Abstract:
:Polycomb Group Proteins (PcG) are a family of epigenetic regulators responsible for the repression of an array of genes important in development and cell fate specification. PcG proteins complex to form two types of epigenetic regulators: Polycomb Repressive Complex 1 and 2 (PRC1 and PRC2). Although the mechanisms regulating PRC2 recruitment and activity in mammals remain poorly understood, recent work has identified a non-canonical PRC2 in mouse embryonic stem cells (mESC) with unique activities required for repression of PRC2 target genes and necessary for mESC differentiation and somatic cell reprogramming. Here we review the functions of PRC2 in embryonic stem cells and explore the role of the newly identified mESC specific PRC2 regulatory subunits Jarid2 (jumonji, AT rich interactive domain 2), Mtf2 (metal response element binding transcription factor 2) and esPRC2p48.
journal_name
Protein Celljournal_title
Protein & cellauthors
Jones A,Wang Hdoi
10.1007/s13238-010-0142-7subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1056-62issue
12eissn
1674-800Xissn
1674-8018journal_volume
1pub_type
杂志文章,评审相关文献
Protein & Cell文献大全abstract::Dendritic cells (DCs) comprise two functionally distinct subsets: plasmacytoid DCs (pDCs) and myeloid DCs (mDCs). pDCs are specialized in rapid and massive secretion of type I interferon (IFN-I) in response to nucleic acids through Toll like receptor (TLR)-7 or TLR-9. In this report, we characterized a CD56(+) DC popu...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-015-0140-x
更新日期:2015-04-01 00:00:00
abstract::Fanconi anemia (FA) is an autosomal or X-linked recessive disorder characterized by chromosomal instability, bone marrow failure, cancer susceptibility, and a profound sensitivity to agents that produce DNA interstrand cross-link (ICL). To date, 15 genes have been identified that, when mutated, result in FA or an FA-l...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-011-1098-y
更新日期:2011-09-01 00:00:00
abstract::Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent pro...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-012-0042-0
更新日期:2012-07-01 00:00:00
abstract::With the smooth move towards the coming expected clinical reports of anticancer pharmaceutical molecules targeting telomeres and telomerase, and also with the exciting success in the extension of lifespan by regulating telomerase activity without increased onset of oncogenesis in laboratory mouse models (Garcia-Cao et...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-013-3002-4
更新日期:2013-08-01 00:00:00
abstract::The human Shwachman-Diamond syndrome (SDS) is an autosomal recessive disease caused by mutations in a highly conserved ribosome assembly factor SBDS. The functional role of SBDS is to cooperate with another assembly factor, elongation factor 1-like (Efl1), to promote the release of eukaryotic initiation factor 6 (eIF6...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-015-0242-5
更新日期:2016-03-01 00:00:00
abstract::The induced pluripotent stem cells (iPSCs), derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without any immune rejectio...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-013-0003-2
更新日期:2014-01-01 00:00:00
abstract::Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious k...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-015-0153-5
更新日期:2015-05-01 00:00:00
abstract::Sterol-regulatory element binding proteins (SREBPs) are the key transcriptional regulators of lipid metabolism. The activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi, where it is sequentially cleaved by site-1 protease (S1P) and site-2 protease and releases a...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-020-00753-3
更新日期:2020-07-14 00:00:00
abstract::Ultraviolet-B (UV-B) is a relatively minor component of sunlight, but can induce stress-related physiological processes or UV-B-specific photomorphogenic responses in plants. In the last decade, significant progress has been made in understanding the UV-B photomorphogenic pathway, including identification of the key c...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-013-3036-7
更新日期:2013-07-01 00:00:00
abstract::Macroautophagy is an evolutionarily conserved intracellular degradation system used by life ranging from yeasts to mammals. The core autophagic machinery is composed of ATG (autophagy-related) protein constituents. One particular member of the ATG protein family, Atg7, has been the focus of recent research. Atg7 acts ...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-015-0195-8
更新日期:2015-10-01 00:00:00
abstract::In the original publication the PDB numbers were not cited. ...
journal_title:Protein & cell
pub_type: 已发布勘误
doi:10.1007/s13238-019-0619-y
更新日期:2019-07-01 00:00:00
abstract::The Escherichia coli fadR protein product, a paradigm/prototypical FadR regulator, positively regulates fabA and fabB, the two critical genes for unsaturated fatty acid (UFA) biosynthesis. However the scenario in the other Ɣ-proteobacteria, such as Shewanella with the marine origin, is unusual in that Rodionov and cow...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-015-0172-2
更新日期:2015-09-01 00:00:00
abstract::Osteosarcoma is the most common primary sarcoma of bone, and it is a leading cause of cancer death among adolescents and young adults. However, the molecular mechanism underlying osteosarcoma carcinogenesis remains poorly understood. Recently, cyclin-dependent kinase 6 (CDK6) was identified as an important oncogene. W...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-016-0277-2
更新日期:2016-06-01 00:00:00
abstract::Dehydration is one of the key steps in the biosynthesis of mycolic acids and is vital to the growth of Mycobacterium tuberculosis (Mtb). Consequently, stalling dehydration cures tuberculosis (TB). Clinically used anti-TB drugs like thiacetazone (TAC) and isoxyl (ISO) as well as flavonoids inhibit the enzyme activity o...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-015-0181-1
更新日期:2015-07-01 00:00:00
abstract::Precision medicine emerges as a new approach that takes into account individual variability. Successful realization of precision medicine requires disease models that are able to incorporate personalized disease information and recapitulate disease development processes at the molecular, cellular and organ levels. Wit...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-016-0368-0
更新日期:2017-05-01 00:00:00
abstract::The liver is the largest internal organ in mammals, and is important for the maintenance of normal physiological functions of other tissues and organs. Hepatitis, cirrhosis, liver cancer and other chronic liver diseases are serious threats to human health, and these problems are compounded by a scarcity of liver donor...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-011-1023-4
更新日期:2011-03-01 00:00:00
abstract::Studies on chronic myeloid leukemia (CML) have served as a paradigm for cancer research and therapy. These studies involve the identification of the first cancer-associated chromosomal abnormality and the subsequent development of tyrosine kinase inhibitors (TKIs) that inhibit BCR-ABL kinase activity in CML. It become...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-013-2115-0
更新日期:2013-03-01 00:00:00
abstract::The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly supervised, providing a fundamental mechanism of host defense. Pathogeni...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-016-0320-3
更新日期:2016-11-01 00:00:00
abstract::Flea-borne transmission is a recent evolutionary adaptation that distinguishes the deadly Yersinia pestis from its progenitor Y. Pseudotuberculosis, a mild pathogen transmitted via the food-borne route. Y. Pestis synthesizes biofilms in the flea gut, which is important for fleaborne transmission. Yersinia biofilms are...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-011-1024-3
更新日期:2011-03-01 00:00:00
abstract::Treatment of latent tuberculosis infection remains an important goal of global TB eradication. To this end, targets that are essential for intracellular survival of Mycobacterium tuberculosis are particularly attractive. Arylamine N-acetyltransferase (NAT) represents such a target as it is, along with the enzymes enco...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-010-0037-7
更新日期:2010-04-01 00:00:00
abstract::The fungus Trichophyton schoenleinii (T. schoenleinii) is the causative agent of Trichophytosis and Tinea favosa of the scalp in certain regions of Eurasia and Africa. Human innate immune system plays an important role in combating with various pathogens including fungi. The inflammasome is one of the most critical ar...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-013-2127-9
更新日期:2013-07-01 00:00:00
abstract::Recently, phage display technology has been announced as the recipient of Nobel Prize in Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and could be further enriched th...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-019-0639-7
更新日期:2019-11-01 00:00:00
abstract::A chimeric protein called Wallerian degeneration slow (Wld(S)) was first discovered in a spontaneous mutant strain of mice that exhibited delayed Wallerian degeneration. This provides a useful tool in elucidating the mechanisms of axon degeneration. Over-expression of Wld(S) attenuates the axon degeneration that is as...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-010-0021-2
更新日期:2010-03-01 00:00:00
abstract::In recent years, human cancer genome projects provide unprecedented opportunities for the discovery of cancer genes and signaling pathways that contribute to tumor development. While numerous gene mutations can be identified from each cancer genome, what these mutations mean for cancer is a challenging question to add...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-014-0122-4
更新日期:2015-01-01 00:00:00
abstract::While the majority of all human cancers counteract telomere shortening by expressing telomerase, ~15% of all cancers maintain telomere length by a telomerase-independent mechanism known as alternative lengthening of telomeres (ALT). Here, we show that high load of intrinsic DNA damage is present in ALT cancer cells, l...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-019-0634-z
更新日期:2019-11-01 00:00:00
abstract::Diabetes mellitus has become one of the most common chronic diseases, thereby posing a major challenge to global health. Characterized by high levels of blood glucose (hyperglycemia), diabetes usually results from a loss of insulin-producing β-cells in the pancreas, leading to a deficiency of insulin (type 1 diabetes)...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-012-2055-0
更新日期:2012-10-01 00:00:00
abstract::Vision formation is classically based on projections from retinal ganglion cells (RGC) to the lateral geniculate nucleus (LGN) and the primary visual cortex (V1). Neurons in the mouse V1 are tuned to light stimuli. Although the cellular information of the retina and the LGN has been widely studied, the transcriptome p...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-020-00720-y
更新日期:2020-06-01 00:00:00
abstract::Mutations in the fused in sarcoma/translocated in liposarcoma (FUS/TLS) gene have been associated with amyotrophic lateral sclerosis (ALS). FUS-positive neuropathology is reported in a range of neurodegenerative diseases, including ALS and fronto-temporal lobar degeneration with ubiquitin-positive pathology (FTLDU). T...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-011-1014-5
更新日期:2011-02-01 00:00:00
abstract::The self-renewal and multipotent potentials in neural stem cells (NSCs) maintain the normal physiological functions of central nervous system (CNS). The abnormal differentiation of NSCs would lead to CNS disorders. However, the mechanisms of how NSCs differentiate into astrocytes, oligodendrocytes (OLs) and neurons ar...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-012-0014-4
更新日期:2012-03-01 00:00:00
abstract::Hearing impairment (HI) affects 1/1000 children and over 2% of the aged population. We have previously reported that mutations in the gene encoding gap junction protein connexin-31 (C×31) are associated with HI. The pathological mechanism of the disease mutations remains unknown. Here, we show that expression of C×31 ...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-010-0118-7
更新日期:2010-10-01 00:00:00