Tamoxifen and the risk of ovarian cancer in BRCA1 mutation carriers.

abstract：OBJECTIVE:Although the epidemiology of typical endometrial carcinomas (grades 1-2 endometrioid or Type I) is well established, less is known regarding higher grade endometrioid or non-endometrioid carcinomas (Type II). Within a large Gynecologic Oncology Group trial (GOG-210), which included central pathology review, w...

journal_title：Gynecologic oncology

authors： Brinton LA,Felix AS,McMeekin DS,Creasman WT,Sherman ME,Mutch D,Cohn DE,Walker JL,Moore RG,Downs LS,Soslow RA,Zaino R

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to define the clinical-therapeutical approach to endometrial cancer now being followed in some of the most important centers of reference for gynecological cancer in North America by means of a questionnaire. STUDY DESIGN:The questionnaire focused on four principal areas: (1) surgic...

journal_title：Gynecologic oncology

authors： Maggino T,Romagnolo C,Landoni F,Sartori E,Zola P,Gadducci A

更新日期：1998-03-01 00:00:00

abstract：:PI3K/AKT/mTOR pathway is a crucial mediator of tumor progression. As the PI3K/Akt pathway is heavily deregulated in breast cancer, the application of mTOR inhibitors in breast cancer patients seems warranted. This is the first systematic review according to PRISMA guidelines to synthesize all available data of mTOR in...

journal_title：Gynecologic oncology

authors： Zagouri F,Sergentanis TN,Chrysikos D,Filipits M,Bartsch R

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Paclitaxel is most commonly infused over 3 hs rather than the original schedule of 24 h as the briefer infusion duration results in greater convenience, similar efficacy, significantly less myelosuppression, and less cost. While differences in toxicity between 3- and 24-h infusions are well described, there i...

journal_title：Gynecologic oncology

authors： Jennens R,Rischin D,Yuen K,Toner G,Millward M

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:The aim of our study was to retrospectively examine the proliferating cell nuclear antigen (PCNA) immunoreactivity of tumor cells in curettage specimens containing endometrioid adenocarcinoma and obtained immediately before definitive surgical staging. This PCNA index was compared with the one subsequently de...

journal_title：Gynecologic oncology

authors： Garzetti GG,Ciavattini A,Goteri G,De Nictolis M,Romanini C

更新日期：1996-04-01 00:00:00

abstract：:The CA 125 radioimmunoassay has been increasingly used to monitor the course of patients with ovarian epithelial carcinomas. The purpose of this report is to describe our experience in the use of this assay and to better define its clinical utility. Fifty-one patients had serum CA 125 follow-up during primary chemothe...

journal_title：Gynecologic oncology

authors： Podczaski E,Whitney C,Manetta A,Larson JE,Kirk J,Stevens CW,Lyter J,Mortel R

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:The purpose of this study is to evaluate the significance of the c-Met/hepatocyte growth factor receptor expression in invasive cervical carcinoma. METHODS:Ninety-Four patients with FIGO stage 1B disease, treated primarily with surgery, were studied immunohistochemically. Of the cases, 67 were squamous carci...

journal_title：Gynecologic oncology

authors： Baykal C,Ayhan A,Al A,Yüce K,Ayhan A

更新日期：2003-02-01 00:00:00

abstract：:Less extensive surgical treatment has become possible for limited vulvar cancer. However, primary closure is advisable only when the defect is minimal and tissue replacement is always needed in radical excisions. Local flaps are always considered the first choice because of their characteristics of similarity to the r...

journal_title：Gynecologic oncology

authors： Tateo A,Tateo S,Bernasconi C,Zara C

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:The consequences of defective homologous recombination and other DNA repair pathways are important in disease outcomes of numerous tumor types. The objective of this study was to explore BRCA1, PARP, FANCD2, PTEN, H2AX, and ATM protein expression in endometrial cancer (EC). METHODS:PARP1, γH2AX, ATM, FANCD2,...

journal_title：Gynecologic oncology

authors： Mhawech-Fauceglia P,Wang D,Kim G,Sharifian M,Chen X,Liu Q,Lin YG,Liu S,Pejovic T

更新日期：2014-03-01 00:00:00

abstract：:Fifty consecutive patients with documented advanced or recurrent endometrial carcinoma from 1978 through 1985 were prospectively treated with melphalan, 5-fluorouracil, medroxyprogesterone acetate (MFP) as first-line chemotherapy. From 1987 through 1993, 50 consecutive patients with documented advanced or recurrent en...

journal_title：Gynecologic oncology

authors： Cornelison TL,Baker TR,Piver MS,Driscoll DL

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:Increased activity of Sp family of transcription factors is a frequent and critical event in cancer development and progression. Genes governing tumor growth, invasion and angiogenesis are regulated by Sp factors, like Sp1, Sp3 or Sp4, and are frequently over-expressed in tumors. Targeting Sp factors has been...

journal_title：Gynecologic oncology

authors： Previdi S,Malek A,Albertini V,Riva C,Capella C,Broggini M,Carbone GM,Rohr J,Catapano CV

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:To evaluate testing for high-risk human papillomavirus (HR HPV) E6/E7 mRNA transcripts 6 months after conisation for cervical intraepithelial neoplasia grade 2 or worse (CIN2+) to determine the risk of residual CIN2+. METHODS:We prospectively followed 344 women treated for CIN2+ by conisation. HR HPV mRNA te...

journal_title：Gynecologic oncology

authors： Tropé A,Jonassen CM,Sjøborg KD,Nygård M,Dahl FA,Alfsen GC,Lie AK

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:To determine the impact of geographic location on advanced-stage ovarian cancer care adherence to the National Comprehensive Cancer Network (NCCN) guidelines in relation to race and socioeconomic status (SES). METHODS:Patients diagnosed with stage IIIC/IV epithelial ovarian cancer (1/1/96-12/31/06) were iden...

journal_title：Gynecologic oncology

authors： Bristow RE,Chang J,Ziogas A,Anton-Culver H,Vieira VM

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:Preclinical evaluation of the anti-neoplastic activity of an insulin-like growth factor I receptor (IGF-IR) kinase inhibitor in ovarian cancer. METHODS:The OVCAR-3 and OVCAR-4 cell lines were investigated under serum-free tissue culture conditions. IGF-I and IGF-II production were evaluated by standard ELIS...

journal_title：Gynecologic oncology

authors： Gotlieb WH,Bruchim I,Gu J,Shi Y,Camirand A,Blouin MJ,Zhao Y,Pollak MN

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:The hepatocyte growth factor (HGF) receptor c-Met plays an important role in tumor dissemination by activating mitogenic signaling pathways. The goal of this study was to investigate immunohistochemical (IHC) staining patterns of HGF and c-Met in endometrioid endometrial cancer (EC) and uterine serous cancer ...

journal_title：Gynecologic oncology

authors： Bishop EA,Lengyel ER,Yamada SD,Montag A,Temkin SM

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of interleukin-7 (IL-7) gene transfection into an established ovarian carcinoma cell line (SKOV3) in vitro and evaluate the tumorigenicity of SKOV3-IL-7 in severe combined immunodeficient (SCID) mice. METHODS:IL-7 gene was transfected into SKOV3 cells by liposome. IL-7 mRNA and prot...

journal_title：Gynecologic oncology

authors： Xie X,Ye DF,Chen HZ,Lu WG,Fu YF,Cheng B,Zhu H

更新日期：2004-02-01 00:00:00

abstract：:Surgical assessment of aortocaval lymph nodes in patients with unresectable primary cervical cancer helps in planning radiation treatment ports. Removal of enlarged lymph nodes may also serve a therapeutic purpose in reducing the tumor load to be sterilized by radiation. An extraperitoneal dissection is considered to ...

journal_title：Gynecologic oncology

authors： Vasilev SA

更新日期：1995-02-01 00:00:00

abstract：:The relationship between fertility drug use and risk of borderline ovarian cancer has been analyzed using data from a case-control study. Cases were 93 women aged 23 to 64 years with histologically confirmed diagnosis of borderline ovarian tumor (according to the World Health Organization criteria) who were admitted t...

journal_title：Gynecologic oncology

authors： Parazzini F,Negri E,La Vecchia C,Moroni S,Polatti A,Chiaffarino F,Surace M,Ricci E

更新日期：1998-03-01 00:00:00

abstract：:Ovarian cancer is the leading cause of gynecologic cancer deaths in the U.S. The concept of intraperitoneal drug delivery for therapy of intraperitoneal cancers, such as ovarian cancer, arose in the 1960s. The field of intraperitoneal cisplatin therapy for ovarian cancer was initiated in the late 1970s and early 1980s...

journal_title：Gynecologic oncology

authors： Alberts DS,Markman M,Muggia F,Ozols RF,Eldermire E,Bookman MA,Chen T,Curtin J,Hess LM,Liebes L,Young RC,Trimble E

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:To determine the effectiveness of chemotherapy alone as postoperative adjuvant therapy for intermediate- and high-risk cervical cancer. METHODS:The study group comprised of 65 consecutive patients with stage IB or IIA squamous cell or adenosquamous cervical cancer who were initially treated with radical hyst...

journal_title：Gynecologic oncology

authors： Takeshima N,Umayahara K,Fujiwara K,Hirai Y,Takizawa K,Hasumi K

更新日期：2006-11-01 00:00:00

abstract：:Between October 1985 and January 1989, 33 patients with stage I (31) or clinically occult stage II (2) endometrial cancer at a high risk for recurrence were entered in a prospective study evaluating adjuvant cisplatin, doxorubicin, and cyclophosphamide (PAC) chemotherapy. Eligibility criteria included grade 2 tumors w...

journal_title：Gynecologic oncology

authors： Stringer CA,Gershenson DM,Burke TW,Edwards CL,Gordon AN,Wharton JT

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate the role of 2-[fluorine-18]-fluoro-2-deoxy-d-glucose positron emission tomography (FDG PET) in the diagnosis of recurrent ovarian cancer. METHODS:One hundred six FDG PET scans performed in 54 patients in the follow-up after cytoreductive surgery and chemotherapy of ova...

journal_title：Gynecologic oncology

authors： Zimny M,Siggelkow W,Schröder W,Nowak B,Biemann S,Rath W,Buell U

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:The goal of this study was to evaluate the interexaminer variation in the assessment of postmenopausal ovaries using transvaginal ultrasound (TVU). METHODS:One hundred eighty-eight cancer screening trial participants undergoing TVU were reassessed by a second TVU examination. RESULTS:Although first examiner...

journal_title：Gynecologic oncology

authors： Modugno F,Weissfeld JL,Hill LM

更新日期：2000-05-01 00:00:00

abstract：:Of 369 patients with apparent advanced ovarian cancer entered on a randomized trial between September 1979 and June 1983, 56 survived more than 5 years. Central pathology review confirmed the diagnosis in 318 cases (15 cases not ovarian primary, 36 slides did not reach central review). Two hundred ninety-eight were in...

journal_title：Gynecologic oncology

authors： Tattersall MH,Swanson CE,Solomon HJ

更新日期：1992-12-01 00:00:00

abstract：:Open biopsy of the left scalene lymph nodes has been utilized to identify distant spread of cervical carcinoma in selected groups of patients who do not have other clinical evidence of disseminated disease. Twenty-one patients with primary cervical carcinoma and histologically proven para-aortic lymph node metastases ...

journal_title：Gynecologic oncology

authors： Burke TW,Heller PB,Hoskins WJ,Weiser EB,Nash JD,Park RC

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVE:To determine whether chemotherapy-induced neutropenia (C-iN) is associated with improved survival in a population of primary advanced ovarian cancer and peritoneal carcinoma patients treated with a carboplatin plus paclitaxel chemotherapy backbone. METHODS:A post-hoc exploratory analysis of Gynecologic Oncol...

journal_title：Gynecologic oncology

authors： Tewari KS,Java JJ,Gatcliffe TA,Bookman MA,Monk BJ

更新日期：2014-06-01 00:00:00

abstract：:HIV infection among women is increasing in the United States. Since January 1993, cervical cancer has been considered an AIDS-defining illness. We report a rare case of squamous cell carcinoma arising in a teratoma of the uterine cervix in an HIV-infected patient. This patient was treated with a radical hysterectomy, ...

journal_title：Gynecologic oncology

authors： Bell MC,Schmidt-Grimminger DC,Connor MG,Alvarez RD

更新日期：1996-03-01 00:00:00

abstract：:Ovarian management at the time of radical hysterectomy for cervical cancer was reviewed retrospectively over a 7-year period. All patients had early-stage cancer except three who had stage IIB disease. Approximately 80% of patients had squamous cancer and 20% adenocarcinoma or adenosquamous carcinoma. The mean age was...

journal_title：Gynecologic oncology

authors： Owens S,Roberts WS,Fiorica JV,Hoffman MS,LaPolla JP,Cavanagh D

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:To examine outcomes after pelvic exenteration in women treated with modern chemoradiation and surgical techniques. METHODS:All patients at our institution with a diagnosis of gynecologic malignancy who underwent pelvic exenteration after treatment with chemoradiation between 1/90 and 6/08 were evaluated wit...

journal_title：Gynecologic oncology

authors： McLean KA,Zhang W,Dunsmoor-Su RF,Shah CA,Gray HJ,Swensen RE,Goff BA

更新日期：2011-04-01 00:00:00

abstract：:The existing means of detecting recurrent ovarian carcinoma are notoriously poor. Positron emission tomography (PET) is a form of computer-assisted imaging which produces images reflective of the biochemistry of the tissues rather than their physical characteristics. PET imaging with the positron emitting glucose anal...

journal_title：Gynecologic oncology

authors： Karlan BY,Hawkins R,Hoh C,Lee M,Tse N,Cane P,Glaspy J

更新日期：1993-11-01 00:00:00