Abstract:
:Therapeutic monoclonal antibodies are among the most effective biotherapeutics to date. An important aspect of antibodies is their ability to bind antigen while at the same time recruit immune effector functions. The majority of approved recombinant monoclonal antibody therapies are of the human IgG1 subclass, which can engage both humoral and cellular components of the immune system. The wealth of information generated about antibodies has afforded investigators the ability to molecularly engineer antibodies to modulate effector functions. Here, we review various antibody engineering efforts intended to improve efficacy and safety relative to the human IgG isotype. Further, we will discuss proposed mechanisms by which engineering approaches led to modified interactions with immune components and provide examples of clinical studies using next generation antibodies.
journal_name
Protein Celljournal_title
Protein & cellauthors
Wang X,Mathieu M,Brezski RJdoi
10.1007/s13238-017-0473-8subject
Has Abstractpub_date
2018-01-01 00:00:00pages
63-73issue
1eissn
1674-800Xissn
1674-8018pii
10.1007/s13238-017-0473-8journal_volume
9pub_type
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