An examination of the OMIM database for associating mutation to a consensus reference sequence.

abstract：:The liver is the largest internal organ in mammals, and is important for the maintenance of normal physiological functions of other tissues and organs. Hepatitis, cirrhosis, liver cancer and other chronic liver diseases are serious threats to human health, and these problems are compounded by a scarcity of liver donor...

journal_title：Protein & cell

authors： Chen X,Zeng F

更新日期：2011-03-01 00:00:00

abstract：:Studies on chronic myeloid leukemia (CML) have served as a paradigm for cancer research and therapy. These studies involve the identification of the first cancer-associated chromosomal abnormality and the subsequent development of tyrosine kinase inhibitors (TKIs) that inhibit BCR-ABL kinase activity in CML. It become...

journal_title：Protein & cell

authors： Zhang H,Li S

更新日期：2013-03-01 00:00:00

abstract：:Human pluripotent stem cells (hPSCs) are an important system to study early human development, model human diseases, and develop cell replacement therapies. However, genetic manipulation of hPSCs is challenging and a method to simultaneously activate multiple genomic sites in a controllable manner is sorely needed. He...

journal_title：Protein & cell

authors： Guo J,Ma D,Huang R,Ming J,Ye M,Kee K,Xie Z,Na J

更新日期：2017-05-01 00:00:00

abstract：:The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly supervised, providing a fundamental mechanism of host defense. Pathogeni...

journal_title：Protein & cell

authors： Xia P,Wang S,Gao P,Gao G,Fan Z

更新日期：2016-11-01 00:00:00

abstract：:The self-renewal and multipotent potentials in neural stem cells (NSCs) maintain the normal physiological functions of central nervous system (CNS). The abnormal differentiation of NSCs would lead to CNS disorders. However, the mechanisms of how NSCs differentiate into astrocytes, oligodendrocytes (OLs) and neurons ar...

journal_title：Protein & cell

authors： Wang K,Wang H,Wang J,Xie Y,Chen J,Yan H,Liu Z,Wen T

更新日期：2012-03-01 00:00:00

abstract：:Recently, phage display technology has been announced as the recipient of Nobel Prize in Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and could be further enriched th...

journal_title：Protein & cell

authors： Saw PE,Song EW

更新日期：2019-11-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulation of glucose transporter 1 (GLUT1, SLC2A1), a key glycolytic gene to maintain pluripotency. By combining the g...

journal_title：Protein & cell

authors： Yu L,Ji KY,Zhang J,Xu Y,Ying Y,Mai T,Xu S,Zhang QB,Yao KT,Xu Y

更新日期：2019-09-01 00:00:00

abstract：:This study was designed to evaluate ERK5 expression in lung cancer and malignant melanoma progression and to ascertain the involvement of ERK5 signaling in lung cancer and melanoma. We show that ERK5 expression is abundant in human lung cancer samples, and elevated ERK5 expression in lung cancer was linked to the acqu...

journal_title：Protein & cell

authors： Jiang W,Cai F,Xu H,Lu Y,Chen J,Liu J,Cao N,Zhang X,Chen X,Huang Q,Zhuang H,Hua ZC

更新日期：2020-11-01 00:00:00

abstract：:While the majority of all human cancers counteract telomere shortening by expressing telomerase, ~15% of all cancers maintain telomere length by a telomerase-independent mechanism known as alternative lengthening of telomeres (ALT). Here, we show that high load of intrinsic DNA damage is present in ALT cancer cells, l...

journal_title：Protein & cell

authors： Ge Y,Wu S,Zhang Z,Li X,Li F,Yan S,Liu H,Huang J,Zhao Y

更新日期：2019-11-01 00:00:00

abstract：:We recently found that growth factor receptor-bound (Grb) protein 14 is a novel physiological modulator of photoreceptor specific cyclic nucleotide-gated channel alpha subunit (CNGA1). Grb14 promotes the CNG channel closure through its Ras-associating (RA) domain. In the current study we show that this RA domain-media...

journal_title：Protein & cell

authors： Gupta VK,Rajala A,Rodgers KK,Rajala RV

更新日期：2011-11-01 00:00:00

abstract：:S-Nitros(yl)ation is a ubiquitous redox-based post-translational modification of protein cysteine thiols by nitric oxide or its derivatives, which transduces the bioactivity of nitric oxide (NO) by regulation of protein conformation, activity, stability, localization and protein-protein interactions. These years, more...

journal_title：Protein & cell

authors： Zhang X,Huang B,Zhang L,Zhang Y,Zhao Y,Guo X,Qiao X,Chen C

更新日期：2012-12-01 00:00:00

abstract：:The cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in host defense by sensing cytosolic DNA derived from microbial pathogens or mis-located cellular DNA. Upon DNA binding, cGAS utilizes GTP and ATP as substrates to synthesize cGAMP, leading to MITA-mediated innate immune response. In this study, we ident...

journal_title：Protein & cell

authors： Li M,Shu HB

更新日期：2020-08-01 00:00:00

abstract：:Leukocyte immunoglobulin-like receptors (LILRs), also called CD85s, ILTs, or LIRs, are important mediators of immune activation and tolerance that contain tandem immunoglobulin (Ig)-like folds. There are 11 (in addition to two pseudogenes) LILRs in total, two with two Ig-like domains (D1D2) and the remaining nine with...

journal_title：Protein & cell

authors： Nam G,Shi Y,Ryu M,Wang Q,Song H,Liu J,Yan J,Qi J,Gao GF

更新日期：2013-10-01 00:00:00

abstract：:The nervous system is one of the most complicated organ systems in invertebrates and vertebrates. Down syndrome cell adhesion molecule (DSCAM) of the immunoglobulin (Ig) superfamily is expressed widely in the nervous system during embryonic development. Previous studies in Drosophila suggest that Dscam plays important...

journal_title：Protein & cell

authors： Xu Y,Ye H,Shen Y,Xu Q,Zhu L,Liu J,Wu JY

更新日期：2011-08-01 00:00:00

abstract：:Sometimes crystals cannot diffract X-rays beyond 3.0 Å resolution due to the intrinsic flexibility associated with the protein. Low resolution diffraction data not only pose a challenge to structure determination, but also hamper interpretation of mechanistic details. Crystals of a 25.6 kDa non-Pfam, hypothetical prot...

journal_title：Protein & cell

authors： Su J,Li Y,Shaw N,Zhou W,Zhang M,Xu H,Wang BC,Liu ZJ

更新日期：2010-05-01 00:00:00

abstract：:Osteosarcoma is the most common primary sarcoma of bone, and it is a leading cause of cancer death among adolescents and young adults. However, the molecular mechanism underlying osteosarcoma carcinogenesis remains poorly understood. Recently, cyclin-dependent kinase 6 (CDK6) was identified as an important oncogene. W...

journal_title：Protein & cell

authors： Zhu K,Liu L,Zhang J,Wang Y,Liang H,Fan G,Jiang Z,Zhang CY,Chen X,Zhou G

更新日期：2016-06-01 00:00:00

abstract：:With the smooth move towards the coming expected clinical reports of anticancer pharmaceutical molecules targeting telomeres and telomerase, and also with the exciting success in the extension of lifespan by regulating telomerase activity without increased onset of oncogenesis in laboratory mouse models (Garcia-Cao et...

journal_title：Protein & cell

authors： Lu Y,Wei B,Zhang T,Chen Z,Ye J

更新日期：2013-08-01 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal or X-linked recessive disorder characterized by chromosomal instability, bone marrow failure, cancer susceptibility, and a profound sensitivity to agents that produce DNA interstrand cross-link (ICL). To date, 15 genes have been identified that, when mutated, result in FA or an FA-l...

journal_title：Protein & cell

authors： Su X,Huang J

更新日期：2011-09-01 00:00:00

abstract：:Treatment of latent tuberculosis infection remains an important goal of global TB eradication. To this end, targets that are essential for intracellular survival of Mycobacterium tuberculosis are particularly attractive. Arylamine N-acetyltransferase (NAT) represents such a target as it is, along with the enzymes enco...

journal_title：Protein & cell

authors： Abuhammad AM,Lowe ED,Fullam E,Noble M,Garman EF,Sim E

更新日期：2010-04-01 00:00:00

abstract：:A chimeric protein called Wallerian degeneration slow (Wld(S)) was first discovered in a spontaneous mutant strain of mice that exhibited delayed Wallerian degeneration. This provides a useful tool in elucidating the mechanisms of axon degeneration. Over-expression of Wld(S) attenuates the axon degeneration that is as...

journal_title：Protein & cell

authors： Feng Y,Yan T,He Z,Zhai Q

更新日期：2010-03-01 00:00:00

abstract：:Alzheimer's disease (AD) pathogenesis is characterized by senile plaques in the brain and evidence of oxidative damage. Oxidative stress may precede plaque formation in AD; however, the link between oxidative damage and plaque formation remains unknown. Presenilins are transmembrane proteins in which mutations lead to...

journal_title：Protein & cell

authors： Wangler MF,Reiter LT,Zimm G,Trimble-Morgan J,Wu J,Bier E

更新日期：2011-07-01 00:00:00

abstract：:In the original publication the PDB numbers were not cited. ...

journal_title：Protein & cell

authors： Yu J,Zhang B,Zhang Y,Xu CQ,Zhuo W,Ge J,Li J,Gao N,Li Y,Yang M

更新日期：2019-07-01 00:00:00

abstract：:Flea-borne transmission is a recent evolutionary adaptation that distinguishes the deadly Yersinia pestis from its progenitor Y. Pseudotuberculosis, a mild pathogen transmitted via the food-borne route. Y. Pestis synthesizes biofilms in the flea gut, which is important for fleaborne transmission. Yersinia biofilms are...

journal_title：Protein & cell

authors： Zhou D,Yang R

更新日期：2011-03-01 00:00:00

abstract：:Siva-1, as a p53-inducible gene, has been shown to induce extensive apoptosis in a number of different cell lines. Recent evidence suggests that Siva-1 functions as a part of the auto-regulatory feedback loop that restrains p53 through facilitating Mdm2-mediated p53 degradation. Also, Siva-1 plays an important role in...

journal_title：Protein & cell

authors： Mei Y,Wu M

更新日期：2012-02-01 00:00:00

abstract：:SARS coronavirus (SARS-CoV) develops an antagonistic mechanism by which to evade the antiviral activities of interferon (IFN). Previous studies suggested that SARS-CoV papain-like protease (PLpro) inhibits activation of the IRF3 pathway, which would normally elicit a robust IFN response, but the mechanism(s) used by S...

journal_title：Protein & cell

authors： Chen X,Yang X,Zheng Y,Yang Y,Xing Y,Chen Z

更新日期：2014-05-01 00:00:00

abstract：:CUE domain-containing 2 (CUEDC2) is a protein involved in the regulation of the cell cycle, inflammation, and tumorigenesis and is highly expressed in many types of tumors. CUEDC2 is phosphorylated by Cdk1 during mitosis and promotes the release of anaphase-promoting complex or cyclosome (APC/C) from checkpoint inhibi...

journal_title：Protein & cell

authors： Man J,Zhang X

更新日期：2011-09-01 00:00:00

abstract：:The sigma-1 receptor is a molecular chaperone protein highly enriched in the brain. Recent studies linked it to many diseases, such as drug addition, Alzheimer's disease, stroke, depression, and even cancer. Sigma-1 receptor is enriched in lipid rafts, which are membrane microdomains essential in signaling processes. ...

journal_title：Protein & cell

authors： Li J,Liu B,Gao X,Ma Z,CaoSong T,Mei YA,Zheng Y

更新日期：2012-02-01 00:00:00

abstract：:New anti-tubercular drugs and drug targets are urgently needed to reduce the time for treatment and also to identify agents that will be effective against Mycobacterium tuberculosis persisting intracellularly. Mycobacteria have a unique cell wall. Deletion of the gene for arylamine N-acetyltransferase (NAT) decreases ...

journal_title：Protein & cell

authors： Westwood IM,Bhakta S,Russell AJ,Fullam E,Anderton MC,Kawamura A,Mulvaney AW,Vickers RJ,Bhowruth V,Besra GS,Lalvani A,Davies SG,Sim E

更新日期：2010-01-01 00:00:00

abstract：:T-cell receptor (TCR)-engineered T cells are a novel option for adoptive cell therapy used for the treatment of several advanced forms of cancer. Work using TCR-engineered T cells began more than two decades ago, with numerous preclinical studies showing that such cells could mediate tumor lysis and eradication. The s...

journal_title：Protein & cell

authors： Ping Y,Liu C,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：:Dementia is a comprehensive category of brain diseases that is great enough to affect a person's daily functioning. The most common type of dementia is Alzheimer's disease, which makes most of cases. New researches indicate that gastrointestinal tract microbiota are directly linked to dementia pathogenesis through tri...

journal_title：Protein & cell

authors： Alkasir R,Li J,Li X,Jin M,Zhu B

更新日期：2017-02-01 00:00:00