Abstract:
:Ductus arteriosus and foramen ovale were described by Galen without understanding their functions. His beliefs in soul localization and spiritization within the left ventricle established religious pneumatology which became a theological need in the Middle Ages. Pulmonary transit was recognized by Servetus and Colombo after the Reformation around 1550. This prompted Harvey's full understanding of the fetal circulation. Botallo did not describe the ductus arteriosus, but in 1564 redescribed the foramen ovale, making his way into the nomina anatomica by mistake. Most authors of the 19th and 20th century believed ductal patency to be passive, and postnatal closure to be an active process, explained by mechanical theories. After the discovery of prostaglandins by Bergstrom and Vane, Coceani proved that ductal patency is maintained by the relaxant action of prostaglandins.
journal_name
Neonatologyjournal_title
Neonatologyauthors
Obladen Mdoi
10.1159/000308367subject
Has Abstractpub_date
2011-01-01 00:00:00pages
83-9issue
2eissn
1661-7800issn
1661-7819pii
000308367journal_volume
99pub_type
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