MiR-15a-5p regulates viability and matrix degradation of human osteoarthritis chondrocytes via targeting VEGFA.

abstract：:Environmental factors during fetal life program the health outcomes regarding many diseases in future life. This idea has been supported by worldwide epidemiological studies, but the underlying mechanisms are still poorly understood. Three questions should be answered. (i) Does a common underlying cause of ordinary pa...

journal_title：Bioscience trends

authors： Basovich SN

更新日期：2013-02-01 00:00:00

abstract：:Since the first outbreak of human infection with avian influenza A (H7N9) virus was identified in 2013, five seasonal outbreaks have occurred in China. The fifth outbreak started earlier than usual. A sudden increase in cases of human infection with avian influenza A (H7N9) virus has been reported in China since Septe...

journal_title：Bioscience trends

authors： Shen Y,Lu H

更新日期：2017-03-22 00:00:00

abstract：:Obesity has become a severe public health problem worldwide. Crocin, a natural product, has been reported to have a number of pharmacological activities, including anti-inflammatory, anti-cancer, neuroprotective, antihypertensive, and cardioprotective action. The aims of the current study were to identify the benefici...

journal_title：Bioscience trends

authors： Gu M,Luo L,Fang K

更新日期：2018-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the 2-day seminar in 2 consecutive years respectively for community health professionals. We prepared the child-rearing support manual (CRSM) and conducted a seminar program to improve skills to provide mental assessments and postnatal care support for mothers and their famili...

journal_title：Bioscience trends

authors： Kamibeppu K,Furuta M,Yamashita H,Sugishita K,Suzumiya H,Yoshida K

更新日期：2009-02-01 00:00:00

abstract：:MLS128 is an anti-carbohydrate monoclonal antibody (mAb) that binds three or two consecutive Tn-antigens. MLS128 bound 110-210 kDa glycoproteins (GPs) and inhibited the growth of LS180 and HT29 colon and MCF-7 breast cancer cells. One possible mechanism of MLS128's inhibition of growth may be via insulin-like growth f...

journal_title：Bioscience trends

authors： Zamri N,Masuda N,Oura F,Yajima Y,Nakada H,Fujita-Yamaguchi Y

更新日期：2012-12-01 00:00:00

abstract：:Bu-Shen-Ning-Xin decoction (BSNXD), a traditional Chinese medicine, has been used to prevent and treat age-related diseases such as postmenopausal osteoporosis (PMO) for decades. This study sought to investigate the underlying mechanisms of BSNXD in terms of receptor activation of nuclear factor κB ligand (RANKL)-indu...

journal_title：Bioscience trends

authors： Gui Y,Qiu X,Xu Y,Li D,Wang L

更新日期：2015-06-01 00:00:00

abstract：:Tissue engineering has been one of the most promising strategies for the regeneration of impaired tissue. Application of three-dimensional porous scaffolds has greatly improved the outcome of tissue engineering in many categories. Cell seeding is one of the key issues in tissue regeneration. It depends not only on the...

journal_title：Bioscience trends

authors： Dai W,Dong J,Chen G,Uemura T

更新日期：2009-12-01 00:00:00

abstract：:To determine the feasibility of using a nanoparticle immunoassay for clinical therapeutic drug monitoring (TDM) of docetaxel concentrations, a sensitive and simple method of liquid chromatography-tandem mass spectrometry (LC-MS/MS) was established to measure the docetaxel concentration in human plasma and the results ...

journal_title：Bioscience trends

authors： Geng C,Li P,Chen X,Yuan G,Guo N,Liu H,Zhang R,Guo R

更新日期：2017-05-23 00:00:00

abstract：:Benign portal vein stenosis is a rare complication following pancreaticoduodenectomy. Because a direct surgical approach to the portal vein is difficult due to severe adhesions following pancreaticoduodenectomy, portal vein stent placement is considered a good treatment option. Herein, we report 3 cases of severe port...

journal_title：Bioscience trends

authors： Sawai Y,Kokudo T,Sakamoto Y,Takao H,Kazami Y,Nishioka Y,Akamatsu N,Arita J,Kaneko J,Hasegawa K

更新日期：2019-01-22 00:00:00

abstract：:Malignant mesothelioma (MM) is an insidious, lethal asbestos-related cancer that is poorly responsive to current treatments. Specific and sensitive biomarkers providing early MM diagnosis in exposed subjects, who are at high-risk of developing it, are sorely needed. MicroRNAs (miRNAs) are endogenous, non-coding, small...

journal_title：Bioscience trends

authors： Micolucci L,Rippo MR,Olivieri F,Procopio AD

更新日期：2017-03-22 00:00:00

abstract：:We identified the prevalence of depression and quality of life (QOL) of Japanese children with childhood cancer after discharge using the Birleson Depression Self-rating Scale for Children (DSRS-C) and the Pediatric Quality of Life Inventory (PedsQL). Subjects were 118 caregivers who raised children ages 2-18 with chi...

journal_title：Bioscience trends

authors： Wakimizu R,Hiraga N,Furuya K,Fukushima T,Tsuchida M,Koike K,Yamamoto T

更新日期：2011-12-01 00:00:00

abstract：:Human herpesvirus 8 (HHV8) is an important opportunistic infection of HIV/AIDS. However, very little is known about antibody seropositivities to HHV8 lytic and latent antigens among HIV-infected patients in China. Therefore, a cross-sectional study was conducted to explore HHV8 serostatus among 316 HIV-infected patien...

journal_title：Bioscience trends

authors： Zhang TJ,He N,Ding YY,Jiang QW,Wood C

更新日期：2012-06-01 00:00:00

abstract：:Information about the muscarinic receptor subtype(s) mediating pulmonary circulatory vasodilator responses to acetylcholine (ACh) is limited. The aim of this study was to pharmacologically characterize the muscarinic receptors associated with ACh-induced pulmonary vasodilation in a pulmonary hypertension model. Vasodi...

journal_title：Bioscience trends

authors： Orii R,Sugawara Y,Sawamura S,Yamada Y

更新日期：2010-10-01 00:00:00

abstract：:Dengue is an acute febrile illness resulting from infection by a flavivirus transmitted by the Aedes mosquito. It is characterized by bleeding manifestations and a plasma leak syndrome. Hepatic involvement in the form of elevation in transaminases is common. However, acute hepatic failure is uncommon. It is not known ...

journal_title：Bioscience trends

authors： Agarwal MP,Giri S,Sharma V,Roy U,Gharsangi K

更新日期：2011-01-01 00:00:00

abstract：:Information about medical students' choice of specialty can be helpful for planning health manpower. However, such information from medical students in Malaysian medical schools is lacking. We carried out a cross-sectional questionnaire survey among fourth- and fifth-year medical undergraduate students at Melaka-Manip...

journal_title：Bioscience trends

authors： Chew YW,Rajakrishnan S,Low CA,Jayapalan PK,Sreeramareddy CT

更新日期：2011-01-01 00:00:00

abstract：:In Japan, a cost-containment policy has been implemented with health care system reform. Increasing medical expenses are inevitable due to aging of the population, health transitions, and expanded and advanced medical services. Policies such as the introduction of regressive reimbursement for inpatient services as par...

journal_title：Bioscience trends

authors： Idezuki Y

更新日期：2008-04-01 00:00:00

abstract：:The purpose of the present study was to evaluate whether pulse pressure variation (PPV) and stroke volume variation (SVV) can predict fluid responsiveness in patients with intra-abdominal hypertension (IAH) in either a supine or Trendelenburg position. Forty mechanically ventilated patients that exhibited IAH resultin...

journal_title：Bioscience trends

authors： Liu X,Fu Q,Mi W,Liu H,Zhang H,Wang P

更新日期：2013-04-01 00:00:00

abstract：:Coronavirus disease 19 (COVID-19) has become a pandemic around the world. With the explosive growth of confirmed cases, emergency medical supplies are facing global shortage, which restricts the treatment of seriously ill patients and protection of medical staff. Taking China, the United States, Australia, and Canada ...

journal_title：Bioscience trends

authors： Wang X,Wu W,Song P,He J

更新日期：2020-09-21 00:00:00

abstract：:Hepatitis C, caused by the hepatitis C virus (HCV) that attacks the liver and leads to inflammation, is a severe threat to human health. Pegylated interferon α (INF-α) and ribavirin based therapy was once the standard therapy for HCV infection. However, it is suboptimal in efficacy and poorly tolerated in some patient...

journal_title：Bioscience trends

authors： Gao J,Ju C

更新日期：2017-03-22 00:00:00

abstract：:In patients at risk of hepatocarcinogenesis, tumors are frequently detected with atypical radiological patterns related to hepatocellular carcinoma (HCC) on imaging studies. Despite their high potential for malignancy, whether to resect such lesions immediately is controversial. Based on histological findings, patient...

journal_title：Bioscience trends

authors： Higaki T,Midorikawa Y,Nakashima Y,Nakayama H,Matsuoka S,Moriyama M,Sugitani M,Takayama T

更新日期：2017-07-24 00:00:00

abstract：:Our purpose was to explore the remission of insulin resistance after bariatric surgery to discover the mechanism of diabetes remission excluding dietary factors. A retrospective case control study was conducted on patients with type 2 diabetes, who underwent laparoscopic sleeve gastrectomy (LSG) or laparoscopic gastri...

journal_title：Bioscience trends

authors： Zhu Y,Sun Z,Du Y,Xu G,Gong K,Zhu B,Zhang N

更新日期：2017-01-01 00:00:00

abstract：:Malignant pericardial effusion is one of the severe complications in advanced lung cancer patients, seriously affecting the patient's cardiopulmonary function and even life. Pericardial drainage and instillation of anti-neoplastic drugs in the pericardial cavity seems to offer the best chance of controlling pericardia...

journal_title：Bioscience trends

authors： Sun T,Zhang Y,Shen Y,Hu K,Zuo M

更新日期：2014-08-01 00:00:00

abstract：:Adjuvant therapy after resection of hepatocellular carcinoma (HCC) is limited. Here, we evaluated the effects of postoperative sorafenib on recurrence and survival in HCC patients. Recurrence-free survival and overall survival were analyzed as the main endpoint, recurrence rate, and mortality rate were analyzed as sec...

journal_title：Bioscience trends

authors： Zhang W,Zhao G,Wei K,Zhang Q,Ma W,Song T,Wu Q,Zhang T,Kong D,Li Q

更新日期：2014-12-01 00:00:00

abstract：:Hepatitis B induced by hepatitis B virus (HBV) remains a major public health problem worldwide. Although several antiviral drugs have been approved for hepatitis B, they cause significant dose-dependent side-effects (interferon-alpha) and drug resistance (lamivudine, etc.). Safe and potent new anti-HBV drugs are urgen...

journal_title：Bioscience trends

authors： Cui X,Wang Y,Kokudo N,Fang D,Tang W

更新日期：2010-04-01 00:00:00

abstract：:Salmonella enterica serovar Typhimurium (Salmonella), a pathogenic bacterium, is a major cause of foodborne diseases worldwide. Salmonella injects multiple virulence factors, called effectors, into cells and causes multiple rearrangements of cellular biological reactions that are important for Salmonella proliferation...

journal_title：Bioscience trends

authors： Sun X,Kawata K,Miki A,Wada Y,Nagahama M,Takaya A,Akimitsu N

更新日期：2020-09-21 00:00:00

abstract：:Once-daily tacrolimus (denoted here simply as OD) is a recently developed extended release drug formulation. The purpose of the present study was to pharmacokinetically evaluate tacrolimus exposure and determine the feasibility of its de novo use in liver transplant recipients in the perioperative period. This was an ...

journal_title：Bioscience trends

authors： Sugawara Y,Miyata Y,Kaneko J,Tamura S,Aoki T,Sakamoto Y,Hasegawa K,Yamashiki N,Kokudo N

更新日期：2011-08-01 00:00:00

abstract：:Inflammation-based markers are considered prognostic indicators for patients with hepatocellular carcinoma (HCC) after liver resection. However, there is little information concerning whether they are useful for HCC patients with clinically significant portal hypertension (CSPH). In this study, 1452 patients were enro...

journal_title：Bioscience trends

authors： Qin L,Li C,Xie F,Wang Z,Wen T

更新日期：2020-09-21 00:00:00

abstract：:This study is an extension of the previous enhancement of dissolution properties of repaglinide using liquisolid compacts. The development and validation of a highperformance liquid chromatography (HPLC) assay for the determination of repaglinide concentration in rabbit plasma for pharmacokinetic studies is described....

journal_title：Bioscience trends

authors： El-Houssieny BM,Wahman L,Arafa NM

更新日期：2010-02-01 00:00:00

abstract：:The maternal mortality ratio in Laos in 2005 was 660 per 100,000 lives birth which was the third highest in Asia-Pacific Region. The objective was to determine the availability and use of emergency obstetric care (EmOC) in provincial and district hospitals in Borikhamxay, Khammouane, and Savannakhet provinces using UN...

journal_title：Bioscience trends

authors： Douangphachanh X,Ali M,Outavong P,Alongkon P,Sing M,Chushi K

更新日期：2010-12-01 00:00:00

abstract：:At the end of 2013, a Japanese newspaper reported that 4,173 children were unidentified or missing in Japan. The article concluded that child abuse was a matter of national concern. In examining the strengths and weaknesses of Japan's welfare system in regard to child abuse, it would seem that a weakness exists with r...

journal_title：Bioscience trends

authors： Takahashi K,Kanda H,Sugaya N

更新日期：2014-08-01 00:00:00