Abstract:
:Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on the epigenetic bio-markers to predict aging rate with high accuracy. This progress enlightens us in many aspects particularly in applying this novel set of bio-markers on studying the mechanism of aging rate using adult tissue-specific stem cells, building up a potential quantitative model to explore the mechanism for other epigenetic factors like non-coding RNA, and understanding the principle and mechanism of 3D chromatin structure in epigenetic modulation.
journal_name
Protein Celljournal_title
Protein & cellauthors
Li M,Liu W,Yuan T,Bai R,Liu GH,Zhang W,Qu Jdoi
10.1007/s13238-013-3913-0subject
Has Abstractpub_date
2013-10-01 00:00:00pages
723-5issue
10eissn
1674-800Xissn
1674-8018journal_volume
4pub_type
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