Gastric acid normosecretion is not essential in the pathogenesis of mild erosive gastroesophageal reflux disease in relation to Helicobacter pylori status.

abstract：:The present study investigated how reflux-induced esophagitis affects the smooth muscle reactivity of the esophageal body. Two different esophagitis models were used: acid gastric and mixed duodenogastric reflux. All test animals apart from the controls developed gross and histologic evidence of esophagitis. Contracti...

journal_title：Digestive diseases and sciences

authors： Tugay M,Yildiz F,Utkan T,Müezzinoğlu B,Erden F,Gacar N,Ulak G

更新日期：2003-11-01 00:00:00

abstract：:The purpose of this study was to investigate the potential of a computerized auscultation method for providing an objective, quantitative measure characteristic of irritable bowel syndrome. Bowel sounds from irritable bowel patients and normal controls were digitized using an electronic stethoscope. Computerized analy...

journal_title：Digestive diseases and sciences

authors： Craine BL,Silpa M,O'Toole CJ

更新日期：1999-09-01 00:00:00

abstract：:The perception that chronic hepatitis C is an asymptomatic disease contrasts with many studies that show a strong association between chronic hepatitis C, hepatocellular cancer, and fatal liver disease. In order to resolve these issues, it is logical to directly evaluate the quality of life in patients with chronic he...

journal_title：Digestive diseases and sciences

authors： Carithers RL Jr,Sugano D,Bayliss M

更新日期：1996-12-01 00:00:00

abstract：:Despite progress in therapeutic approaches for the elimination of hepatitis C, chronic hepatitis C virus infection remains an important cause of liver disease. Therapeutic intervention with the currently available interferon-based treatment regimens is quite successful, but treatment is difficult to tolerate and is co...

journal_title：Digestive diseases and sciences

authors： Davis GL,Krawczynski K,Szabo G

更新日期：2007-04-01 00:00:00

abstract：:A pathogenic role of nitric oxide has been suggested in acute and chronic intestinal inflammation. We took the opportunity offered by studies in patients with excluded colon, which represents a model of chronic intestinal inflammation with no exogenous nitrite or nitrate supply, to evaluate the quantity and the qualit...

journal_title：Digestive diseases and sciences

authors： Neut C,Guillemot F,Colombel JF

更新日期：1997-12-01 00:00:00

abstract：:Gastrointestinal motor dysfunction persists in a large number of children subjected to surgical treatment for Hirschsprung's disease, indicating abnormalities in the remaining intestine. The aim of the study was to detect possible alterations in frequency and topographic distribution of enteric neurons and interstitia...

journal_title：Digestive diseases and sciences

authors： Sandgren K,Larsson LT,Ekblad E

更新日期：2002-05-01 00:00:00

abstract：:Hepatocellular carcinoma represents an increasing therapeutic challenge due to its high incidence and early metastasis. Numerous studies have demonstrated the influence of the vascular system on tumor growth and development. In addition, the role of leukocyte-endothelium interaction in tumor vessels is of particular s...

journal_title：Digestive diseases and sciences

authors： Maksan SM,Araib PM,Ryschich E,Gebhard MM,Schmidt J

更新日期：2004-05-01 00:00:00

abstract：:An experimental model of massive (80%) small bowel resection and antiperistaltic colon interposition in between the remnant jejunum and ileum was created in rhesus monkeys. The gastrointestinal functions were assessed preoperatively and at different periods after the operation. Progressive increase in the transit time...

journal_title：Digestive diseases and sciences

authors： Sidhu GS,Narasimharao KL,Usha Rani V,Sarkar AK,Mitra SK

更新日期：1985-05-01 00:00:00

abstract：:To study the clinicopathologic features of hepatitis C viremic patients negative for hepatitis C antibodies (anti-HCV) by current second-generation assay, we categorized 139 consecutive histologically verified patients with chronic non-A, non-B hepatitis into three groups: 121 (87%) were positive for second-generation...

journal_title：Digestive diseases and sciences

authors： Kao JH,Lai MY,Hwang YT,Yang PM,Chen PJ,Sheu JC,Wang TH,Hsu HC,Chen DS

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND AND AIM:The association between nonalcoholic fatty liver disease (NAFLD) and apolipoprotein C3 gene (APOC3) promoter region single-nucleotide polymorphisms (SNPs) rs2854117 and rs2854116 is controversial. The aim of this study was to investigate the relationship between other polymorphisms of APOC3 and NAFLD...

journal_title：Digestive diseases and sciences

authors： Zhang RN,Zheng RD,Mi YQ,Zhou D,Shen F,Chen GY,Zhu CY,Pan Q,Fan JG

更新日期：2016-08-01 00:00:00

abstract：:Basal gastric acid output was analyzed prospectively in 110 patients with endoscopically documented duodenal ulcer disease to determine the frequency of gastric acid hypersecretion in patients with bleeding versus nonbleeding ulcers. Thirty-eight patients with stigmata of an actively or recently bleeding duodenal ulce...

journal_title：Digestive diseases and sciences

authors： Collen MJ,Kalloo AN,Sheridan MJ

更新日期：1993-02-01 00:00:00

abstract：:Idiopathic chronic constipation has been correlated to neural abnormalities that consist of a reduced number of myenteric plexus neurons and a decreased concentration of VIP-positive nerve fibers within the circular muscle. Recent studies hypothesized the involvement of nitric oxide in motility disorders of the human ...

journal_title：Digestive diseases and sciences

authors： Cortesini C,Cianchi F,Infantino A,Lise M

更新日期：1995-11-01 00:00:00

abstract：:The present study aimed to clarify the endoscopic ultrasonography (EUS) features of nonneoplastic (cholesterol polyps and adenomyomatosis) and neoplastic (adenoma and adenocarcinoma) gallbladder polyps and to evaluate the effectiveness and limitation of EUS in the differential diagnosis of these lesions. We retrospect...

journal_title：Digestive diseases and sciences

authors： Akatsu T,Aiura K,Shimazu M,Ueda M,Wakabayashi G,Tanabe M,Kawachi S,Kitajima M

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:While the short-term benefits of exclusive enteral nutrition (EEN) for induction of remission in children with Crohn's disease (CD) are well documented, the longer-term outcomes are less clear. AIM:This retrospective study aimed to ascertain the outcomes for up to 24 months following EEN in a group of child...

journal_title：Digestive diseases and sciences

authors： Lambert B,Lemberg DA,Leach ST,Day AS

更新日期：2012-08-01 00:00:00

abstract：:Ornithine decarboxylase (ODC) activity has been associated with mucosal growth and injury, yet, little information is available on ODC activity during gastric ulcer healing. We measured ODC activity in the ulcer base submucosa and the surrounding mucosa at 1 cm and 2 cm and assessed ulcer surface healing and a histolo...

journal_title：Digestive diseases and sciences

authors： Marcuard SP,Silverman JF,Finley JL,Seidel ER

更新日期：1992-07-01 00:00:00

abstract：:We observed five cases of unusual extraperitoneal presentation of diverticulitis during an 11 year period. During that time, a total of 263 patients were operated for diverticulitis. Patients 1-4 presented with an inflammatory spread of diverticulitis through the abdominal wall; in patient 5 multiple abscesses were pr...

journal_title：Digestive diseases and sciences

authors： Rothenbuehler JM,Oertli D,Harder F

更新日期：1993-11-01 00:00:00

abstract：:Prevalence estimates for irritable bowel syndrome from surveys in Western countries are 4.4% to 22%, generally higher in women than men, and only a minority seek health care. There are few studies of bowel patterns in Asian countries. We conducted a survey of a nonpatient population in Ho Chi Minh City, Vietnam, to de...

journal_title：Digestive diseases and sciences

authors： Zuckerman MJ,Nguyen G,Ho H,Nguyen L,Gregory GG

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Restoring normal fecal flora through intestinal microbiota transplantation (IMT) was successful in curing recurrent Clostridium difficile infection (CDI). However, only a few cases have been reported of IMT being utilized for the treatment of severe or fulminant CDI. AIM:Is IMT a simple and effective treatm...

journal_title：Digestive diseases and sciences

authors： Zainah H,Hassan M,Shiekh-Sroujieh L,Hassan S,Alangaden G,Ramesh M

更新日期：2015-01-01 00:00:00

abstract：:Fasting antroduodenal motor activity was studied in 15 dyspeptic patients with chronic superficial antral gastritis and Helicobacter pylori infection (group A), 10 dyspeptic patients with chronic superficial antral gastritis without Helicobacter pylori infection (group B), and eight healthy control subjects (group C) ...

journal_title：Digestive diseases and sciences

authors： Testoni PA,Bagnolo F,Masci E,Colombo E,Tittobello A

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Fibromyalgia (FM) is a disorder characterized by widespread chronic pain as core symptom and a broad range of comorbidities. Despite the prevalence of gastrointestinal (GI) comorbidities in patients with FM, GI functions have rarely been investigated in animal models of FM. AIMS:The purpose of the present s...

journal_title：Digestive diseases and sciences

authors： Uchida M,Kobayashi O,Yoshida M,Miwa M,Miura R,Saito H,Nagakura Y

更新日期：2019-09-01 00:00:00

abstract：:Pancreatic polypeptide (PP) has been shown to be released postprandially in several species. In this study we tested the efficacy of an amino acid solution (905 mOsM), 0.1 N HCl (300 mOsM), 905 mOsM NaCl, 300 mOsM glucose, corn oil, and balloon distention within the stomach, duodenum, or ileum in stimulating release o...

journal_title：Digestive diseases and sciences

authors： Duke GE,Kimmel JR,Durham K,Pollock HG,Bertoy R,Rains-Epstein D

更新日期：1982-09-01 00:00:00

abstract：:Peptide YY (PYY) is an important modulator of stimulated pancreatic exocrine secretion. PYY acts proximal to the acinar cell but the exact site and mechanism of action are unknown. The aim of the present study is to determine the pathway through which PYY exerts its effect on the exocrine pancreas in awake rats under ...

journal_title：Digestive diseases and sciences

authors： Deng X,Guarita DR,Wood PG,Kriess C,Whitcomb DC

更新日期：2001-01-01 00:00:00

abstract：:There is a growing body of experimental and clinical evidence to suggest that oral or rectal administration of 5-ASA or 5-ASA conjugates is associated with significant adverse side effects including pancreatitis, hepatitis, and renal toxicity. The objective of this study was to assess the ability of 5-ASA to interact ...

journal_title：Digestive diseases and sciences

authors： Grisham MB,Ware K,Marshall S,Yamada T,Sandhu IS

更新日期：1992-09-01 00:00:00

abstract：:The role of carbonic anhydrase in the process of proximal duodenal mucosal bicarbonate secretion was investigated in the guinea pig. In a series of experiments in vivo, the duodenum was perfused with 24 mmol/liter NaHCO3 solution (+ NaCl for isotonicity) to ensure that active duodenal HCO3- secretion against a concent...

journal_title：Digestive diseases and sciences

authors： Muallem R,Reimer R,Odes HS,Schwenk M,Beil W,Sewing KF

更新日期：1994-05-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is widely considered to be the hepatic manifestation of the metabolic syndrome and is closely linked to dyslipidemia, obesity, and insulin resistance. Patients with NAFLD have increased mortality when compared to the general population, primarily related to cardiovascular disea...

journal_title：Digestive diseases and sciences

authors： Simon TG,Corey KE,Chung RT,Giugliano R

更新日期：2016-12-01 00:00:00

abstract：:To investigate the colonic adenoma-adenocarcinoma progression sequence, DNA ploidy analysis was performed on hyperplastic polyps to adenocarcinomas. DNA ploidy data were then compared with immunocytochemical staining for proliferating cell nuclear antigen (PCNA). In hyperplastic polyps to villous adenomas, all cases w...

journal_title：Digestive diseases and sciences

authors： Tomita T

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND AND AIMS:The present study aimed to identify the differential expressed genes that are related to acute pancreatitis. METHODS:Microarray datasets GSE109227 and GSE3644 were downloaded from the public database and analyzed to screen the genes. Afterward, integrated analysis of these genes were performed, inc...

journal_title：Digestive diseases and sciences

authors： Fan L,Hui X,Mao Y,Zhou J

更新日期：2020-06-01 00:00:00

abstract：:Experimental graft-versus-host disease (GVHD) causes immune-mediated intestinal injury. The adhesion molecule lymphocyte function associated antigen-1 (LFA-1) is involved in leukocyte homing to areas of inflammatory injury. Our hypothesis was that LFA-1 is increased in the GVHD injured small bowel and colon. We found ...

journal_title：Digestive diseases and sciences

authors： Poritz LS,Olt GJ,Ruggiero FM,Colony P,Tilberg AF,Koltun WA

更新日期：1998-02-01 00:00:00

abstract：:Our objective was to investigate the expression of HMGA1 mRNA and protein in hepatocellular carcinoma (HCC) and the correlation between its expression and clinical pathological characteristics and prognosis. HMGA1 expression was determined at both the mRNA level and the protein level in 30 HCC tissues and their corres...

journal_title：Digestive diseases and sciences

authors： Chang ZG,Yang LY,Wang W,Peng JX,Huang GW,Tao YM,Ding X

更新日期：2005-10-01 00:00:00

abstract：:Gastroparesis often precludes gastric enteral nutrition (EN) in critically ill patients. Our aim was to determine the feasibility of bedside microendoscopic placement of nasointestinal feeding tubes to facilitate enteral nutrition in critically ill patients with poor gastric emptying. Nine mechanically ventilated pati...

journal_title：Digestive diseases and sciences

authors： Taylor SJ,Przemioslo R,Manara AR

更新日期：2003-04-01 00:00:00