Quantitative prognostic features in FIGO I ovarian cancer patients without postoperative treatment.

abstract：OBJECTIVES:To compare complete hydatidiform mole (CHM) clinical presentation and risk factors associated with GTN development between North American and South American adolescents. METHODS:This non-concurrent cohort study was undertaken including adolescents with CHM referred to centers in North America (New England T...

journal_title：Gynecologic oncology

authors： Soares RR,Maestá I,Colón J,Braga A,Salazar A,Charry RC,Sun SY,Goldstein DP,Berkowitz RS

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:To assess the role of additional biopsies performed with loop electrosurgical excisional procedure (LEEP) in predicting the likelihood of persistent high grade intraepithelial neoplasia. METHODS:Clinicopathologic data were abstracted from women who underwent excision of high grade intraepithelial lesions bet...

journal_title：Gynecologic oncology

authors： Cui Y,Sangi-Haghpeykar H,Patsner B,Bump JMM,Williams-Brown MY,Binder GL,Masand RP,Anderson ML

更新日期：2017-03-01 00:00:00

abstract：:Two patients with a history of stage IB cervical cancer who had undergone prior radical abdominal hysterectomy, omental J-flap placement, and postoperative whole pelvic radiation therapy required subsequent exploratory laparotomy with resection of omental J-flap for treatment of chronic abdominal pain 5 and 2 years, r...

journal_title：Gynecologic oncology

authors： Patsner B

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:In a previous study using the same cases of squamous cervical neoplasia and microinvasive carcinoma (MICA) we found an association between FHIT gene deletion and infection with high-risk HPV (HR HPV). The purpose of this study was to evaluate Fhit protein expression by immunohistochemistry in order to determi...

journal_title：Gynecologic oncology

authors： Butler D,Collins C,Mabruk M,Leader MB,Kay EW

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the utility of DNA flow cytometry as a prognostic indicator for risk of recurrence and overall survival in patients with early stage adenocarcinomas of the uterine cervix. METHODS:DNA flow cytometry was performed to determine ploidy, DNA index, and proliferative index i...

journal_title：Gynecologic oncology

authors： Magtibay PM,Perrone JF,Stanhope CR,Katzmann JA,Keeney GL,Li H

更新日期：1999-11-01 00:00:00

abstract：:Ovarian management at the time of radical hysterectomy for cervical cancer was reviewed retrospectively over a 7-year period. All patients had early-stage cancer except three who had stage IIB disease. Approximately 80% of patients had squamous cancer and 20% adenocarcinoma or adenosquamous carcinoma. The mean age was...

journal_title：Gynecologic oncology

authors： Owens S,Roberts WS,Fiorica JV,Hoffman MS,LaPolla JP,Cavanagh D

更新日期：1989-12-01 00:00:00

abstract：OBJECTIVE:To compare the detection rate of genital human papillomavirus (HPV) infection in self- and physician-obtained samples. DESIGN:Systematic review and meta-analysis. DATA SOURCES:Studies published between 1966 and November 2005 identified through Medline and Embase that compared both sampling methods. MAIN OU...

journal_title：Gynecologic oncology

authors： Petignat P,Faltin DL,Bruchim I,Tramèr MR,Franco EL,Coutlée F

更新日期：2007-05-01 00:00:00

abstract：:Incisional herniae are relatively frequent complications of abdominal incisions. Hernia repair techniques have taken advantage of the strength provided by prosthetic mesh grafts. Subsequent surgery in these patients must incorporate a strategy for managing the mesh material. The goals are adequate exposure for surgery...

journal_title：Gynecologic oncology

authors： Buekers TE,Sorosky JI,Buller RE

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:To present the clinical application of the multispectral imaging colposcopic system (MIS colposcopy). METHODS:MIS colposcopy was performed on 123 enrolled women. After a 3% acetic acid application, sequential images were captured, analyzed, and stored automatically. Directed biopsies were taken from distinct...

journal_title：Gynecologic oncology

authors： Orfanoudaki IM,Themelis GC,Sifakis SK,Fragouli DH,Panayiotides JG,Vazgiouraki EM,Koumantakis EE

更新日期：2005-01-01 00:00:00

abstract：:Flow cytometric cell cycle analysis was performed on paraffin-embedded blocks from 49 patients with stage I endometrial carcinoma. Care was taken to separate tumor tissue from normal tissue in each specimen; normal tissue was used as a control for each individual specimen. DNA index, proliferative activity, and cell D...

journal_title：Gynecologic oncology

authors： Vecek N,Nola M,Marusić M,Babić D,Uzarević B,Sabioncello A,Petrovecki M,Ljubić-Racunica N,Marinović T

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVES:Diagnosis and treatment for a life threatening illness such as cancer are known to be psychologically impactful. However, little is known about the influence that non-cancer life stressors have on the quality of life (QOL) of ovarian cancer patients. The goal of the present study was to examine associations ...

journal_title：Gynecologic oncology

authors： Lutgendorf SK,Slavich GM,Degeest K,Goodheart M,Bender D,Thaker PH,Penedo F,Zimmerman B,Lucci J 3rd,Mendez L,Collins K,Sood AK

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:Brachytherapy plays a major role in the treatment of patients with carcinoma of the cervix. However, routine intracavitary brachytherapy may not be feasible or adequate to treat locally advanced disease. The purpose of this prospective study was to assess treatment outcome for patients with locally advanced g...

journal_title：Gynecologic oncology

authors： Agrawal PP,Singhal SS,Neema JP,Suryanarayan UK,Vyas RK,Rathi AK,Bahadur AK

更新日期：2005-10-01 00:00:00

abstract：:Forty-three patients with ovarian cancer were entered on this trial and treated with intravenous (iv) cyclophosphamide (C) and doxorubicin (A), and intraperitoneal (ip) cisplatin (DDP), every 21 days for eight cycles. Following iv hydration, the cisplatin was administered through an intraperitoneal catheter in 2 L of ...

journal_title：Gynecologic oncology

authors： Morgan RJ Jr,Braly P,Cecchi G,Leong L,Shibata S,Margolin K,Somlo G,McNamara M,Longmate J,Schinke S,Raschko J,Nagasawa S,Kogut N,Parker P,Stein A,Cho J,Smith E,Coluzzi P,Najera L,Johnson D,Womack E,Doroshow JH

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:To evaluate C-reactive protein (CRP) serum levels as a preoperative predictive marker for ovarian cancer in patients with adnexal masses. METHODS:CRP serum levels of 1843 adnexal masses and subsequent surgery were investigated (patients with benign ovarian tumors: n=1423; borderline tumor of the ovary [BTO]:...

journal_title：Gynecologic oncology

authors： Reiser E,Aust S,Seebacher V,Reinthaller A,Helmy-Bader S,Schwameis R,Grimm C,Polterauer S

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:Differentiation between grade-1 endometrial cancer (EC) and atypical endometrial hyperplasia (AEH) is crucial to determine optimal surgical management. However, discrepancies exist between preoperative diagnosis of AEH and final histology. Our aim was to establish clusters of immunohistochemical markers to d...

journal_title：Gynecologic oncology

authors： Laas E,Ballester M,Cortez A,Gonin J,Daraï E,Graesslin O

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Previous studies have identified loss of chromosomal regions 7p12-q11.2 and 8p12-p21 in choriocarcinoma suggesting that suppressor genes involved in tumour development may be located within these regions. Our objectives were to refine the regions of loss and evaluate these deletions as prognostic indicators ...

journal_title：Gynecologic oncology

authors： Burke B,Sebire NJ,Moss J,Hodges MD,Seckl MJ,Newlands ES,Fisher RA

更新日期：2006-11-01 00:00:00

abstract：:One of the complications of an inguinal lymphadenectomy is formation of a lymphocyst. The literature dealing with management of this complication is scant. In this report we present a patient who developed an inguinal lymphocyst which did not respond to percutaneous drainage, but was successfully treated with scleroth...

journal_title：Gynecologic oncology

authors： Khorram O,Stern JL

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVE:The present study was undertaken to analyze the impact of epigenetic alterations with a main focus on nuclear area, aneuploidy, hyperploidy, and proliferation in 70 ovarian cancer specimens. METHODS:Morphometric changes and somatic chromosomal ploidy status were assessed by Feulgen spectrophotometry. DNA-hyp...

journal_title：Gynecologic oncology

authors： Zeimet AG,Fiegl H,Goebel G,Kopp F,Allasia C,Reimer D,Steppan I,Mueller-Holzner E,Ehrlich M,Marth C

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:Chimeric antigen receptor (CAR)-T cell strategies ideally target a surface antigen that is exclusively and uniformly expressed by tumors; however, no such antigen is known for high-grade serous ovarian carcinoma (HGSC). A potential solution involves combinatorial antigen targeting with AND or OR logic-gating....

journal_title：Gynecologic oncology

authors： Banville AC,Wouters MCA,Oberg AL,Goergen KM,Maurer MJ,Milne K,Ashkani J,Field E,Ghesquiere C,Jones SJM,Block MS,Nelson BH

更新日期：2021-02-01 00:00:00

abstract：:Ovarian germ cell tumors (GCTs) are rare in adults, but are more common in adolescents and young adults. Contemporary management of ovarian GCTs is evolving as collaboration among pediatric, medical, and gynecologic oncologists increases, and studies increasingly incorporate female adult patients. Despite an improved ...

journal_title：Gynecologic oncology

authors： Veneris JT,Mahajan P,Frazier AL

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:This two-stage Phase II study assessed the activity of single agent alisertib in patients with recurrent/persistent uterine leiomyosarcoma (uLMS). METHODS:Eligibility criteria included histologically-confirmed, recurrent or persistent uLMS, age≥18, 1-2 prior cytotoxic regimens, and RECIST version 1.1 measura...

journal_title：Gynecologic oncology

authors： Hyman DM,Sill MW,Lankes HA,Piekarz R,Shahin MS,Ridgway MR,Backes F,Tenney ME,Mathews CA,Hoffman JS,Aghajanian C,Hensley ML

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:Based on our previous report showing that orobol, a potent phosphatidylinositol 4-kinase (PI4K) inhibitor, produced cisplatin (DDP) sensitivity, we have determined the mechanism of orobol-sensitization effect. METHODS AND RESULTS:Orobol produced >2-fold DDP sensitivity in human ovarian carcinoma 2008 cells ...

journal_title：Gynecologic oncology

authors： Isonishi S,Saitou M,Yasuda M,Ochiai K,Tanaka T

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:Chemoradiation based on cisplatin is the standard treatment for locally advanced cervical carcinoma; however, the optimal scheduling and dosing have still not been established. This study was conducted to determine the maximum-tolerated dose (MTD) of cisplatin for daily administration during pelvic radiothera...

journal_title：Gynecologic oncology

authors： Mitsuhashi A,Uno T,Tanaka N,Suzuka K,Tate S,Yamazawa K,Matsui H,Yamamoto S,Ito H,Sekiya S

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Epidemiological data indicate that endometriosis increases the risk of epithelial ovarian cancer (EOC), but the mechanism of cancer transition is unknown. Results from genome-wide association studies (GWAS) and transcriptome sequencing have demonstrated that genes located in the 1p36 region are important in b...

journal_title：Gynecologic oncology

authors： Falconer H,Sundqvist J,Xu H,Vodolazkaia A,Fassbender A,Kyama C,Bokor A,D'Hooghe TM

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:To assess toxicity and efficacy of weekly high-dose methotrexate-etoposide (HD MTX-ETO) in high-risk gestational trophoblastic neoplasia (GTN). METHODS:Retrospective chart review of high-risk GTN patients treated with HD MTX-ETO (methotrexate 1000 mg/m² day 1, etoposide 100 mg/m² days 1 and 2, q 1 wk). RESU...

journal_title：Gynecologic oncology

authors： Han SN,Amant F,Leunen K,Devi UK,Neven P,Berteloot P,Vergote I

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:Voiding dysfunctions represent a leading morbidity after radical hysterectomy performed in patients with early-stage cervical cancer. The aim of this study was to perform ad hoc analysis of factors influencing voiding recovery in SENTIX (SENTinel lymph node biopsy in cervIX cancer) trial. METHODS:The SENTIX ...

journal_title：Gynecologic oncology

authors： Zapardiel I,Kocian R,Köhler C,Klat J,Germanova A,Jacob A,Bajsova S,Böhmer G,Lay L,Gil-Ibañez B,Havelka P,Kipp B,Szewczyk G,Toth R,Staringer JC,De Santiago J,Coronado PJ,Poka R,Laky R,Luyckx M,Fastrez M,Dusek L,

更新日期：2021-01-05 00:00:00

abstract：:Forty-one eligible patients with metastatic or recurrent carcinoma of the uterine cervix received 149 courses of carboplatin. The drug was administered at a starting dosage of 400 mg/m2 IV every 28 days. The overall response rate was 15% (two complete responses, four partial responses; 95% confidence interval 6-29%) a...

journal_title：Gynecologic oncology

authors： Weiss GR,Green S,Hannigan EV,Boutselis JG,Surwit EA,Wallace DL,Alberts DS

更新日期：1990-12-01 00:00:00

abstract：OBJECTIVE:To determine whether intra-operative radiation therapy (IORT) at the time of pelvic exenteration (PE) or laterally extended endopelvic resection (LEER) improves progression-free survival (PFS) in patients with recurrent, previously irradiated gynecologic cancers. METHODS:We conducted a single institution ret...

journal_title：Gynecologic oncology

authors： Backes FJ,Billingsley CC,Martin DD,Tierney BJ,Eisenhauer EL,Cohn DE,O'Malley DM,Salani R,Copeland LJ,Fowler JM

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Improvements in surgical technique of pelvic exenteration have mainly occurred in the reconstructive phase of the procedure. Quality of life seems to be improved when performing continent rather than non-continent urinary diversion [1]. Unfortunately, Miami continent urinary pouch is a surgical technique not...

journal_title：Gynecologic oncology

authors： Angeles MA,Martínez-Gómez C,Martinez A,Ferron G

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:We assessed the efficacy and toxicity of once-weekly topotecan (Hycamtin; GlaxoSmithKline) for relapsed or persistent epithelial ovarian cancer (EOC) and primary peritoneal carcinoma (PPC). METHODS:Patients with recurrent or persistent EOC and PPC previously treated with > or = 1 course of platinum-based ch...

journal_title：Gynecologic oncology

authors： Safra T,Menczer J,Bernstein R,Shpigel S,Inbar MJ,Grisaru D,Golan A,Levy T

更新日期：2007-04-01 00:00:00