Factors Associated with Adverse Events during Tracheal Intubation in the NICU.

Abstract:

BACKGROUND:The incidence of adverse tracheal intubation-associated events (TIAEs) and associated patient, practice, and intubator characteristics in the neonatal intensive care unit (NICU) setting are unknown. OBJECTIVES:To determine the incidence of adverse TIAEs and to identify factors associated with TIAEs in the NICU. METHODS:Single-site prospective observational cohort study of infants who were intubated in a level 4 referral NICU between September 1, 2011 and November 30, 2013. A standardized pediatric airway registry was implemented to document patient, practice, and intubator characteristics and outcomes of intubation encounters. The primary outcome was adverse TIAEs. RESULTS:Adverse TIAEs occurred in 153 of 701 (22%) tracheal intubation encounters. Factors that were independently associated with lower incidence of TIAEs in logistic regression included attending physician (vs. resident; odds ratio (OR) 0.4, 95% CI: 0.16, 0.98) and use of paralytic medication (OR 0.45, 95% CI: 0.25, 0.81). Severe oxygen desaturations (≥ 20% decrease in oxygen saturation) occurred in 51.1% of encounters and were more common in tracheal intubations performed by residents (62.8%), compared to fellows (43.2%) or attendings (47.5%; p = 0.008). CONCLUSIONS:Adverse TIAEs and severe oxygen desaturation events are common in the NICU setting. Modifiable risk factors associated with TIAEs identified include intubator training level and use of paralytic medications.

journal_name

Neonatology

journal_title

Neonatology

authors

Foglia EE,Ades A,Napolitano N,Leffelman J,Nadkarni V,Nishisaki A

doi

10.1159/000381252

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

23-9

issue

1

eissn

1661-7800

issn

1661-7819

pii

000381252

journal_volume

108

pub_type

杂志文章
  • End-of-Life Care and Survival without Major Brain Damage in Newborns at the Limit of Viability.

    abstract:BACKGROUND:The probabilities of survival and survival without major brain damage (MBD) are low in newborns at the limit of viability. Survival without MBD constitutes a major concern for parents and professionals. OBJECTIVES:To know the probabilities of survival without MBD in newborns ≤26 weeks' gestational age (GA) ...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000452195

    authors: García-Muñoz Rodrigo F,Urquía Martí L,García Hernández JÁ,Figueras Aloy J,García-Alix Pérez A,SEN1500 Network of the Spanish Neonatal Society.

    更新日期:2017-01-01 00:00:00

  • High faecal calprotectin levels in healthy, exclusively breast-fed infants.

    abstract:BACKGROUND:Faecal calprotectin has been proposed as a sensitive marker for gastrointestinal inflammation in children and adults. High levels have been reported in healthy newborns and during the first months of life; the effect of the kind of feeding on the calprotectin concentration in stools is controversial. OBJECT...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000255161

    authors: Savino F,Castagno E,Calabrese R,Viola S,Oggero R,Miniero R

    更新日期:2010-06-01 00:00:00

  • Chest Compressions during Sustained Inflations Improve Recovery When Compared to a 3:1 Compression:Ventilation Ratio during Cardiopulmonary Resuscitation in a Neonatal Porcine Model of Asphyxia.

    abstract:BACKGROUND:Recently, sustained inflations (SI) during chest compression (CC) (CC+SI) have been suggested as an alternative to the current approach during neonatal resuscitation. No previous study compared CC+SI using CC rates of 90/min to the current 3:1 compression:ventilation ratio (C:V). OBJECTIVE:To determine whet...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000477998

    authors: Li ES,Görens I,Cheung PY,Lee TF,Lu M,O'Reilly M,Schmölzer GM

    更新日期:2017-01-01 00:00:00

  • Neonatal Umbilical Arterial Catheter Removal Is Accompanied by a Marked Decline in Phlebotomy Blood Loss.

    abstract:BACKGROUND:Umbilical arterial catheters (UACs) are frequently used in critically ill neonates. UAC are convenient, reliable, and allow for caregiver convenience in performing painless arterial blood sampling. We hypothesized that UAC removal in extremely low birth weight (ELBW) neonates will result in significantly les...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000506907

    authors: Carroll PD,Zimmerman MB,Nalbant D,Gingerich EL,An G,Cress GA,Veng-Pedersen P,Widness JA

    更新日期:2020-01-01 00:00:00

  • Increased Carbon Monoxide Washout Rates in Newborn Infants.

    abstract:BACKGROUND:Endogenous carbon monoxide (CO) production is primarily due to heme degradation, which also results in the equimolar production of bilirubin. Thus, estimates of total body CO production can serve as indices of total body bilirubin formation. The elimination rate of CO from a person's body (CO washout rate) a...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000503635

    authors: Stevenson DK,Wong RJ,Ostrander CR,Maric I,Vreman HJ,Cohen RS

    更新日期:2020-01-01 00:00:00

  • Cerebral Oxygenation, Superior Vena Cava Flow, Severe Intraventricular Hemorrhage and Mortality in 60 Very Low Birth Weight Infants.

    abstract:BACKGROUND:Brain vulnerability in the critically ill preterm newborn may be related to the burden of cerebral hypoxygenation and hypoperfusion during the immediate postnatal period. OBJECTIVE:We determined the association between adverse outcomes [death or high grade intraventricular hemorrhage (IVH)] and continuous c...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000438452

    authors: Cerbo RM,Scudeller L,Maragliano R,Cabano R,Pozzi M,Tinelli C,Bollani L,Stronati M

    更新日期:2015-01-01 00:00:00

  • Oral ibuprofen versus intravenous ibuprofen or intravenous indomethacin for the treatment of patent ductus arteriosus in preterm infants: a systematic review and meta-analysis.

    abstract:BACKGROUND:Pharmacological closure of patent ductus arteriosus (PDA) is commonly achieved by intravenous (IV) administration of ibuprofen or indomethacin. Occasionally, oral ibuprofen is used for PDA treatment although its efficacy and safety are unclear. OBJECTIVES:To systematically review randomized and quasi-random...

    journal_title:Neonatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000335332

    authors: Neumann R,Schulzke SM,Bührer C

    更新日期:2012-01-01 00:00:00

  • Non-invasive cardiac output monitoring in neonates using bioreactance: a comparison with echocardiography.

    abstract:OBJECTIVES:Non-invasive cardiac output monitoring is a potentially useful clinical tool in the neonatal setting. Our aim was to evaluate a new method of non-invasive continuous cardiac output (CO) measurement (NICOM™) based on the principle of bioreactance in neonates. METHODS:In this prospective observational study, ...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000337295

    authors: Weisz DE,Jain A,McNamara PJ,EL-Khuffash A

    更新日期:2012-01-01 00:00:00

  • Educating neonatal nurses in Brazil: a before-and-after study with interrupted time series analysis.

    abstract:BACKGROUND:Preterm birth contributes significantly to infant mortality and morbidity, including blindness from retinopathy of prematurity (ROP). Access to intensive neonatal care is expanding in many countries, but care is not always optimal, one factor being that nursing is often by inadequately trained nurse assistan...

    journal_title:Neonatology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000362532

    authors: Gilbert C,Darlow B,Zin A,Sivasubramaniam S,Shah S,Gianini N,Beecroft G,Lopes Moreira ME

    更新日期:2014-01-01 00:00:00

  • Randomised Controlled Trials for Informing Perinatal Care.

    abstract:BACKGROUND:Randomised controlled trials provide the best evidence for the effects of interventions and are a key tool in the effort to improve the care and outcomes for newborn infants. METHODS:We discuss the role of randomisation for minimising selection bias in clinical trials and describe examples of seminal trials...

    journal_title:Neonatology

    pub_type: 杂志文章,评审

    doi:10.1159/000499881

    authors: Gale C,McGuire W,Juszczak E

    更新日期:2020-01-01 00:00:00

  • Postnatal hydrocortisone for preventing or treating bronchopulmonary dysplasia in preterm infants: a systematic review.

    abstract:BACKGROUND:Corticosteroids have been used widely after birth in preterm infants with respiratory failure; hydrocortisone may be preferable to other corticosteroids for this purpose. OBJECTIVES:To determine if postnatal hydrocortisone is useful to prevent or treat bronchopulmonary dysplasia (BPD) in preterm infants. M...

    journal_title:Neonatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000279992

    authors: Doyle LW,Ehrenkranz RA,Halliday HL

    更新日期:2010-01-01 00:00:00

  • Lack of Evidence for Time or Dose Relationship between Antenatal Magnesium Sulfate and Intestinal Injury in Extremely Preterm Neonates.

    abstract:BACKGROUND:Recent studies reported conflicting results on the relationship between antenatal magnesium sulfate (MgSO4) exposure and neonatal intestinal injury. Most studies have not assessed MgSO4 exposure quantitatively and none reported the exposure timing. OBJECTIVES:The aim of this work was to assess whether there...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000497412

    authors: Mikhael M,Bronson C,Zhang L,Curran M,Rodriguez H,Bhakta KY

    更新日期:2019-01-01 00:00:00

  • Effect of Bifidobacterium lactis on the incidence of nosocomial infections in very-low-birth-weight infants: a randomized controlled trial.

    abstract:BACKGROUND:Nosocomial infections endanger preterm infants. OBJECTIVE:The aim of the present controlled randomized trial was to investigate whether Bifidobacterium lactis reduces the incidence of nosocomial infections in infants with very low birth weight (VLBW; <1,500 g) <30 weeks of gestation. PATIENTS AND METHODS:I...

    journal_title:Neonatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000280291

    authors: Mihatsch WA,Vossbeck S,Eikmanns B,Hoegel J,Pohlandt F

    更新日期:2010-01-01 00:00:00

  • The Changing Landscape in Supporting Preterm Infants at Birth.

    abstract::Noninvasive ventilation for preterm infants at birth has been recommended and universally adopted. The umbilical cord is often clamped immediately in order to provide the support the infant needs for stabilization. However, recent scientific data from experimental studies that involve animals in transition and human s...

    journal_title:Neonatology

    pub_type: 杂志文章,评审

    doi:10.1159/000497421

    authors: Te Pas AB,Hooper SB,Dekker J

    更新日期:2019-01-01 00:00:00

  • Volume-targeted versus pressure-limited ventilation for preterm infants: a systematic review and meta-analysis.

    abstract:BACKGROUND:The causes of bronchopulmonary dysplasia (BPD) are multifactorial. Overdistension of the lung (volutrauma) is considered an important contribution. As an alternative to traditional pressure-limited ventilation (PLV), modern neonatal ventilators offer modes which can target a set tidal volume. OBJECTIVES:To ...

    journal_title:Neonatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000326080

    authors: Wheeler KI,Klingenberg C,Morley CJ,Davis PG

    更新日期:2011-01-01 00:00:00

  • Social Birth: Rites of Passage for the Newborn.

    abstract::Rites of passage mark important changes during human life and, for the neonate, its transition from intrauterine life into society. Their original intent was to purify the body from blood and meconium. But the cleansing rites had a spiritual dimension from the very start. When the rites of Mesopotamian, Egyptian, Jewi...

    journal_title:Neonatology

    pub_type: 历史文章,杂志文章

    doi:10.1159/000477955

    authors: Obladen M

    更新日期:2017-01-01 00:00:00

  • Effect of oxygen on the expression of hypoxia-inducible factors in human fetal lung explants.

    abstract:BACKGROUND:Fetal lung development requires proper coordination between lung epithelial and vascular morphogenesis. A major determinant in lung vascular development is vascular endothelial growth factor (VEGF), which is regulated by hypoxia-inducible factors (HIFs). VEGF is expressed in the airway epithelium, while its ...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000261018

    authors: Rajatapiti P,de Rooij JD,Beurskens LW,Keijzer R,Tibboel D,Rottier RJ,de Krijger RR

    更新日期:2010-06-01 00:00:00

  • Automated Quantification of Fragmented Red Blood Cells: Neonatal Reference Intervals and Clinical Disorders of Neonatal Intensive Care Unit Patients with High Values.

    abstract:BACKGROUND:Schistocytes are circulating erythrocyte fragments. They can be identified microscopically from a blood smear; but automated systems evaluate more cells and avoid inconsistencies in microscopy. Studies using adult subjects indicate that automated quantification of schistocytes can be clinically useful. Howev...

    journal_title:Neonatology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000491626

    authors: Judkins AJ,MacQueen BC,Christensen RD,Henry E,Snow GL,Bennett ST

    更新日期:2019-01-01 00:00:00

  • The Relationship between Oxidative Stress, Intermittent Hypoxemia, and Hospital Duration in Moderate Preterm Infants.

    abstract:INTRODUCTION:Lipid peroxidation products are present following oxidation of polyunsaturated fatty acids in the eye, brain, and various cell membranes. Elevated levels of lipid peroxidation products and increased intermittent hypoxemia (IH) events have been associated with adverse outcomes in extremely preterm infants. ...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000509038

    authors: Shah VP,Raffay TM,Martin RJ,Vento M,Sánchez-Illana Á,Piñeiro-Ramos JD,Kuligowski J,Di Fiore JM

    更新日期:2020-01-01 00:00:00

  • Alveolar Airspace Size in Healthy and Diseased Infant Lungs Measured via Hyperpolarized 3He Gas Diffusion Magnetic Resonance Imaging.

    abstract:BACKGROUND:Alveolar development and lung parenchymal simplification are not well characterized in vivo in neonatal patients with respiratory morbidities, such as bronchopulmonary dysplasia (BPD). Hyperpolarized (HP) gas diffusion magnetic resonance imaging (MRI) is a sensitive, safe, nonionizing, and noninvasive biomar...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000511084

    authors: Higano NS,Thomen RP,Quirk JD,Huyck HL,Hahn AD,Fain SB,Pryhuber GS,Woods JC

    更新日期:2020-11-11 00:00:00

  • Minocycline blocks acute bilirubin-induced neurological dysfunction in jaundiced Gunn rats.

    abstract:BACKGROUND:Extreme hyperbilirubinemia is treated with double volume exchange transfusion, which may take hours to commence. A neuroprotective agent that could be administered immediately might be clinically useful. Minocycline, an anti-inflammatory and anti-apoptotic semisynthetic tetracycline, prevents hyperbilirubine...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000103740

    authors: Geiger AS,Rice AC,Shapiro SM

    更新日期:2007-01-01 00:00:00

  • The Specificity of the WINROP Algorithm Can Be Significantly Increased by Reassessment of the WINROP Alarm.

    abstract:BACKGROUND:Retinopathy of prematurity (ROP) is a sight-threatening disease affecting extremely preterm infants. The introduction of new ROP screening surveillance systems, with higher sensitivity and specificity than established ROP screening guidelines, has the potential to reduce the number of stressful eye examinati...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000435770

    authors: Lundgren P,Stoltz Sjöström E,Domellöf M,Smith L,Wu C,VanderVeen D,Hellström A,Löfqvist C

    更新日期:2015-01-01 00:00:00

  • Ventilation-Induced Brain Injury in Preterm Neonates: A Review of Potential Therapies.

    abstract::Mechanical ventilation is a risk factor for cerebral inflammation and brain injury in preterm neonates. The risk increases proportionally with the intensity of treatment. Recent studies have shown that cerebral inflammation and injury can be initiated in the delivery room. At present, initiation of intermittent positi...

    journal_title:Neonatology

    pub_type: 杂志文章,评审

    doi:10.1159/000444918

    authors: Barton SK,Tolcos M,Miller SL,Christoph-Roehr C,Schmölzer GM,Moss TJ,Hooper SB,Wallace EM,Polglase GR

    更新日期:2016-01-01 00:00:00

  • Dynamic Light Scattering: A New Noninvasive Technology for Neonatal Heart Rate Monitoring.

    abstract:BACKGROUND:Heart rate (HR) detection in premature infants using electrocardiography (ECG) is challenging due to a low signal amplitude and the fragility of the premature skin. Recently, the dynamic light scattering (DLS) technique has been miniaturized, allowing noninvasive HR measurements with a single sensor. OBJECT...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000506771

    authors: Gangaram-Panday NH,van Essen T,Goos TG,de Jonge RCJ,Reiss IKM,van Weteringen W

    更新日期:2020-01-01 00:00:00

  • Diagnostic value of an interleukin-6 bedside test in term and preterm neonates at the time of clinical suspicion of early- and late-onset bacterial infection.

    abstract:BACKGROUND:For quick detection or exclusion of neonatal early-onset bacterial infection (EOBI) or late-onset bacterial infection (LOBI), interleukin (IL)-6 is used. Its clinical use is sometimes limited due to prolonged recall times. Therefore, an IL-6 bedside test was established. OBJECTIVE:To compare the diagnostic ...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000336632

    authors: Batfalsky A,Lohr A,Heussen N,Neunhoeffer F,Orlikowsky TW

    更新日期:2012-01-01 00:00:00

  • Effect of Phenobarbitone on Amplitude-Integrated Electroencephalography in Neonates with Hypoxic-Ischemic Encephalopathy during Hypothermia.

    abstract:BACKGROUND:Phenobarbitone induces suppression of cerebral electrical activity on amplitude-integrated electroencephalography (aEEG) in neonates with hypoxic-ischemic encephalopathy (HIE); however, its effect during therapeutic hypothermia (TH) has not been well characterized. OBJECTIVE:To evaluate the effect of phenob...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000511540

    authors: Deshpande P,Jain A,McNamara PJ

    更新日期:2021-01-07 00:00:00

  • Congenital ichthyosis in severe type II Gaucher disease with a homozygous null mutation.

    abstract::This paper describes a neonate with type II Gaucher disease. The phenotype was unusually severe with congenital ichthyosis, hepatosplenomegaly, muscular hypotonia, myoclonus and respiratory failure. Electron microscopy of the skin revealed lamellar body contents in the stratum corneum interstices, appearances consider...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000324116

    authors: Haverkaemper S,Marquardt T,Hausser I,Timme K,Kuehn T,Hertzberg C,Rossi R

    更新日期:2011-01-01 00:00:00

  • The use of the WINROP screening algorithm for the prediction of retinopathy of prematurity in a Chinese population.

    abstract:BACKGROUND:Retinopathy of prematurity (ROP) is a gestational age (GA)-related illness that can lead to blindness in premature infants. Timely screening of premature infants could improve visual prognosis. OBJECTIVE:To evaluate the WINROP algorithm as a method of predicting severe ROP in a Chinese population. METHODS:...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000351297

    authors: Sun H,Kang W,Cheng X,Chen C,Xiong H,Guo J,Zhou C,Zhang Y,Hellström A,Löfqvist C,Zhu C

    更新日期:2013-01-01 00:00:00

  • A Randomized Controlled Trial of Immediate versus Delayed Umbilical Cord Clamping in Multiple-Birth Infants Born Preterm.

    abstract:BACKGROUND:Delayed cord clamping (DCC) improves placental transfusion and increases blood volume in preterm infants when compared with immediate cord clamping (ICC). However, evidence to support DCC in multiple-birth preterm infants is still lacking. OBJECTIVE:To compare the outcomes of ICC versus DCC in preterm infan...

    journal_title:Neonatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000494132

    authors: Ruangkit C,Bumrungphuet S,Panburana P,Khositseth A,Nuntnarumit P

    更新日期:2019-01-01 00:00:00

  • Long-Term Neurodevelopmental Outcome after Doxapram for Apnea of Prematurity.

    abstract:BACKGROUND:Doxapram has been advocated as a treatment for persistent apnea of prematurity (AOP). OBJECTIVE:To evaluate the effect of doxapram on long-term neurodevelopmental outcome in preterm infants as its safety still needs to be established. METHODS:From a retrospective cohort of preterm infants with a gestationa...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000444006

    authors: Ten Hove CH,Vliegenthart RJ,Te Pas AB,Brouwer E,Rijken M,van Wassenaer-Leemhuis AG,van Kaam AH,Onland W

    更新日期:2016-01-01 00:00:00