Adjuvant sorafenib reduced mortality and prolonged overall survival and post-recurrence survival in hepatocellular carcinoma patients after curative resection: a single-center experience.

abstract：:Environmental factors during fetal life program the health outcomes regarding many diseases in future life. This idea has been supported by worldwide epidemiological studies, but the underlying mechanisms are still poorly understood. Three questions should be answered. (i) Does a common underlying cause of ordinary pa...

journal_title：Bioscience trends

authors： Basovich SN

更新日期：2013-02-01 00:00:00

abstract：:In-stent restenosis is highly related to the deposition of inflammatory extracellular matrix and the migration of endothelial and vascular smooth muscle cells. The miR-17/TIMP-1/interleukin pathway regulates vascular matrix remodeling and plays an important role in the inflammatory reaction. This study identified miR-...

journal_title：Bioscience trends

authors： Jiang F,Zhang X,Lu YM,Li YG,Zhou X,Wang YS

更新日期：2019-11-13 00:00:00

abstract：:In oocytes, many maternally supplied products are stored, and these products play important roles in cell cycle regulation and early development. Mos protein, which is coded on the c-mos gene, promotes oocyte maturation and is involved in MAP-kinase signaling pathway. In Xenopus, maternally supplied c-mos mRNA undergo...

journal_title：Bioscience trends

authors： Suzuki H,Tsukahara T,Inoue K

更新日期：2009-06-01 00:00:00

abstract：:This study is an extension of the previous enhancement of dissolution properties of repaglinide using liquisolid compacts. The development and validation of a highperformance liquid chromatography (HPLC) assay for the determination of repaglinide concentration in rabbit plasma for pharmacokinetic studies is described....

journal_title：Bioscience trends

authors： El-Houssieny BM,Wahman L,Arafa NM

更新日期：2010-02-01 00:00:00

abstract：:We have recently demonstrated that unconjugated bilirubin (UCB) limits the overexpression of adhesion molecules and inhibits the PMN endothelial adhesion induced by the pro-inflammatory cytokine TNFalpha. To understand the molecular events involved we investigated whether the inhibitory effect is determined by a direc...

journal_title：Bioscience trends

authors： Mazzone GL,Rigato I,Ostrow JD,Tiribelli C

更新日期：2009-08-01 00:00:00

abstract：:Antibiotics are medicines used to prevent and treat bacterial infections. Antibiotic resistance occurs when bacteria change in response to the use of these medicines. Antibiotic resistance is rising to dangerously high levels in all parts of the world, leading to higher medical costs, prolonged hospital stays, and inc...

journal_title：Bioscience trends

authors： Tang Q,Song P,Li J,Kong F,Sun L,Xu L

更新日期：2016-02-01 00:00:00

abstract：:A research project involving sheets of retinal pigment epithelium constructed from iPS cells derived from patients with age-related maculopathy is one step closer to being approved for clinical trials by the Japanese Government. Now is the time to make therapies using iPS cells clinically available. ...

journal_title：Bioscience trends

authors： Song P,Inagaki Y,Sugawara Y,Kokudo N

更新日期：2013-06-01 00:00:00

abstract：:The emerging novel coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has swept across the world and become a global threat to public health. More than 200 countries and territories worldwide are suffering from this COVID-19 pandemic. Worryingly, no specific vaccine...

journal_title：Bioscience trends

authors： Dong X,Tian Z,Shen C,Zhao C

更新日期：2020-11-04 00:00:00

abstract：:This meta-analysis aimed to review the regeneration rate of future liver remnant (FLR) and perioperative outcomes after associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) and two-stage hepatectomy (TSH). A web search was performed in "MEDLINE", "EMBASE", and "SCIENCE DIRECT" databases ...

journal_title：Bioscience trends

authors： Sun Z,Tang W,Sakamoto Y,Hasegawa K,Kokudo N

更新日期：2015-10-01 00:00:00

abstract：:The initial processes involved in radiation carcinogenesis have not been clearly elucidated. We isolated mouse mutant cells exhibiting plasticity in their mutation phenotypes. These mutant cells were originally isolated from an irradiated cell population as 6-thioguanine resistant (6TGR) mutants that were deficient in...

journal_title：Bioscience trends

authors： Yamauchi M,Fukutsu K,Sakagami M,Yamada Y

更新日期：2010-08-01 00:00:00

abstract：:The dominant-negative inhibition of KCNJ2-encoded inward rectifier potassium channels (Kir2) is currently considered the best approach to biological pacemakers. We hypothesized that inhibition of the inward rectifier potassium current (IK1) in ventricular myocytes by RNA interference (RNAi) would convert ventricular m...

journal_title：Bioscience trends

authors： Hu B,Zhu XL,Fan QX,Li HX,Zou CW

更新日期：2012-02-01 00:00:00

abstract：:We construct and validate a non-invasive clinical scoring model to predict mortality in HIV/TB patients at end stage of AIDS in China. There were 1,007 HIV/TB patients admitted to Beijing Ditan Hospital from August 2009 to January 2018 included in this study, who were randomly assigned to form derivation cohort and va...

journal_title：Bioscience trends

authors： Zhang Z,Xu L,Pang X,Zeng Y,Hao Y,Wang Y,Wu L,Gao G,Yang D,Zhao H,Xiao J

更新日期：2019-05-12 00:00:00

abstract：:The maternal mortality ratio in Laos in 2005 was 660 per 100,000 lives birth which was the third highest in Asia-Pacific Region. The objective was to determine the availability and use of emergency obstetric care (EmOC) in provincial and district hospitals in Borikhamxay, Khammouane, and Savannakhet provinces using UN...

journal_title：Bioscience trends

authors： Douangphachanh X,Ali M,Outavong P,Alongkon P,Sing M,Chushi K

更新日期：2010-12-01 00:00:00

abstract：:To determine the feasibility of using a nanoparticle immunoassay for clinical therapeutic drug monitoring (TDM) of docetaxel concentrations, a sensitive and simple method of liquid chromatography-tandem mass spectrometry (LC-MS/MS) was established to measure the docetaxel concentration in human plasma and the results ...

journal_title：Bioscience trends

authors： Geng C,Li P,Chen X,Yuan G,Guo N,Liu H,Zhang R,Guo R

更新日期：2017-05-23 00:00:00

abstract：:Salmonella enterica serovar Typhimurium (Salmonella), a pathogenic bacterium, is a major cause of foodborne diseases worldwide. Salmonella injects multiple virulence factors, called effectors, into cells and causes multiple rearrangements of cellular biological reactions that are important for Salmonella proliferation...

journal_title：Bioscience trends

authors： Sun X,Kawata K,Miki A,Wada Y,Nagahama M,Takaya A,Akimitsu N

更新日期：2020-09-21 00:00:00

abstract：:The purpose of this study was to evaluate the 2-day seminar in 2 consecutive years respectively for community health professionals. We prepared the child-rearing support manual (CRSM) and conducted a seminar program to improve skills to provide mental assessments and postnatal care support for mothers and their famili...

journal_title：Bioscience trends

authors： Kamibeppu K,Furuta M,Yamashita H,Sugishita K,Suzumiya H,Yoshida K

更新日期：2009-02-01 00:00:00

abstract：:Human herpesvirus 8 (HHV8) is an important opportunistic infection of HIV/AIDS. However, very little is known about antibody seropositivities to HHV8 lytic and latent antigens among HIV-infected patients in China. Therefore, a cross-sectional study was conducted to explore HHV8 serostatus among 316 HIV-infected patien...

journal_title：Bioscience trends

authors： Zhang TJ,He N,Ding YY,Jiang QW,Wood C

更新日期：2012-06-01 00:00:00

abstract：:Atrazine (ATR), one of the most widely used herbicides worldwide, has caused a series of toxicological and environmental problems. This study sought to investigate the effects of ATR on the immune system of mice. Four-week-old female C57B l/6 mice were treated with 5, 25, and 125 mg/kg ATR for 28 days. On day 29, bloo...

journal_title：Bioscience trends

authors： Zhao S,Liu J,Zhao F,Liu W,Li N,Suo Q,Zhao J,Zhao L

更新日期：2013-08-01 00:00:00

abstract：:It has been hypothesized that subjective well-being (SWB) is determined by a combination of individual characteristics, social environment, and physical environment. However, few studies have simultaneously examined the relationships of the social and physical attributes of a neighborhood with SWB. Accordingly, the pr...

journal_title：Bioscience trends

authors： Gao J,Weaver SR,Fu H,Jia Y,Li J

更新日期：2017-11-20 00:00:00

abstract：:Malignant mesothelioma (MM) is an insidious, lethal asbestos-related cancer that is poorly responsive to current treatments. Specific and sensitive biomarkers providing early MM diagnosis in exposed subjects, who are at high-risk of developing it, are sorely needed. MicroRNAs (miRNAs) are endogenous, non-coding, small...

journal_title：Bioscience trends

authors： Micolucci L,Rippo MR,Olivieri F,Procopio AD

更新日期：2017-03-22 00:00:00

abstract：:Complete loss of function in the WRN: RecQ3 DNA/RNA helicase gene causes Werner Syndrome (WS). WS patients with genetic instability manifest an early onset of age-related diseases including diabetes mellitus (DM), osteoporosis, atherosclerosis, and malignancy as well as early death. In 1,420 patients, WS was reported ...

journal_title：Bioscience trends

authors： Goto M

更新日期：2008-08-01 00:00:00

abstract：:Information about medical students' choice of specialty can be helpful for planning health manpower. However, such information from medical students in Malaysian medical schools is lacking. We carried out a cross-sectional questionnaire survey among fourth- and fifth-year medical undergraduate students at Melaka-Manip...

journal_title：Bioscience trends

authors： Chew YW,Rajakrishnan S,Low CA,Jayapalan PK,Sreeramareddy CT

更新日期：2011-01-01 00:00:00

abstract：:Human serum albumin (HSA) is used as an important plasma volume expander in clinical practice. In the present study, HSA was N-terminally PEGylated and a PEGylated HAS (PEG-HSA) carrying one chain of PEG (20 kDa) per HSA molecule was obtained. The purity, secondary structure and hydrodynamic radius of the modified pro...

journal_title：Bioscience trends

authors： Zhao T,Yang Y,Zong A,Tan H,Song X,Meng S,Song C,Pang G,Wang F

更新日期：2012-04-01 00:00:00

abstract：:Bu-Shen-Ning-Xin decoction (BSNXD), a traditional Chinese medicine, has been used to prevent and treat age-related diseases such as postmenopausal osteoporosis (PMO) for decades. This study sought to investigate the underlying mechanisms of BSNXD in terms of receptor activation of nuclear factor κB ligand (RANKL)-indu...

journal_title：Bioscience trends

authors： Gui Y,Qiu X,Xu Y,Li D,Wang L

更新日期：2015-06-01 00:00:00

abstract：:Transplantation with Wharton's jelly derived mesenchymal stem cells (WJ-MSCs) showed great benefits for restoring myocardial function. However, the outcome of WJ-MSCs transplantation was unsuccessful due to multiple factors including oxidative damage. The presence of oxidative stress due to myocardium injury influence...

journal_title：Bioscience trends

authors： Nimsanor N,Phetfong J,Kitiyanant N,Kamprom W,Supokawej A

更新日期：2019-11-13 00:00:00

abstract：:Human papillomavirus (HPV) infections are common and generally harmless, but persistent infections can bring health problems like cancer and genital warts. For the uninfected group, HPV vaccines provide safe and effective protection, but they're type-restricted and expensive. For those infected, so far there have been...

journal_title：Bioscience trends

authors： Lin J,Chen L,Qiu X,Zhang N,Guo Q,Wang Y,Wang M,Gober HJ,Li D,Wang L

更新日期：2017-07-24 00:00:00

abstract：:Inflammation-based markers are considered prognostic indicators for patients with hepatocellular carcinoma (HCC) after liver resection. However, there is little information concerning whether they are useful for HCC patients with clinically significant portal hypertension (CSPH). In this study, 1452 patients were enro...

journal_title：Bioscience trends

authors： Qin L,Li C,Xie F,Wang Z,Wen T

更新日期：2020-09-21 00:00:00

abstract：:Once-daily tacrolimus (denoted here simply as OD) is a recently developed extended release drug formulation. The purpose of the present study was to pharmacokinetically evaluate tacrolimus exposure and determine the feasibility of its de novo use in liver transplant recipients in the perioperative period. This was an ...

journal_title：Bioscience trends

authors： Sugawara Y,Miyata Y,Kaneko J,Tamura S,Aoki T,Sakamoto Y,Hasegawa K,Yamashiki N,Kokudo N

更新日期：2011-08-01 00:00:00

abstract：:Dengue is an acute febrile illness resulting from infection by a flavivirus transmitted by the Aedes mosquito. It is characterized by bleeding manifestations and a plasma leak syndrome. Hepatic involvement in the form of elevation in transaminases is common. However, acute hepatic failure is uncommon. It is not known ...

journal_title：Bioscience trends

authors： Agarwal MP,Giri S,Sharma V,Roy U,Gharsangi K

更新日期：2011-01-01 00:00:00

abstract：:Benign portal vein stenosis is a rare complication following pancreaticoduodenectomy. Because a direct surgical approach to the portal vein is difficult due to severe adhesions following pancreaticoduodenectomy, portal vein stent placement is considered a good treatment option. Herein, we report 3 cases of severe port...

journal_title：Bioscience trends

authors： Sawai Y,Kokudo T,Sakamoto Y,Takao H,Kazami Y,Nishioka Y,Akamatsu N,Arita J,Kaneko J,Hasegawa K

更新日期：2019-01-22 00:00:00