Genome engineering of stem cell organoids for disease modeling.


:Precision medicine emerges as a new approach that takes into account individual variability. Successful realization of precision medicine requires disease models that are able to incorporate personalized disease information and recapitulate disease development processes at the molecular, cellular and organ levels. With recent development in stem cell field, a variety of tissue organoids can be derived from patient specific pluripotent stem cells and adult stem cells. In combination with the state-of-the-art genome editing tools, organoids can be further engineered to mimic disease-relevant genetic and epigenetic status of a patient. This has therefore enabled a rapid expansion of sophisticated in vitro disease models, offering a unique system for fundamental and biomedical research as well as the development of personalized medicine. Here we summarize some of the latest advances and future perspectives in engineering stem cell organoids for human disease modeling.


Protein Cell


Protein & cell


Sun Y,Ding Q




Has Abstract


2017-05-01 00:00:00














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    pub_type: 杂志文章


    authors: Li M,Shu HB

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    journal_title:Protein & cell

    pub_type: 杂志文章,评审


    authors: Wang X,Mathieu M,Brezski RJ

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    pub_type: 杂志文章,评审


    authors: Kumar M,Nath S,Prasad HK,Sharma GD,Li Y

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    authors: Zhang X,Huang B,Zhang L,Zhang Y,Zhao Y,Guo X,Qiao X,Chen C

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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


    authors: Zhan Y,Wu L

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    authors: Xu Y,Ye H,Shen Y,Xu Q,Zhu L,Liu J,Wu JY

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    pub_type: 杂志文章


    authors: Zhang L,Liu S,Liu N,Zhang Y,Liu M,Li D,Seto E,Yao TP,Shui W,Zhou J

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    pub_type: 杂志文章


    authors: Wang K,Wang H,Wang J,Xie Y,Chen J,Yan H,Liu Z,Wen T

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    journal_title:Protein & cell

    pub_type: 杂志文章,评审


    authors: Xiong J

    更新日期:2015-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Ma C,Yan K,Tan D,Li N,Zhang Y,Yuan Y,Li Z,Dong MQ,Lei J,Gao N

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    authors: Xiao J,Xiong Y,Yang LT,Wang JQ,Zhou ZM,Dong LW,Shi XJ,Zhao X,Luo J,Song BL

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Ma Y,Tong X,Xu X,Li X,Lou Z,Rao Z

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  • Proteomic and transcriptomic analysis of visual long-term memory in Drosophila melanogaster.

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    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Jiang H,Hou Q,Gong Z,Liu L

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    authors: Jiang W,Cai F,Xu H,Lu Y,Chen J,Liu J,Cao N,Zhang X,Chen X,Huang Q,Zhuang H,Hua ZC

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    authors: Zhang H,Zheng B,Gao R,Feng Y

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    journal_title:Protein & cell

    pub_type: 杂志文章,评审


    authors: Feng Y,Yan T,He Z,Zhai Q

    更新日期:2010-03-01 00:00:00

  • Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.

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    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Xiong R,Zhang L,Li S,Sun Y,Ding M,Wang Y,Zhao Y,Wu Y,Shang W,Jiang X,Shan J,Shen Z,Tong Y,Xu L,Chen Y,Liu Y,Zou G,Lavillete D,Zhao Z,Wang R,Zhu L,Xiao G,Lan K,Li H,Xu K

    更新日期:2020-10-01 00:00:00

  • The evolving landscape in the therapy of acute myeloid leukemia.

    abstract::Acute myeloid leukemia (AML) is a heterogeneous clonal disorder of myeloid precursors arrested in their maturation, creating a diverse disease entity with a wide range of responses to historically standard treatment approaches. While significant progress has been made in characterizing and individualizing the disease ...

    journal_title:Protein & cell

    pub_type: 杂志文章,评审


    authors: Peloquin GL,Chen YB,Fathi AT

    更新日期:2013-10-01 00:00:00

  • Crystal structure of a novel non-Pfam protein PF2046 solved using low resolution B-factor sharpening and multi-crystal averaging methods.

    abstract::Sometimes crystals cannot diffract X-rays beyond 3.0 Å resolution due to the intrinsic flexibility associated with the protein. Low resolution diffraction data not only pose a challenge to structure determination, but also hamper interpretation of mechanistic details. Crystals of a 25.6 kDa non-Pfam, hypothetical prot...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Su J,Li Y,Shaw N,Zhou W,Zhang M,Xu H,Wang BC,Liu ZJ

    更新日期:2010-05-01 00:00:00

  • A novel xeno-free and feeder-cell-free system for human pluripotent stem cell culture.

    abstract::While human induced pluripotent stem cells (hiPSCs) have promising applications in regenerative medicine, most of the hiPSC lines available today are not suitable for clinical applications due to contamination with nonhuman materials, such as sialic acid, and potential pathogens from animal-product-containing cell cul...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Wang Q,Mou X,Cao H,Meng Q,Ma Y,Han P,Jiang J,Zhang H,Ma Y

    更新日期:2012-01-01 00:00:00

  • Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset.

    abstract::Dendritic cells (DCs) comprise two functionally distinct subsets: plasmacytoid DCs (pDCs) and myeloid DCs (mDCs). pDCs are specialized in rapid and massive secretion of type I interferon (IFN-I) in response to nucleic acids through Toll like receptor (TLR)-7 or TLR-9. In this report, we characterized a CD56(+) DC popu...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Yu H,Zhang P,Yin X,Yin Z,Shi Q,Cui Y,Liu G,Wang S,Piccaluga PP,Jiang T,Zhang L

    更新日期:2015-04-01 00:00:00

  • Effect of the microbial lipopeptide on tumor cell lines: apoptosis induced by disturbing the fatty acid composition of cell membrane.

    abstract::Microbial lipopeptides play an important role in apoptosis induction of tumor cells. However, there is little knowledge about the relationship between apoptosis induction and membrane fatty acids. The present study focused on the effects of lipopeptides produced by Bacillus subtilis HSO121 on Bcap-37 cell lines. 3-(4,...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Liu X,Tao X,Zou A,Yang S,Zhang L,Mu B

    更新日期:2010-06-01 00:00:00

  • Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding.

    abstract::Leukocyte immunoglobulin-like receptors (LILRs), also called CD85s, ILTs, or LIRs, are important mediators of immune activation and tolerance that contain tandem immunoglobulin (Ig)-like folds. There are 11 (in addition to two pseudogenes) LILRs in total, two with two Ig-like domains (D1D2) and the remaining nine with...

    journal_title:Protein & cell

    pub_type: 杂志文章


    authors: Nam G,Shi Y,Ryu M,Wang Q,Song H,Liu J,Yan J,Qi J,Gao GF

    更新日期:2013-10-01 00:00:00