当前位置： SCI文献检索 > GYNECOLOGIC ONCOLOGY期刊下所有文献 > Analysis of outcomes and prognostic factors after fertility-sparing surgery in malignant ovarian germ cell tumors.

Analysis of outcomes and prognostic factors after fertility-sparing surgery in malignant ovarian germ cell tumors.

Abstract：

OBJECTIVE:To evaluate the oncologic and reproductive outcomes and to analyze prognostic factors after fertility-sparing surgery in patients with early and advanced malignant ovarian germ cell tumors (MOGCTs). METHODS:This study included 171 patients who underwent fertility-sparing surgery. Data were gathered from patients' medical records. Survival analysis was performed using the log-rank test and Cox's proportional hazards model. Reproductive outcomes were analyzed. RESULTS:Twenty-five patients (14.6%) had recurrent disease, and five patients (2.9%) died of disease during the median follow-up time of 86months (range, 9-294months). The 5-year disease-free survival (DFS) was 86%, and the 5-year overall survival (OS) was 97%. The 5-year DFS was 84% for stage I and 89% for stage II-IV. The 5-year OS was 99% for stage I and 91% for stage II-IV. In multivariate analysis, yolk sac tumor, incomplete staging surgery, and residual tumor were independent risk factors for reduced DFS, and yolk sac tumor and residual tumor were independent risk factors for reduced OS. Reproductive and obstetric outcomes were evaluable in 124 patients, and 106 patients (85.5%) had regular menstruation, 12 patients (9.7%) had irregular menstruation, and six patients (4.8%) had premature menopause. Twenty patients tried to conceive, 15 patients (75%) succeeded in achieving 21 pregnancies, and 13 of the patients (65%) gave birth to 20 healthy babies. CONCLUSION:Fertility-sparing surgery has excellent survival outcomes in young women with MOGCTs, even in advanced stages. Reproductive and obstetric outcomes were promising. Yolk sac tumor, incomplete surgical staging, and residual tumor were independent prognostic factors.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Park JY,Kim DY,Suh DS,Kim JH,Kim YM,Kim YT,Nam JH

doi

10.1016/j.ygyno.2017.03.023

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

513-518

issue

3

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(17)30239-1

journal_volume

145

pub_type

杂志文章

相关文献

GYNECOLOGIC ONCOLOGY文献大全
  • Colorectal function preservation in posterior and total supralevator exenteration for gynecologic malignancies: an 89-patient series.

    abstract：OBJECTIVE:The objective of this study was to analyze our experience with colorectal function preservation at the time of pelvic exenteration. METHODS:Between January 1980 and December 2001, 201 pelvic exenterations for gynecologic malignancies were performed in our hospital. Ninety-eight were supralevator exenteration...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/s0090-8258(03)00069-6

    authors： Moutardier V,Houvenaeghel G,Lelong B,Mokart D,Delpero JR

    更新日期：2003-04-01 00:00:00

  • Anticancer effects of (-)-epigallocatechin-3-gallate on ovarian carcinoma cell lines.

    abstract：PURPOSE:A constituent of green tea, (-)-epigallocatechin-3-gallate (EGCG), has been known to possess anti-cancer properties. In this study, we investigated the time-course anticancer effects of EGCG on human ovarian cancer cells to provide insights into the molecular-level understanding of growth suppression mechanism ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2004.05.031

    authors： Huh SW,Bae SM,Kim YW,Lee JM,Namkoong SE,Lee IP,Kim SH,Kim CK,Ahn WS

    更新日期：2004-09-01 00:00:00

  • Electronic patient-reported symptom monitoring in patients recovering from ambulatory minimally invasive gynecologic surgery: A prospective pilot study.

    abstract：OBJECTIVE:To evaluate the feasibility of an electronic symptom-tracking platform for patients recovering from ambulatory surgery. METHOD:We assessed user response to an electronic system designed to self-report symptoms. Endpoints included compliance, postoperative symptoms, patient satisfaction. An 8-item symptom inv...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2020.07.004

    authors： Zivanovic O,Chen LY,Vickers A,Straubhar A,Baser R,Veith M,Aiken N,Carter J,Curran K,Simon B,Mueller J,Jewell E,Chi DS,Sonoda Y,Abu-Rustum NR,Leitao MM Jr

    更新日期：2020-10-01 00:00:00

  • Molecular evidence linking primary cancer of the fallopian tube to BRCA1 germline mutations.

    abstract：OBJECTIVES:BRCA1 and BRCA2 germline mutations increase the risk of ovarian and breast cancer. Fallopian tube cancer has occasionally been observed in breast-ovarian cancer families. At our family cancer clinic we recently encountered two cases of Fallopian tube cancer within two families harboring a BRCA1 germline muta...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1999.5623

    authors： Zweemer RP,van Diest PJ,Verheijen RH,Ryan A,Gille JJ,Sijmons RH,Jacobs IJ,Menko FH,Kenemans P

    更新日期：2000-01-01 00:00:00

  • Post-diagnosis use of antihypertensive medications and the risk of death from ovarian cancer.

    abstract：OBJECTIVE:To examine associations between post-diagnosis use of antihypertensive (AH) medications including thiazide diuretics (TDs), angiotensin converting enzyme inhibitors (ACEIs), beta blockers (BBs) [both non-selective (NSBBs) and selective (SBBs)] and calcium channel blockers (CCBs) and ovarian cancer-specific su...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2019.05.030

    authors： Harding BN,Delaney JA,Urban RR,Weiss NS

    更新日期：2019-08-01 00:00:00

  • Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California Phase II Consortia.

    abstract：OBJECTIVES:The objectives of this phase II trial were to assess the activity and tolerability of the combination of bevacizumab and erlotinib in patients with recurrent ovarian, primary peritoneal or fallopian tube cancer. METHODS:This was a single arm, multicenter phase II trial with overall objective response as the...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ygyno.2008.02.009

    authors： Nimeiri HS,Oza AM,Morgan RJ,Friberg G,Kasza K,Faoro L,Salgia R,Stadler WM,Vokes EE,Fleming GF,Chicago Phase II Consortium.,PMH Phase II Consortium.,California Phase II Consortium.

    更新日期：2008-07-01 00:00:00

  • Vascular endothelial growth factor (VEGF) up-regulates epidermal growth factor receptor (EGF-R) in cervical cancer in vitro: this action is mediated through HPV-E6 in HPV-positive cancers.

    abstract：OBJECTIVES:Epidermal Growth Factor Receptor (EGF-R) up-regulation in cervical cancer cells leads to an increase in cell proliferative Insulin-like Growth Factor II (IGF-II) and Vascular Endothelial Growth Factor (VEGF) and a decrease of the anti-proliferative IGF-binding protein-3 (IGF-BP3). The objectives for this stu...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2004.12.011

    authors： Mathur RS,Mathur SP

    更新日期：2005-04-01 00:00:00

  • Should the presence of lymphvascular space involvement be used to assign patients to adjuvant therapy following hysterectomy for unstaged endometrial cancer?

    abstract：:Objective. Thegoal of this study was to determine the influence of LVSI (lymphvascular space involvement) on the risk of lymph node metastases from endometrial cancer.Methods. All patients with surgically staged endometrial cancer from 1998 to 2000 were identified from divisional databases. The influence of LVSI on th...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.2002.6825

    authors： Cohn DE,Horowitz NS,Mutch DG,Kim SM,Manolitsas T,Fowler JM

    更新日期：2002-12-01 00:00:00

  • Cell kinetics: a prognostic marker in epithelial ovarian cancer.

    abstract：:The proliferative activities (3H-thymidine labeling index, LI) of 72 primary ovarian cancers and 76 metastatic lesions from untreated patients were evaluated. Overall, median LI values for primary and metastatic lesions were similar (7.8 vs 7.0%), but cell kinetics significantly differed in metastases from different s...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0090-8258(89)90003-6

    authors： Silvestrini R,Daidone MG,Bolis G,Fontanelli R,Landoni F,Andreola S,Colombi R

    更新日期：1989-10-01 00:00:00

  • Enhancement of sensitivity to cisplatin by orobol is associated with increased mitochondrial cytochrome c release in human ovarian carcinoma cells.

    abstract：OBJECTIVES:Based on our previous report showing that orobol, a potent phosphatidylinositol 4-kinase (PI4K) inhibitor, produced cisplatin (DDP) sensitivity, we have determined the mechanism of orobol-sensitization effect. METHODS AND RESULTS:Orobol produced >2-fold DDP sensitivity in human ovarian carcinoma 2008 cells ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/s0090-8258(03)00316-0

    authors： Isonishi S,Saitou M,Yasuda M,Ochiai K,Tanaka T

    更新日期：2003-08-01 00:00:00

  • Development and characterization of an IL-4-secreting human ovarian carcinoma cell line.

    abstract：:Human ovarian carcinoma cell lines were genetically engineered to secrete the cytokine interleukin-4 (IL-4) by retroviral-mediated gene transduction. These cells were transduced with the LXSN retroviral vector containing the human IL-4 gene and the neomycin resistance selection marker. Numerous IL-4-secreting clones w...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1995.1216

    authors： Santin AD,Ioli GR,Hiserodt JC,Rose GS,Graf MR,Tocco LM,Lander JK,Eck LM,Burger RA,DiSaia PJ

    更新日期：1995-08-01 00:00:00

  • Psychological adjustment to familial-genetic risk assessment for ovarian cancer: predictors of nonadherence to surveillance recommendations.

    abstract：OBJECTIVE:To evaluate whether self-report measures of psychological distress and perceived risk were associated with nonadherence to recommended ovarian cancer surveillance. METHODS:Eighty-three patients attending the Familial Ovarian Cancer Clinic (FOCC) at Princess Margaret Hospital were assessed psychosocially prio...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.2001.6461

    authors： Ritvo P,Irvine J,Robinson G,Brown L,Murphy KJ,Matthew A,Rosen B

    更新日期：2002-01-01 00:00:00

  • Quantitative prognostic features in FIGO I ovarian cancer patients without postoperative treatment.

    abstract：:To identify FIGO I ovarian cancer patients at high risk, prognostic values of quantitative pathological features (volume percentage of epithelium, mitotic activity index, mean (MNA) and standard deviation of nuclear profile area, and volume-weighted mean nuclear volume (MNV) have been investigated in comparison with c...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1997.4884

    authors： Brugghe J,Baak JP,Wiltshaw E,Brinkhuis M,Meijer GA,Fisher C

    更新日期：1998-01-01 00:00:00

  • Correlation of NK T-like CD3+CD56+ cells and CD4+CD25+(hi) regulatory T cells with VEGF and TNFalpha in ascites from advanced ovarian cancer: Association with platinum resistance and prognosis in patients receiving first-line, platinum-based chemotherapy.

    abstract：BACKGROUND:Several cytokines have been associated with immune regulation and prognosis in ovarian cancer. CD4+CD25+ Tregs and CD3+CD56+ NK-like T cells are involved in the immune response against the tumor. We have investigated the association of cytokines in the ascites from patients with ovarian cancer with these pop...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2007.10.018

    authors： Bamias A,Koutsoukou V,Terpos E,Tsiatas ML,Liakos C,Tsitsilonis O,Rodolakis A,Voulgaris Z,Vlahos G,Papageorgiou T,Papatheodoridis G,Archimandritis A,Antsaklis A,Dimopoulos MA

    更新日期：2008-02-01 00:00:00

  • Endometrial cancer and obesity: epidemiology, biomarkers, prevention and survivorship.

    abstract：:Endometrial cancer is the most common gynecologic malignancy in the Western world and is strongly associated with obesity. Despite the fact that most cases are diagnosed in early, more favorable stages, endometrial cancer incidence and mortality rates are on the rise. Morbidly obese women with endometrial cancer are m...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2009.03.039

    authors： Fader AN,Arriba LN,Frasure HE,von Gruenigen VE

    更新日期：2009-07-01 00:00:00

  • A binary histologic grading system for ovarian serous carcinoma is an independent prognostic factor: a population-based study of 4317 women diagnosed in Denmark 1978-2006.

    abstract：OBJECTIVE:To evaluate the prognostic significance of histologic grade on survival of ovarian serous cancer in Denmark during nearly 30 years. METHODS:Using the nationwide Danish Pathology Data Bank, we evaluated 4317 women with ovarian serous carcinoma in 1978-2006. All pathology reports were scrutinized and tumors cl...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2012.02.028

    authors： Hannibal CG,Vang R,Junge J,Kjaerbye-Thygesen A,Kurman RJ,Kjaer SK

    更新日期：2012-06-01 00:00:00

  • The efficacy of concurrent weekly carboplatin with radiotherapy in the treatment of cervical cancer: A meta-analysis.

    abstract：OBJECTIVES:We aimed to evaluate whether carboplatin has a comparable efficacy with cisplatin as part of weekly concurrent chemoradiotherapy for cervical cancer (Car-RT vs. Cis-RT). METHODS:A literature search was conducted and both prospective and retrospective studies that evaluated the efficacy of Car-RT for cervica...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ygyno.2018.07.005

    authors： Xue R,Cai X,Xu H,Wu S,Huang H

    更新日期：2018-09-01 00:00:00

  • Bladder function after modified posterior exenteration for primary gynecological cancer.

    abstract：OBJECTIVE:Bladder dysfunction caused by autonomic nerve injury is a well-recognized complication of pelvic surgery. Modified posterior exenteration with or without nerve preservation was performed in patients with primary ovarian, tubal, peritoneal, and endometrial cancer. The aim of this retrospective study was to eva...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2013.01.013

    authors： Kato K,Tate S,Nishikimi K,Shozu M

    更新日期：2013-04-01 00:00:00

  • Tamoxifen and the risk of ovarian cancer in BRCA1 mutation carriers.

    abstract：OBJECTIVE:BRCA1 mutation carriers have a high rate of both breast and ovarian cancer. Tamoxifen is a selective estrogen receptor modulator (SERM), which is used for the treatment of primary breast cancer and for the prevention of contralateral breast cancer. Our objective is to assess if tamoxifen treatment is associat...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2009.06.012

    authors： Vicus D,Rosen B,Lubinski J,Domchek S,Kauff ND,Lynch HT,Isaacs C,Tung N,Sun P,Narod SA,Hereditary Ovarian Cancer Clinical Study Group.

    更新日期：2009-10-01 00:00:00

  • Complete remission of gestational choriocarcinoma with choroidal metastasis treated with systemic chemotherapy alone: case report and review of literature.

    abstract：BACKGROUND:Gestational choriocarcinoma is a malignant tumor that frequently metastasizes to the highly vascularized organs such as the lung, brain, and liver via hematogenous spread. However, this tumor rarely metastasizes to the eye and only a few cases of metastasis to the choroid have been reported. CASE:A 17-year-...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1006/gyno.2001.6415

    authors： Ino K,Mitsui T,Nomura S,Kikkawa F,Mizutani S

    更新日期：2001-12-01 00:00:00

  • A retrospective study of tamoxifen and endometrial cancer in breast cancer patients.

    abstract：OBJECTIVE:To assess the relationship between low-dose tamoxifen, usage and endometrial cancer in breast cancer patients. METHODS:In this case-control study, the records of the 1017 patients treated at Wilford Hall Medical Center for primary breast cancer between 1978 and 1989 were reviewed. Dose and duration of tamoxi...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1995.0005

    authors： Robinson DC,Bloss JD,Schiano MA

    更新日期：1995-11-01 00:00:00

  • Paratubal borderline serous tumors.

    abstract：BACKGROUND:While ovarian borderline tumors are common, their fallopian tube counterparts are extremely rare. We describe the first case of a serous borderline paratubal tumor with a review of the literature on paratubal and tubal low malignant potential tumors. CASE:A 26 year-old woman presented with acute onset of sh...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2008.12.019

    authors： Seamon LG,Holt CN,Suarez A,Richardson DL,Carlson MJ,O'Malley DM

    更新日期：2009-04-01 00:00:00

  • How accurate is frozen section histology of pelvic lymph nodes in patients with endometrial cancer?

    abstract：OBJECTIVE:Recent prospective data support the trend towards systematic retroperitoneal lymphadenectomy in patients with high-risk endometrial cancer. Because para-aortic node involvement in the absence of pelvic node involvement is uncommon, a reliable finding of negative pelvic lymph nodes (PLN) at intraoperative froz...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2009.07.007

    authors： Pristauz G,Bader AA,Regitnig P,Haas J,Winter R,Tamussino K

    更新日期：2009-10-01 00:00:00

  • Bokhman Redux: Endometrial cancer "types" in the 21st century.

    abstract：:In 1983 Jan V. Bokhman, M.D. published a landmark paper entitled "Two Pathogenetic Types of Endometrial Carcinoma" in which an enduring dualistic view of endometrial cancer was first proposed. "Type I" cancers are thought to represent estrogen driven mostly low grade endometrioid tumors strongly associated with obesit...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2016.12.010

    authors： Suarez AA,Felix AS,Cohn DE

    更新日期：2017-02-01 00:00:00

  • HPV mRNA tests for the detection of cervical intraepithelial neoplasia: a systematic review.

    abstract：OBJECTIVE:Perform a systematic review to determine the test performance of HPV mRNA testing compared to DNA testing using CIN2+ as the target condition. METHODS:We searched bibliographic databases (MEDLINE, EMBASE and Cochrane Library) from January 1996 through August 2010 using a predefined search strategy. The refer...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2010.11.013

    authors： Burger EA,Kornør H,Klemp M,Lauvrak V,Kristiansen IS

    更新日期：2011-03-01 00:00:00

  • Potential predictors of chemotherapy response in ovarian cancer--how do we define chemosensitivity?

    abstract：OBJECTIVE:The aim of this study was to assess whether microvessel density (measured by CD31), vascular endothelial growth factor (VEGF) or multidrug resistance (MDR1) could determine the response to chemotherapy or act as prognostic factors in ovarian cancer. METHODS:Seventy-nine ovarian specimens were immunostained. ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2006.08.039

    authors： O'Toole SA,Sheppard BL,Laios A,O'Leary JJ,McGuinness EP,D'Arcy T,Bonnar J

    更新日期：2007-02-01 00:00:00

  • Occult choriocarcinoma discovered by positron emission tomography/computed tomography imaging following a successful pregnancy.

    abstract：BACKGROUND:Positron emission tomography (PET) is commonly used to detect occult or recurrent malignancy, including tumors of the female genital tract. Recently, there have been reports of PET scans used in patients with Gestational Trophoblastic Disease (GTD). CASE:A 22-year-old female presented with vaginal bleeding ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2005.01.049

    authors： Numnum TM,Leath CA 3rd,Straughn JM Jr,Conner MG,Barnes MN 3rd

    更新日期：2005-05-01 00:00:00

  • The accuracy of frozen section by tumor weight for ovarian epithelial neoplasms.

    abstract：:This study evaluated the effect ovarian weight has on the accuracy of frozen sections in serous and mucinous ovarian tumors. The study group included 294 patients who had an initial frozen section (189 serous and 105 mucinous tumors) at surgery. The pathology reports were separated into subgroups (benign, borderline, ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1997.4836

    authors： Puls L,Heidtman E,Hunter JE,Crane M,Stafford J

    更新日期：1997-10-01 00:00:00

  • A cervical teratoma with invasive squamous cell carcinoma in an HIV-infected patient: a case report.

    abstract：:HIV infection among women is increasing in the United States. Since January 1993, cervical cancer has been considered an AIDS-defining illness. We report a rare case of squamous cell carcinoma arising in a teratoma of the uterine cervix in an HIV-infected patient. This patient was treated with a radical hysterectomy, ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1996.0076

    authors： Bell MC,Schmidt-Grimminger DC,Connor MG,Alvarez RD

    更新日期：1996-03-01 00:00:00

  • POSTN/TGFBI-associated stromal signature predicts poor prognosis in serous epithelial ovarian cancer.

    abstract：OBJECTIVE:To identify molecular prognosticators and therapeutic targets for high-grade serous epithelial ovarian cancers (EOCs) using genetic analyses driven by biologic features of EOC pathogenesis. METHODS:Ovarian tissue samples (n = 172; 122 serous EOCs, 30 other EOCs, 20 normal/benign) collected prospectively from...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2013.12.021

    authors： Karlan BY,Dering J,Walsh C,Orsulic S,Lester J,Anderson LA,Ginther CL,Fejzo M,Slamon D

    更新日期：2014-02-01 00:00:00