Chest Compressions during Sustained Inflations Improve Recovery When Compared to a 3:1 Compression:Ventilation Ratio during Cardiopulmonary Resuscitation in a Neonatal Porcine Model of Asphyxia.

abstract：BACKGROUND:Randomised controlled trials provide the best evidence for the effects of interventions and are a key tool in the effort to improve the care and outcomes for newborn infants. METHODS:We discuss the role of randomisation for minimising selection bias in clinical trials and describe examples of seminal trials...

journal_title：Neonatology

authors： Gale C,McGuire W,Juszczak E

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Cardiac troponin T (cTnT) has been proposed as specific biochemical marker for myocardial infarction in adults. Cardiac function in neonates could be influenced by the severity of respiratory distress and its ventilatory management. OBJECTIVES:To establish a normal range of cTnT in healthy neonates, compare...

journal_title：Neonatology

authors： Awada H,Al-Tannir M,Ziade MF,Alameh J,El Rajab M

更新日期：2007-01-01 00:00:00

abstract：:Mechanical ventilation is a risk factor for cerebral inflammation and brain injury in preterm neonates. The risk increases proportionally with the intensity of treatment. Recent studies have shown that cerebral inflammation and injury can be initiated in the delivery room. At present, initiation of intermittent positi...

journal_title：Neonatology

authors： Barton SK,Tolcos M,Miller SL,Christoph-Roehr C,Schmölzer GM,Moss TJ,Hooper SB,Wallace EM,Polglase GR

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Despite increasing survival in the smallest preterm infants, the incidence of chronic lung disease has not decreased. Research into ventilatory strategies has concentrated on minimising barotrauma, volutrauma and atelectotrauma, but little attention has been paid to the role of bias gas flow rates and the po...

journal_title：Neonatology

authors： Bach KP,Kuschel CA,Oliver MH,Bloomfield FH

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Transcutaneous bilirubin (TcB) devices are commonly used for screening of hyperbilirubinemia in term and near-term infants not exposed to phototherapy. However, the accuracy of TcB devices in infants exposed to phototherapy is unclear. OBJECTIVES:To conduct a systematic review of studies comparing TcB devic...

journal_title：Neonatology

authors： Nagar G,Vandermeer B,Campbell S,Kumar M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Brain vulnerability in the critically ill preterm newborn may be related to the burden of cerebral hypoxygenation and hypoperfusion during the immediate postnatal period. OBJECTIVE:We determined the association between adverse outcomes [death or high grade intraventricular hemorrhage (IVH)] and continuous c...

journal_title：Neonatology

authors： Cerbo RM,Scudeller L,Maragliano R,Cabano R,Pozzi M,Tinelli C,Bollani L,Stronati M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Preterm infants with signs of poor perfusion are often treated with volume expansion, although evidence regarding its effect on cerebral perfusion is lacking. Moreover, the effect is questionable in preterm infants with an adequate cerebrovascular autoregulation (CAR). A useful measure to assess perfusion is...

journal_title：Neonatology

authors： Kooi EM,van der Laan ME,Verhagen EA,Van Braeckel KN,Bos AF

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Oxidative stress in the newborn period may cause cell injury and inflammation if the antioxidant capacity is insufficient. To monitor antioxidant and inflammatory activity we examined by in vivo imaging various strains of luciferase reporter mice whose light-emitting properties were regulated by response e...

journal_title：Neonatology

authors： Dohlen G,Odland HH,Carlsen H,Blomhoff R,Thaulow E,Saugstad OD

更新日期：2008-01-01 00:00:00

abstract：:This paper describes a neonate with type II Gaucher disease. The phenotype was unusually severe with congenital ichthyosis, hepatosplenomegaly, muscular hypotonia, myoclonus and respiratory failure. Electron microscopy of the skin revealed lamellar body contents in the stratum corneum interstices, appearances consider...

journal_title：Neonatology

authors： Haverkaemper S,Marquardt T,Hausser I,Timme K,Kuehn T,Hertzberg C,Rossi R

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Substantial health care resources are expended on standardised formal neonatal resuscitation training (SFNRT) programmes, but their effectiveness has not been proven. OBJECTIVES:To determine whether SFNRT programmes reduce neonatal mortality and morbidity, improve acquisition and retention of knowledge and ...

journal_title：Neonatology

authors： Pammi M,Dempsey EM,Ryan CA,Barrington KJ

更新日期：2016-01-01 00:00:00

abstract：:Treatment of sick neonates originated in maternity and foundling hospitals in the 19th century. Nosocomial infections and difficult logistics of wet-nursing prevented admission of neonates in most children's hospitals well into the 20th century. In this article, 31 hospitals are described, all located in large cities,...

journal_title：Neonatology

authors： Obladen M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Phenobarbital and midazolam are commonly used drugs in (near-)term neonates treated with therapeutic hypothermia for hypoxic-ischaemic encephalopathy, for sedation, and/or as anti-epileptic drug. Phenobarbital is an inducer of cytochrome P450 (CYP) 3A, while midazolam is a CYP3A substrate. Therefore, co-trea...

journal_title：Neonatology

authors： Favié LMA,Groenendaal F,van den Broek MPH,Rademaker CMA,de Haan TR,van Straaten HLM,Dijk PH,van Heijst A,Simons SHP,Dijkman KP,Rijken M,Zonnenberg IA,Cools F,Zecic A,van der Lee JH,Nuytemans DHGM,van Bel F,Egberts TCG,

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Delayed cord clamping (DCC) improves placental transfusion and increases blood volume in preterm infants when compared with immediate cord clamping (ICC). However, evidence to support DCC in multiple-birth preterm infants is still lacking. OBJECTIVE:To compare the outcomes of ICC versus DCC in preterm infan...

journal_title：Neonatology

authors： Ruangkit C,Bumrungphuet S,Panburana P,Khositseth A,Nuntnarumit P

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Meconium displaces surfactant from the alveolar surface and inhibits its function. The development of active synthetic surfactants is complicated, especially to synthesize the hydrophobic surfactant proteins SP-B and SP-C. A synthetic surfactant, CHF5633 containing SP-B and SP-C analogs, has been designed to...

journal_title：Neonatology

authors： Salvesen B,Curstedt T,Mollnes TE,Saugstad OD

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Sustained lung inflation (SLI) applied at birth has been demonstrated to lead to clearance of lung fluid and achievement of a precocious functional residual capacity in animal studies. OBJECTIVES:To verify if the application of SLI in preterm infants at birth may reduce the need for mechanical ventilation a...

journal_title：Neonatology

authors： Lista G,Fontana P,Castoldi F,Cavigioli F,Dani C

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Minimizing initial neonatal blood draws and their associated pain is important. The placenta has ample fetal blood that is otherwise discarded; obtaining admission laboratory evaluations from fetal umbilical venous blood (FUVB) may provide a suitable alternative. OBJECTIVE:We hypothesized that obtaining an ...

journal_title：Neonatology

authors： Greer R,Safarulla A,Koeppel R,Aslam M,Bany-Mohammed FM

更新日期：2019-01-01 00:00:00

abstract：:Treatment of retinopathy of prematurity (ROP) is currently evolving. Novel therapeutic options are emerging that have the potential to complement existing therapies and improve treatment outcomes. However, any new therapeutic option must be thoroughly evaluated before existing (and successful) treatment paradigms can ...

journal_title：Neonatology

authors： Stahl A,Hellstrom A,Smith LE

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Small for gestational age (SGA) neonates are at increased risk of mortality and morbidity, including necrotizing enterocolitis (NEC), but detailed information on the incidence and risk factors of NEC in SGA neonates is lacking. OBJECTIVE:This study aims to estimate the incidence of NEC in a large cohort of ...

journal_title：Neonatology

authors： Ree IM,Smits-Wintjens VE,Rijntjes-Jacobs EG,Pelsma IC,Steggerda SJ,Walther FJ,Lopriore E

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Long-gap esophageal atresia (LGEA) may have clinical and syndromic presentations different from those of esophageal atresia (EA) that affects shorter segments of the esophagus (non-LGEA). This may suggest unique underlying developmental mechanisms. OBJECTIVES:We sought to characterize clinical differences b...

journal_title：Neonatology

authors： Bairdain S,Zurakowski D,Vargas SO,Stenquist N,McDonald M,Towne MC,Miller DT,Jennings RW,Kantor DB,Agrawal PB

更新日期：2017-01-01 00:00:00

abstract：:We describe a case highlighting several controversial and important topics regarding neonatal cardiopulmonary resuscitation (CPR). Current neonatal guidelines recommend a 3:1 compression:ventilation ratio; however, the most effective ratio of delivering chest compressions (CC) remains controversial. We report a case o...

journal_title：Neonatology

authors： Li ES,Cheung PY,Pichler G,Aziz K,Schmölzer GM

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Early host-microbe interaction provides important maturational stimuli for the developing immune system. The role of prenatal microbial contact remains elusive. OBJECTIVES:Our aim was to investigate whether microbes in placenta or amniotic fluid affect fetal innate immune gene expression during late pregnan...

journal_title：Neonatology

authors： Rautava S,Collado MC,Salminen S,Isolauri E

更新日期：2012-01-01 00:00:00

abstract：:Rites of passage mark important changes during human life and, for the neonate, its transition from intrauterine life into society. Their original intent was to purify the body from blood and meconium. But the cleansing rites had a spiritual dimension from the very start. When the rites of Mesopotamian, Egyptian, Jewi...

journal_title：Neonatology

authors： Obladen M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Endogenous carbon monoxide (CO) production is primarily due to heme degradation, which also results in the equimolar production of bilirubin. Thus, estimates of total body CO production can serve as indices of total body bilirubin formation. The elimination rate of CO from a person's body (CO washout rate) a...

journal_title：Neonatology

authors： Stevenson DK,Wong RJ,Ostrander CR,Maric I,Vreman HJ,Cohen RS

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Phenobarbitone (PB) is the first-line anti-convulsant for neonatal seizures. The use of peritoneal dialysis (PD) to enhance drug elimination in cases of neonatal PB overdose has not been reported. OBJECTIVE:To report a case of neonatal severe PB toxicity and review the elimination of PB by PD. METHODS:Asse...

journal_title：Neonatology

authors： Le Page AK,Stewart AE,Roehr CC,Johnstone LM,Graudins A

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Streptococcus agalactiae (group B Streptococcus, GBS) is the most common cause of early neonatal infection, but restricting the diagnosis to culture-positive infants may underestimate the burden of GBS disease. Our objective was to determine whether maternal GBS colonization was associated with an increased ...

journal_title：Neonatology

authors： Brigtsen AK,Jacobsen AF,Dedi L,Melby KK,Fugelseth D,Whitelaw A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Preterm infants are at greater risk of developmental impairment and require close follow-up for early and optimal care. OBJECTIVES:The objective of the present study was to determine from which age the parental Ages and Stages Questionnaire (ASQ) allows detection of school difficulties in preterm children <...

journal_title：Neonatology

authors： Halbwachs M,Muller JB,Nguyen The Tich S,Gascoin G,Chauty-Frondas A,Branger B,Rouger V,Roze JC,Flamant C

更新日期：2014-01-01 00:00:00

abstract：UNLABELLED:Near-infrared spectroscopy-derived regional tissue oxygen saturation of haemoglobin (rStO2) reflects venous oxygen saturation. If cerebral metabolism is stable, rStO2 can be used as an estimate of cerebral oxygen delivery. The SafeBoosC phase II randomised clinical trial hypothesises that the burden of hypo-...

journal_title：Neonatology

authors： Pellicer A,Greisen G,Benders M,Claris O,Dempsey E,Fumagalli M,Gluud C,Hagmann C,Hellström-Westas L,Hyttel-Sorensen S,Lemmers P,Naulaers G,Pichler G,Roll C,van Bel F,van Oeveren W,Skoog M,Wolf M,Austin T

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:For quick detection or exclusion of neonatal early-onset bacterial infection (EOBI) or late-onset bacterial infection (LOBI), interleukin (IL)-6 is used. Its clinical use is sometimes limited due to prolonged recall times. Therefore, an IL-6 bedside test was established. OBJECTIVE:To compare the diagnostic ...

journal_title：Neonatology

authors： Batfalsky A,Lohr A,Heussen N,Neunhoeffer F,Orlikowsky TW

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Phenobarbitone induces suppression of cerebral electrical activity on amplitude-integrated electroencephalography (aEEG) in neonates with hypoxic-ischemic encephalopathy (HIE); however, its effect during therapeutic hypothermia (TH) has not been well characterized. OBJECTIVE:To evaluate the effect of phenob...

journal_title：Neonatology

authors： Deshpande P,Jain A,McNamara PJ

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:Pharmacological closure of patent ductus arteriosus (PDA) is commonly achieved by intravenous (IV) administration of ibuprofen or indomethacin. Occasionally, oral ibuprofen is used for PDA treatment although its efficacy and safety are unclear. OBJECTIVES:To systematically review randomized and quasi-random...

journal_title：Neonatology

authors： Neumann R,Schulzke SM,Bührer C

更新日期：2012-01-01 00:00:00