T-cell receptor-engineered T cells for cancer treatment: current status and future directions.


:T-cell receptor (TCR)-engineered T cells are a novel option for adoptive cell therapy used for the treatment of several advanced forms of cancer. Work using TCR-engineered T cells began more than two decades ago, with numerous preclinical studies showing that such cells could mediate tumor lysis and eradication. The success of these trials provided the foundation for clinical trials, including recent clinical successes using TCR-engineered T cells to target New York esophageal squamous cell carcinoma (NY-ESO-1). These successes demonstrate the potential of this approach to treat cancer. In this review, we provide a perspective on the current and future applications of TCR-engineered T cells for the treatment of cancer. Our summary focuses on TCR activation and both pre-clinical and clinical applications of TCR-engineered T cells. We also discuss how to enhance the function of TCR-engineered T cells and prolong their longevity in the tumor microenvironment.


Protein Cell


Protein & cell


Ping Y,Liu C,Zhang Y




Has Abstract


2018-03-01 00:00:00














  • Dscam mutation leads to hydrocephalus and decreased motor function.

    abstract::The nervous system is one of the most complicated organ systems in invertebrates and vertebrates. Down syndrome cell adhesion molecule (DSCAM) of the immunoglobulin (Ig) superfamily is expressed widely in the nervous system during embryonic development. Previous studies in Drosophila suggest that Dscam plays important...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Xu Y,Ye H,Shen Y,Xu Q,Zhu L,Liu J,Wu JY

    更新日期:2011-08-01 00:00:00

  • Proteomic and transcriptomic analysis of visual long-term memory in Drosophila melanogaster.

    abstract::The fruit fly, Drosophila melanogaster, is able to discriminate visual landmarks and form visual long-term memory in a flight simulator. Studies focused on the molecular mechanism of long-term memory have shown that memory formation requires mRNA transcription and protein synthesis. However, little is known about the ...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Jiang H,Hou Q,Gong Z,Liu L

    更新日期:2011-03-01 00:00:00

  • Functional regulation of monocyte-derived dendritic cells by microRNAs.

    abstract::Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent pro...

    journal_title:Protein & cell

    pub_type: 杂志文章,评审


    authors: Zhan Y,Wu L

    更新日期:2012-07-01 00:00:00

  • Mass spectrometry based proteomics profiling of human monocytes.

    abstract::Human monocyte is an important cell type which is involved in various complex human diseases. To better understand the biology of human monocytes and facilitate further studies, we developed the first comprehensive proteome knowledge base specifically for human monocytes by integrating both in vivo and in vitro datase...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Zeng Y,Deng FY,Zhu W,Zhang L,He H,Xu C,Tian Q,Zhang JG,Zhang LS,Hu HG,Deng HW

    更新日期:2017-02-01 00:00:00

  • How will telomeric complex be further contributed to our longevity? - the potential novel biomarkers of telomere complex counteracting both aging and cancer.

    abstract::With the smooth move towards the coming expected clinical reports of anticancer pharmaceutical molecules targeting telomeres and telomerase, and also with the exciting success in the extension of lifespan by regulating telomerase activity without increased onset of oncogenesis in laboratory mouse models (Garcia-Cao et...

    journal_title:Protein & cell

    pub_type: 杂志文章,评审


    authors: Lu Y,Wei B,Zhang T,Chen Z,Ye J

    更新日期:2013-08-01 00:00:00

  • Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.

    abstract::ATP-sensitive potassium channels (KATP) are energy sensors on the plasma membrane. By sensing the intracellular ADP/ATP ratio of β-cells, pancreatic KATP channels control insulin release and regulate metabolism at the whole body level. They are implicated in many metabolic disorders and diseases and are therefore impo...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Wu JX,Ding D,Wang M,Kang Y,Zeng X,Chen L

    更新日期:2018-06-01 00:00:00

  • Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site.

    abstract::Treatment of latent tuberculosis infection remains an important goal of global TB eradication. To this end, targets that are essential for intracellular survival of Mycobacterium tuberculosis are particularly attractive. Arylamine N-acetyltransferase (NAT) represents such a target as it is, along with the enzymes enco...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Abuhammad AM,Lowe ED,Fullam E,Noble M,Garman EF,Sim E

    更新日期:2010-04-01 00:00:00

  • Arrestins: structural disorder creates rich functionality.

    abstract::Arrestins are soluble relatively small 44-46 kDa proteins that specifically bind hundreds of active phosphorylated GPCRs and dozens of non-receptor partners. There are binding partners that demonstrate preference for each of the known arrestin conformations: free, receptor-bound, and microtubule-bound. Recent evidence...

    journal_title:Protein & cell

    pub_type: 杂志文章,评审


    authors: Gurevich VV,Gurevich EV,Uversky VN

    更新日期:2018-12-01 00:00:00

  • An examination of the OMIM database for associating mutation to a consensus reference sequence.

    abstract::Gene mutation (e.g. substitution, insertion and deletion) and related phenotype information are important biomedical knowledge. Many biomedical databases (e.g. OMIM) incorporate such data. However, few studies have examined the quality of this data. In the current study, we examined the quality of protein single-point...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Li Z,Ying B,Liu X,Zhang X,Yu H

    更新日期:2012-03-01 00:00:00

  • Directed hepatic differentiation from embryonic stem cells.

    abstract::The liver is the largest internal organ in mammals, and is important for the maintenance of normal physiological functions of other tissues and organs. Hepatitis, cirrhosis, liver cancer and other chronic liver diseases are serious threats to human health, and these problems are compounded by a scarcity of liver donor...

    journal_title:Protein & cell

    pub_type: 杂志文章,评审


    authors: Chen X,Zeng F

    更新日期:2011-03-01 00:00:00

  • Wld(S), Nmnats and axon degeneration--progress in the past two decades.

    abstract::A chimeric protein called Wallerian degeneration slow (Wld(S)) was first discovered in a spontaneous mutant strain of mice that exhibited delayed Wallerian degeneration. This provides a useful tool in elucidating the mechanisms of axon degeneration. Over-expression of Wld(S) attenuates the axon degeneration that is as...

    journal_title:Protein & cell

    pub_type: 杂志文章,评审


    authors: Feng Y,Yan T,He Z,Zhai Q

    更新日期:2010-03-01 00:00:00

  • MiR-29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6.

    abstract::Osteosarcoma is the most common primary sarcoma of bone, and it is a leading cause of cancer death among adolescents and young adults. However, the molecular mechanism underlying osteosarcoma carcinogenesis remains poorly understood. Recently, cyclin-dependent kinase 6 (CDK6) was identified as an important oncogene. W...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Zhu K,Liu L,Zhang J,Wang Y,Liang H,Fan G,Jiang Z,Zhang CY,Chen X,Zhou G

    更新日期:2016-06-01 00:00:00

  • The role of Smad7 in oral mucositis.

    abstract::Oral mucositis, a severe oral ulceration, is a common toxic effect of radio- or chemoradio-therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatment. Among cancer patients, at least 40% and up to 70%, of individuals treated with standard chemotherapy regimens or upper-body rad...

    journal_title:Protein & cell

    pub_type: 杂志文章,评审


    authors: Bian L,Han G,Zhao CW,Garl PJ,Wang XJ

    更新日期:2015-03-01 00:00:00

  • Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.

    abstract::Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide, such as the on-going outbreak of the novel coronavirus SARS-CoV-2. Herein, we identified two potent inhibitors of human DHODH, S312 and S416, with favorable drug-likeness and pharmacokinetic profiles, which all showed broad-spec...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Xiong R,Zhang L,Li S,Sun Y,Ding M,Wang Y,Zhao Y,Wu Y,Shang W,Jiang X,Shan J,Shen Z,Tong Y,Xu L,Chen Y,Liu Y,Zou G,Lavillete D,Zhao Z,Wang R,Zhu L,Xiao G,Lan K,Li H,Xu K

    更新日期:2020-10-01 00:00:00

  • Secreted miR-34a in astrocytic shedding vesicles enhanced the vulnerability of dopaminergic neurons to neurotoxins by targeting Bcl-2.

    abstract::MicroRNAs (miRNAs) are a class of noncoding RNAs that regulates target gene expression at posttranscriptional level, leading to further biological functions. We have demonstrated that microvesicles (MVs) can deliver miRNAs into target cells as a novel way of intercellular communication. It is reported that in central ...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Mao S,Sun Q,Xiao H,Zhang C,Li L

    更新日期:2015-07-01 00:00:00

  • Polycomb repressive complex 2 in embryonic stem cells: an overview.

    abstract::Polycomb Group Proteins (PcG) are a family of epigenetic regulators responsible for the repression of an array of genes important in development and cell fate specification. PcG proteins complex to form two types of epigenetic regulators: Polycomb Repressive Complex 1 and 2 (PRC1 and PRC2). Although the mechanisms reg...

    journal_title:Protein & cell

    pub_type: 杂志文章,评审


    authors: Jones A,Wang H

    更新日期:2010-12-01 00:00:00

  • Binding of Shewanella FadR to the fabA fatty acid biosynthetic gene: implications for contraction of the fad regulon.

    abstract::The Escherichia coli fadR protein product, a paradigm/prototypical FadR regulator, positively regulates fabA and fabB, the two critical genes for unsaturated fatty acid (UFA) biosynthesis. However the scenario in the other Ɣ-proteobacteria, such as Shewanella with the marine origin, is unusual in that Rodionov and cow...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Zhang H,Zheng B,Gao R,Feng Y

    更新日期:2015-09-01 00:00:00

  • Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity.

    abstract::Histone deacetylase 6 (HDAC6), a predominantly cytoplasmic protein deacetylase, participates in a wide range of cellular processes through its deacetylase activity. However, the diverse functions of HDAC6 cannot be fully elucidated with its known substrates. In an attempt to explore the substrate diversity of HDAC6, w...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Zhang L,Liu S,Liu N,Zhang Y,Liu M,Li D,Seto E,Yao TP,Shui W,Zhou J

    更新日期:2015-01-01 00:00:00

  • UV-B-induced photomorphogenesis in Arabidopsis.

    abstract::Ultraviolet-B (UV-B) is a relatively minor component of sunlight, but can induce stress-related physiological processes or UV-B-specific photomorphogenic responses in plants. In the last decade, significant progress has been made in understanding the UV-B photomorphogenic pathway, including identification of the key c...

    journal_title:Protein & cell

    pub_type: 杂志文章,评审


    authors: Li J,Yang L,Jin D,Nezames CD,Terzaghi W,Deng XW

    更新日期:2013-07-01 00:00:00

  • System approaches reveal the molecular networks involved in neural stem cell differentiation.

    abstract::The self-renewal and multipotent potentials in neural stem cells (NSCs) maintain the normal physiological functions of central nervous system (CNS). The abnormal differentiation of NSCs would lead to CNS disorders. However, the mechanisms of how NSCs differentiate into astrocytes, oligodendrocytes (OLs) and neurons ar...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Wang K,Wang H,Wang J,Xie Y,Chen J,Yan H,Liu Z,Wen T

    更新日期:2012-03-01 00:00:00

  • Phage display screening of therapeutic peptide for cancer targeting and therapy.

    abstract::Recently, phage display technology has been announced as the recipient of Nobel Prize in Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and could be further enriched th...

    journal_title:Protein & cell

    pub_type: 杂志文章,评审


    authors: Saw PE,Song EW

    更新日期:2019-11-01 00:00:00

  • SNObase, a database for S-nitrosation modification.

    abstract::S-Nitros(yl)ation is a ubiquitous redox-based post-translational modification of protein cysteine thiols by nitric oxide or its derivatives, which transduces the bioactivity of nitric oxide (NO) by regulation of protein conformation, activity, stability, localization and protein-protein interactions. These years, more...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Zhang X,Huang B,Zhang L,Zhang Y,Zhao Y,Guo X,Qiao X,Chen C

    更新日期:2012-12-01 00:00:00

  • Human gut microbiota: the links with dementia development.

    abstract::Dementia is a comprehensive category of brain diseases that is great enough to affect a person's daily functioning. The most common type of dementia is Alzheimer's disease, which makes most of cases. New researches indicate that gastrointestinal tract microbiota are directly linked to dementia pathogenesis through tri...

    journal_title:Protein & cell

    pub_type: 杂志文章,评审


    authors: Alkasir R,Li J,Li X,Jin M,Zhu B

    更新日期:2017-02-01 00:00:00

  • Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.

    abstract::The cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in host defense by sensing cytosolic DNA derived from microbial pathogens or mis-located cellular DNA. Upon DNA binding, cGAS utilizes GTP and ATP as substrates to synthesize cGAMP, leading to MITA-mediated innate immune response. In this study, we ident...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Li M,Shu HB

    更新日期:2020-08-01 00:00:00

  • Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers.

    abstract::While the majority of all human cancers counteract telomere shortening by expressing telomerase, ~15% of all cancers maintain telomere length by a telomerase-independent mechanism known as alternative lengthening of telomeres (ALT). Here, we show that high load of intrinsic DNA damage is present in ALT cancer cells, l...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Ge Y,Wu S,Zhang Z,Li X,Li F,Yan S,Liu H,Huang J,Zhao Y

    更新日期:2019-11-01 00:00:00

  • Molecular basis for the inhibition of β-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors.

    abstract::Dehydration is one of the key steps in the biosynthesis of mycolic acids and is vital to the growth of Mycobacterium tuberculosis (Mtb). Consequently, stalling dehydration cures tuberculosis (TB). Clinically used anti-TB drugs like thiacetazone (TAC) and isoxyl (ISO) as well as flavonoids inhibit the enzyme activity o...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Dong Y,Qiu X,Shaw N,Xu Y,Sun Y,Li X,Li J,Rao Z

    更新日期:2015-07-01 00:00:00

  • Integrative analysis of in vivo recording with single-cell RNA-seq data reveals molecular properties of light-sensitive neurons in mouse V1.

    abstract::Vision formation is classically based on projections from retinal ganglion cells (RGC) to the lateral geniculate nucleus (LGN) and the primary visual cortex (V1). Neurons in the mouse V1 are tuned to light stimuli. Although the cellular information of the retina and the LGN has been widely studied, the transcriptome p...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Liu J,Wang M,Sun L,Pan NC,Zhang C,Zhang J,Zuo Z,He S,Wu Q,Wang X

    更新日期:2020-06-01 00:00:00

  • Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.

    abstract::In the original publication the author's name 'Dimitri Lavillete' is published incorrectly. The correct author name should be spelt as 'Dimitri Lavillette' is provided in this correction. ...

    journal_title:Protein & cell

    pub_type: 已发布勘误


    authors: Xiong R,Zhang L,Li S,Sun Y,Ding M,Wang Y,Zhao Y,Wu Y,Shang W,Jiang X,Shan J,Shen Z,Tong Y,Xu L,Chen Y,Liu Y,Zou G,Lavillette D,Zhao Z,Wang R,Zhu L,Xiao G,Lan K,Li H,Xu K

    更新日期:2020-11-09 00:00:00

  • Core pluripotency factors promote glycolysis of human embryonic stem cells by activating GLUT1 enhancer.

    abstract::Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulation of glucose transporter 1 (GLUT1, SLC2A1), a key glycolytic gene to maintain pluripotency. By combining the g...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Yu L,Ji KY,Zhang J,Xu Y,Ying Y,Mai T,Xu S,Zhang QB,Yao KT,Xu Y

    更新日期:2019-09-01 00:00:00

  • Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding.

    abstract::Leukocyte immunoglobulin-like receptors (LILRs), also called CD85s, ILTs, or LIRs, are important mediators of immune activation and tolerance that contain tandem immunoglobulin (Ig)-like folds. There are 11 (in addition to two pseudogenes) LILRs in total, two with two Ig-like domains (D1D2) and the remaining nine with...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Nam G,Shi Y,Ryu M,Wang Q,Song H,Liu J,Yan J,Qi J,Gao GF

    更新日期:2013-10-01 00:00:00