Does sustained lung inflation at birth improve outcome of preterm infants at risk for respiratory distress syndrome?

abstract：AIM:Melatonin is a potent free radical scavenger and an indirect antioxidant. Knowledge about the behavior of melatonin secretion in the early neonatal period, which may relate to its properties at a vital stage during very high antioxidant demands, is limited. PATIENTS AND METHODS:We studied 35 newborns admitted to t...

journal_title：Neonatology

authors： Muñoz-Hoyos A,Bonillo-Perales A,Avila-Villegas R,González-Ripoll M,Uberos J,Florido-Navío J,Molina-Carballo A

更新日期：2007-01-01 00:00:00

abstract：:Volume resuscitation (VR) for the treatment of newborn shock is a rare but potentially lifesaving intervention. Conducting clinical studies to assess the effectiveness of VR in the delivery room during newborn stabilization is challenging. We review the available literature and current management guidelines to determi...

journal_title：Neonatology

authors： Finn D,Roehr CC,Ryan CA,Dempsey EM

更新日期：2017-01-01 00:00:00

abstract：:Treatment of retinopathy of prematurity (ROP) is currently evolving. Novel therapeutic options are emerging that have the potential to complement existing therapies and improve treatment outcomes. However, any new therapeutic option must be thoroughly evaluated before existing (and successful) treatment paradigms can ...

journal_title：Neonatology

authors： Stahl A,Hellstrom A,Smith LE

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Intermittent hypoxic episodes are common among preterm infants, although longer term consequences on growth pattern and cardiovascular regulation are unclear. Furthermore, the effects of intermittent hypoxia (IH) may depend on the pattern of hypoxia-reoxygenation. OBJECTIVES:We tested the hypothesis that a ...

journal_title：Neonatology

authors： Pozo ME,Cave A,Köroğlu OA,Litvin DG,Martin RJ,Di Fiore J,Kc P

更新日期：2012-01-01 00:00:00

abstract：:Noninvasive ventilation for preterm infants at birth has been recommended and universally adopted. The umbilical cord is often clamped immediately in order to provide the support the infant needs for stabilization. However, recent scientific data from experimental studies that involve animals in transition and human s...

journal_title：Neonatology

authors： Te Pas AB,Hooper SB,Dekker J

更新日期：2019-01-01 00:00:00

abstract：:Rites of passage mark important changes during human life and, for the neonate, its transition from intrauterine life into society. Their original intent was to purify the body from blood and meconium. But the cleansing rites had a spiritual dimension from the very start. When the rites of Mesopotamian, Egyptian, Jewi...

journal_title：Neonatology

authors： Obladen M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Neonatal reference values of gallbladder size have been assessed in healthy newborns with enteral feeding regimen. Their applicability to critically ill patients under total parenteral nutrition (TPN) remains to be questioned. OBJECTIVE:Our aim was to evaluate the impact of short-term TPN versus enteral nut...

journal_title：Neonatology

authors： Schmidt B,Roth B,Stützer H,Benz-Bohm G

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Hyperglycaemia is a common complication of prematurity and is associated with neonatal mortality and morbidity, yet the aetiology is incompletely understood. C-peptide has been used in adults to estimate endogenous insulin secretion due to its simple clearance kinetics. OBJECTIVE:To determine insulin secret...

journal_title：Neonatology

authors： Dickson JL,Chase JG,Pretty CG,Gunn CA,Alsweiler JM

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Cerebellar injury is increasingly recognized as a relevant complication of premature birth. However, the prevalence of reduced cerebellar growth and its consequences for neurodevelopmental outcome in preterm infants without overt brain injury remain to be defined in detail. The aim of this study was to ass...

journal_title：Neonatology

authors： Hammerl M,Zagler M,Griesmaier E,Janjic T,Gizewski ER,Kiechl-Kohlendorfer U,Neubauer V

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The probabilities of survival and survival without major brain damage (MBD) are low in newborns at the limit of viability. Survival without MBD constitutes a major concern for parents and professionals. OBJECTIVES:To know the probabilities of survival without MBD in newborns ≤26 weeks' gestational age (GA) ...

journal_title：Neonatology

authors： García-Muñoz Rodrigo F,Urquía Martí L,García Hernández JÁ,Figueras Aloy J,García-Alix Pérez A,SEN1500 Network of the Spanish Neonatal Society.

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Preterm infants with signs of poor perfusion are often treated with volume expansion, although evidence regarding its effect on cerebral perfusion is lacking. Moreover, the effect is questionable in preterm infants with an adequate cerebrovascular autoregulation (CAR). A useful measure to assess perfusion is...

journal_title：Neonatology

authors： Kooi EM,van der Laan ME,Verhagen EA,Van Braeckel KN,Bos AF

更新日期：2013-01-01 00:00:00

abstract：:Transcutaneous electromyography of the diaphragm (dEMG) is a noninvasive and easy applicable tool to measure the electrical activity of the diaphragm. dEMG monitoring has recently been introduced in the neonatal intensive care unit as a novel cardiorespiratory monitor providing direct information on diaphragmatic brea...

journal_title：Neonatology

authors： Kraaijenga JV,Hutten GJ,de Jongh FH,van Kaam AH

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common enzyme deficiency affecting more than 300 million individuals worldwide. Extreme neonatal hyperbilirubinemia, with its severe sequelae of bilirubin neurotoxicity and the potential of death, is the most devastating manifestation of G6PD deficienc...

journal_title：Neonatology

authors： Kaplan M,Wong RJ,Stevenson DK

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Gene expression profiling of the salivary supernatant is emerging as a new and important source of real-time, systemic, biological information. However, existing technologies prevent RNA extraction of small quantities found in neonatal salivary supernatant. OBJECTIVE:The aim of this study was to develop tec...

journal_title：Neonatology

authors： Dietz JA,Johnson KL,Wick HC,Bianchi DW,Maron JL

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Recently, sustained inflations (SI) during chest compression (CC) (CC+SI) have been suggested as an alternative to the current approach during neonatal resuscitation. No previous study compared CC+SI using CC rates of 90/min to the current 3:1 compression:ventilation ratio (C:V). OBJECTIVE:To determine whet...

journal_title：Neonatology

authors： Li ES,Görens I,Cheung PY,Lee TF,Lu M,O'Reilly M,Schmölzer GM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Early host-microbe interaction provides important maturational stimuli for the developing immune system. The role of prenatal microbial contact remains elusive. OBJECTIVES:Our aim was to investigate whether microbes in placenta or amniotic fluid affect fetal innate immune gene expression during late pregnan...

journal_title：Neonatology

authors： Rautava S,Collado MC,Salminen S,Isolauri E

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:International neonatal resuscitation guidelines recommend assessing chest excursion when the heart rate is not improving. However, the accuracy in assessing 'adequate' chest excursion lacks objectivity. AIM:It was the aim of this study to test the accuracy in the assessment of 'adequate' chest excursion by ...

journal_title：Neonatology

authors： Brugada M,Schilleman K,Witlox RS,Walther FJ,Vento M,Te Pas AB

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Phenobarbital and midazolam are commonly used drugs in (near-)term neonates treated with therapeutic hypothermia for hypoxic-ischaemic encephalopathy, for sedation, and/or as anti-epileptic drug. Phenobarbital is an inducer of cytochrome P450 (CYP) 3A, while midazolam is a CYP3A substrate. Therefore, co-trea...

journal_title：Neonatology

authors： Favié LMA,Groenendaal F,van den Broek MPH,Rademaker CMA,de Haan TR,van Straaten HLM,Dijk PH,van Heijst A,Simons SHP,Dijkman KP,Rijken M,Zonnenberg IA,Cools F,Zecic A,van der Lee JH,Nuytemans DHGM,van Bel F,Egberts TCG,

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Hypoxic-ischaemic encephalopathy is a major cause of neurologic impairment and mortality in neonates. Early knowledge of brain injury is important to guide therapeutic decisions and reliably inform the parents. Increased secretoneurin levels have been detected in adult patients suffering from brain injury an...

journal_title：Neonatology

authors： Wechselberger K,Schmid A,Posod A,Höck M,Neubauer V,Fischer-Colbrie R,Kiechl-Kohlendorfer U,Griesmaier E

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Randomised controlled trials provide the best evidence for the effects of interventions and are a key tool in the effort to improve the care and outcomes for newborn infants. METHODS:We discuss the role of randomisation for minimising selection bias in clinical trials and describe examples of seminal trials...

journal_title：Neonatology

authors： Gale C,McGuire W,Juszczak E

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Transcutaneous bilirubin (TcB) devices are commonly used for screening of hyperbilirubinemia in term and near-term infants not exposed to phototherapy. However, the accuracy of TcB devices in infants exposed to phototherapy is unclear. OBJECTIVES:To conduct a systematic review of studies comparing TcB devic...

journal_title：Neonatology

authors： Nagar G,Vandermeer B,Campbell S,Kumar M

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Non-invasive cardiac output monitoring is a potentially useful clinical tool in the neonatal setting. Our aim was to evaluate a new method of non-invasive continuous cardiac output (CO) measurement (NICOM™) based on the principle of bioreactance in neonates. METHODS:In this prospective observational study, ...

journal_title：Neonatology

authors： Weisz DE,Jain A,McNamara PJ,EL-Khuffash A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Premature birth and respiratory distress syndrome (RDS) are risk factors for disturbed lung development and bronchopulmonary dysplasia (BPD). The molecular mechanisms related to prematurity and BPD remain largely unknown. Epithelial expression of the transcription factor GATA-6 has been implicated in normal ...

journal_title：Neonatology

authors： Vähätalo R,Asikainen TM,Karikoski R,Kinnula VL,White CW,Andersson S,Heikinheimo M,Myllärniemi M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:For quick detection or exclusion of neonatal early-onset bacterial infection (EOBI) or late-onset bacterial infection (LOBI), interleukin (IL)-6 is used. Its clinical use is sometimes limited due to prolonged recall times. Therefore, an IL-6 bedside test was established. OBJECTIVE:To compare the diagnostic ...

journal_title：Neonatology

authors： Batfalsky A,Lohr A,Heussen N,Neunhoeffer F,Orlikowsky TW

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:We hypothesized that color Doppler-measured cerebral blood flow velocity (CD-CBFV) as measured in the three feeding arteries of the brain can be used as an estimator of global cerebral blood flow. PATIENTS AND METHODS:CD-CBFV was determined as soon as possible after determination of phase-contrast magnetic ...

journal_title：Neonatology

authors： Benders MJ,Hendrikse J,de Vries L,Groenendaal F,van Bel F

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:High-dose recombinant erythropoietin (rEpo) is neuroprotective in neonatal animal models of brain injury, but the long-term consequences of neonatal exposure have not been studied. OBJECTIVES:We hypothesized that multiple injections of high-dose rEpo during the neonatal period would be safe, and would impro...

journal_title：Neonatology

authors： McPherson RJ,Demers EJ,Juul SE

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To examine the impact of medical complexity among very preterm infants on health care resource use, family, and neurodevelopmental outcomes at 18 months' corrected age. METHODS:This observational cohort study of Canadian infants born < 29 weeks' gestational age in 2009-2011 compared infants with and those wi...

journal_title：Neonatology

authors： Nassel D,Chartrand C,Doré-Bergeron MJ,Lefebvre F,Ballantyne M,Van Overmeire B,Luu TM,on behalf of the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Network.

更新日期：2019-01-01 00:00:00

abstract：:The treatment of preterm newborn rabbits with synthetic surfactants containing simple phospholipid mixtures and peptides gives similar tidal volumes to treatment with poractant alfa (Curosurf®). The addition of both surfactant protein B and C analogs to the phospholipid mixture will stabilize the alveoli, measured as ...

journal_title：Neonatology

authors： Curstedt T,Calkovska A,Johansson J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Faecal calprotectin has been proposed as a sensitive marker for gastrointestinal inflammation in children and adults. High levels have been reported in healthy newborns and during the first months of life; the effect of the kind of feeding on the calprotectin concentration in stools is controversial. OBJECT...

journal_title：Neonatology

authors： Savino F,Castagno E,Calabrese R,Viola S,Oggero R,Miniero R

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Perinatal hypoxic-ischemic brain damage is a major cause of acute mortality and chronic neurological morbidity in infants and children. Oxidative stress due to free radical formation and the initiation of abnormal oxidative reactions appears to play a key role. Docosahexanoic acid (DHA), a main component of ...

journal_title：Neonatology

authors： Solberg R,Longini M,Proietti F,Perrone S,Felici C,Porta A,Saugstad OD,Buonocore G

更新日期：2017-01-01 00:00:00