Genome engineering of stem cell organoids for disease modeling.

abstract：:The self-renewal and multipotent potentials in neural stem cells (NSCs) maintain the normal physiological functions of central nervous system (CNS). The abnormal differentiation of NSCs would lead to CNS disorders. However, the mechanisms of how NSCs differentiate into astrocytes, oligodendrocytes (OLs) and neurons ar...

journal_title：Protein & cell

authors： Wang K,Wang H,Wang J,Xie Y,Chen J,Yan H,Liu Z,Wen T

更新日期：2012-03-01 00:00:00

abstract：:Flea-borne transmission is a recent evolutionary adaptation that distinguishes the deadly Yersinia pestis from its progenitor Y. Pseudotuberculosis, a mild pathogen transmitted via the food-borne route. Y. Pestis synthesizes biofilms in the flea gut, which is important for fleaborne transmission. Yersinia biofilms are...

journal_title：Protein & cell

authors： Zhou D,Yang R

更新日期：2011-03-01 00:00:00

abstract：:ATP-sensitive potassium channels (KATP) are energy sensors on the plasma membrane. By sensing the intracellular ADP/ATP ratio of β-cells, pancreatic KATP channels control insulin release and regulate metabolism at the whole body level. They are implicated in many metabolic disorders and diseases and are therefore impo...

journal_title：Protein & cell

authors： Wu JX,Ding D,Wang M,Kang Y,Zeng X,Chen L

更新日期：2018-06-01 00:00:00

abstract：:In the original publication the PDB numbers were not cited. ...

journal_title：Protein & cell

authors： Yu J,Zhang B,Zhang Y,Xu CQ,Zhuo W,Ge J,Li J,Gao N,Li Y,Yang M

更新日期：2019-07-01 00:00:00

abstract：:The fruit fly, Drosophila melanogaster, is able to discriminate visual landmarks and form visual long-term memory in a flight simulator. Studies focused on the molecular mechanism of long-term memory have shown that memory formation requires mRNA transcription and protein synthesis. However, little is known about the ...

journal_title：Protein & cell

authors： Jiang H,Hou Q,Gong Z,Liu L

更新日期：2011-03-01 00:00:00

abstract：:Dementia is a comprehensive category of brain diseases that is great enough to affect a person's daily functioning. The most common type of dementia is Alzheimer's disease, which makes most of cases. New researches indicate that gastrointestinal tract microbiota are directly linked to dementia pathogenesis through tri...

journal_title：Protein & cell

authors： Alkasir R,Li J,Li X,Jin M,Zhu B

更新日期：2017-02-01 00:00:00

abstract：:Gene mutation (e.g. substitution, insertion and deletion) and related phenotype information are important biomedical knowledge. Many biomedical databases (e.g. OMIM) incorporate such data. However, few studies have examined the quality of this data. In the current study, we examined the quality of protein single-point...

journal_title：Protein & cell

authors： Li Z,Ying B,Liu X,Zhang X,Yu H

更新日期：2012-03-01 00:00:00

abstract：:The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly supervised, providing a fundamental mechanism of host defense. Pathogeni...

journal_title：Protein & cell

authors： Xia P,Wang S,Gao P,Gao G,Fan Z

更新日期：2016-11-01 00:00:00

abstract：:Histone deacetylase 6 (HDAC6), a predominantly cytoplasmic protein deacetylase, participates in a wide range of cellular processes through its deacetylase activity. However, the diverse functions of HDAC6 cannot be fully elucidated with its known substrates. In an attempt to explore the substrate diversity of HDAC6, w...

journal_title：Protein & cell

authors： Zhang L,Liu S,Liu N,Zhang Y,Liu M,Li D,Seto E,Yao TP,Shui W,Zhou J

更新日期：2015-01-01 00:00:00

abstract：:Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious k...

journal_title：Protein & cell

authors： Liang P,Xu Y,Zhang X,Ding C,Huang R,Zhang Z,Lv J,Xie X,Chen Y,Li Y,Sun Y,Bai Y,Songyang Z,Ma W,Zhou C,Huang J

更新日期：2015-05-01 00:00:00

abstract：:Hearing impairment (HI) affects 1/1000 children and over 2% of the aged population. We have previously reported that mutations in the gene encoding gap junction protein connexin-31 (C×31) are associated with HI. The pathological mechanism of the disease mutations remains unknown. Here, we show that expression of C×31 ...

journal_title：Protein & cell

authors： Xia K,Ma H,Xiong H,Pan Q,Huang L,Wang D,Zhang Z

更新日期：2010-10-01 00:00:00

abstract：:The sigma-1 receptor is a molecular chaperone protein highly enriched in the brain. Recent studies linked it to many diseases, such as drug addition, Alzheimer's disease, stroke, depression, and even cancer. Sigma-1 receptor is enriched in lipid rafts, which are membrane microdomains essential in signaling processes. ...

journal_title：Protein & cell

authors： Li J,Liu B,Gao X,Ma Z,CaoSong T,Mei YA,Zheng Y

更新日期：2012-02-01 00:00:00

abstract：:Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on the epigenetic bio-markers to predict aging rate with high accuracy. This progress enlightens us in many aspect...

journal_title：Protein & cell

authors： Li M,Liu W,Yuan T,Bai R,Liu GH,Zhang W,Qu J

更新日期：2013-10-01 00:00:00

abstract：:With the smooth move towards the coming expected clinical reports of anticancer pharmaceutical molecules targeting telomeres and telomerase, and also with the exciting success in the extension of lifespan by regulating telomerase activity without increased onset of oncogenesis in laboratory mouse models (Garcia-Cao et...

journal_title：Protein & cell

authors： Lu Y,Wei B,Zhang T,Chen Z,Ye J

更新日期：2013-08-01 00:00:00

abstract：:Studies on chronic myeloid leukemia (CML) have served as a paradigm for cancer research and therapy. These studies involve the identification of the first cancer-associated chromosomal abnormality and the subsequent development of tyrosine kinase inhibitors (TKIs) that inhibit BCR-ABL kinase activity in CML. It become...

journal_title：Protein & cell

authors： Zhang H,Li S

更新日期：2013-03-01 00:00:00

abstract：:FcγRIIB, the only inhibitory IgG Fc receptor, functions to suppress the hyper-activation of immune cells. Numerous studies have illustrated its inhibitory function through the ITIM motif in the cytoplasmic tail of FcγRIIB. However, later studies revealed that in addition to the ITIM, the transmembrane (TM) domain of F...

journal_title：Protein & cell

authors： Wang J,Li Z,Xu L,Yang H,Liu W

更新日期：2018-12-01 00:00:00

abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary cerebrovascular disease caused by a NOTCH3 mutation. However, the underlying cellular and molecular mechanisms remain unidentified. Here, we generated non-integrative induced pluripotent stem cells...

journal_title：Protein & cell

authors： Ling C,Liu Z,Song M,Zhang W,Wang S,Liu X,Ma S,Sun S,Fu L,Chu Q,Belmonte JCI,Wang Z,Qu J,Yuan Y,Liu GH

更新日期：2019-04-01 00:00:00

abstract：:This study was designed to evaluate ERK5 expression in lung cancer and malignant melanoma progression and to ascertain the involvement of ERK5 signaling in lung cancer and melanoma. We show that ERK5 expression is abundant in human lung cancer samples, and elevated ERK5 expression in lung cancer was linked to the acqu...

journal_title：Protein & cell

authors： Jiang W,Cai F,Xu H,Lu Y,Chen J,Liu J,Cao N,Zhang X,Chen X,Huang Q,Zhuang H,Hua ZC

更新日期：2020-11-01 00:00:00

abstract：:Plexins and semaphorins are a large family of proteins that are involved in cell movement and response. The importance of plexins and semaphorins has been emphasized by their discovery in many organ systems including the nervous (Nkyimbeng-Takwi and Chapoval, 2011; McCormick and Leipzig, 2012; Yaron and Sprinzak, 2012...

journal_title：Protein & cell

authors： Roney K,Holl E,Ting J

更新日期：2013-01-01 00:00:00

abstract：:Osteosarcoma is the most common primary sarcoma of bone, and it is a leading cause of cancer death among adolescents and young adults. However, the molecular mechanism underlying osteosarcoma carcinogenesis remains poorly understood. Recently, cyclin-dependent kinase 6 (CDK6) was identified as an important oncogene. W...

journal_title：Protein & cell

authors： Zhu K,Liu L,Zhang J,Wang Y,Liang H,Fan G,Jiang Z,Zhang CY,Chen X,Zhou G

更新日期：2016-06-01 00:00:00

abstract：:Progranulin (PGRN) is a growth factor implicated in various pathophysiological processes, including wound healing, inflammation, tumorigenesis, and neurodegeneration. It was previously reported that PGRN binds to tumor necrosis factor receptors (TNFR) and has therapeutic effects in inflammatory arthritis (Tang et. al,...

journal_title：Protein & cell

authors： Wang BC,Liu H,Talwar A,Jian J

更新日期：2015-11-01 00:00:00

abstract：:Siva-1, as a p53-inducible gene, has been shown to induce extensive apoptosis in a number of different cell lines. Recent evidence suggests that Siva-1 functions as a part of the auto-regulatory feedback loop that restrains p53 through facilitating Mdm2-mediated p53 degradation. Also, Siva-1 plays an important role in...

journal_title：Protein & cell

authors： Mei Y,Wu M

更新日期：2012-02-01 00:00:00

abstract：:Macroautophagy is an evolutionarily conserved intracellular degradation system used by life ranging from yeasts to mammals. The core autophagic machinery is composed of ATG (autophagy-related) protein constituents. One particular member of the ATG protein family, Atg7, has been the focus of recent research. Atg7 acts ...

journal_title：Protein & cell

authors： Xiong J

更新日期：2015-10-01 00:00:00

abstract：:Dehydration is one of the key steps in the biosynthesis of mycolic acids and is vital to the growth of Mycobacterium tuberculosis (Mtb). Consequently, stalling dehydration cures tuberculosis (TB). Clinically used anti-TB drugs like thiacetazone (TAC) and isoxyl (ISO) as well as flavonoids inhibit the enzyme activity o...

journal_title：Protein & cell

authors： Dong Y,Qiu X,Shaw N,Xu Y,Sun Y,Li X,Li J,Rao Z

更新日期：2015-07-01 00:00:00

abstract：:Cockayne syndrome (CS) is a rare autosomal recessive inherited disorder characterized by a variety of clinical features, including increased sensitivity to sunlight, progressive neurological abnormalities, and the appearance of premature aging. However, the pathogenesis of CS remains unclear due to the limitations of ...

journal_title：Protein & cell

authors： Wang S,Min Z,Ji Q,Geng L,Su Y,Liu Z,Hu H,Wang L,Zhang W,Suzuiki K,Huang Y,Zhang P,Tang TS,Qu J,Yu Y,Liu GH,Qiao J

更新日期：2020-01-01 00:00:00

abstract：:Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent pro...

journal_title：Protein & cell

authors： Zhan Y,Wu L

更新日期：2012-07-01 00:00:00

abstract：:S-Nitros(yl)ation is a ubiquitous redox-based post-translational modification of protein cysteine thiols by nitric oxide or its derivatives, which transduces the bioactivity of nitric oxide (NO) by regulation of protein conformation, activity, stability, localization and protein-protein interactions. These years, more...

journal_title：Protein & cell

authors： Zhang X,Huang B,Zhang L,Zhang Y,Zhao Y,Guo X,Qiao X,Chen C

更新日期：2012-12-01 00:00:00

abstract：:Oral mucositis, a severe oral ulceration, is a common toxic effect of radio- or chemoradio-therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatment. Among cancer patients, at least 40% and up to 70%, of individuals treated with standard chemotherapy regimens or upper-body rad...

journal_title：Protein & cell

authors： Bian L,Han G,Zhao CW,Garl PJ,Wang XJ

更新日期：2015-03-01 00:00:00

abstract：:The liver is the largest internal organ in mammals, and is important for the maintenance of normal physiological functions of other tissues and organs. Hepatitis, cirrhosis, liver cancer and other chronic liver diseases are serious threats to human health, and these problems are compounded by a scarcity of liver donor...

journal_title：Protein & cell

authors： Chen X,Zeng F

更新日期：2011-03-01 00:00:00

abstract：:CUE domain-containing 2 (CUEDC2) is a protein involved in the regulation of the cell cycle, inflammation, and tumorigenesis and is highly expressed in many types of tumors. CUEDC2 is phosphorylated by Cdk1 during mitosis and promotes the release of anaphase-promoting complex or cyclosome (APC/C) from checkpoint inhibi...

journal_title：Protein & cell

authors： Man J,Zhang X

更新日期：2011-09-01 00:00:00