Abstract：
:Bacteria commonly exist in high cell density populations, making them prone to viral predation and horizontal gene transfer (HGT) through transformation and conjugation. To combat these invaders, bacteria possess an arsenal of defenses, such as CRISPR-Cas adaptive immunity. Many bacterial populations coordinate their behavior as cell density increases, using quorum sensing (QS) signaling. In this study, we demonstrate that QS regulation results in increased expression of the type I-E, I-F, and III-A CRISPR-Cas systems in Serratia cells in high-density populations. Strains unable to communicate via QS were less effective at defending against invaders targeted by any of the three CRISPR-Cas systems. Additionally, the acquisition of immunity by the type I-E and I-F systems was impaired in the absence of QS signaling. We propose that bacteria can use chemical communication to modulate the balance between community-level defense requirements in high cell density populations and host fitness costs of basal CRISPR-Cas activity.
journal_name
Mol Celljournal_title
Molecular cellauthors
Patterson AG,Jackson SA,Taylor C,Evans GB,Salmond GPC,Przybilski R,Staals RHJ,Fineran PCdoi
10.1016/j.molcel.2016.11.012subject
Has Abstractpub_date
2016-12-15 00:00:00pages
1102-1108issue
6eissn
1097-2765issn
1097-4164pii
S1097-2765(16)30720-1journal_volume
64pub_type
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