Abstract:
:Optical coherence tomography (OCT)-based elasticity imaging can map soft tissue elasticity based on speckle-tracking of elastic wave propagation using highly sensitive phase measurements of OCT signals. Using a fixed elastic wave source and moving detection, current imaging sequences have difficulty in reconstructing tissue elasticity within speckle-free regions, for example, within the crystalline lens of the eye. We present a moving acoustic radiation force imaging sequence to reconstruct elastic properties within a speckle-free region by tracking elastic wave propagation from multiple laterally moving sources across the field of view. We demonstrate the proposed strategy using heterogeneous and partial speckle-free tissue-mimicking phantoms. Harder inclusions within the speckle-free region can be detected, and the contrast-to-noise ratio slightly enhanced compared to current OCE imaging sequences. The results suggest that a moving source approach may be appropriate for OCE studies within the large speckle-free regions of the crystalline lens.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Hsieh BY,Song S,Nguyen TM,Yoon SJ,Shen TT,Wang RK,O'Donnell Mdoi
10.1117/1.JBO.21.11.116006subject
Has Abstractpub_date
2016-11-01 00:00:00pages
116006issue
11eissn
1083-3668issn
1560-2281pii
2583240journal_volume
21pub_type
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