当前位置： SCI文献检索 > DIGESTIVE DISEASES AND SCIENCES期刊下所有文献 > Exposure to Ambient Air Pollution and the Risk of Inflammatory Bowel Disease: A European Nested Case-Control Study.

Exposure to Ambient Air Pollution and the Risk of Inflammatory Bowel Disease: A European Nested Case-Control Study.

Abstract：

BACKGROUND:Industrialization has been linked to the etiology of inflammatory bowel disease (IBD). AIM:We investigated the association between air pollution exposure and IBD. METHODS:The European Prospective Investigation into Cancer and Nutrition cohort was used to identify cases with Crohn's disease (CD) (n = 38) and ulcerative colitis (UC) (n = 104) and controls (n = 568) from Denmark, France, the Netherlands, and the UK, matched for center, gender, age, and date of recruitment. Air pollution data were obtained from the European Study of Cohorts for Air Pollution Effects. Residential exposure was assessed with land-use regression models for particulate matter with diameters of <10 μm (PM10), <2.5 μm (PM2.5), and between 2.5 and 10 μm (PMcoarse), soot (PM2.5 absorbance), nitrogen oxides, and two traffic indicators. Conditional logistic regression analyses were performed to calculate odds ratios (ORs) with 95 % confidence intervals (CIs). RESULTS:Although air pollution was not significantly associated with CD or UC separately, the associations were mostly similar. Individuals with IBD were less likely to have higher exposure levels of PM2.5 and PM10, with ORs of 0.24 (95 % CI 0.07-0.81) per 5 μg/m(3) and 0.25 (95 % CI 0.08-0.78) per 10 μg/m(3), respectively. There was an inverse but nonsignificant association for PMcoarse. A higher nearby traffic load was positively associated with IBD [OR 1.60 (95 % CI 1.04-2.46) per 4,000,000 motor vehicles × m per day]. Other air pollutants were positively but not significantly associated with IBD. CONCLUSION:Exposure to air pollution was not found to be consistently associated with IBD.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Opstelten JL,Beelen RMJ,Leenders M,Hoek G,Brunekreef B,van Schaik FDM,Siersema PD,Eriksen KT,Raaschou-Nielsen O,Tjønneland A,Overvad K,Boutron-Ruault MC,Carbonnel F,de Hoogh K,Key TJ,Luben R,Chan SSM,Hart AR,Bueno-de-

doi

10.1007/s10620-016-4249-4

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

2963-2971

issue

eissn

0163-2116

issn

1573-2568

pii

10.1007/s10620-016-4249-4

journal_volume

pub_type

杂志文章

在线工具

Exposure to Ambient Air Pollution and the Risk of Inflammatory Bowel Disease: A European Nested Case-Control Study.