Abstract:
BACKGROUND:Preventing the development of allergic skin disease in children is the best way to treat the disease. OBJECTIVES:Ultraviolet (UV)-free blue light phototherapy has been reported to treat atopic eczema. We evaluated the effect of neonatal phototherapy on allergic skin disease in children. METHODS:We randomly recruited 117,041 children from an insurance research database. Those with neonatal jaundice and receiving neonatal phototherapy were classified as the icteric-phototherapy group (n = 4,744), those with neonatal jaundice and not receiving phototherapy were classified as the icteric-non-phototherapy group (n = 5,003), and those without jaundice were classified as the non-icteric group (n = 107,294). We reviewed claims from birth to age 5 years. The prevalence of atopic dermatitis (AD), clinical visit times, and topical prescriptions for allergic skin disease at different ages were compared among groups. RESULTS:AD prevalence was lower in the icteric-phototherapy group than in the icteric-non-phototherapy group. Moreover, clinical visit times for allergic skin disease were lower at age 1-4 years, and topical agent prescription for allergic skin disease were lower at age 1-5 years, in the icteric-phototherapy group than in the icteric-non-phototherapy group. The decreased use of topical agents could reach 64.29%. The 5-year complications of skin disease and cancer in the phototherapy group were not higher. CONCLUSIONS:To our knowledge, this is the first study to report on the effect of UV-free blue light therapy on allergic skin disease in newborns. Blue light therapy in newborns may be a novel method to efficiently prevent allergic skin disease for at least 5 years.
journal_name
Neonatologyjournal_title
Neonatologyauthors
Ku MSdoi
10.1159/000489389subject
Has Abstractpub_date
2018-01-01 00:00:00pages
235-241issue
3eissn
1661-7800issn
1661-7819pii
000489389journal_volume
114pub_type
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