Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.

abstract：:Retinoic acid-inducible gene I (RIG-I) is an important pattern recognition receptor that detects viral RNA and triggers the production of type-I interferons through the downstream adaptor MAVS (also called IPS-1, CARDIF, or VISA). A series of structural studies have elaborated some of the mechanisms of dsRNA recogniti...

journal_title：Protein & cell

authors： Feng M,Ding Z,Xu L,Kong L,Wang W,Jiao S,Shi Z,Greene MI,Cong Y,Zhou Z

更新日期：2013-02-01 00:00:00

abstract：:ATP-sensitive potassium channels (KATP) are energy sensors on the plasma membrane. By sensing the intracellular ADP/ATP ratio of β-cells, pancreatic KATP channels control insulin release and regulate metabolism at the whole body level. They are implicated in many metabolic disorders and diseases and are therefore impo...

journal_title：Protein & cell

authors： Wu JX,Ding D,Wang M,Kang Y,Zeng X,Chen L

更新日期：2018-06-01 00:00:00

abstract：:The cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in host defense by sensing cytosolic DNA derived from microbial pathogens or mis-located cellular DNA. Upon DNA binding, cGAS utilizes GTP and ATP as substrates to synthesize cGAMP, leading to MITA-mediated innate immune response. In this study, we ident...

journal_title：Protein & cell

authors： Li M,Shu HB

更新日期：2020-08-01 00:00:00

abstract：:In recent years, human cancer genome projects provide unprecedented opportunities for the discovery of cancer genes and signaling pathways that contribute to tumor development. While numerous gene mutations can be identified from each cancer genome, what these mutations mean for cancer is a challenging question to add...

journal_title：Protein & cell

authors： Yu T,Bachman J,Lai ZC

更新日期：2015-01-01 00:00:00

abstract：:Coronaviruses are the causative agent of respiratory and enteric diseases in animals and humans. One example is SARS, which caused a worldwide health threat in 2003. In coronaviruses, the structural protein N (nucleocapsid protein) associates with the viral RNA to form the filamentous nucleocapsid and plays a crucial ...

journal_title：Protein & cell

authors： Ma Y,Tong X,Xu X,Li X,Lou Z,Rao Z

更新日期：2010-07-01 00:00:00

abstract：:The fruit fly, Drosophila melanogaster, is able to discriminate visual landmarks and form visual long-term memory in a flight simulator. Studies focused on the molecular mechanism of long-term memory have shown that memory formation requires mRNA transcription and protein synthesis. However, little is known about the ...

journal_title：Protein & cell

authors： Jiang H,Hou Q,Gong Z,Liu L

更新日期：2011-03-01 00:00:00

abstract：:The self-renewal and multipotent potentials in neural stem cells (NSCs) maintain the normal physiological functions of central nervous system (CNS). The abnormal differentiation of NSCs would lead to CNS disorders. However, the mechanisms of how NSCs differentiate into astrocytes, oligodendrocytes (OLs) and neurons ar...

journal_title：Protein & cell

authors： Wang K,Wang H,Wang J,Xie Y,Chen J,Yan H,Liu Z,Wen T

更新日期：2012-03-01 00:00:00

abstract：:While the majority of all human cancers counteract telomere shortening by expressing telomerase, ~15% of all cancers maintain telomere length by a telomerase-independent mechanism known as alternative lengthening of telomeres (ALT). Here, we show that high load of intrinsic DNA damage is present in ALT cancer cells, l...

journal_title：Protein & cell

authors： Ge Y,Wu S,Zhang Z,Li X,Li F,Yan S,Liu H,Huang J,Zhao Y

更新日期：2019-11-01 00:00:00

abstract：:Human monocyte is an important cell type which is involved in various complex human diseases. To better understand the biology of human monocytes and facilitate further studies, we developed the first comprehensive proteome knowledge base specifically for human monocytes by integrating both in vivo and in vitro datase...

journal_title：Protein & cell

authors： Zeng Y,Deng FY,Zhu W,Zhang L,He H,Xu C,Tian Q,Zhang JG,Zhang LS,Hu HG,Deng HW

更新日期：2017-02-01 00:00:00

abstract：:Progranulin (PGRN) is a growth factor implicated in various pathophysiological processes, including wound healing, inflammation, tumorigenesis, and neurodegeneration. It was previously reported that PGRN binds to tumor necrosis factor receptors (TNFR) and has therapeutic effects in inflammatory arthritis (Tang et. al,...

journal_title：Protein & cell

authors： Wang BC,Liu H,Talwar A,Jian J

更新日期：2015-11-01 00:00:00

abstract：:With the smooth move towards the coming expected clinical reports of anticancer pharmaceutical molecules targeting telomeres and telomerase, and also with the exciting success in the extension of lifespan by regulating telomerase activity without increased onset of oncogenesis in laboratory mouse models (Garcia-Cao et...

journal_title：Protein & cell

authors： Lu Y,Wei B,Zhang T,Chen Z,Ye J

更新日期：2013-08-01 00:00:00

abstract：:Vision formation is classically based on projections from retinal ganglion cells (RGC) to the lateral geniculate nucleus (LGN) and the primary visual cortex (V1). Neurons in the mouse V1 are tuned to light stimuli. Although the cellular information of the retina and the LGN has been widely studied, the transcriptome p...

journal_title：Protein & cell

authors： Liu J,Wang M,Sun L,Pan NC,Zhang C,Zhang J,Zuo Z,He S,Wu Q,Wang X

更新日期：2020-06-01 00:00:00

abstract：:The induced pluripotent stem cells (iPSCs), derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without any immune rejectio...

journal_title：Protein & cell

authors： Cao J,Li X,Lu X,Zhang C,Yu H,Zhao T

更新日期：2014-01-01 00:00:00

abstract：:Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on the epigenetic bio-markers to predict aging rate with high accuracy. This progress enlightens us in many aspect...

journal_title：Protein & cell

authors： Li M,Liu W,Yuan T,Bai R,Liu GH,Zhang W,Qu J

更新日期：2013-10-01 00:00:00

abstract：:Alzheimer's disease (AD) pathogenesis is characterized by senile plaques in the brain and evidence of oxidative damage. Oxidative stress may precede plaque formation in AD; however, the link between oxidative damage and plaque formation remains unknown. Presenilins are transmembrane proteins in which mutations lead to...

journal_title：Protein & cell

authors： Wangler MF,Reiter LT,Zimm G,Trimble-Morgan J,Wu J,Bier E

更新日期：2011-07-01 00:00:00

abstract：:Dehydration is one of the key steps in the biosynthesis of mycolic acids and is vital to the growth of Mycobacterium tuberculosis (Mtb). Consequently, stalling dehydration cures tuberculosis (TB). Clinically used anti-TB drugs like thiacetazone (TAC) and isoxyl (ISO) as well as flavonoids inhibit the enzyme activity o...

journal_title：Protein & cell

authors： Dong Y,Qiu X,Shaw N,Xu Y,Sun Y,Li X,Li J,Rao Z

更新日期：2015-07-01 00:00:00

abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary cerebrovascular disease caused by a NOTCH3 mutation. However, the underlying cellular and molecular mechanisms remain unidentified. Here, we generated non-integrative induced pluripotent stem cells...

journal_title：Protein & cell

authors： Ling C,Liu Z,Song M,Zhang W,Wang S,Liu X,Ma S,Sun S,Fu L,Chu Q,Belmonte JCI,Wang Z,Qu J,Yuan Y,Liu GH

更新日期：2019-04-01 00:00:00

abstract：:CUE domain-containing 2 (CUEDC2) is a protein involved in the regulation of the cell cycle, inflammation, and tumorigenesis and is highly expressed in many types of tumors. CUEDC2 is phosphorylated by Cdk1 during mitosis and promotes the release of anaphase-promoting complex or cyclosome (APC/C) from checkpoint inhibi...

journal_title：Protein & cell

authors： Man J,Zhang X

更新日期：2011-09-01 00:00:00

abstract：:The liver is the largest internal organ in mammals, and is important for the maintenance of normal physiological functions of other tissues and organs. Hepatitis, cirrhosis, liver cancer and other chronic liver diseases are serious threats to human health, and these problems are compounded by a scarcity of liver donor...

journal_title：Protein & cell

authors： Chen X,Zeng F

更新日期：2011-03-01 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal or X-linked recessive disorder characterized by chromosomal instability, bone marrow failure, cancer susceptibility, and a profound sensitivity to agents that produce DNA interstrand cross-link (ICL). To date, 15 genes have been identified that, when mutated, result in FA or an FA-l...

journal_title：Protein & cell

authors： Su X,Huang J

更新日期：2011-09-01 00:00:00

abstract：:SARS coronavirus (SARS-CoV) develops an antagonistic mechanism by which to evade the antiviral activities of interferon (IFN). Previous studies suggested that SARS-CoV papain-like protease (PLpro) inhibits activation of the IRF3 pathway, which would normally elicit a robust IFN response, but the mechanism(s) used by S...

journal_title：Protein & cell

authors： Chen X,Yang X,Zheng Y,Yang Y,Xing Y,Chen Z

更新日期：2014-05-01 00:00:00

abstract：:Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious k...

journal_title：Protein & cell

authors： Liang P,Xu Y,Zhang X,Ding C,Huang R,Zhang Z,Lv J,Xie X,Chen Y,Li Y,Sun Y,Bai Y,Songyang Z,Ma W,Zhou C,Huang J

更新日期：2015-05-01 00:00:00

abstract：:The fungus Trichophyton schoenleinii (T. schoenleinii) is the causative agent of Trichophytosis and Tinea favosa of the scalp in certain regions of Eurasia and Africa. Human innate immune system plays an important role in combating with various pathogens including fungi. The inflammasome is one of the most critical ar...

journal_title：Protein & cell

authors： Li H,Wu S,Mao L,Lei G,Zhang L,Lu A,An L,Yang G,Abliz P,Meng G

更新日期：2013-07-01 00:00:00

abstract：:Thymic epithelial cells (TECs) are one of the most important components in thymic microenvironment supporting thymocyte development and maturation. TECs, composed of cortical and medullary TECs, are derived from a common bipotent progenitor, mediating thymocyte positive and negative selections. Multiple levels of sign...

journal_title：Protein & cell

authors： Sun L,Luo H,Li H,Zhao Y

更新日期：2013-05-01 00:00:00

abstract：:Dendritic cells (DCs) comprise two functionally distinct subsets: plasmacytoid DCs (pDCs) and myeloid DCs (mDCs). pDCs are specialized in rapid and massive secretion of type I interferon (IFN-I) in response to nucleic acids through Toll like receptor (TLR)-7 or TLR-9. In this report, we characterized a CD56(+) DC popu...

journal_title：Protein & cell

authors： Yu H,Zhang P,Yin X,Yin Z,Shi Q,Cui Y,Liu G,Wang S,Piccaluga PP,Jiang T,Zhang L

更新日期：2015-04-01 00:00:00

abstract：:Arrestins are soluble relatively small 44-46 kDa proteins that specifically bind hundreds of active phosphorylated GPCRs and dozens of non-receptor partners. There are binding partners that demonstrate preference for each of the known arrestin conformations: free, receptor-bound, and microtubule-bound. Recent evidence...

journal_title：Protein & cell

authors： Gurevich VV,Gurevich EV,Uversky VN

更新日期：2018-12-01 00:00:00

abstract：:While human induced pluripotent stem cells (hiPSCs) have promising applications in regenerative medicine, most of the hiPSC lines available today are not suitable for clinical applications due to contamination with nonhuman materials, such as sialic acid, and potential pathogens from animal-product-containing cell cul...

journal_title：Protein & cell

authors： Wang Q,Mou X,Cao H,Meng Q,Ma Y,Han P,Jiang J,Zhang H,Ma Y

更新日期：2012-01-01 00:00:00

abstract：:Hearing impairment (HI) affects 1/1000 children and over 2% of the aged population. We have previously reported that mutations in the gene encoding gap junction protein connexin-31 (C×31) are associated with HI. The pathological mechanism of the disease mutations remains unknown. Here, we show that expression of C×31 ...

journal_title：Protein & cell

authors： Xia K,Ma H,Xiong H,Pan Q,Huang L,Wang D,Zhang Z

更新日期：2010-10-01 00:00:00

abstract：:The inherent evolvability of promiscuous enzymes endows them with great potential to be artificially evolved for novel functions. Previously, we succeeded in transforming a promiscuous acylaminoacyl peptidase (apAAP) from the hyperthermophilic archaeon Aeropyrum pernix K1 into a specific carboxylesterase by making a s...

journal_title：Protein & cell

authors： Liu C,Yang G,Wu L,Tian G,Zhang Z,Feng Y

更新日期：2011-06-01 00:00:00

abstract：:The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly supervised, providing a fundamental mechanism of host defense. Pathogeni...

journal_title：Protein & cell

authors： Xia P,Wang S,Gao P,Gao G,Fan Z

更新日期：2016-11-01 00:00:00