DHA Reduces Oxidative Stress after Perinatal Asphyxia: A Study in Newborn Piglets.

Abstract:

BACKGROUND:Perinatal hypoxic-ischemic brain damage is a major cause of acute mortality and chronic neurological morbidity in infants and children. Oxidative stress due to free radical formation and the initiation of abnormal oxidative reactions appears to play a key role. Docosahexanoic acid (DHA), a main component of brain membrane phospholipids, may act as a neuroprotectant after hypoxia-ischemia by regulating multiple molecular pathways and gene expression. OBJECTIVES:The aims of this study were to test the hypothesis that DHA provides significant protection against lipoperoxidation damage in the cerebral cortex and hippocampus in a neonatal piglet model of severe hypoxia-reoxygenation. METHODS:Newborn piglets, Noroc (LYLD), were subjected to severe global hypoxia. One group was resuscitated with ambient air (21% group, n = 11) and another also received 5 mg/kg of DHA 4 h after the end of hypoxia (21% DHA group, n = 10). After 9.5 h, tissues from the prefrontal cortex and hippocampus were sampled and the levels of isoprostanes, neuroprostanes, neurofurans, and F2-dihomo-isoprostanes were determined by the liquid chromatography triple quadrupole mass spectrometry technique. RESULTS:Lipid peroxidation biomarkers were significantly lower in both the cortex and hippocampus in the DHA-treated group compared with the untreated group. CONCLUSIONS:The present study demonstrates that DHA administration after severe hypoxia in newborn piglets has an antioxidative effect in the brain, suggesting a protective potential of DHA if given after injuries to the brain.

journal_name

Neonatology

journal_title

Neonatology

authors

Solberg R,Longini M,Proietti F,Perrone S,Felici C,Porta A,Saugstad OD,Buonocore G

doi

10.1159/000454982

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

1-8

issue

1

eissn

1661-7800

issn

1661-7819

pii

000454982

journal_volume

112

pub_type

杂志文章
  • Early neonatal special care units and their scientific achievements.

    abstract::Treatment of sick neonates originated in maternity and foundling hospitals in the 19th century. Nosocomial infections and difficult logistics of wet-nursing prevented admission of neonates in most children's hospitals well into the 20th century. In this article, 31 hospitals are described, all located in large cities,...

    journal_title:Neonatology

    pub_type: 历史文章,杂志文章

    doi:10.1159/000336285

    authors: Obladen M

    更新日期:2012-01-01 00:00:00

  • Reduced Cerebellar Size at Term-Equivalent Age Is Related to a 17% Lower Mental Developmental Index in Very Preterm Infants without Brain Injury.

    abstract:INTRODUCTION:Cerebellar injury is increasingly recognized as a relevant complication of premature birth. However, the prevalence of reduced cerebellar growth and its consequences for neurodevelopmental outcome in preterm infants without overt brain injury remain to be defined in detail. The aim of this study was to ass...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000502491

    authors: Hammerl M,Zagler M,Griesmaier E,Janjic T,Gizewski ER,Kiechl-Kohlendorfer U,Neubauer V

    更新日期:2020-01-01 00:00:00

  • Optimising Intravenous Volume Resuscitation of the Newborn in the Delivery Room: Practical Considerations and Gaps in Knowledge.

    abstract::Volume resuscitation (VR) for the treatment of newborn shock is a rare but potentially lifesaving intervention. Conducting clinical studies to assess the effectiveness of VR in the delivery room during newborn stabilization is challenging. We review the available literature and current management guidelines to determi...

    journal_title:Neonatology

    pub_type: 杂志文章,评审

    doi:10.1159/000475456

    authors: Finn D,Roehr CC,Ryan CA,Dempsey EM

    更新日期:2017-01-01 00:00:00

  • Neonatal Phototherapy: A Novel Therapy to Prevent Allergic Skin Disease for At Least 5 Years.

    abstract:BACKGROUND:Preventing the development of allergic skin disease in children is the best way to treat the disease. OBJECTIVES:Ultraviolet (UV)-free blue light phototherapy has been reported to treat atopic eczema. We evaluated the effect of neonatal phototherapy on allergic skin disease in children. METHODS:We randomly...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000489389

    authors: Ku MS

    更新日期:2018-01-01 00:00:00

  • The Neuroprotective Effects of Hypothermia on Bilirubin-Induced Neurotoxicity in vitro.

    abstract:BACKGROUND:In high-risk newborns indirect hyperbilirubinemia can lead to acute bilirubin encephalopathy and kernicterus. Despite the current therapeutic modalities, preventing or reversing the neurotoxicity cannot be achieved in all infants. OBJECTIVE:To investigate the neuroprotective effects of hypothermia on biliru...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000487221

    authors: Kuter N,Aysit-Altuncu N,Ozturk G,Ozek E

    更新日期:2018-01-01 00:00:00

  • Is screening for renal anomalies warranted in neonates with isolated single umbilical artery?

    abstract:AIM:To determine the prevalence of renal anomalies in patients with an isolated single umbilical artery (SUA). METHODS:We performed a retrospective study of all renal ultrasound examinations assessed at our centre between January 1998 and December 2008 in neonates with SUA with or without associated anomalies. RESULT...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000253151

    authors: de Boom ML,Kist-van Holthe JE,Sramek A,Lardenoye SW,Walther FJ,Lopriore E

    更新日期:2010-01-01 00:00:00

  • Effect of Bifidobacterium lactis on the incidence of nosocomial infections in very-low-birth-weight infants: a randomized controlled trial.

    abstract:BACKGROUND:Nosocomial infections endanger preterm infants. OBJECTIVE:The aim of the present controlled randomized trial was to investigate whether Bifidobacterium lactis reduces the incidence of nosocomial infections in infants with very low birth weight (VLBW; <1,500 g) <30 weeks of gestation. PATIENTS AND METHODS:I...

    journal_title:Neonatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000280291

    authors: Mihatsch WA,Vossbeck S,Eikmanns B,Hoegel J,Pohlandt F

    更新日期:2010-01-01 00:00:00

  • Melatonin levels during the first week of life and their relation with the antioxidant response in the perinatal period.

    abstract:AIM:Melatonin is a potent free radical scavenger and an indirect antioxidant. Knowledge about the behavior of melatonin secretion in the early neonatal period, which may relate to its properties at a vital stage during very high antioxidant demands, is limited. PATIENTS AND METHODS:We studied 35 newborns admitted to t...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000102957

    authors: Muñoz-Hoyos A,Bonillo-Perales A,Avila-Villegas R,González-Ripoll M,Uberos J,Florido-Navío J,Molina-Carballo A

    更新日期:2007-01-01 00:00:00

  • Comparison of Neonatal Intubation Practice and Outcomes between the Neonatal Intensive Care Unit and Delivery Room.

    abstract:BACKGROUND:Characteristics of neonatal tracheal intubations (TI) may vary between the neonatal intensive care unit (NICU) and delivery room (DR). The impact of the setting on TI outcomes is not well characterized. OBJECTIVE:The aim of this study was to define variation in neonatal TI practice between settings, and ide...

    journal_title:Neonatology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000502611

    authors: Herrick HM,Glass KM,Johnston LC,Singh N,Shults J,Ades A,Nadkarni V,Nishisaki A,Foglia EE,for the NEAR4NEOS Investigators.

    更新日期:2020-01-01 00:00:00

  • Ventilator gas flow rates affect inspiratory time and ventilator efficiency index in term lambs.

    abstract:BACKGROUND:Despite increasing survival in the smallest preterm infants, the incidence of chronic lung disease has not decreased. Research into ventilatory strategies has concentrated on minimising barotrauma, volutrauma and atelectotrauma, but little attention has been paid to the role of bias gas flow rates and the po...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000220765

    authors: Bach KP,Kuschel CA,Oliver MH,Bloomfield FH

    更新日期:2009-01-01 00:00:00

  • Randomized crossover comparison of proportional assist ventilation and patient-triggered ventilation in extremely low birth weight infants with evolving chronic lung disease.

    abstract:BACKGROUND:Refinement of ventilatory techniques remains a challenge given the persistence of chronic lung disease of preterm infants. METHODS:To test the hypothesis that proportional assist ventilation (PAV) will allow to lower the ventilator pressure at equivalent fractions of inspiratory oxygen (FiO(2)) and arterial...

    journal_title:Neonatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1159/000098376

    authors: Schulze A,Rieger-Fackeldey E,Gerhardt T,Claure N,Everett R,Bancalari E

    更新日期:2007-01-01 00:00:00

  • Effect of Concurrent Src Kinase Inhibition with Short-Duration Hypothermia on Ca2+/Calmodulin Kinase IV Activity and Neuropathology after Hypoxia-Ischemia in the Newborn Swine Brain.

    abstract:BACKGROUND:Hypoxia-ischemia (HI) results in increased activation of Ca2+/calmodulin kinase IV (CaM kinase IV) mediated by Src kinase. Therapeutic hypothermia ameliorates neuronal injury in the newborn. HYPOTHESIS:Inhibition of Src kinase concurrently with hypothermia further attenuates the hypoxia-induced increased ac...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000480067

    authors: Kratimenos P,Koutroulis I,Jain A,Malaeb S,Delivoria-Papadopoulos M

    更新日期:2018-01-01 00:00:00

  • Chest Compressions during Sustained Inflations Improve Recovery When Compared to a 3:1 Compression:Ventilation Ratio during Cardiopulmonary Resuscitation in a Neonatal Porcine Model of Asphyxia.

    abstract:BACKGROUND:Recently, sustained inflations (SI) during chest compression (CC) (CC+SI) have been suggested as an alternative to the current approach during neonatal resuscitation. No previous study compared CC+SI using CC rates of 90/min to the current 3:1 compression:ventilation ratio (C:V). OBJECTIVE:To determine whet...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000477998

    authors: Li ES,Görens I,Cheung PY,Lee TF,Lu M,O'Reilly M,Schmölzer GM

    更新日期:2017-01-01 00:00:00

  • Lack of Evidence for Time or Dose Relationship between Antenatal Magnesium Sulfate and Intestinal Injury in Extremely Preterm Neonates.

    abstract:BACKGROUND:Recent studies reported conflicting results on the relationship between antenatal magnesium sulfate (MgSO4) exposure and neonatal intestinal injury. Most studies have not assessed MgSO4 exposure quantitatively and none reported the exposure timing. OBJECTIVES:The aim of this work was to assess whether there...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000497412

    authors: Mikhael M,Bronson C,Zhang L,Curran M,Rodriguez H,Bhakta KY

    更新日期:2019-01-01 00:00:00

  • Very Preterm Infants with Technological Dependence at Home: Impact on Resource Use and Family.

    abstract:OBJECTIVE:To examine the impact of medical complexity among very preterm infants on health care resource use, family, and neurodevelopmental outcomes at 18 months' corrected age. METHODS:This observational cohort study of Canadian infants born < 29 weeks' gestational age in 2009-2011 compared infants with and those wi...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000496494

    authors: Nassel D,Chartrand C,Doré-Bergeron MJ,Lefebvre F,Ballantyne M,Van Overmeire B,Luu TM,on behalf of the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Network.

    更新日期:2019-01-01 00:00:00

  • Clinical Outcome for Congenital Diaphragmatic Hernia at the Age of 1 Year in the Era of Fetal Intervention.

    abstract:BACKGROUND:Congenital diaphragmatic hernia (CDH) is an abnormal development of the diaphragm leading to high neonatal mortality and morbidity. Beyond the neonatal period, prospective data on overall long-term outcome in CDH survivors is scarce. In particular, for those treated with fetoscopic endoluminal tracheal occlu...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000479145

    authors: Van Ginderdeuren E,Allegaert K,Decaluwe H,Deprest J,Debeer A,Proesmans M

    更新日期:2017-01-01 00:00:00

  • Oral Propranolol: A New Treatment for Infants with Retinopathy of Prematurity?

    abstract:INTRODUCTION:Oral propranolol has improved the treatment of infantile hemangiomas, and a pediatric oral solution of propranolol has recently been licensed in the USA and Europe. In very preterm infants, infantile hemangiomas are associated with the occurrence of retinopathy of prematurity (ROP), and both diseases share...

    journal_title:Neonatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000381659

    authors: Bührer C,Bassler D

    更新日期:2015-01-01 00:00:00

  • Use of a Mechanical Ventilator with Respiratory Function Monitoring Provides More Consistent Ventilation during Simulated Neonatal Resuscitation.

    abstract:INTRODUCTION:Positive pressure ventilation (PPV) with T-Piece and self-inflating bag (SIB) during neonatal resuscitation after birth is associated with variability in ventilation. The use of a ventilator with respiratory function monitoring (RFM) for PPV, however, has not been evaluated. OBJECTIVE:To determine if vent...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000503257

    authors: Jain D,D'Ugard C,Aguilar A,Del Moral T,Bancalari E,Claure N

    更新日期:2020-01-01 00:00:00

  • Effects of bilirubin on neutrophil responses in newborn infants.

    abstract:BACKGROUND:Newborns are susceptible to inflammatory diseases due to defects in clearing activated immune cells from tissues. Therefore, mechanisms have likely evolved to protect neonates from leukocyte-mediated cytotoxicity. Bilirubin has antioxidant activity, and it is possible that it also exerts effects on cellular ...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000343097

    authors: Weinberger B,Archer FE,Kathiravan S,Hirsch DS,Kleinfeld AM,Vetrano AM,Hegyi T

    更新日期:2013-01-01 00:00:00

  • Bronchopulmonary Dysplasia: 50 Years after the Original Description.

    abstract::Bronchopulmonary dysplasia (BPD) is one of the few diseases in neonatal medicine that has continued to evolve since its first description about 50 years ago. Over these years, advancements in neonatal medicine such as antenatal steroids and exogenous surfactant therapy have significantly reduced neonatal mortality and...

    journal_title:Neonatology

    pub_type: 杂志文章,评审

    doi:10.1159/000497422

    authors: Bancalari E,Jain D

    更新日期:2019-01-01 00:00:00

  • The Specificity of the WINROP Algorithm Can Be Significantly Increased by Reassessment of the WINROP Alarm.

    abstract:BACKGROUND:Retinopathy of prematurity (ROP) is a sight-threatening disease affecting extremely preterm infants. The introduction of new ROP screening surveillance systems, with higher sensitivity and specificity than established ROP screening guidelines, has the potential to reduce the number of stressful eye examinati...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000435770

    authors: Lundgren P,Stoltz Sjöström E,Domellöf M,Smith L,Wu C,VanderVeen D,Hellström A,Löfqvist C

    更新日期:2015-01-01 00:00:00

  • Optimal techniques for mRNA extraction from neonatal salivary supernatant.

    abstract:BACKGROUND:Gene expression profiling of the salivary supernatant is emerging as a new and important source of real-time, systemic, biological information. However, existing technologies prevent RNA extraction of small quantities found in neonatal salivary supernatant. OBJECTIVE:The aim of this study was to develop tec...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000328026

    authors: Dietz JA,Johnson KL,Wick HC,Bianchi DW,Maron JL

    更新日期:2012-01-01 00:00:00

  • Social Birth: Rites of Passage for the Newborn.

    abstract::Rites of passage mark important changes during human life and, for the neonate, its transition from intrauterine life into society. Their original intent was to purify the body from blood and meconium. But the cleansing rites had a spiritual dimension from the very start. When the rites of Mesopotamian, Egyptian, Jewi...

    journal_title:Neonatology

    pub_type: 历史文章,杂志文章

    doi:10.1159/000477955

    authors: Obladen M

    更新日期:2017-01-01 00:00:00

  • Respiratory function and near infrared spectroscopy recording during cardiopulmonary resuscitation in an extremely preterm newborn.

    abstract::We describe a case highlighting several controversial and important topics regarding neonatal cardiopulmonary resuscitation (CPR). Current neonatal guidelines recommend a 3:1 compression:ventilation ratio; however, the most effective ratio of delivering chest compressions (CC) remains controversial. We report a case o...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000357609

    authors: Li ES,Cheung PY,Pichler G,Aziz K,Schmölzer GM

    更新日期:2014-01-01 00:00:00

  • Increased Carbon Monoxide Washout Rates in Newborn Infants.

    abstract:BACKGROUND:Endogenous carbon monoxide (CO) production is primarily due to heme degradation, which also results in the equimolar production of bilirubin. Thus, estimates of total body CO production can serve as indices of total body bilirubin formation. The elimination rate of CO from a person's body (CO washout rate) a...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000503635

    authors: Stevenson DK,Wong RJ,Ostrander CR,Maric I,Vreman HJ,Cohen RS

    更新日期:2020-01-01 00:00:00

  • Effect of Phototherapy on the Reliability of Transcutaneous Bilirubin Devices in Term and Near-Term Infants: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Transcutaneous bilirubin (TcB) devices are commonly used for screening of hyperbilirubinemia in term and near-term infants not exposed to phototherapy. However, the accuracy of TcB devices in infants exposed to phototherapy is unclear. OBJECTIVES:To conduct a systematic review of studies comparing TcB devic...

    journal_title:Neonatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000442195

    authors: Nagar G,Vandermeer B,Campbell S,Kumar M

    更新日期:2016-01-01 00:00:00

  • A randomised crossover trial of clinical algorithm for oxygen saturation targeting in preterm infants with frequent desaturation episodes.

    abstract:OBJECTIVES:Strategies for oxygen therapy for preterm infants, such as the Vermont-Oxford's 'Breathsavers' guidelines, seek to strike a balance between the potential risks of the extremes of hyperoxia and hypoxia in preterm infants. Using an algorithm based on those guidelines, we aimed to compare the proportion of time...

    journal_title:Neonatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000368295

    authors: Clarke A,Yeomans E,Elsayed K,Medhurst A,Berger P,Skuza E,Tan K

    更新日期:2015-01-01 00:00:00

  • Assessment of Risk Indicators for Targeted Cytomegalovirus Screening in Neonates.

    abstract:BACKGROUND:In the absence of universal screening for congenital cytomegalovirus (cCMV) infection, the aim of this study was to assess the outcomes of a targeted screening protocol based on maternal and neonatal risk indicators. METHODS:The medical records of 2,623 neonates born in our maternal hospital between June 20...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000512525

    authors: Levit Y,Dym L,Yochpaz S,Manor Y,Adler A,Halutz O,Grisaru-Soen G,Herzlich J,Marom R

    更新日期:2020-12-22 00:00:00

  • Secretoneurin Serum Levels in Healthy Term Neonates and Neonates with Hypoxic-Ischaemic Encephalopathy.

    abstract:BACKGROUND:Hypoxic-ischaemic encephalopathy is a major cause of neurologic impairment and mortality in neonates. Early knowledge of brain injury is important to guide therapeutic decisions and reliably inform the parents. Increased secretoneurin levels have been detected in adult patients suffering from brain injury an...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000444245

    authors: Wechselberger K,Schmid A,Posod A,Höck M,Neubauer V,Fischer-Colbrie R,Kiechl-Kohlendorfer U,Griesmaier E

    更新日期:2016-01-01 00:00:00

  • Factors Associated with Adverse Events during Tracheal Intubation in the NICU.

    abstract:BACKGROUND:The incidence of adverse tracheal intubation-associated events (TIAEs) and associated patient, practice, and intubator characteristics in the neonatal intensive care unit (NICU) setting are unknown. OBJECTIVES:To determine the incidence of adverse TIAEs and to identify factors associated with TIAEs in the N...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000381252

    authors: Foglia EE,Ades A,Napolitano N,Leffelman J,Nadkarni V,Nishisaki A

    更新日期:2015-01-01 00:00:00