schoenleinii) is the causative agent of Trichophytosis and Tinea favosa of the scalp in certain regions of Eurasia and Africa. Human innate immune system plays an important role in combating with various pathogens including fungi. The inflammasome is one of the most critical ar...

journal_title：Protein & cell

authors： Li H,Wu S,Mao L,Lei G,Zhang L,Lu A,An L,Yang G,Abliz P,Meng G

更新日期：2013-07-01 00:00:00

abstract：:Dementia is a comprehensive category of brain diseases that is great enough to affect a person's daily functioning. The most common type of dementia is Alzheimer's disease, which makes most of cases. New researches indicate that gastrointestinal tract microbiota are directly linked to dementia pathogenesis through tri...

journal_title：Protein & cell

authors： Alkasir R,Li J,Li X,Jin M,Zhu B

更新日期：2017-02-01 00:00:00

abstract：:Arrestins are soluble relatively small 44-46 kDa proteins that specifically bind hundreds of active phosphorylated GPCRs and dozens of non-receptor partners. There are binding partners that demonstrate preference for each of the known arrestin conformations: free, receptor-bound, and microtubule-bound. Recent evidence...

journal_title：Protein & cell

authors： Gurevich VV,Gurevich EV,Uversky VN

更新日期：2018-12-01 00:00:00

abstract：:Treatment of latent tuberculosis infection remains an important goal of global TB eradication. To this end, targets that are essential for intracellular survival of Mycobacterium tuberculosis are particularly attractive. Arylamine N-acetyltransferase (NAT) represents such a target as it is, along with the enzymes enco...

journal_title：Protein & cell

authors： Abuhammad AM,Lowe ED,Fullam E,Noble M,Garman EF,Sim E

更新日期：2010-04-01 00:00:00