Abstract:
:FcγRIIB, the only inhibitory IgG Fc receptor, functions to suppress the hyper-activation of immune cells. Numerous studies have illustrated its inhibitory function through the ITIM motif in the cytoplasmic tail of FcγRIIB. However, later studies revealed that in addition to the ITIM, the transmembrane (TM) domain of FcγRIIB is also indispensable for its inhibitory function. Indeed, recent epidemiological studies revealed that a non-synonymous single nucleotide polymorphism (rs1050501) within the TM domain of FcγRIIB, responsible for the I232T substitution, is associated with the susceptibility to systemic lupus erythematosus (SLE). In this review, we will summarize these epidemiological and functional studies of FcγRIIB-I232T in the past few years, and will further discuss the mechanisms accounting for the functional loss of FcγRIIB-I232T. Our review will help the reader gain a deeper understanding of the importance of the TM domain in mediating the inhibitory function of FcγRIIB and may provide insights to a new therapeutic target for the associated diseases.
journal_name
Protein Celljournal_title
Protein & cellauthors
Wang J,Li Z,Xu L,Yang H,Liu Wdoi
10.1007/s13238-018-0509-8subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1004-1012issue
12eissn
1674-800Xissn
1674-8018pii
10.1007/s13238-018-0509-8journal_volume
9pub_type
杂志文章,评审相关文献
Protein & Cell文献大全abstract::Gene mutation (e.g. substitution, insertion and deletion) and related phenotype information are important biomedical knowledge. Many biomedical databases (e.g. OMIM) incorporate such data. However, few studies have examined the quality of this data. In the current study, we examined the quality of protein single-point...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-012-2037-2
更新日期:2012-03-01 00:00:00
abstract::Retinoic acid-inducible gene I (RIG-I) is an important pattern recognition receptor that detects viral RNA and triggers the production of type-I interferons through the downstream adaptor MAVS (also called IPS-1, CARDIF, or VISA). A series of structural studies have elaborated some of the mechanisms of dsRNA recogniti...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-012-2088-4
更新日期:2013-02-01 00:00:00
abstract::The induced pluripotent stem cells (iPSCs), derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without any immune rejectio...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-013-0003-2
更新日期:2014-01-01 00:00:00
abstract::Therapeutic monoclonal antibodies are among the most effective biotherapeutics to date. An important aspect of antibodies is their ability to bind antigen while at the same time recruit immune effector functions. The majority of approved recombinant monoclonal antibody therapies are of the human IgG1 subclass, which c...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-017-0473-8
更新日期:2018-01-01 00:00:00
abstract::We recently found that growth factor receptor-bound (Grb) protein 14 is a novel physiological modulator of photoreceptor specific cyclic nucleotide-gated channel alpha subunit (CNGA1). Grb14 promotes the CNG channel closure through its Ras-associating (RA) domain. In the current study we show that this RA domain-media...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-011-1115-1
更新日期:2011-11-01 00:00:00
abstract::Ultraviolet-B (UV-B) is a relatively minor component of sunlight, but can induce stress-related physiological processes or UV-B-specific photomorphogenic responses in plants. In the last decade, significant progress has been made in understanding the UV-B photomorphogenic pathway, including identification of the key c...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-013-3036-7
更新日期:2013-07-01 00:00:00
abstract::Sometimes crystals cannot diffract X-rays beyond 3.0 Å resolution due to the intrinsic flexibility associated with the protein. Low resolution diffraction data not only pose a challenge to structure determination, but also hamper interpretation of mechanistic details. Crystals of a 25.6 kDa non-Pfam, hypothetical prot...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-010-0045-7
更新日期:2010-05-01 00:00:00
abstract::Fanconi anemia (FA) is an autosomal or X-linked recessive disorder characterized by chromosomal instability, bone marrow failure, cancer susceptibility, and a profound sensitivity to agents that produce DNA interstrand cross-link (ICL). To date, 15 genes have been identified that, when mutated, result in FA or an FA-l...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-011-1098-y
更新日期:2011-09-01 00:00:00
abstract::Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on the epigenetic bio-markers to predict aging rate with high accuracy. This progress enlightens us in many aspect...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-013-3913-0
更新日期:2013-10-01 00:00:00
abstract::Thymic epithelial cells (TECs) are one of the most important components in thymic microenvironment supporting thymocyte development and maturation. TECs, composed of cortical and medullary TECs, are derived from a common bipotent progenitor, mediating thymocyte positive and negative selections. Multiple levels of sign...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-013-3014-0
更新日期:2013-05-01 00:00:00
abstract::T-cell receptor (TCR)-engineered T cells are a novel option for adoptive cell therapy used for the treatment of several advanced forms of cancer. Work using TCR-engineered T cells began more than two decades ago, with numerous preclinical studies showing that such cells could mediate tumor lysis and eradication. The s...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-016-0367-1
更新日期:2018-03-01 00:00:00
abstract::Oral mucositis, a severe oral ulceration, is a common toxic effect of radio- or chemoradio-therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatment. Among cancer patients, at least 40% and up to 70%, of individuals treated with standard chemotherapy regimens or upper-body rad...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-014-0130-4
更新日期:2015-03-01 00:00:00
abstract::In recent years, human cancer genome projects provide unprecedented opportunities for the discovery of cancer genes and signaling pathways that contribute to tumor development. While numerous gene mutations can be identified from each cancer genome, what these mutations mean for cancer is a challenging question to add...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-014-0122-4
更新日期:2015-01-01 00:00:00
abstract::While human induced pluripotent stem cells (hiPSCs) have promising applications in regenerative medicine, most of the hiPSC lines available today are not suitable for clinical applications due to contamination with nonhuman materials, such as sialic acid, and potential pathogens from animal-product-containing cell cul...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-012-2002-0
更新日期:2012-01-01 00:00:00
abstract::Dehydration is one of the key steps in the biosynthesis of mycolic acids and is vital to the growth of Mycobacterium tuberculosis (Mtb). Consequently, stalling dehydration cures tuberculosis (TB). Clinically used anti-TB drugs like thiacetazone (TAC) and isoxyl (ISO) as well as flavonoids inhibit the enzyme activity o...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-015-0181-1
更新日期:2015-07-01 00:00:00
abstract::Dendritic cells (DCs) comprise two functionally distinct subsets: plasmacytoid DCs (pDCs) and myeloid DCs (mDCs). pDCs are specialized in rapid and massive secretion of type I interferon (IFN-I) in response to nucleic acids through Toll like receptor (TLR)-7 or TLR-9. In this report, we characterized a CD56(+) DC popu...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-015-0140-x
更新日期:2015-04-01 00:00:00
abstract::Coronaviruses are the causative agent of respiratory and enteric diseases in animals and humans. One example is SARS, which caused a worldwide health threat in 2003. In coronaviruses, the structural protein N (nucleocapsid protein) associates with the viral RNA to form the filamentous nucleocapsid and plays a crucial ...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-010-0079-x
更新日期:2010-07-01 00:00:00
abstract::New anti-tubercular drugs and drug targets are urgently needed to reduce the time for treatment and also to identify agents that will be effective against Mycobacterium tuberculosis persisting intracellularly. Mycobacteria have a unique cell wall. Deletion of the gene for arylamine N-acetyltransferase (NAT) decreases ...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-010-0006-1
更新日期:2010-01-01 00:00:00
abstract::The inherent evolvability of promiscuous enzymes endows them with great potential to be artificially evolved for novel functions. Previously, we succeeded in transforming a promiscuous acylaminoacyl peptidase (apAAP) from the hyperthermophilic archaeon Aeropyrum pernix K1 into a specific carboxylesterase by making a s...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-011-1057-7
更新日期:2011-06-01 00:00:00
abstract::Leukocyte immunoglobulin-like receptors (LILRs), also called CD85s, ILTs, or LIRs, are important mediators of immune activation and tolerance that contain tandem immunoglobulin (Ig)-like folds. There are 11 (in addition to two pseudogenes) LILRs in total, two with two Ig-like domains (D1D2) and the remaining nine with...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-013-3908-x
更新日期:2013-10-01 00:00:00
abstract::Sterol-regulatory element binding proteins (SREBPs) are the key transcriptional regulators of lipid metabolism. The activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi, where it is sequentially cleaved by site-1 protease (S1P) and site-2 protease and releases a...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-020-00753-3
更新日期:2020-07-14 00:00:00
abstract::Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious k...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-015-0153-5
更新日期:2015-05-01 00:00:00
abstract::Progranulin (PGRN) is a growth factor implicated in various pathophysiological processes, including wound healing, inflammation, tumorigenesis, and neurodegeneration. It was previously reported that PGRN binds to tumor necrosis factor receptors (TNFR) and has therapeutic effects in inflammatory arthritis (Tang et. al,...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-015-0213-x
更新日期:2015-11-01 00:00:00
abstract::Histone deacetylase 6 (HDAC6), a predominantly cytoplasmic protein deacetylase, participates in a wide range of cellular processes through its deacetylase activity. However, the diverse functions of HDAC6 cannot be fully elucidated with its known substrates. In an attempt to explore the substrate diversity of HDAC6, w...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-014-0102-8
更新日期:2015-01-01 00:00:00
abstract::The fruit fly, Drosophila melanogaster, is able to discriminate visual landmarks and form visual long-term memory in a flight simulator. Studies focused on the molecular mechanism of long-term memory have shown that memory formation requires mRNA transcription and protein synthesis. However, little is known about the ...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-011-1019-0
更新日期:2011-03-01 00:00:00
abstract::Macroautophagy is an evolutionarily conserved intracellular degradation system used by life ranging from yeasts to mammals. The core autophagic machinery is composed of ATG (autophagy-related) protein constituents. One particular member of the ATG protein family, Atg7, has been the focus of recent research. Atg7 acts ...
journal_title:Protein & cell
pub_type: 杂志文章,评审
doi:10.1007/s13238-015-0195-8
更新日期:2015-10-01 00:00:00
abstract::MTUS1 (microtubule-associated tumor suppressor 1) has been identified that can function as a tumor suppressor gene in many malignant tumors. However, the function and mechanisms underlying the regulation of MTUS1 are unclear. In the present study, we reported that miR-19a and miR-19b (miR-19a/b) promote proliferation ...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-017-0393-7
更新日期:2017-06-01 00:00:00
abstract::Human monocyte is an important cell type which is involved in various complex human diseases. To better understand the biology of human monocytes and facilitate further studies, we developed the first comprehensive proteome knowledge base specifically for human monocytes by integrating both in vivo and in vitro datase...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-016-0342-x
更新日期:2017-02-01 00:00:00
abstract::Osteosarcoma is the most common primary sarcoma of bone, and it is a leading cause of cancer death among adolescents and young adults. However, the molecular mechanism underlying osteosarcoma carcinogenesis remains poorly understood. Recently, cyclin-dependent kinase 6 (CDK6) was identified as an important oncogene. W...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-016-0277-2
更新日期:2016-06-01 00:00:00
abstract::The Escherichia coli fadR protein product, a paradigm/prototypical FadR regulator, positively regulates fabA and fabB, the two critical genes for unsaturated fatty acid (UFA) biosynthesis. However the scenario in the other Ɣ-proteobacteria, such as Shewanella with the marine origin, is unusual in that Rodionov and cow...
journal_title:Protein & cell
pub_type: 杂志文章
doi:10.1007/s13238-015-0172-2
更新日期:2015-09-01 00:00:00