Abstract:
BACKGROUND:Characteristics of neonatal tracheal intubations (TI) may vary between the neonatal intensive care unit (NICU) and delivery room (DR). The impact of the setting on TI outcomes is not well characterized. OBJECTIVE:The aim of this study was to define variation in neonatal TI practice between settings, and identify the association between setting and TI success and safety outcomes. DESIGN:This was a retrospective cohort study of TIs in the National Emergency Airway Registry for Neonates from October 2014 to September 2017. The setting (NICU vs. DR) was the exposure of interest. The outcomes were first attempt success, course success, success within 4 attempts, adverse TI-associated events, severe desaturation, and bradycardia. We compared TI characteristics and outcomes between settings in univariable analysis. Factors significant in univariable analysis (p < 0.1) were included in a logistic regression model, with adjustment for clustering by center, to identify the independent impact of the setting on TI outcomes. RESULTS:There were 3,145 TI encounters (2279 NICU, 866 DR) in 9 centers. Almost all baseline characteristics significantly varied between settings. First attempt success rates were 48% (NICU) and 46% (DR). In multivariable analysis, the setting was not associated with first attempt success. DR was associated with a higher adjusted OR (aOR) of success within 4 attempts (1.48, 95% CI 1.06-2.08) and a lower aOR for bradycardia (0.43, 95% CI 0.26-0.71). CONCLUSION:Significant differences in patient, provider, and practice characteristics exist between NICU and DR TIs. There is substantial room for improvement in first attempt success rates. These results suggest interventions to improve safety and success need to be targeted to the distinct setting.
journal_name
Neonatologyjournal_title
Neonatologyauthors
Herrick HM,Glass KM,Johnston LC,Singh N,Shults J,Ades A,Nadkarni V,Nishisaki A,Foglia EE,for the NEAR4NEOS Investigators.doi
10.1159/000502611subject
Has Abstractpub_date
2020-01-01 00:00:00pages
65-72issue
1eissn
1661-7800issn
1661-7819pii
000502611journal_volume
117pub_type
杂志文章,多中心研究相关文献
Neonatology文献大全abstract:OBJECTIVES:Strategies for oxygen therapy for preterm infants, such as the Vermont-Oxford's 'Breathsavers' guidelines, seek to strike a balance between the potential risks of the extremes of hyperoxia and hypoxia in preterm infants. Using an algorithm based on those guidelines, we aimed to compare the proportion of time...
journal_title:Neonatology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000368295
更新日期:2015-01-01 00:00:00
abstract::We describe a case highlighting several controversial and important topics regarding neonatal cardiopulmonary resuscitation (CPR). Current neonatal guidelines recommend a 3:1 compression:ventilation ratio; however, the most effective ratio of delivering chest compressions (CC) remains controversial. We report a case o...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000357609
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Carriers of Staphylococcus aureus strains can be the source of epidemic infection for patients. OBJECTIVES:A molecular epidemiological analysis of an impetigo bullosa outbreak in a neonatal ward was performed in order to determine a potential source of the infection and possible routes of subsequent spreadi...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000204961
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Nosocomial infections endanger preterm infants. OBJECTIVE:The aim of the present controlled randomized trial was to investigate whether Bifidobacterium lactis reduces the incidence of nosocomial infections in infants with very low birth weight (VLBW; <1,500 g) <30 weeks of gestation. PATIENTS AND METHODS:I...
journal_title:Neonatology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000280291
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have a beneficial effect on bronchopulmonary dysplasia (BPD), which is the most common complication of extreme preterm birth. OBJECTIVES:To study the inflammatory, structural and functional effects of caffeine in an animal mode...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000442937
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Umbilical arterial catheters (UACs) are frequently used in critically ill neonates. UAC are convenient, reliable, and allow for caregiver convenience in performing painless arterial blood sampling. We hypothesized that UAC removal in extremely low birth weight (ELBW) neonates will result in significantly les...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000506907
更新日期:2020-01-01 00:00:00
abstract:AIM:Melatonin is a potent free radical scavenger and an indirect antioxidant. Knowledge about the behavior of melatonin secretion in the early neonatal period, which may relate to its properties at a vital stage during very high antioxidant demands, is limited. PATIENTS AND METHODS:We studied 35 newborns admitted to t...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000102957
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common enzyme deficiency affecting more than 300 million individuals worldwide. Extreme neonatal hyperbilirubinemia, with its severe sequelae of bilirubin neurotoxicity and the potential of death, is the most devastating manifestation of G6PD deficienc...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000489820
更新日期:2018-01-01 00:00:00
abstract::The treatment of preterm newborn rabbits with synthetic surfactants containing simple phospholipid mixtures and peptides gives similar tidal volumes to treatment with poractant alfa (Curosurf®). The addition of both surfactant protein B and C analogs to the phospholipid mixture will stabilize the alveoli, measured as ...
journal_title:Neonatology
pub_type: 杂志文章,评审
doi:10.1159/000349942
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Refinement of ventilatory techniques remains a challenge given the persistence of chronic lung disease of preterm infants. METHODS:To test the hypothesis that proportional assist ventilation (PAV) will allow to lower the ventilator pressure at equivalent fractions of inspiratory oxygen (FiO(2)) and arterial...
journal_title:Neonatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000098376
更新日期:2007-01-01 00:00:00
abstract::Ductus arteriosus and foramen ovale were described by Galen without understanding their functions. His beliefs in soul localization and spiritization within the left ventricle established religious pneumatology which became a theological need in the Middle Ages. Pulmonary transit was recognized by Servetus and Colombo...
journal_title:Neonatology
pub_type: 历史文章,杂志文章
doi:10.1159/000308367
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Positive pressure ventilation (PPV) with T-Piece and self-inflating bag (SIB) during neonatal resuscitation after birth is associated with variability in ventilation. The use of a ventilator with respiratory function monitoring (RFM) for PPV, however, has not been evaluated. OBJECTIVE:To determine if vent...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000503257
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Heart rate (HR) detection in premature infants using electrocardiography (ECG) is challenging due to a low signal amplitude and the fragility of the premature skin. Recently, the dynamic light scattering (DLS) technique has been miniaturized, allowing noninvasive HR measurements with a single sensor. OBJECT...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000506771
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:High-dose recombinant erythropoietin (rEpo) is neuroprotective in neonatal animal models of brain injury, but the long-term consequences of neonatal exposure have not been studied. OBJECTIVES:We hypothesized that multiple injections of high-dose rEpo during the neonatal period would be safe, and would impro...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000096969
更新日期:2007-01-01 00:00:00
abstract::Volume resuscitation (VR) for the treatment of newborn shock is a rare but potentially lifesaving intervention. Conducting clinical studies to assess the effectiveness of VR in the delivery room during newborn stabilization is challenging. We review the available literature and current management guidelines to determi...
journal_title:Neonatology
pub_type: 杂志文章,评审
doi:10.1159/000475456
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:In the absence of universal screening for congenital cytomegalovirus (cCMV) infection, the aim of this study was to assess the outcomes of a targeted screening protocol based on maternal and neonatal risk indicators. METHODS:The medical records of 2,623 neonates born in our maternal hospital between June 20...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000512525
更新日期:2020-12-22 00:00:00
abstract:BACKGROUND:Surface temperatures of fibreoptic phototherapy pads using a high intensity blue light-emitting diode (LED) light source have not been studied. OBJECTIVES:The aim of this study was to measure the temperature of LED fibreoptic phototherapy pads during phototherapy in a bench-top study, and to determine tempe...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000464318
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Although liver can be injured under the hypoxic-ischemic encephalopathy (HIE) condition, there is currently no histopathological evidence. Therapeutic hypothermia is used to protect the brain; however, the therapeutic potential for concomitant liver injury is unknown. OBJECTIVES:This study aimed to histopat...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000450721
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To examine the impact of medical complexity among very preterm infants on health care resource use, family, and neurodevelopmental outcomes at 18 months' corrected age. METHODS:This observational cohort study of Canadian infants born < 29 weeks' gestational age in 2009-2011 compared infants with and those wi...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000496494
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Despite increasing survival in the smallest preterm infants, the incidence of chronic lung disease has not decreased. Research into ventilatory strategies has concentrated on minimising barotrauma, volutrauma and atelectotrauma, but little attention has been paid to the role of bias gas flow rates and the po...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000220765
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Recurrent and prolonged seizures are harmful for the developing brain, emphasizing the importance of early seizure recognition and effective therapy. Amplitude-integrated electroencephalography (aEEG) has become a valuable tool to diagnose epileptic seizures, and, in parallel, genetic etiologies are increasi...
journal_title:Neonatology
pub_type: 杂志文章,多中心研究
doi:10.1159/000478651
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Oxidative stress in the newborn period may cause cell injury and inflammation if the antioxidant capacity is insufficient. To monitor antioxidant and inflammatory activity we examined by in vivo imaging various strains of luciferase reporter mice whose light-emitting properties were regulated by response e...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000107777
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Randomised controlled trials provide the best evidence for the effects of interventions and are a key tool in the effort to improve the care and outcomes for newborn infants. METHODS:We discuss the role of randomisation for minimising selection bias in clinical trials and describe examples of seminal trials...
journal_title:Neonatology
pub_type: 杂志文章,评审
doi:10.1159/000499881
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Oral propranolol has improved the treatment of infantile hemangiomas, and a pediatric oral solution of propranolol has recently been licensed in the USA and Europe. In very preterm infants, infantile hemangiomas are associated with the occurrence of retinopathy of prematurity (ROP), and both diseases share...
journal_title:Neonatology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000381659
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Gene expression profiling of the salivary supernatant is emerging as a new and important source of real-time, systemic, biological information. However, existing technologies prevent RNA extraction of small quantities found in neonatal salivary supernatant. OBJECTIVE:The aim of this study was to develop tec...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000328026
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Periventricular white matter (PWM) is particularly vulnerable in very preterm infants. Non-cystic white matter injury, known as non-cystic periventricular leukomalacia (ncPVL), is the commonest 'lesion' affecting the preterm brain. There is no consensus about whether ncPVL can be reliably identified from cer...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000357937
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Recent studies indicate an increasing use of less invasive surfactant administration. Different techniques have been shown with distinct risks and benefits. The aim of this study was to develop a new method that simplifies this procedure. OBJECTIVES:An applicator was developed and tested on a manikin to mak...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000450823
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:To compare the ultrasound examination with pH-metry in order to evaluate the diagnostic accuracy of sonography for diagnosis of gastro-oesophageal reflux (GOR) in preterm infants. METHODS:A prospective study was conducted on 31 premature infants <34 weeks with clinically diagnosed GOR. First, they underwent...
journal_title:Neonatology
pub_type: 临床试验,杂志文章
doi:10.1159/000097447
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:International neonatal resuscitation guidelines recommend assessing chest excursion when the heart rate is not improving. However, the accuracy in assessing 'adequate' chest excursion lacks objectivity. AIM:It was the aim of this study to test the accuracy in the assessment of 'adequate' chest excursion by ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000322009
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Numerous studies in cultured cells indicate that damage to mitochondrial DNA (mtDNA) dictates cellular responses to oxidant stress, yet the consequences of mtDNA damage have not been studied directly in the preterm lung. OBJECTIVE:We sought to determine whether hyperoxia-induced fetal lung dysmorphogenesis ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000342632
更新日期:2013-01-01 00:00:00