Abstract:
:The sigma-1 receptor is a molecular chaperone protein highly enriched in the brain. Recent studies linked it to many diseases, such as drug addition, Alzheimer's disease, stroke, depression, and even cancer. Sigma-1 receptor is enriched in lipid rafts, which are membrane microdomains essential in signaling processes. One of those signaling processes is ADAM17- and ADAM10-dependent ectodomain shedding. By using an alkaline phosphatase tagged substrate reporter system, we have shown that ADAM10-dependent BTC shedding was very sensitive to both membrane lipid component change and sigma-1 receptor agonist DHEAS treatment while ADAM17-dependent HB-EGF shedding was not; and overexpression of sigma-1 receptor diminished ADAM17- and ADAM10-dependent shedding. Our results indicate that sigma-1 receptor plays an important role in modifying the function of transmembrane proteases.
journal_name
Protein Celljournal_title
Protein & cellauthors
Li J,Liu B,Gao X,Ma Z,CaoSong T,Mei YA,Zheng Ydoi
10.1007/s13238-012-2006-9subject
Has Abstractpub_date
2012-02-01 00:00:00pages
153-9issue
2eissn
1674-800Xissn
1674-8018journal_volume
3pub_type
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