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NAFLD and liver transplantation: Current burden and expected challenges.

Abstract：

:Because of global epidemics of obesity and type 2 diabetes, the prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing both in Europe and the United States, becoming one of the most frequent causes of chronic liver disease and predictably, one of the leading causes of liver transplantation both for end-stage liver disease and hepatocellular carcinoma. For most transplant teams around the world this will raise many challenges in terms of pre- and post-transplant management. Here we review the multifaceted impact of NAFLD on liver transplantation and will discuss: (1) NAFLD as a frequent cause of cryptogenic cirrhosis, end-stage chronic liver disease, and hepatocellular carcinoma; (2) prevalence of NAFLD as an indication for liver transplantation both in Europe and the United States; (3) the impact of NAFLD on the donor pool; (4) the access of NAFLD patients to liver transplantation and their management on the waiting list in regard to metabolic, renal and vascular comorbidities; (5) the prevalence and consequences of post-transplant metabolic syndrome, recurrent and de novo NAFLD; (6) the alternative management and therapeutic options to improve the long-term outcomes with particular emphasis on the correction and control of metabolic comorbidities.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Pais R,Barritt AS 4th,Calmus Y,Scatton O,Runge T,Lebray P,Poynard T,Ratziu V,Conti F

doi

10.1016/j.jhep.2016.07.033

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1245-1257

issue

6

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(16)30403-2

journal_volume

65

pub_type

杂志文章,评审

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