A randomised crossover trial of clinical algorithm for oxygen saturation targeting in preterm infants with frequent desaturation episodes.

abstract：BACKGROUND:The incidence of adverse tracheal intubation-associated events (TIAEs) and associated patient, practice, and intubator characteristics in the neonatal intensive care unit (NICU) setting are unknown. OBJECTIVES:To determine the incidence of adverse TIAEs and to identify factors associated with TIAEs in the N...

journal_title：Neonatology

authors： Foglia EE,Ades A,Napolitano N,Leffelman J,Nadkarni V,Nishisaki A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Extreme hyperbilirubinemia is treated with double volume exchange transfusion, which may take hours to commence. A neuroprotective agent that could be administered immediately might be clinically useful. Minocycline, an anti-inflammatory and anti-apoptotic semisynthetic tetracycline, prevents hyperbilirubine...

journal_title：Neonatology

authors： Geiger AS,Rice AC,Shapiro SM

更新日期：2007-01-01 00:00:00

abstract：:We describe a case highlighting several controversial and important topics regarding neonatal cardiopulmonary resuscitation (CPR). Current neonatal guidelines recommend a 3:1 compression:ventilation ratio; however, the most effective ratio of delivering chest compressions (CC) remains controversial. We report a case o...

journal_title：Neonatology

authors： Li ES,Cheung PY,Pichler G,Aziz K,Schmölzer GM

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Targeted milrinone treatment for low left ventricular output (LVO) reduces the incidence of acute cardiorespiratory instability following ligation of patent ductus arteriosus (PDA) in preterm infants. Despite this, some infants continue to experience postoperative deterioration. Adrenal insufficiency related...

journal_title：Neonatology

authors： EL-Khuffash A,McNamara PJ,Lapointe A,Jain A

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Meconium displaces surfactant from the alveolar surface and inhibits its function. The development of active synthetic surfactants is complicated, especially to synthesize the hydrophobic surfactant proteins SP-B and SP-C. A synthetic surfactant, CHF5633 containing SP-B and SP-C analogs, has been designed to...

journal_title：Neonatology

authors： Salvesen B,Curstedt T,Mollnes TE,Saugstad OD

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Heart rate (HR) detection in premature infants using electrocardiography (ECG) is challenging due to a low signal amplitude and the fragility of the premature skin. Recently, the dynamic light scattering (DLS) technique has been miniaturized, allowing noninvasive HR measurements with a single sensor. OBJECT...

journal_title：Neonatology

authors： Gangaram-Panday NH,van Essen T,Goos TG,de Jonge RCJ,Reiss IKM,van Weteringen W

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:No survey has been published in recent years which primarily focuses on the prescription of inhaled corticosteroids in neonatal practice. Thus, the utilization rate of inhaled corticosteroids is unknown. OBJECTIVES:To elucidate the current utilization rate of inhaled corticosteroids in the prevention and th...

journal_title：Neonatology

authors： Maas C,Poets CF,Bassler D

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Intermittent hypoxic episodes are common among preterm infants, although longer term consequences on growth pattern and cardiovascular regulation are unclear. Furthermore, the effects of intermittent hypoxia (IH) may depend on the pattern of hypoxia-reoxygenation. OBJECTIVES:We tested the hypothesis that a ...

journal_title：Neonatology

authors： Pozo ME,Cave A,Köroğlu OA,Litvin DG,Martin RJ,Di Fiore J,Kc P

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Carriers of Staphylococcus aureus strains can be the source of epidemic infection for patients. OBJECTIVES:A molecular epidemiological analysis of an impetigo bullosa outbreak in a neonatal ward was performed in order to determine a potential source of the infection and possible routes of subsequent spreadi...

journal_title：Neonatology

authors： Jursa-Kulesza J,Kordek A,Kopron K,Wojciuk B,Giedrys-Kalemba S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:International neonatal resuscitation guidelines recommend assessing chest excursion when the heart rate is not improving. However, the accuracy in assessing 'adequate' chest excursion lacks objectivity. AIM:It was the aim of this study to test the accuracy in the assessment of 'adequate' chest excursion by ...

journal_title：Neonatology

authors： Brugada M,Schilleman K,Witlox RS,Walther FJ,Vento M,Te Pas AB

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Newborns are prone to infections, which are independent predictors of neonatal mortality and morbidity. Neutrophil extracellular traps (NETs) are structures composed of chromatin and antimicrobial molecules that capture and kill pathogens. NETs may play an important role in the innate immune system and, thus...

journal_title：Neonatology

authors： Lipp P,Ruhnau J,Lange A,Vogelgesang A,Dressel A,Heckmann M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The identification of factors involved in the postnatal growth of preterm infants will help achieve growth similar to that of term infants. OBJECTIVES:As per protocol: to compare body composition in very preterm infants at term-corrected age (TCA) with that in term infants, and to explore relationships betw...

journal_title：Neonatology

authors： Tremblay G,Boudreau C,Bélanger S,St-Onge O,Pronovost E,Simonyan D,Marc I

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Premature birth is a significant health care burden. Xenon (Xe) is a general anesthetic with neuroprotective effects. OBJECTIVES:Here, we investigate the neuroprotective role of Xe in a lipopolysaccharide (LPS)- and hypoxia-ischemia (HI)-induced white matter damage (WMD) model. METHODS:Three-day-old Spragu...

journal_title：Neonatology

authors： Yin X,Zhao J,Jiang H,Li L,Jiang J,Xi H,Peng X,Yin X,Shi X,Zhang L

更新日期：2018-01-01 00:00:00

abstract：:The treatment of preterm newborn rabbits with synthetic surfactants containing simple phospholipid mixtures and peptides gives similar tidal volumes to treatment with poractant alfa (Curosurf®). The addition of both surfactant protein B and C analogs to the phospholipid mixture will stabilize the alveoli, measured as ...

journal_title：Neonatology

authors： Curstedt T,Calkovska A,Johansson J

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:Non-invasive cardiac output monitoring is a potentially useful clinical tool in the neonatal setting. Our aim was to evaluate a new method of non-invasive continuous cardiac output (CO) measurement (NICOM™) based on the principle of bioreactance in neonates. METHODS:In this prospective observational study, ...

journal_title：Neonatology

authors： Weisz DE,Jain A,McNamara PJ,EL-Khuffash A

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Oral propranolol has improved the treatment of infantile hemangiomas, and a pediatric oral solution of propranolol has recently been licensed in the USA and Europe. In very preterm infants, infantile hemangiomas are associated with the occurrence of retinopathy of prematurity (ROP), and both diseases share...

journal_title：Neonatology

authors： Bührer C,Bassler D

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Faecal calprotectin has been proposed as a sensitive marker for gastrointestinal inflammation in children and adults. High levels have been reported in healthy newborns and during the first months of life; the effect of the kind of feeding on the calprotectin concentration in stools is controversial. OBJECT...

journal_title：Neonatology

authors： Savino F,Castagno E,Calabrese R,Viola S,Oggero R,Miniero R

更新日期：2010-06-01 00:00:00

abstract：:Despite recent advances in the perinatal management of neonatal respiratory distress syndrome (RDS), controversies still exist. We report the updated recommendations of a European panel of expert neonatologists who had developed consensus guidelines after critical examination of the most up-to-date evidence in 2007. T...

journal_title：Neonatology

authors： Sweet DG,Carnielli V,Greisen G,Hallman M,Ozek E,Plavka R,Saugstad OD,Simeoni U,Speer CP,Halliday HL,European Association of Perinatal Medicine.

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Hypoxia-ischemia (HI) results in increased activation of Ca2+/calmodulin kinase IV (CaM kinase IV) mediated by Src kinase. Therapeutic hypothermia ameliorates neuronal injury in the newborn. HYPOTHESIS:Inhibition of Src kinase concurrently with hypothermia further attenuates the hypoxia-induced increased ac...

journal_title：Neonatology

authors： Kratimenos P,Koutroulis I,Jain A,Malaeb S,Delivoria-Papadopoulos M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:While hypoxic events with bradycardias are a frequent occurrence during the first weeks of life in preterm infants, the impact of preterm birth on maturation of the cardiovascular response to hypoxia in early postnatal life is unknown. OBJECTIVES:In the present study, we tested the hypothesis that preterm b...

journal_title：Neonatology

authors： Pladys P,Arsenault J,Reix P,Rouillard Lafond J,Moreau-Bussière F,Praud JP

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:High-dose recombinant erythropoietin (rEpo) is neuroprotective in neonatal animal models of brain injury, but the long-term consequences of neonatal exposure have not been studied. OBJECTIVES:We hypothesized that multiple injections of high-dose rEpo during the neonatal period would be safe, and would impro...

journal_title：Neonatology

authors： McPherson RJ,Demers EJ,Juul SE

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Despite increasing survival in the smallest preterm infants, the incidence of chronic lung disease has not decreased. Research into ventilatory strategies has concentrated on minimising barotrauma, volutrauma and atelectotrauma, but little attention has been paid to the role of bias gas flow rates and the po...

journal_title：Neonatology

authors： Bach KP,Kuschel CA,Oliver MH,Bloomfield FH

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Hyperglycaemia is a common complication of prematurity and is associated with neonatal mortality and morbidity, yet the aetiology is incompletely understood. C-peptide has been used in adults to estimate endogenous insulin secretion due to its simple clearance kinetics. OBJECTIVE:To determine insulin secret...

journal_title：Neonatology

authors： Dickson JL,Chase JG,Pretty CG,Gunn CA,Alsweiler JM

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Sustained lung inflation (SLI) applied at birth has been demonstrated to lead to clearance of lung fluid and achievement of a precocious functional residual capacity in animal studies. OBJECTIVES:To verify if the application of SLI in preterm infants at birth may reduce the need for mechanical ventilation a...

journal_title：Neonatology

authors： Lista G,Fontana P,Castoldi F,Cavigioli F,Dani C

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Doxapram has been advocated as a treatment for persistent apnea of prematurity (AOP). OBJECTIVE:To evaluate the effect of doxapram on long-term neurodevelopmental outcome in preterm infants as its safety still needs to be established. METHODS:From a retrospective cohort of preterm infants with a gestationa...

journal_title：Neonatology

authors： Ten Hove CH,Vliegenthart RJ,Te Pas AB,Brouwer E,Rijken M,van Wassenaer-Leemhuis AG,van Kaam AH,Onland W

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Fetal lung development requires proper coordination between lung epithelial and vascular morphogenesis. A major determinant in lung vascular development is vascular endothelial growth factor (VEGF), which is regulated by hypoxia-inducible factors (HIFs). VEGF is expressed in the airway epithelium, while its ...

journal_title：Neonatology

authors： Rajatapiti P,de Rooij JD,Beurskens LW,Keijzer R,Tibboel D,Rottier RJ,de Krijger RR

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Small for gestational age (SGA) neonates are at increased risk of mortality and morbidity, including necrotizing enterocolitis (NEC), but detailed information on the incidence and risk factors of NEC in SGA neonates is lacking. OBJECTIVE:This study aims to estimate the incidence of NEC in a large cohort of ...

journal_title：Neonatology

authors： Ree IM,Smits-Wintjens VE,Rijntjes-Jacobs EG,Pelsma IC,Steggerda SJ,Walther FJ,Lopriore E

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Preterm birth contributes significantly to infant mortality and morbidity, including blindness from retinopathy of prematurity (ROP). Access to intensive neonatal care is expanding in many countries, but care is not always optimal, one factor being that nursing is often by inadequately trained nurse assistan...

journal_title：Neonatology

authors： Gilbert C,Darlow B,Zin A,Sivasubramaniam S,Shah S,Gianini N,Beecroft G,Lopes Moreira ME

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Numerous studies in cultured cells indicate that damage to mitochondrial DNA (mtDNA) dictates cellular responses to oxidant stress, yet the consequences of mtDNA damage have not been studied directly in the preterm lung. OBJECTIVE:We sought to determine whether hyperoxia-induced fetal lung dysmorphogenesis ...

journal_title：Neonatology

authors： Gebb SA,Decoux A,Waggoner A,Wilson GL,Gillespie MN

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Although liver can be injured under the hypoxic-ischemic encephalopathy (HIE) condition, there is currently no histopathological evidence. Therapeutic hypothermia is used to protect the brain; however, the therapeutic potential for concomitant liver injury is unknown. OBJECTIVES:This study aimed to histopat...

journal_title：Neonatology

authors： Kubo H,Shimono R,Nakamura S,Koyano K,Jinnai W,Yamato S,Yasuda S,Nakamura M,Tanaka A,Fujii T,Kanenishi K,Chiba Y,Miki T,Kusaka T,Ueno M

更新日期：2017-01-01 00:00:00