Abstract:
:T-cell receptor (TCR)-engineered T cells are a novel option for adoptive cell therapy used for the treatment of several advanced forms of cancer. Work using TCR-engineered T cells began more than two decades ago, with numerous preclinical studies showing that such cells could mediate tumor lysis and eradication. The success of these trials provided the foundation for clinical trials, including recent clinical successes using TCR-engineered T cells to target New York esophageal squamous cell carcinoma (NY-ESO-1). These successes demonstrate the potential of this approach to treat cancer. In this review, we provide a perspective on the current and future applications of TCR-engineered T cells for the treatment of cancer. Our summary focuses on TCR activation and both pre-clinical and clinical applications of TCR-engineered T cells. We also discuss how to enhance the function of TCR-engineered T cells and prolong their longevity in the tumor microenvironment.
journal_name
Protein Celljournal_title
Protein & cellauthors
Ping Y,Liu C,Zhang Ydoi
10.1007/s13238-016-0367-1subject
Has Abstractpub_date
2018-03-01 00:00:00pages
254-266issue
3eissn
1674-800Xissn
1674-8018pii
10.1007/s13238-016-0367-1journal_volume
9pub_type
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