Volume-targeted versus pressure-limited ventilation for preterm infants: a systematic review and meta-analysis.

abstract：BACKGROUND:Faecal calprotectin has been proposed as a sensitive marker for gastrointestinal inflammation in children and adults. High levels have been reported in healthy newborns and during the first months of life; the effect of the kind of feeding on the calprotectin concentration in stools is controversial. OBJECT...

journal_title：Neonatology

authors： Savino F,Castagno E,Calabrese R,Viola S,Oggero R,Miniero R

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Streptococcus agalactiae (group B Streptococcus, GBS) is the most common cause of early neonatal infection, but restricting the diagnosis to culture-positive infants may underestimate the burden of GBS disease. Our objective was to determine whether maternal GBS colonization was associated with an increased ...

journal_title：Neonatology

authors： Brigtsen AK,Jacobsen AF,Dedi L,Melby KK,Fugelseth D,Whitelaw A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Restrictive use of invasive mechanical ventilation (IMV) in preterm infants reduces the risk of bronchopulmonary dysplasia (BPD). Our objective was to determine its effect on neurodevelopmental impairment (NDI) at 24 months' corrected age (CA). METHODS:This retrospective single-center cohort s...

journal_title：Neonatology

authors： Vliegenthart RJS,Onland W,van Wassenaer-Leemhuis AG,De Jaegere APM,Aarnoudse-Moens CSH,van Kaam AH

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Preterm infants with signs of poor perfusion are often treated with volume expansion, although evidence regarding its effect on cerebral perfusion is lacking. Moreover, the effect is questionable in preterm infants with an adequate cerebrovascular autoregulation (CAR). A useful measure to assess perfusion is...

journal_title：Neonatology

authors： Kooi EM,van der Laan ME,Verhagen EA,Van Braeckel KN,Bos AF

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To examine the impact of medical complexity among very preterm infants on health care resource use, family, and neurodevelopmental outcomes at 18 months' corrected age. METHODS:This observational cohort study of Canadian infants born < 29 weeks' gestational age in 2009-2011 compared infants with and those wi...

journal_title：Neonatology

authors： Nassel D,Chartrand C,Doré-Bergeron MJ,Lefebvre F,Ballantyne M,Van Overmeire B,Luu TM,on behalf of the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Network.

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:Strategies for oxygen therapy for preterm infants, such as the Vermont-Oxford's 'Breathsavers' guidelines, seek to strike a balance between the potential risks of the extremes of hyperoxia and hypoxia in preterm infants. Using an algorithm based on those guidelines, we aimed to compare the proportion of time...

journal_title：Neonatology

authors： Clarke A,Yeomans E,Elsayed K,Medhurst A,Berger P,Skuza E,Tan K

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Fetal lung development requires proper coordination between lung epithelial and vascular morphogenesis. A major determinant in lung vascular development is vascular endothelial growth factor (VEGF), which is regulated by hypoxia-inducible factors (HIFs). VEGF is expressed in the airway epithelium, while its ...

journal_title：Neonatology

authors： Rajatapiti P,de Rooij JD,Beurskens LW,Keijzer R,Tibboel D,Rottier RJ,de Krijger RR

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:The identification of factors involved in the postnatal growth of preterm infants will help achieve growth similar to that of term infants. OBJECTIVES:As per protocol: to compare body composition in very preterm infants at term-corrected age (TCA) with that in term infants, and to explore relationships betw...

journal_title：Neonatology

authors： Tremblay G,Boudreau C,Bélanger S,St-Onge O,Pronovost E,Simonyan D,Marc I

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Preterm birth contributes significantly to infant mortality and morbidity, including blindness from retinopathy of prematurity (ROP). Access to intensive neonatal care is expanding in many countries, but care is not always optimal, one factor being that nursing is often by inadequately trained nurse assistan...

journal_title：Neonatology

authors： Gilbert C,Darlow B,Zin A,Sivasubramaniam S,Shah S,Gianini N,Beecroft G,Lopes Moreira ME

更新日期：2014-01-01 00:00:00

abstract：:The treatment of preterm newborn rabbits with synthetic surfactants containing simple phospholipid mixtures and peptides gives similar tidal volumes to treatment with poractant alfa (Curosurf®). The addition of both surfactant protein B and C analogs to the phospholipid mixture will stabilize the alveoli, measured as ...

journal_title：Neonatology

authors： Curstedt T,Calkovska A,Johansson J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Sustained lung inflation (SLI) applied at birth has been demonstrated to lead to clearance of lung fluid and achievement of a precocious functional residual capacity in animal studies. OBJECTIVES:To verify if the application of SLI in preterm infants at birth may reduce the need for mechanical ventilation a...

journal_title：Neonatology

authors： Lista G,Fontana P,Castoldi F,Cavigioli F,Dani C

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Surface temperatures of fibreoptic phototherapy pads using a high intensity blue light-emitting diode (LED) light source have not been studied. OBJECTIVES:The aim of this study was to measure the temperature of LED fibreoptic phototherapy pads during phototherapy in a bench-top study, and to determine tempe...

journal_title：Neonatology

authors： Ng PL,Carlisle T,Ly M,Morris SA

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Long-gap esophageal atresia (LGEA) may have clinical and syndromic presentations different from those of esophageal atresia (EA) that affects shorter segments of the esophagus (non-LGEA). This may suggest unique underlying developmental mechanisms. OBJECTIVES:We sought to characterize clinical differences b...

journal_title：Neonatology

authors： Bairdain S,Zurakowski D,Vargas SO,Stenquist N,McDonald M,Towne MC,Miller DT,Jennings RW,Kantor DB,Agrawal PB

更新日期：2017-01-01 00:00:00

abstract：:Noninvasive ventilation for preterm infants at birth has been recommended and universally adopted. The umbilical cord is often clamped immediately in order to provide the support the infant needs for stabilization. However, recent scientific data from experimental studies that involve animals in transition and human s...

journal_title：Neonatology

authors： Te Pas AB,Hooper SB,Dekker J

更新日期：2019-01-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD) is one of the few diseases in neonatal medicine that has continued to evolve since its first description about 50 years ago. Over these years, advancements in neonatal medicine such as antenatal steroids and exogenous surfactant therapy have significantly reduced neonatal mortality and...

journal_title：Neonatology

authors： Bancalari E,Jain D

更新日期：2019-01-01 00:00:00

abstract：:Volume resuscitation (VR) for the treatment of newborn shock is a rare but potentially lifesaving intervention. Conducting clinical studies to assess the effectiveness of VR in the delivery room during newborn stabilization is challenging. We review the available literature and current management guidelines to determi...

journal_title：Neonatology

authors： Finn D,Roehr CC,Ryan CA,Dempsey EM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Newborns are prone to infections, which are independent predictors of neonatal mortality and morbidity. Neutrophil extracellular traps (NETs) are structures composed of chromatin and antimicrobial molecules that capture and kill pathogens. NETs may play an important role in the innate immune system and, thus...

journal_title：Neonatology

authors： Lipp P,Ruhnau J,Lange A,Vogelgesang A,Dressel A,Heckmann M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Numerous studies in cultured cells indicate that damage to mitochondrial DNA (mtDNA) dictates cellular responses to oxidant stress, yet the consequences of mtDNA damage have not been studied directly in the preterm lung. OBJECTIVE:We sought to determine whether hyperoxia-induced fetal lung dysmorphogenesis ...

journal_title：Neonatology

authors： Gebb SA,Decoux A,Waggoner A,Wilson GL,Gillespie MN

更新日期：2013-01-01 00:00:00

abstract：:The aim of this article is to educate neonatal caregivers about metagenomics. This scientific field uses novel and ever changing molecular methods to identify how infants become colonized with microbes after birth. Publications using metagenomics appear infrequently in the neonatal literature because clinicians are un...

journal_title：Neonatology

authors： Sherman MP,Minnerly J,Curtiss W,Rangwala S,Kelley ST

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Premature infants with severe bronchopulmonary dysplasia (sBPD) are at risk of pulmonary hypertension (PH). Serum brain natriuretic peptide (BNP) is used to predict disease severity in adult PH. Its diagnostic utility in sBPD-associated PH is unknown. OBJECTIVE:The aim of this paper was to determine the acc...

journal_title：Neonatology

authors： Avitabile CM,Ansems S,Wang Y,Fraga MV,Kirpalani HM,Zhang H,Mercer-Rosa L,Jensen EA

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Ventilatory pressures should target the range between the upper and lower inflection point of the pressure volume curve in order to avoid atelecto- and volutrauma. During high-frequency oscillatory ventilation (HFOV), this range is difficult to determine. Quadrant impedance measurement (QIM) has recently bee...

journal_title：Neonatology

authors： Burkhardt W,Kurth F,Pitterle M,Blassnig N,Wemhöner A,Rüdiger M

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Therapeutic hypothermia (HT) is the standard treatment for newborns after perinatal asphyxia. Preclinical studies report that HT is more effective when started early. METHODS:Eighty cooled newborns were analyzed and grouped according to when cooling was started after birth: early (≤180 min) or late (>181 min...

journal_title：Neonatology

authors： Thoresen M,Tooley J,Liu X,Jary S,Fleming P,Luyt K,Jain A,Cairns P,Harding D,Sabir H

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Hyperglycaemia is a common complication of prematurity and is associated with neonatal mortality and morbidity, yet the aetiology is incompletely understood. C-peptide has been used in adults to estimate endogenous insulin secretion due to its simple clearance kinetics. OBJECTIVE:To determine insulin secret...

journal_title：Neonatology

authors： Dickson JL,Chase JG,Pretty CG,Gunn CA,Alsweiler JM

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:For quick detection or exclusion of neonatal early-onset bacterial infection (EOBI) or late-onset bacterial infection (LOBI), interleukin (IL)-6 is used. Its clinical use is sometimes limited due to prolonged recall times. Therefore, an IL-6 bedside test was established. OBJECTIVE:To compare the diagnostic ...

journal_title：Neonatology

authors： Batfalsky A,Lohr A,Heussen N,Neunhoeffer F,Orlikowsky TW

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Premature birth and respiratory distress syndrome (RDS) are risk factors for disturbed lung development and bronchopulmonary dysplasia (BPD). The molecular mechanisms related to prematurity and BPD remain largely unknown. Epithelial expression of the transcription factor GATA-6 has been implicated in normal ...

journal_title：Neonatology

authors： Vähätalo R,Asikainen TM,Karikoski R,Kinnula VL,White CW,Andersson S,Heikinheimo M,Myllärniemi M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Intermittent hypoxic episodes are common among preterm infants, although longer term consequences on growth pattern and cardiovascular regulation are unclear. Furthermore, the effects of intermittent hypoxia (IH) may depend on the pattern of hypoxia-reoxygenation. OBJECTIVES:We tested the hypothesis that a ...

journal_title：Neonatology

authors： Pozo ME,Cave A,Köroğlu OA,Litvin DG,Martin RJ,Di Fiore J,Kc P

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Retinopathy of prematurity (ROP) is a sight-threatening disease affecting extremely preterm infants. The introduction of new ROP screening surveillance systems, with higher sensitivity and specificity than established ROP screening guidelines, has the potential to reduce the number of stressful eye examinati...

journal_title：Neonatology

authors： Lundgren P,Stoltz Sjöström E,Domellöf M,Smith L,Wu C,VanderVeen D,Hellström A,Löfqvist C

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Bronchopulmonary dysplasia (BPD), severe retinopathy of prematurity (sROP), and cystic periventricular leukomalacia (cPVL) are 3 major morbidities with long-term neurodevelopmental impairments in preterm infants. OBJECTIVE:To investigate the strength of associations and identify key risk factors shared by B...

journal_title：Neonatology

authors： Wang LW,Lin YC,Wang ST,Huang CC,on behalf of the Taiwan Premature Infant Developmental Collaborative Study Group.

更新日期：2018-01-01 00:00:00

abstract：:There is mounting evidence that early continuous positive airway pressure (CPAP) from birth is feasible and safe even in very preterm infants. However, many infants will develop respiratory distress syndrome (RDS) and require surfactant treatment. Combining a noninvasive ventilation approach with a strategy for surfac...

journal_title：Neonatology

authors： Blennow M,Bohlin K

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Gene expression profiling of the salivary supernatant is emerging as a new and important source of real-time, systemic, biological information. However, existing technologies prevent RNA extraction of small quantities found in neonatal salivary supernatant. OBJECTIVE:The aim of this study was to develop tec...

journal_title：Neonatology

authors： Dietz JA,Johnson KL,Wick HC,Bianchi DW,Maron JL

更新日期：2012-01-01 00:00:00