Abstract:
BACKGROUND:Newborns are susceptible to inflammatory diseases due to defects in clearing activated immune cells from tissues. Therefore, mechanisms have likely evolved to protect neonates from leukocyte-mediated cytotoxicity. Bilirubin has antioxidant activity, and it is possible that it also exerts effects on cellular immune responses in jaundiced infants. OBJECTIVES:We hypothesize that bilirubin increases expression of antioxidant genes and decreases production of inflammatory proteins in neonatal neutrophils. METHODS:Neutrophils were isolated from umbilical cord blood, and from adults for comparison, and treated with bilirubin (10-300 µmol/l, equivalent to unbound bilirubin 3-40 nmol/l), in the presence or absence of lipopolysaccharide (LPS). Expression of genes for antioxidant enzymes [superoxide dismutase (SOD), heme-oxygenase-1 (HO-1)] and heme-dependent enzymes involved in inflammation [NADPH oxidase-1 (NOX-1), cyclooxygenase-2 (COX-2)] was measured by PCR. Inflammatory cytokines were measured by bead array analysis using flow cytometry. RESULTS:We found that LPS induced production of interleukin (IL)-8, IL-1β, and macrophage inhibitory protein-1β (MIP-1β). Bilirubin increased basal production of IL-8 and IL-1β, but downregulated LPS-induced generation of IL-8 and MIP-1β. It also upregulated SOD and HO-1 gene expression. We observed an unexpected bilirubin-induced increase in gene expression of NOX-1 in LPS-activated cells, and of COX-2 in both resting and activated cells. CONCLUSIONS:These findings suggest that bilirubin suppresses inflammation and increases antioxidant enzyme generation in activated neonatal neutrophils. The unexpected increases in NOX-1 and COX-2 expression may represent an early response, with physiologic effects mitigated by increased antioxidant activity. Further studies will be needed to define levels of bilirubin that optimize its protective effects, while minimizing potential inflammatory toxicity.
journal_name
Neonatologyjournal_title
Neonatologyauthors
Weinberger B,Archer FE,Kathiravan S,Hirsch DS,Kleinfeld AM,Vetrano AM,Hegyi Tdoi
10.1159/000343097subject
Has Abstractpub_date
2013-01-01 00:00:00pages
105-11issue
2eissn
1661-7800issn
1661-7819pii
000343097journal_volume
103pub_type
杂志文章相关文献
Neonatology文献大全abstract::The treatment of preterm newborn rabbits with synthetic surfactants containing simple phospholipid mixtures and peptides gives similar tidal volumes to treatment with poractant alfa (Curosurf®). The addition of both surfactant protein B and C analogs to the phospholipid mixture will stabilize the alveoli, measured as ...
journal_title:Neonatology
pub_type: 杂志文章,评审
doi:10.1159/000349942
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The identification of factors involved in the postnatal growth of preterm infants will help achieve growth similar to that of term infants. OBJECTIVES:As per protocol: to compare body composition in very preterm infants at term-corrected age (TCA) with that in term infants, and to explore relationships betw...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000450882
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The probabilities of survival and survival without major brain damage (MBD) are low in newborns at the limit of viability. Survival without MBD constitutes a major concern for parents and professionals. OBJECTIVES:To know the probabilities of survival without MBD in newborns ≤26 weeks' gestational age (GA) ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000452195
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Corticosteroids have been used widely after birth in preterm infants with respiratory failure; hydrocortisone may be preferable to other corticosteroids for this purpose. OBJECTIVES:To determine if postnatal hydrocortisone is useful to prevent or treat bronchopulmonary dysplasia (BPD) in preterm infants. M...
journal_title:Neonatology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000279992
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Preterm birth contributes significantly to infant mortality and morbidity, including blindness from retinopathy of prematurity (ROP). Access to intensive neonatal care is expanding in many countries, but care is not always optimal, one factor being that nursing is often by inadequately trained nurse assistan...
journal_title:Neonatology
pub_type: 临床试验,杂志文章
doi:10.1159/000362532
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:With the increasing incidence of births of very preterm very-low-birth-weight infants, there is a demand for echocardiographic reference values of cardiac dimensions. OBJECTIVES:The aim of this study was to provide reference values of cardiac valve annulus diameters in a cohort of extremely preterm very-low...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000488387
更新日期:2018-01-01 00:00:00
abstract::Volume resuscitation (VR) for the treatment of newborn shock is a rare but potentially lifesaving intervention. Conducting clinical studies to assess the effectiveness of VR in the delivery room during newborn stabilization is challenging. We review the available literature and current management guidelines to determi...
journal_title:Neonatology
pub_type: 杂志文章,评审
doi:10.1159/000475456
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Nasal continuous positive airway pressure (NCPAP) is a well-studied treatment for respiratory problems in preterm infants. However, the best strategy for NCPAP weaning is unknown. OBJECTIVE:We aimed to compare the success of progressive pressure wean versus sudden wean for discontinuation of NCPAP in preter...
journal_title:Neonatology
pub_type: meta分析
doi:10.1159/000507863
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Delayed cord clamping (DCC) improves placental transfusion and increases blood volume in preterm infants when compared with immediate cord clamping (ICC). However, evidence to support DCC in multiple-birth preterm infants is still lacking. OBJECTIVE:To compare the outcomes of ICC versus DCC in preterm infan...
journal_title:Neonatology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000494132
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Intermittent hypoxic episodes are common among preterm infants, although longer term consequences on growth pattern and cardiovascular regulation are unclear. Furthermore, the effects of intermittent hypoxia (IH) may depend on the pattern of hypoxia-reoxygenation. OBJECTIVES:We tested the hypothesis that a ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000338096
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Various studies have shown an association between low birth weight and the prevalence of elevated blood pressure later in life. However, a relationship between birth weight and blood pressure in the neonatal period has not been investigated yet. OBJECTIVE:To study the relationship between birth weight and b...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000203338
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Gene expression profiling of the salivary supernatant is emerging as a new and important source of real-time, systemic, biological information. However, existing technologies prevent RNA extraction of small quantities found in neonatal salivary supernatant. OBJECTIVE:The aim of this study was to develop tec...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000328026
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Retinopathy of prematurity (ROP) is a gestational age (GA)-related illness that can lead to blindness in premature infants. Timely screening of premature infants could improve visual prognosis. OBJECTIVE:To evaluate the WINROP algorithm as a method of predicting severe ROP in a Chinese population. METHODS:...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000351297
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Therapeutic hypothermia (HT) is the standard treatment for newborns after perinatal asphyxia. Preclinical studies report that HT is more effective when started early. METHODS:Eighty cooled newborns were analyzed and grouped according to when cooling was started after birth: early (≤180 min) or late (>181 min...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000353948
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Preventing the development of allergic skin disease in children is the best way to treat the disease. OBJECTIVES:Ultraviolet (UV)-free blue light phototherapy has been reported to treat atopic eczema. We evaluated the effect of neonatal phototherapy on allergic skin disease in children. METHODS:We randomly...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000489389
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Premature birth and respiratory distress syndrome (RDS) are risk factors for disturbed lung development and bronchopulmonary dysplasia (BPD). The molecular mechanisms related to prematurity and BPD remain largely unknown. Epithelial expression of the transcription factor GATA-6 has been implicated in normal ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000317827
更新日期:2011-01-01 00:00:00
abstract:AIM:Melatonin is a potent free radical scavenger and an indirect antioxidant. Knowledge about the behavior of melatonin secretion in the early neonatal period, which may relate to its properties at a vital stage during very high antioxidant demands, is limited. PATIENTS AND METHODS:We studied 35 newborns admitted to t...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000102957
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Bronchopulmonary dysplasia (BPD), severe retinopathy of prematurity (sROP), and cystic periventricular leukomalacia (cPVL) are 3 major morbidities with long-term neurodevelopmental impairments in preterm infants. OBJECTIVE:To investigate the strength of associations and identify key risk factors shared by B...
journal_title:Neonatology
pub_type: 杂志文章,多中心研究
doi:10.1159/000487505
更新日期:2018-01-01 00:00:00
abstract:UNLABELLED:Near-infrared spectroscopy-derived regional tissue oxygen saturation of haemoglobin (rStO2) reflects venous oxygen saturation. If cerebral metabolism is stable, rStO2 can be used as an estimate of cerebral oxygen delivery. The SafeBoosC phase II randomised clinical trial hypothesises that the burden of hypo-...
journal_title:Neonatology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000351346
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Oxidative stress in the newborn period may cause cell injury and inflammation if the antioxidant capacity is insufficient. To monitor antioxidant and inflammatory activity we examined by in vivo imaging various strains of luciferase reporter mice whose light-emitting properties were regulated by response e...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000107777
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Surface temperatures of fibreoptic phototherapy pads using a high intensity blue light-emitting diode (LED) light source have not been studied. OBJECTIVES:The aim of this study was to measure the temperature of LED fibreoptic phototherapy pads during phototherapy in a bench-top study, and to determine tempe...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000464318
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Inflammation due to perinatal infection (PI) and perinatal asphyxia (PA) may cause damage to various tissues and very often to the immature brain of the fetus and the newborn. Previously, we have shown that the neonatal immune system has the ability to produce increased chemokine protein levels in the serum ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000097127
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have a beneficial effect on bronchopulmonary dysplasia (BPD), which is the most common complication of extreme preterm birth. OBJECTIVES:To study the inflammatory, structural and functional effects of caffeine in an animal mode...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000442937
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Meconium displaces surfactant from the alveolar surface and inhibits its function. The development of active synthetic surfactants is complicated, especially to synthesize the hydrophobic surfactant proteins SP-B and SP-C. A synthetic surfactant, CHF5633 containing SP-B and SP-C analogs, has been designed to...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000356065
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Alveolar development and lung parenchymal simplification are not well characterized in vivo in neonatal patients with respiratory morbidities, such as bronchopulmonary dysplasia (BPD). Hyperpolarized (HP) gas diffusion magnetic resonance imaging (MRI) is a sensitive, safe, nonionizing, and noninvasive biomar...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000511084
更新日期:2020-11-11 00:00:00
abstract:OBJECTIVES:Non-invasive cardiac output monitoring is a potentially useful clinical tool in the neonatal setting. Our aim was to evaluate a new method of non-invasive continuous cardiac output (CO) measurement (NICOM™) based on the principle of bioreactance in neonates. METHODS:In this prospective observational study, ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000337295
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Newborns are prone to infections, which are independent predictors of neonatal mortality and morbidity. Neutrophil extracellular traps (NETs) are structures composed of chromatin and antimicrobial molecules that capture and kill pathogens. NETs may play an important role in the innate immune system and, thus...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000452615
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:In the absence of universal screening for congenital cytomegalovirus (cCMV) infection, the aim of this study was to assess the outcomes of a targeted screening protocol based on maternal and neonatal risk indicators. METHODS:The medical records of 2,623 neonates born in our maternal hospital between June 20...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000512525
更新日期:2020-12-22 00:00:00
abstract:BACKGROUND:Small for gestational age (SGA) neonates are at increased risk of mortality and morbidity, including necrotizing enterocolitis (NEC), but detailed information on the incidence and risk factors of NEC in SGA neonates is lacking. OBJECTIVE:This study aims to estimate the incidence of NEC in a large cohort of ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000356033
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:To compare the ultrasound examination with pH-metry in order to evaluate the diagnostic accuracy of sonography for diagnosis of gastro-oesophageal reflux (GOR) in preterm infants. METHODS:A prospective study was conducted on 31 premature infants <34 weeks with clinically diagnosed GOR. First, they underwent...
journal_title:Neonatology
pub_type: 临床试验,杂志文章
doi:10.1159/000097447
更新日期:2007-01-01 00:00:00