Abstract:
BACKGROUND:Inhaled glucocorticoids may increase the risk of pneumonia in adults. Thus, respiratory infections may be a potential explanation for the non-significantly increased mortality seen in the glucocorticoid group in the largest randomized trial on inhaled glucocorticoids for preventing bronchopulmonary dysplasia in preterm infants published to date (NEuroSIS). OBJECTIVE:To evaluate the effect of inhaled budesonide on the risk of death due to respiratory infections in the NEuroSIS trial. METHODS:We performed post hoc analyses of prospectively collected data from 856 preterm infants on presumed but not culture-proven sepsis and antimicrobial drug use. Additionally, pulmonary complications reported on adverse event forms, death certificates and autopsy reports were compared between study groups. RESULTS:Treatment groups did not differ in the number of episodes with suspected sepsis (184/437 [42.1%] in the budesonide vs. 171/419 [40.8%] in the placebo group). Neither the number of patients receiving antimicrobial drugs nor the length of antimicrobial treatment differed between groups. Our analyses for pulmonary adverse events as well as for pulmonary complications reported on death certificates and autopsy reports did not suggest a negative impact of inhaled budesonide on these outcomes. CONCLUSION:The current analysis does not support the assumption that respiratory tract infections explain the increased mortality seen in the glucocorticoid group in the NEuroSIS trial.
journal_name
Neonatologyjournal_title
Neonatologyauthors
Koch A,Kreutzer K,von Oldershausen G,Poets CF,Bassler D,NEuroSIS Trial Group.doi
10.1159/000468507subject
Has Abstractpub_date
2017-01-01 00:00:00pages
110-113issue
2eissn
1661-7800issn
1661-7819pii
000468507journal_volume
112pub_type
杂志文章,随机对照试验相关文献
Neonatology文献大全abstract:BACKGROUND:Newborns are prone to infections, which are independent predictors of neonatal mortality and morbidity. Neutrophil extracellular traps (NETs) are structures composed of chromatin and antimicrobial molecules that capture and kill pathogens. NETs may play an important role in the innate immune system and, thus...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000452615
更新日期:2017-01-01 00:00:00
abstract::This paper describes a neonate with type II Gaucher disease. The phenotype was unusually severe with congenital ichthyosis, hepatosplenomegaly, muscular hypotonia, myoclonus and respiratory failure. Electron microscopy of the skin revealed lamellar body contents in the stratum corneum interstices, appearances consider...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000324116
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Lipid peroxidation products are present following oxidation of polyunsaturated fatty acids in the eye, brain, and various cell membranes. Elevated levels of lipid peroxidation products and increased intermittent hypoxemia (IH) events have been associated with adverse outcomes in extremely preterm infants. ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000509038
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:While hypoxic events with bradycardias are a frequent occurrence during the first weeks of life in preterm infants, the impact of preterm birth on maturation of the cardiovascular response to hypoxia in early postnatal life is unknown. OBJECTIVES:In the present study, we tested the hypothesis that preterm b...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000110868
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Pharmacological closure of patent ductus arteriosus (PDA) is commonly achieved by intravenous (IV) administration of ibuprofen or indomethacin. Occasionally, oral ibuprofen is used for PDA treatment although its efficacy and safety are unclear. OBJECTIVES:To systematically review randomized and quasi-random...
journal_title:Neonatology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000335332
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Phenobarbitone (PB) is the first-line anti-convulsant for neonatal seizures. The use of peritoneal dialysis (PD) to enhance drug elimination in cases of neonatal PB overdose has not been reported. OBJECTIVE:To report a case of neonatal severe PB toxicity and review the elimination of PB by PD. METHODS:Asse...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000481879
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Schistocytes are circulating erythrocyte fragments. They can be identified microscopically from a blood smear; but automated systems evaluate more cells and avoid inconsistencies in microscopy. Studies using adult subjects indicate that automated quantification of schistocytes can be clinically useful. Howev...
journal_title:Neonatology
pub_type: 杂志文章,多中心研究
doi:10.1159/000491626
更新日期:2019-01-01 00:00:00
abstract::Volume resuscitation (VR) for the treatment of newborn shock is a rare but potentially lifesaving intervention. Conducting clinical studies to assess the effectiveness of VR in the delivery room during newborn stabilization is challenging. We review the available literature and current management guidelines to determi...
journal_title:Neonatology
pub_type: 杂志文章,评审
doi:10.1159/000475456
更新日期:2017-01-01 00:00:00
abstract::Despite recent advances in the perinatal management of neonatal respiratory distress syndrome (RDS), controversies still exist. We report the updated recommendations of a European panel of expert neonatologists who had developed consensus guidelines after critical examination of the most up-to-date evidence in 2007. T...
journal_title:Neonatology
pub_type: 杂志文章,实务指引
doi:10.1159/000297773
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:No survey has been published in recent years which primarily focuses on the prescription of inhaled corticosteroids in neonatal practice. Thus, the utilization rate of inhaled corticosteroids is unknown. OBJECTIVES:To elucidate the current utilization rate of inhaled corticosteroids in the prevention and th...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000316978
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Recent studies reported conflicting results on the relationship between antenatal magnesium sulfate (MgSO4) exposure and neonatal intestinal injury. Most studies have not assessed MgSO4 exposure quantitatively and none reported the exposure timing. OBJECTIVES:The aim of this work was to assess whether there...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000497412
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have a beneficial effect on bronchopulmonary dysplasia (BPD), which is the most common complication of extreme preterm birth. OBJECTIVES:To study the inflammatory, structural and functional effects of caffeine in an animal mode...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000442937
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Surface temperatures of fibreoptic phototherapy pads using a high intensity blue light-emitting diode (LED) light source have not been studied. OBJECTIVES:The aim of this study was to measure the temperature of LED fibreoptic phototherapy pads during phototherapy in a bench-top study, and to determine tempe...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000464318
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Phenobarbital and midazolam are commonly used drugs in (near-)term neonates treated with therapeutic hypothermia for hypoxic-ischaemic encephalopathy, for sedation, and/or as anti-epileptic drug. Phenobarbital is an inducer of cytochrome P450 (CYP) 3A, while midazolam is a CYP3A substrate. Therefore, co-trea...
journal_title:Neonatology
pub_type: 杂志文章,多中心研究
doi:10.1159/000499330
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:We hypothesized that color Doppler-measured cerebral blood flow velocity (CD-CBFV) as measured in the three feeding arteries of the brain can be used as an estimator of global cerebral blood flow. PATIENTS AND METHODS:CD-CBFV was determined as soon as possible after determination of phase-contrast magnetic ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000342336
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Fetal lung development requires proper coordination between lung epithelial and vascular morphogenesis. A major determinant in lung vascular development is vascular endothelial growth factor (VEGF), which is regulated by hypoxia-inducible factors (HIFs). VEGF is expressed in the airway epithelium, while its ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000261018
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Recently, sustained inflations (SI) during chest compression (CC) (CC+SI) have been suggested as an alternative to the current approach during neonatal resuscitation. No previous study compared CC+SI using CC rates of 90/min to the current 3:1 compression:ventilation ratio (C:V). OBJECTIVE:To determine whet...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000477998
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The identification of factors involved in the postnatal growth of preterm infants will help achieve growth similar to that of term infants. OBJECTIVES:As per protocol: to compare body composition in very preterm infants at term-corrected age (TCA) with that in term infants, and to explore relationships betw...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000450882
更新日期:2017-01-01 00:00:00
abstract:UNLABELLED:Near-infrared spectroscopy-derived regional tissue oxygen saturation of haemoglobin (rStO2) reflects venous oxygen saturation. If cerebral metabolism is stable, rStO2 can be used as an estimate of cerebral oxygen delivery. The SafeBoosC phase II randomised clinical trial hypothesises that the burden of hypo-...
journal_title:Neonatology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000351346
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Characteristics of neonatal tracheal intubations (TI) may vary between the neonatal intensive care unit (NICU) and delivery room (DR). The impact of the setting on TI outcomes is not well characterized. OBJECTIVE:The aim of this study was to define variation in neonatal TI practice between settings, and ide...
journal_title:Neonatology
pub_type: 杂志文章,多中心研究
doi:10.1159/000502611
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Hypoxic-ischaemic encephalopathy is a major cause of neurologic impairment and mortality in neonates. Early knowledge of brain injury is important to guide therapeutic decisions and reliably inform the parents. Increased secretoneurin levels have been detected in adult patients suffering from brain injury an...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000444245
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Minimizing initial neonatal blood draws and their associated pain is important. The placenta has ample fetal blood that is otherwise discarded; obtaining admission laboratory evaluations from fetal umbilical venous blood (FUVB) may provide a suitable alternative. OBJECTIVE:We hypothesized that obtaining an ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000491993
更新日期:2019-01-01 00:00:00
abstract::We report the successful and safe use of levosimendan, a new calcium-sensitizing agent with positive inotropic and vasodilatory action, in 2 critically ill term newborns with acute heart failure and pulmonary hypertension in the absence of any underlying heart malformation and/or previous cardiosurgical procedures. Du...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000329848
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Hyperglycaemia is a common complication of prematurity and is associated with neonatal mortality and morbidity, yet the aetiology is incompletely understood. C-peptide has been used in adults to estimate endogenous insulin secretion due to its simple clearance kinetics. OBJECTIVE:To determine insulin secret...
journal_title:Neonatology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000381206
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Eye drop treatment routinely used to obtain mydriasis prior to fundoscopy in neonates requires repeated instillations of mydriatic agents that can lead to systemic side effects. OBJECTIVES:The aim of this study was to compare the mydriatic efficacy and tolerance of administration of phenylephrine and tropic...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000493723
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Cardiac troponin T (cTnT) has been proposed as specific biochemical marker for myocardial infarction in adults. Cardiac function in neonates could be influenced by the severity of respiratory distress and its ventilatory management. OBJECTIVES:To establish a normal range of cTnT in healthy neonates, compare...
journal_title:Neonatology
pub_type: 临床试验,杂志文章
doi:10.1159/000100964
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The postnatal heart responds to biomechanical stress with hypertrophy. The fetal heart may also undergo hyperplasia, but the percentage of mitotically active cardiomyocytes decreases throughout gestation. The signaling pathways controlling growth and proliferation in the fetal heart are poorly understood. O...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000107729
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Congenital diaphragmatic hernia (CDH) is an abnormal development of the diaphragm leading to high neonatal mortality and morbidity. Beyond the neonatal period, prospective data on overall long-term outcome in CDH survivors is scarce. In particular, for those treated with fetoscopic endoluminal tracheal occlu...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000479145
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Lipid metabolism is vital to fetal development and cardiometabolic health and the final weeks of gestation are known to be a time of intense metabolic activity. New techniques such as lipidomics allow investigation of a complex lipidomic profile in infants. OBJECTIVES:This research aimed to (1) describe var...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000487506
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common enzyme deficiency affecting more than 300 million individuals worldwide. Extreme neonatal hyperbilirubinemia, with its severe sequelae of bilirubin neurotoxicity and the potential of death, is the most devastating manifestation of G6PD deficienc...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000489820
更新日期:2018-01-01 00:00:00