Abstract:
:Precision medicine emerges as a new approach that takes into account individual variability. Successful realization of precision medicine requires disease models that are able to incorporate personalized disease information and recapitulate disease development processes at the molecular, cellular and organ levels. With recent development in stem cell field, a variety of tissue organoids can be derived from patient specific pluripotent stem cells and adult stem cells. In combination with the state-of-the-art genome editing tools, organoids can be further engineered to mimic disease-relevant genetic and epigenetic status of a patient. This has therefore enabled a rapid expansion of sophisticated in vitro disease models, offering a unique system for fundamental and biomedical research as well as the development of personalized medicine. Here we summarize some of the latest advances and future perspectives in engineering stem cell organoids for human disease modeling.
journal_name
Protein Celljournal_title
Protein & cellauthors
Sun Y,Ding Qdoi
10.1007/s13238-016-0368-0subject
Has Abstractpub_date
2017-05-01 00:00:00pages
315-327issue
5eissn
1674-800Xissn
1674-8018pii
10.1007/s13238-016-0368-0journal_volume
8pub_type
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