当前位置： SCI文献检索 > GYNECOLOGIC ONCOLOGY期刊下所有文献 > Bokhman Redux: Endometrial cancer "types" in the 21st century.

Bokhman Redux: Endometrial cancer "types" in the 21st century.

Abstract：

:In 1983 Jan V. Bokhman, M.D. published a landmark paper entitled "Two Pathogenetic Types of Endometrial Carcinoma" in which an enduring dualistic view of endometrial cancer was first proposed. "Type I" cancers are thought to represent estrogen driven mostly low grade endometrioid tumors strongly associated with obesity and other components of the metabolic syndrome. "Type II" cancers represent higher grade non-endometrioid tumors for which the latter associations are less significant. Basic tenets of this dichotomy including significant prognostic differences have been abundantly confirmed by later literature. The construct has in turn contributed a useful framework for decades of teaching and scientific advancement across disciplines. However, recent large epidemiologic studies indicate a more complex web of risk factors with obesity and hormones likely playing an important role across the entire endometrial cancer histologic and clinical spectrum. Moreover, high quality molecular data and refinements in pathologic classification challenge any simplistic classification of endometrial cancer. For example, the Cancer Genome Atlas (TCGA) recently defined four clinically distinct endometrial cancer types based on their overall mutational burden, specific p53, POLE and PTEN mutations, microsatellite instability and histology. Additionally, new histologic categories with clear prognostic implications have been accepted and it is becoming evident from an epidemiologic point of view that metabolic factors may play an important role in endometrial cancer overall. While Bokhman's intuitive dualistic model remains relevant when working with large registries and databases lacking granular information; most other efforts should integrate clinical, pathological and molecular specifics into more nuanced classifications.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Suarez AA,Felix AS,Cohn DE

doi

10.1016/j.ygyno.2016.12.010

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

243-249

issue

2

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(16)31668-7

journal_volume

144

pub_type

杂志文章

相关文献

GYNECOLOGIC ONCOLOGY文献大全
  • Costs of treatment and outcomes associated with second-line therapy and greater for relapsed ovarian cancer.

    abstract：OBJECTIVES:Most women with epithelial ovarian cancer (EOC) will develop disease progression or recurrence with resistance to platinum therapy. We report overall costs and treatment outcomes associated with topotecan or gemcitabine administration in platinum- and paclitaxel-resistant EOC patients. METHODS:Patients who ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2004.01.014

    authors： Prasad M,Ben-Porat L,Hoppe B,Aghajanian C,Sabbatini P,Chi DS,Hensley ML

    更新日期：2004-04-01 00:00:00

  • Systemic therapy for advanced uterine sarcoma: a systematic review of the literature.

    abstract：OBJECTIVE:To conduct a systematic review of the literature regarding the systemic treatment of advanced uterine sarcoma and provide an evidence-based summary of the available literature. METHODS:MEDLINE, EMBASE, and the Cochrane Library databases were searched. "Uterine sarcoma," "leiomyosarcoma," "mixed mesodermal tu...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2005.01.041

    authors： Kanjeekal S,Chambers A,Fung MF,Verma S

    更新日期：2005-05-01 00:00:00

  • Rhabdomyosarcoma of the vagina in a postmenopausal woman: report of a case and review of the literature.

    abstract：:Most rhabdomyosarcomas (RMSs) of the female genital tract occur in infants and young children as sarcoma botryoides. Vaginal RMS occurring in a postmenopausal woman is extremely rare. To our knowledge, only three vaginal RMSs have been reported in patients who were over 50 years of age. Herein, the first case in Taiwa...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1006/gyno.1995.1251

    authors： Shy SW,Lee WH,Chen D,Ho SY

    更新日期：1995-09-01 00:00:00

  • Early experience of robotic-assisted laparoscopy for extraperitoneal para-aortic lymphadenectomy up to the left renal vein.

    abstract：OBJECTIVE:To describe our early experience with robotic-assisted laparoscopy for extraperitoneal para-aortic lymphadenectomy up to the left renal vein, including Da Vinci robot positioning. METHODS:Six patients underwent robotic-assisted laparoscopy using the Da Vinci apparatus. The patients included a man with a pT2 ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2009.04.032

    authors： Narducci F,Lambaudie E,Houvenaeghel G,Collinet P,Leblanc E

    更新日期：2009-10-01 00:00:00

  • p53 protein overexpression: a strong prognostic factor in uterine papillary serous carcinoma.

    abstract：:Uterine papillary serous carcinoma (UPSC) is an uncommon but aggressive type of endometrial cancer associated with rapid progression of disease and poor prognosis. We investigated 23 cases of UPSC. p53 expression was studied in archival paraffin-embedded tissue by immunohistochemistry. Eleven tumors (47.8%) showed p53...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1998.5113

    authors： Bancher-Todesca D,Gitsch G,Williams KE,Kohlberger P,Neunteufel W,Obermair A,Heinze G,Breitenecker G,Hacker NF

    更新日期：1998-10-01 00:00:00

  • Inversely and adaptively planned interstitial brachytherapy: A single implant approach.

    abstract：OBJECTIVE:To evaluate the efficacy, feasibility and safety of image-based, inversely and adaptively planned high-dose rate interstitial brachytherapy (HDR-ISBT) to treat advanced primary or recurrent gynecologic malignancy in a single implant, three-consecutive-day regimen. METHODS:Clinical demographics and outcome da...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2018.11.020

    authors： Hanania AN,Myers P,Yoder AK,Bulut A,Henry Yu Z,Eraj S,Bowers J,Bonnen MD,Echeverria A,Hall TR,Anderson ML,Ludwig M

    更新日期：2019-02-01 00:00:00

  • Bcl-X(L) is functionally non-equivalent for the regulation of growth and survival in human ovarian cancer cells.

    abstract：OBJECTIVE:To investigate the role of Bcl-X(L) on the growth and survival of human ovarian carcinoma cells. METHODS:In this study, we enforced down-regulation of Bcl-X(L) by RNA interference in ovarian carcinoma cell lines CaOV3, SKOV3ip1 and OVCAR3 cell lines expressing various levels of Bcl-X(L). We also established ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2005.08.028

    authors： Dodier P,Piché A

    更新日期：2006-02-01 00:00:00

  • Utility of pre-operative serum CA-125 in the management of uterine papillary serous carcinoma.

    abstract：OBJECTIVE:To evaluate the usefulness of pre-operative serum CA-125 in the management of women diagnosed with uterine papillary serous carcinoma (UPSC). We hypothesized that elevated pre-operative levels of serum CA-125 correlate with higher disease stage and poorer prognosis. METHODS:Patients diagnosed with UPSC and m...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2008.05.027

    authors： Olawaiye AB,Rauh-Hain JA,Withiam-Leitch M,Rueda B,Goodman A,del Carmen MG

    更新日期：2008-09-01 00:00:00

  • Clinical significance of enlarged cardiophrenic lymph nodes in advanced ovarian cancer: Implications for survival.

    abstract：OBJECTIVE:Advanced ovarian cancer (OC) commonly spreads to cardiophrenic lymph nodes (CPLNs), and is often visible on preoperative imaging. We investigated the prognostic significance of abnormal CPLNs in OC detected by preoperative CT scans using three different definitions. METHODS:Patients undergoing primary debulk...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2017.10.024

    authors： Mert I,Kumar A,Sheedy SP,Weaver AL,McGree ME,Kim B,Cliby WA

    更新日期：2018-01-01 00:00:00

  • Evaluation of the performance of the ACS NSQIP surgical risk calculator in gynecologic oncology patients undergoing laparotomy.

    abstract：OBJECTIVE:The objective of this study was to evaluate the ability of the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) surgical risk calculator to predict complications in gynecologic oncology patients undergoing laparotomy. METHODS:A chart review of patients who underwent la...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2016.02.015

    authors： Rivard C,Nahum R,Slagle E,Duininck M,Isaksson Vogel R,Teoh D

    更新日期：2016-05-01 00:00:00

  • Therapeutic potential of the new TRIB3-mediated cell autophagy anticancer drug ABTL0812 in endometrial cancer.

    abstract：OBJECTIVES:The PI3K/AKT/mTOR pathway is frequently overactivated in endometrial cancer (EC). We assessed the efficacy of ABTL0812, a novel first-in-class molecule presenting a unique mechanism of action inhibiting this pathway. METHODS:We investigated the effects of ABTL0812 on proliferation, cell death and modulation...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2019.03.002

    authors： Felip I,Moiola CP,Megino-Luque C,Lopez-Gil C,Cabrera S,Solé-Sánchez S,Muñoz-Guardiola P,Megias-Roda E,Pérez-Montoyo H,Alfon J,Yeste-Velasco M,Santacana M,Dolcet X,Reques A,Oaknin A,Rodríguez-Freixinos V,Lizcano JM,Domèn

    更新日期：2019-05-01 00:00:00

  • Sustained complete remission in a patient with platinum-resistant ovarian yolk sac tumor.

    abstract：BACKGROUND:Yolk sac tumors of the ovary are generally very responsive to chemotherapy; however, they are difficult to manage in the setting of platinum resistance where treatment options are limited and outcomes are poorer. CASE:We present a 39-year-old woman who had a platinum-resistant yolk sac ovarian tumor. She ac...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.2001.6327

    authors： Jeyakumar A,Chalas E,Hindenburg A

    更新日期：2001-09-01 00:00:00

  • Metachronous metastases from renal cell carcinoma to uterine cervix and vagina: case report and review of literature.

    abstract：BACKGROUND:Although renal cell carcinoma (RCC) is characterized with unpredictable clinical presentation, multiple genital tract metastases are still surprising and mode of spread is obscure. CASE:We report a case of RCC metastases to uterine cervix and vagina 1 year after radical nephrectomy in a 19-year-old virgin. ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2005.06.004

    authors： Bozaci EA,Atabekoğlu C,Sertçelik A,Unlü C,Ortaç F

    更新日期：2005-10-01 00:00:00

  • A comparison of cisplatin/paclitaxel and carboplatin/paclitaxel in stage IVB, recurrent or persistent cervical cancer.

    abstract：OBJECTIVE:Cisplatin-based combination therapy produces higher response rates and improved survival, in comparison to single-agent cisplatin in the treatment of cervical cancer. Cisplatin and paclitaxel (PT) requires a prolonged infusion and is less convenient and more toxic than the combination of carboplatin and pacli...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2006.12.031

    authors： Moore KN,Herzog TJ,Lewin S,Giuntoli RL,Armstrong DK,Rocconi RP,Spannuth WA,Gold MA

    更新日期：2007-05-01 00:00:00

  • Regional lymph node recurrence following local excision for microinvasive vulvar carcinoma.

    abstract：:A case of microinvasive squamous cell carcinoma of the vulva is reported in which regional lymph node recurrence was noted after excisional therapy. Review of the initial pathology revealed only 0.72 mm of invasion. The results of a literature survey regarding microinvasive vulvar carcinoma are discussed. ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/0090-8258(89)90123-6

    authors： Atamdede F,Hoogerland D

    更新日期：1989-07-01 00:00:00

  • A correlation of cell cycle perturbations with chemosensitivity in human ovarian cancer cells exposed to cytotoxic drugs in vitro.

    abstract：:To test the association between cytotoxicity and in vitro cell cycle perturbations we systematically studied cell cycle perturbations after exposing human ovarian cancer cells to nine commonly used cytotoxic agents. Three principal patterns of cell cycle alterations were observed: a sequential S-G2/M block after expos...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1995.1182

    authors： Petru E,Sevin BU,Haas J,Ramos R,Perras J

    更新日期：1995-07-01 00:00:00

  • Patient reported outcome measures among patients with vulvar cancer at various stages of treatment, recurrence, and survivorship.

    abstract：OBJECTIVE:Our goal was to pragmatically describe patient reported outcomes (PROs) in a typical clinic population of vulvar cancer patients, as prior studies of vulvar cancer PROs have examined clinical trial participants. METHODS:A prospective PRO program was implemented in the Gynecologic Oncology clinic of a tertiar...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2020.10.022

    authors： Alimena S,Sullivan MW,Philp L,Dorney K,Hubbell H,Del Carmen MG,Goodman A,Bregar A,Growdon WB,Eisenhauer EL,Sisodia RC

    更新日期：2021-01-01 00:00:00

  • Endometrial cancer surgery in Arizona: a statewide analysis of access to care.

    abstract：OBJECTIVES:To investigate access to surgical care for endometrial cancer in Arizona. METHODS:The Arizona HealthQuery (AZHQ) data warehouse with claims information on over 7 million patients in Arizona was searched using the International Classification of Disease (ICD-9) codes and Current Procedural Terminology (CPT) ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2010.11.028

    authors： Benjamin I,Dalton H,Qiu Y,Cayco L,Johnson WG,Balducci J

    更新日期：2011-04-01 00:00:00

  • Anastrozole therapy in recurrent ovarian adult granulosa cell tumors: a report of 2 cases.

    abstract：BACKGROUND:Ovarian sex cord stromal tumors are frequently hormonally active, and adult granulosa cell tumors often demonstrate estrogen receptor positivity. Thus, hormonal agents have been evaluated as potential treatments for advanced stage or recurrent adult granulosa cell tumors. CASE:Two cases of patients with rec...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2006.06.022

    authors： Freeman SA,Modesitt SC

    更新日期：2006-11-01 00:00:00

  • Correlation of CA125 and CA19-9 serum levels with clinical course and second-look findings in patients with ovarian carcinoma.

    abstract：:CA125 and CA19-9 levels were serially evaluated in blood samples from 21 patients during and after integrated surgical and chemotherapeutic treatment for ovarian carcinoma. Serial measurement of CA125 and CA19-9 correlated with clinical course of disease in 89.7 and 72.7% of instances, respectively. The decrease of se...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/0090-8258(87)90173-9

    authors： Fioretti P,Gadducci A,Ferdeghini M,Bartolini T,Bianchi R,Facchini V

    更新日期：1987-11-01 00:00:00

  • Effectiveness of serotonin-receptor antagonist antiemetic therapy over successive courses of carboplatin-based chemotherapy.

    abstract：PURPOSE:There are extremely limited data available in the general oncology or gynecologic cancer literature to document the effectiveness of antiemetic therapy over multiple courses of cytotoxic chemotherapy. METHODS:To examine this highly clinically relevant issue, we analyzed the complete treatment course of patient...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.2002.6656

    authors： Markman MR,Peterson G,Kulp B,Markman M

    更新日期：2002-06-01 00:00:00

  • Sacral metastasis in a patient with endometrial cancer: case report and review of the literature.

    abstract：BACKGROUND:Bone involvement in endometrial cancer has been described in less than 15% of the patients with metastatic disease. The medical literature reports 29 cases, although none involving the sacrum. CASE:We present a case of a 62-year-old woman who underwent surgery for endometrial adenocarcinoma in December 2002...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2008.04.005

    authors： Albareda J,Herrera M,Lopez Salva A,Garcia Donas J,Gonzalez R

    更新日期：2008-12-01 00:00:00

  • Cisplatin, adriamycin, etoposide, megestrol acetate versus melphalan, 5-fluorouracil, medroxyprogesterone acetate in the treatment of endometrial carcinoma.

    abstract：:Fifty consecutive patients with documented advanced or recurrent endometrial carcinoma from 1978 through 1985 were prospectively treated with melphalan, 5-fluorouracil, medroxyprogesterone acetate (MFP) as first-line chemotherapy. From 1987 through 1993, 50 consecutive patients with documented advanced or recurrent en...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章

    doi：10.1006/gyno.1995.0015

    authors： Cornelison TL,Baker TR,Piver MS,Driscoll DL

    更新日期：1995-11-01 00:00:00

  • Proceedings of a GOG workshop on intraperitoneal therapy for ovarian cancer.

    abstract：:Ovarian cancer is the leading cause of gynecologic cancer deaths in the U.S. The concept of intraperitoneal drug delivery for therapy of intraperitoneal cancers, such as ovarian cancer, arose in the 1960s. The field of intraperitoneal cisplatin therapy for ovarian cancer was initiated in the late 1970s and early 1980s...

    journal_title：Gynecologic oncology

    pub_type： 共识发展会议,杂志文章

    doi：10.1016/j.ygyno.2006.09.012

    authors： Alberts DS,Markman M,Muggia F,Ozols RF,Eldermire E,Bookman MA,Chen T,Curtin J,Hess LM,Liebes L,Young RC,Trimble E

    更新日期：2006-12-01 00:00:00

  • Human papillomavirus associated with adenocarcinoma and adenosquamous carcinoma of the cervix: analysis by in situ hybridization.

    abstract：:The incidence of adenocarcinoma of the cervix appears to be increasing. Recent reports have demonstrated an association between adenocarcinoma of the cervix and human papillomavirus (HPV) by Southern blot hybridizations. In situ deoxyribonucleic acid (DNA) hybridization was performed on paraffin-embedded specimens to ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/0090-8258(89)90076-0

    authors： Gordon AN,Bornstein J,Kaufman RH,Estrada RG,Adams E,Adler-Storthz K

    更新日期：1989-12-01 00:00:00

  • HPV status in sentinel nodes might be a prognostic factor in cervical cancer.

    abstract：OBJECTIVE:Although there have been studies that focused on the correlation between the HPV presence of pelvic lymph nodes and pathological metastasis in patients with cervical cancer, the biologic role of HPV DNA in lymph nodes still remains uncertain. We performed this study to investigate the correlation between the ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2006.12.016

    authors： Lee YS,Rhim CC,Lee HN,Lee KH,Park JS,Namkoong SE

    更新日期：2007-05-01 00:00:00

  • Assessment of pretreatment laparotomy in patients with cervical carcinoma prior to radiotherapy.

    abstract：:One hundred fifty-five patients with cervical cancer not amenable to radical surgery underwent selective, paraaortic lymphadenectomy and exploratory laparotomy prior to the initiation of radiotherapy. Fifty-one patients underwent transperitoneal lymphadenectomy; the remainder had the procedure performed using the extr...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/0090-8258(89)90606-9

    authors： Podczaski ES,Palombo C,Manetta A,Andrews C,Larson J,DeGeest K,Mortel R

    更新日期：1989-04-01 00:00:00

  • Heparanase expression correlates with poor survival in metastatic ovarian carcinoma.

    abstract：OBJECTIVE:To analyze the expression of Heparanase, an enzyme involved in cancer metastasis and angiogenesis, in ovarian and breast carcinoma cells in effusions. METHODS:Heparanase protein expression was analyzed in malignant effusions from ovarian (=200) and breast (=41) carcinoma patients using immunocytochemistry. T...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2006.08.045

    authors： Davidson B,Shafat I,Risberg B,Ilan N,Trope' CG,Vlodavsky I,Reich R

    更新日期：2007-02-01 00:00:00

  • Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis.

    abstract：OBJECTIVE:The aim of this study was to evaluate clinical manifestations, management options, and prognosis for women presenting with gestational trophoblastic tumors with vaginal metastasis. METHOD:Fifty-one patients with vaginal metastases were analyzed retrospectively between January 1985 and September 2000. Vaginal...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.2001.6540

    authors： Yingna S,Yang X,Xiuyu Y,Hongzhao S

    更新日期：2002-03-01 00:00:00

  • Endometrial clear cell carcinoma metastatic to the paranasal sinuses: a case report and review of the literature.

    abstract：BACKGROUND:Paranasal sinus metastasis following endometrial carcinoma is extremely rare and a reflection of disseminated disease. CASE:We report a case of a 72-year-old woman who presented ethmoid and sphenoid sinus metastasis, 14 months after total abdominal hysterectomy and bilateral salpingo-oophorectomy due to an ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2004.04.005

    authors： Ilvan S,Akyildiz EU,Calay Z,Celikoyar M,Sahinler I

    更新日期：2004-07-01 00:00:00