Abstract:
:The nervous system is one of the most complicated organ systems in invertebrates and vertebrates. Down syndrome cell adhesion molecule (DSCAM) of the immunoglobulin (Ig) superfamily is expressed widely in the nervous system during embryonic development. Previous studies in Drosophila suggest that Dscam plays important roles in neural development including axon branching, dendritic tiling and cell spacing. However, the function of the mammalian DSCAM gene in the formation of the nervous system remains unclear. Here, we show that Dscam ( del17 ) mutant mice exhibit severe hydrocephalus, decreased motor function and impaired motor learning ability. Our data indicate that the mammalian DSCAM gene is critical for the formation of the central nervous system.
journal_name
Protein Celljournal_title
Protein & cellauthors
Xu Y,Ye H,Shen Y,Xu Q,Zhu L,Liu J,Wu JYdoi
10.1007/s13238-011-1072-8subject
Has Abstractpub_date
2011-08-01 00:00:00pages
647-55issue
8eissn
1674-800Xissn
1674-8018journal_volume
2pub_type
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