ALLogeneic Heart STem Cells to Achieve Myocardial Regeneration (ALLSTAR) Trial: Rationale and Design.

abstract：:In this study the time course of homing and the body distribution of systemically delivered bone marrow mesenchymal stem cells (BM-MSCs) after myocardial infarction (MI) were evaluated. BM-MSCs were isolated from Wistar rats, expanded in vitro, and their phenotypical characterization was performed by flow cytometer. R...

journal_title：Cell transplantation

authors： Assis AC,Carvalho JL,Jacoby BA,Ferreira RL,Castanheira P,Diniz SO,Cardoso VN,Goes AM,Ferreira AJ

更新日期：2010-01-01 00:00:00

abstract：:Posttransplant infusion of viable donor bone marrow cells (DBMC) has been shown in our previous studies to promote acceptance of incompatible kidney allografts in rhesus monkeys after treatment with polyclonal antithymocyte globulin to deplete peripheral T-lymphocytes. In this nonhuman primate model, the infusion of t...

journal_title：Cell transplantation

authors： Smith JP,Kasten-Jolly J,Rebellato L,Haisch CE,Thomas JM

更新日期：1997-07-01 00:00:00

abstract：:We have recently documented that oral Linomide (quinoline-3-carboxamide) prevents autoimmune insulitis, islet destruction, and diabetes in NOD mice treated at an early stage (5 wk of age) of the disease. In this report, we show that treatment of female NOD mice with advanced disease (age 23-24 wk) by syngeneic islet t...

journal_title：Cell transplantation

authors： Slavin S,Weiss L,Xia W,Gross DJ

更新日期：1996-11-01 00:00:00

abstract：:The therapeutic use of stem cells to treat diseases and injuries is a promising tool in regenerative medicine. The umbilical cord provides a rich source of stem cells; we have previously reported a population of stem cells isolated from Wharton's jelly. In this report, we aimed to isolate a novel cell population that ...

journal_title：Cell transplantation

authors： Patel AN,Vargas V,Revello P,Bull DA

更新日期：2013-01-01 00:00:00

abstract：:Hypoxia is an adverse condition that can jeopardize the function of a bioartificial pancreatic construct. In this study we have investigated the effects of short-term hypoxic exposure (up to 24 h) on the bioenergetic status, metabolism, and insulin secretion of perfused pancreatic constructs composed of alginate/poly-...

journal_title：Cell transplantation

authors： Papas KK,Long RC Jr,Constantinidis I,Sambanis A

更新日期：2000-05-01 00:00:00

abstract：:This study aimed to explore the characteristics of TGFBR1-epidermal growth factor receptor (EGFR)-CTNNB1-CDH1 axis in regulating the invasion and migration in lung cancer. Using the small interfering RNA technology, EGFR was silenced in H2170 and H1299 cells. Then, the colony formation, migration, and invasion abiliti...

journal_title：Cell transplantation

authors： Liu R,Zhang Y,Ding Y,Zhang S,Pan L

更新日期：2020-01-01 00:00:00

abstract：:Major skin burns are difficult to treat. Patients often require special care and long-term hospitalization. Besides specific complications associated with the wounds themselves, there may be impairment of the immune system and of other organs. Mesenchymal stromal cells (MSCs) are a recent therapeutic alternative to tr...

journal_title：Cell transplantation

authors： Caliari-Oliveira C,Yaochite JN,Ramalho LN,Palma PV,Carlos D,Cunha Fde Q,De Souza DA,Frade MA,Covas DT,Malmegrim KC,Oliveira MC,Voltarelli JC

更新日期：2016-01-01 00:00:00

abstract：:During in vivo intracerebral infusions, the ability to perform accurate targeting towards a 3D-specific point allows control of the anatomical variable and identification of the effects of variations in other factors. Intraoperative MRI navigation systems are currently being used in the clinic, yet their use in nonhum...

journal_title：Cell transplantation

authors： Emborg ME,Joers V,Fisher R,Brunner K,Carter V,Ross C,Raghavan R,Brady M,Raschke J,Kubota K,Alexander A

更新日期：2010-01-01 00:00:00

abstract：:Successful repair of damage in cerebral palsy (CP) needs effective clinical interventions other than simply symptomatic treatments. To elucidate the feasibility of using olfactory ensheathing cells (OECs) to treat CP in children and adolescents, we conducted a randomized controlled clinical trial (RCT) on 33 patients....

journal_title：Cell transplantation

authors： Chen L,Huang H,Xi H,Xie Z,Liu R,Jiang Z,Zhang F,Liu Y,Chen D,Wang Q,Wang H,Ren Y,Zhou C

更新日期：2010-01-01 00:00:00

abstract：:We attempted to regenerate bone in a significant osseous defect with various stem cells from deciduous teeth, extracted from puppies, and grafted them into a parent canine mandible as an allograft, parent dental pulp, and bone marrow by tissue engineering and regenerative medicine technology using platelet-rich plasm...

journal_title：Cell transplantation

authors： Yamada Y,Ito K,Nakamura S,Ueda M,Nagasaka T

更新日期：2011-01-01 00:00:00

abstract：:Cell replacement therapy by intracerebral transplantation of fetal dopaminergic neurons has become a promising therapeutic option for patients suffering from Parkinson's disease during the last decades. However, limited availability of human fetal tissue as well as ethical issues, lack of alternative nonfetal donor ce...

journal_title：Cell transplantation

authors： Rath A,Klein A,Papazoglou A,Pruszak J,Garcia J,Krause M,Maciaczyk J,Dunnett SB,Nikkhah G

更新日期：2013-01-01 00:00:00

abstract：:Gene therapy as well as methods capable of returning cells to a pluripotent state (iPS) have enabled the correction of genetic deficiencies in syngenic adult progenitors, reducing the need for immunosuppression in cell therapy approaches. However, in diseases involving mutations that lead to the complete lack of a pr...

journal_title：Cell transplantation

authors： Even Y,Bennett JL,Sekulovic S,So L,Yi L,McNagny K,Humphries RK,Rossi FM

更新日期：2011-01-01 00:00:00

abstract：:Grafting autologous cultured satellite cells in irreversibly injured rat extensor digitorum longus EDL muscle leads to myofiber regeneration at the grafting site. In this study, we investigated whether cell grafts induced functional improvement and correlated mechanophysiological findings with histological observation...

journal_title：Cell transplantation

authors： Alameddine HS,Louboutin JP,Dehaupas M,Sébille A,Fardeau M

更新日期：1994-01-01 00:00:00

abstract：:We investigated the effects of transplantation of CXCR4-overexpressing adipose tissue-derived stem cells (ADSCs) into a mouse diabetic hindlimb ischemia model on homing and engraftment as early as 48 h after transplant. CXCR4-overexpressing ADSCs were intramuscularly or intravenously injected into diabetic mice with h...

journal_title：Cell transplantation

authors： Kim M,Kim DI,Kim EK,Kim CW

更新日期：2017-02-16 00:00:00

abstract：:Alzheimer's disease (AD) is a type of neurodegenerative disorder and the most common form of dementia. MicroRNA (miRNA) has been shown to play a role in various diseases, including AD. It also has been reported to regulate autophagy. We extracted miRNA from blood samples and constructed an miRNA-101a lentivirus vector...

journal_title：Cell transplantation

authors： Li Q,Wang Y,Peng W,Jia Y,Tang J,Li W,Zhang JH,Yang J

更新日期：2019-08-01 00:00:00

abstract：:Hepatocyte transplantation is an alternative therapy to orthotopic liver transplantation for the treatment of liver diseases. However, the supply of hepatocytes is limited given the shortage of organs available to isolate good-functioning quality cells. Neonatal livers may be a potential source alternative to adult li...

journal_title：Cell transplantation

authors： Tolosa L,Pareja-Ibars E,Donato MT,Cortés M,López S,Jiménez N,Mir J,Castell JV,Gómez-Lechón MJ

更新日期：2014-01-01 00:00:00

abstract：:The biohybrid artificial pancreas is designed to enclose pancreatic tissues with a selectively permeable membrane that immunoisolates the graft from the host immune system, allowing those endocrine tissues to survive and control glucose metabolism for an extended period of time. The pancreatic B cell line MIN6 is esta...

journal_title：Cell transplantation

authors： Kawakami Y,Inoue K,Hayashi H,Wang WJ,Setoyama H,Gu YJ,Imamura M,Iwata H,Ikada Y,Nozawa M,Miyazaki J

更新日期：1997-09-01 00:00:00

abstract：:As a putative marker of cerebral small vessel disease, cerebral microbleeds (CMBs) have been associated with vascular cognitive impairment. Both iron accumulation and amyloid protein precursor (APP) dysregulation are recognized as pathological hallmarks underlying the progression of CMBs, but their cross-talk is not y...

journal_title：Cell transplantation

authors： Gong L,Tian X,Zhou J,Dong Q,Tan Y,Lu Y,Wu J,Zhao Y,Liu X

更新日期：2019-08-01 00:00:00

abstract：:Addition of embryonic striatal tissue, usually as a combination of the lateral and medial ganglionic eminences, to intrastriatal mesencephalic grafts has previously been reported to enhance recovery of drug-induced rotational behavior in the host and to modify axonal fiber outgrowth from the grafted dopaminergic neuro...

journal_title：Cell transplantation

authors： Emgård-Mattson M,Karlsson J,Nakao N,Brundin P

更新日期：1997-05-01 00:00:00

abstract：:Cell therapy has been shown to be a promising alternative therapy for neurorestoration, and more than 30 different types of cells have been shown to possess some capability to restore lost or damaged neurological functions. Chinese physicians have successfully applied cell therapy to many neurological diseases and dam...

journal_title：Cell transplantation

authors： Chinese Branch of International Association of Neurorestoratology (IANR).,Preparatory Committee of Chinese Association of Neurorestoratology.

更新日期：2013-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) hold great promise for bone regeneration. However, the power of mesenchymal stem cells has not been applied to structural bone allografts in clinical practice. This study designed a new strategy to enhance the efficiency of allografts for segmental bone regeneration. Isolated MSCs were cu...

journal_title：Cell transplantation

authors： Zou XH,Cai HX,Yin Z,Chen X,Jiang YZ,Hu H,Ouyang HW

更新日期：2009-01-01 00:00:00

abstract：:Recent advances in tissue engineering technologies have highlighted the ability to create functional liver systems using isolated hepatocytes in vivo. Considering the serious shortage of donor livers that can be used for hepatocyte isolation, it has remained imperative to establish a hepatocyte propagation protocol t...

journal_title：Cell transplantation

authors： Ohashi K,Tatsumi K,Tateno C,Kataoka M,Utoh R,Yoshizato K,Okano T

更新日期：2012-01-01 00:00:00

abstract：:Development of a tissue-engineered neo-kidney augment (NKA) requires evaluation of defined, therapeutically relevant cell and cell/biomaterial composites (NKA constructs) for regenerative potential in mammalian kidney. Previous work identified primary renal cell populations that extended survival and improved renal f...

journal_title：Cell transplantation

authors： Basu J,Genheimer CW,Rivera EA,Payne R,Mihalko K,Guthrie K,Bruce AT,Robbins N,McCoy D,Sangha N,Ilagan R,Knight T,Spencer T,Wagner BJ,Jayo MJ,Jain D,Ludlow JW,Halberstadt C

更新日期：2011-01-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) mobilizes peripheral blood stem cells (PBSCs) derived from bone marrow. We hypothesized that intraspinal transplantation of PBSCs mobilized by G-CSF could promote functional recovery after spinal cord injury. Spinal cords of adult nonobese diabetes/severe immunodeficiency ...

journal_title：Cell transplantation

authors： Takahashi H,Koda M,Hashimoto M,Furuya T,Sakuma T,Kato K,Okawa A,Inada T,Kamiya K,Ota M,Maki S,Takahashi K,Yamazaki M,Mannoji C

更新日期：2016-01-01 00:00:00

abstract：:Articular cartilage is an avascular tissue composed of chondrocytes, a unique cell type responsible for abundant matrix synthesis and maintenance. When damaged, it never heals spontaneously under physiological circumstances. Therefore, the delivery of mesenchymal stem cells using hydrogel has been considered for cart...

journal_title：Cell transplantation

authors： Merceron C,Portron S,Masson M,Lesoeur J,Fellah BH,Gauthier O,Geffroy O,Weiss P,Guicheux J,Vinatier C

更新日期：2011-01-01 00:00:00

abstract：:The main purpose of this work has been to establish a new culturing technique to improve the chondrogenic commitment of isolated adult human chondrocytes, with the aim of being used during cell-based therapies or tissue engineering strategies. By using a rather novel technique to generate scaffold-free three-dimension...

journal_title：Cell transplantation

authors： Martinez I,Elvenes J,Olsen R,Bertheussen K,Johansen O

更新日期：2008-01-01 00:00:00

abstract：:Functional demands on a bioartificial liver support (BAL) device are not limited to biosynthetic activities, but must also encompass metabolic removal of potentially toxic substances. For most BALs, however, the concept and design are exclusively directed to biosynthetic support. To add the ability to metabolize and r...

journal_title：Cell transplantation

authors： Takahashi M,Sakurai M,Enosawa S,Omasa T,Tsuruoka S,Matsumura T

更新日期：2006-01-01 00:00:00

abstract：:Development of β-cells from human embryonic stem cells (hESCs) could compensate for the shortage of islet donors required for diabetes therapy. Although pancreatic progenitors have been derived from hESCs using various protocols, no fully functional b-cells could be generated in vitro. We evaluated the in vivo growth ...

journal_title：Cell transplantation

authors： Sui L,Mfopou JK,Chen B,Sermon K,Bouwens L

更新日期：2013-01-01 00:00:00

abstract：:Facioscapulohumeral muscular dystrophy (FSHD) is the third most frequent inherited myopathy. We previously demonstrated that mesoangioblasts can be efficiently isolated from FSHD muscles, although their differentiation ability into skeletal muscle was variably impaired. This correlates with overall disease severity a...

journal_title：Cell transplantation

authors： Morosetti R,Gidaro T,Broccolini A,Gliubizzi C,Sancricca C,Tonali PA,Ricci E,Mirabella M

更新日期：2011-01-01 00:00:00

abstract：:Transplantation therapies aimed at repairing neurodegenerative and neuropathological conditions of the central nervous system (CNS) have utilized and tested a variety of cell candidates, each with its own unique set of advantages and disadvantages. The use and popularity of each cell type is guided by a number of fact...

journal_title：Cell transplantation

authors： Kramer AS,Harvey AR,Plant GW,Hodgetts SI

更新日期：2013-01-01 00:00:00