Abstract:
OBJECTIVE:To evaluate the prognostic significance of histologic grade on survival of ovarian serous cancer in Denmark during nearly 30 years. METHODS:Using the nationwide Danish Pathology Data Bank, we evaluated 4317 women with ovarian serous carcinoma in 1978-2006. All pathology reports were scrutinized and tumors classified as either low-grade serous carcinomas (LGSC) or high-grade serous carcinomas (HGSC). Tumors in which the original pathology reports were described as well-differentiated were classified as LGSC, and those that were described as moderately or poorly differentiated were classified as HGSC. We obtained histologic slides from the pathology departments for women with a diagnosis of well-differentiated serous carcinoma during 1997-2006, which were then reviewed by expert gynecologic pathologists. Data were analyzed using Kaplan-Meier methods and Cox proportional hazards regression analysis with follow-up through June 2009. RESULTS:Women with HGSC had a significantly increased risk of dying (HR=1.9; 95% CI: 1.6-2.3) compared with women with LGSC while adjusting for age and stage. Expert review of 171 women originally classified as well-differentiated in 1997-2006 were interpreted as LGSC in 30% of cases, whereas 12% were interpreted as HGSC and 50% as serous borderline ovarian tumors (SBT). Compared with women with confirmed LGSC, women with SBT at review had a significantly lower risk of dying (HR=0.5; 95% CI: 0.22-0.99), and women with HGSC at review had a non-significantly increased risk of dying (HR=1.6; 95% CI: 0.7-3.4). CONCLUSIONS:A binary grading system is a significant predictor of survival for ovarian serous carcinoma.
journal_name
Gynecol Oncoljournal_title
Gynecologic oncologyauthors
Hannibal CG,Vang R,Junge J,Kjaerbye-Thygesen A,Kurman RJ,Kjaer SKdoi
10.1016/j.ygyno.2012.02.028subject
Has Abstractpub_date
2012-06-01 00:00:00pages
655-60issue
3eissn
0090-8258issn
1095-6859pii
S0090-8258(12)00154-0journal_volume
125pub_type
杂志文章abstract:OBJECTIVE:Although there have been studies that focused on the correlation between the HPV presence of pelvic lymph nodes and pathological metastasis in patients with cervical cancer, the biologic role of HPV DNA in lymph nodes still remains uncertain. We performed this study to investigate the correlation between the ...
journal_title:Gynecologic oncology
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更新日期:2007-05-01 00:00:00
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journal_title:Gynecologic oncology
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更新日期:2006-09-01 00:00:00
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journal_title:Gynecologic oncology
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doi:10.1006/gyno.1997.4626
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journal_title:Gynecologic oncology
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doi:10.1006/gyno.1998.5176
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journal_title:Gynecologic oncology
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doi:10.1016/0090-8258(85)90261-6
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doi:10.1006/gyno.2001.6139
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1006/gyno.1999.5516
更新日期:1999-10-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章,评审
doi:10.1016/0090-8258(92)90120-8
更新日期:1992-11-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1016/j.ygyno.2004.08.024
更新日期:2004-12-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1006/gyno.1995.1260
更新日期:1995-10-01 00:00:00
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journal_title:Gynecologic oncology
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更新日期:2009-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-12-01 00:00:00
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journal_title:Gynecologic oncology
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更新日期:2018-01-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-07-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章,评审
doi:10.1006/gyno.1999.5553
更新日期:1999-10-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1016/j.ygyno.2007.01.042
更新日期:2007-06-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1016/j.ygyno.2011.08.012
更新日期:2011-12-01 00:00:00
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更新日期:2016-05-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1016/j.ygyno.2003.09.002
更新日期:2004-01-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1006/gyno.2001.6270
更新日期:2001-08-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1016/j.ygyno.2020.04.692
更新日期:2020-07-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ygyno.2004.09.013
更新日期:2005-01-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1016/j.ygyno.2015.09.077
更新日期:2016-01-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1016/j.ygyno.2009.11.031
更新日期:2010-03-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1016/j.ygyno.2009.06.041
更新日期:2009-10-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1016/j.ygyno.2014.04.011
更新日期:2014-07-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章,评审
doi:10.1016/j.ygyno.2014.08.013
更新日期:2014-11-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1016/j.ygyno.2007.12.029
更新日期:2008-12-01 00:00:00