Abstract:
:Purpose To determine whether fructose 1,6-bisphosphatase 1 (FBP1) expression is associated with fluorine 18 (18F) fluorodeoxyglucose (FDG) accumulation in patients with hepatocellular carcinoma (HCC) and to investigate how FBP1 expression and 18F FDG uptake are related to tumor differentiation grade and metabolism and whether the molecular mechanism involves hypoxia-inducible factor 1-α (HIF1A) transcriptional activity. Materials and Methods This retrospective study was approved by the institutional review board with informed consent. Eighty-five patients with HCC underwent 18F FDG combined positron emission tomography and computed tomography (PET/CT). The relationship between maximum standardized uptake (SUVmax) and expression of FBP1, glucose transporter 1 (GLUT1), and hexokinase 2 (HK2) was analyzed with immunohistochemical analysis. In vitro FBP1 overexpression in HCC cells was used to examine the role of FBP1 in tumor metabolism, and its effect on HIF1A transcriptional activity was investigated with quantitative polymerase chain reaction and luciferase reporter assay. Spearman rank correlation was applied to determine the association between FBP1 expression and SUVmax. Results There was an inverse relationship between FBP1 expression and SUVmax (P = .003). SUVmax was higher in patients with poorly differentiated HCC (mean, 6.7 ± 3.6 [standard deviation]) than in those with well- (mean, 2.6 ± 0.7, P < .001) or moderately (mean, 4.1 ± 2.3, P < .001) differentiated HCC. FBP1 expression was significantly lower in patients with poorly differentiated HCC (mean, 0.6 ± 0.2) than in those with well- (mean, 1.4 ± 0.6, P = .006) or moderately (mean, 1.2 ± 0.2, P = .007) differentiated HCC. FBP1 overexpression in HCC cells led to a significant decrease in GLUT1 expression (P = .034), 18F FDG uptake (P = .023), and HIF1A transcriptional activity (P = .001). Conclusion SUVmax in patients with HCC is inversely associated with FBP1 expression, and FBP1 may inhibit 18F FDG uptake via the HIF1A pathway. SUVmax is higher in patients with poorly differentiated HCC than in those with well- or moderately differentiated HCC, which could be the result of lower FBP1 expression in the former. © RSNA, 2017.
journal_name
Radiologyjournal_title
Radiologyauthors
Chen R,Li J,Zhou X,Liu J,Huang Gdoi
10.1148/radiol.2017161607subject
Has Abstractpub_date
2017-09-01 00:00:00pages
844-853issue
3eissn
0033-8419issn
1527-1315journal_volume
284pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract::Quality control in diagnostic radiography begins with production of predictable exposures. The authors describe a technique which permits determination of the variation of mR/mAs for the entire diagnostic range of times and currents in only about 1 hour. The mR/mAs in newly installed units has been shown to vary by as...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/122.2.489
更新日期:1977-02-01 00:00:00
abstract::Between the portal vein and the inferior vena cava lies a small space that may be occupied by multiple anatomic structures including the caudate and papillary processes of the caudate lobe of the liver, portacaval lymph nodes, replaced or accessory right hepatic arteries, posterosuperior pancreaticoduodenal vessels, t...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.156.2.4011910
更新日期:1985-08-01 00:00:00
abstract::Mammography utilization remains below the level needed to achieve the National Cancer Institute's year-2000 goals for reducing breast cancer mortality by 50%. Previous research has identified both patient and physician barriers. The authors interviewed 600 randomly selected women who were offered a free mammographic e...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.172.1.2740510
更新日期:1989-07-01 00:00:00
abstract:PURPOSE:To prospectively determine the accuracy of 64-section computed tomographic (CT) angiography for the depiction of coronary artery disease (CAD) that induces perfusion defects at myocardial perfusion imaging with single photon emission computed tomography (SPECT), by using myocardial perfusion imaging as the refe...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2482071307
更新日期:2008-08-01 00:00:00
abstract::Ninety malignant hepatic neoplasms were studied by gray scale ultrasound. Four different ultrasonic patterns were observed: (a) discrete, relatively echo-free masses; (b) discrete, relatively echogenic masses; (c) totally echo-free masses; and (d) a diffuse alteration of echo architecture without discrete masses. Ther...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/124.1.203
更新日期:1977-07-01 00:00:00
abstract:PURPOSE:To evaluate the imaging characteristics of an amorphous silicon flat-panel detector (FPD) for digital chest radiography. MATERIALS AND METHODS:The 41 x 41-cm digital FPD is constructed on a single monolithic glass substrate with a structured cesium iodide scintillator layer and an amorphous silicon thin-film t...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.218.3.r01fe45683
更新日期:2001-03-01 00:00:00
abstract:PURPOSE:To report the prevalence of qualitative radiographic findings for femoroacetabular impingement (FAI) and associations among them and to characterize the inter- and intraobserver variability of these interpretations. MATERIALS AND METHODS:This study is part of an institutional review board-approved population-b...
journal_title:Radiology
pub_type: 杂志文章,随机对照试验
doi:10.1148/radiol.11102354
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To optimize detection and diagnosis of breast lesions with contrast-enhanced magnetic resonance (MR) imaging. MATERIALS AND METHODS:A three-dimensional fast low-angle shot pulse sequence was used for a group comparison consisting of 76 high-dose (0.16 mmol gadopentetate dimeglumine per kilogram of body weight)...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.191.3.8184040
更新日期:1994-06-01 00:00:00
abstract:PURPOSE:To assess the ability of helium 3 ((3)He) magnetic resonance (MR) imaging of regional alveolar partial pressure of oxygen (Pao2) to depict smoking-induced functional alterations and to compare its efficacy to that of current diagnostic techniques. MATERIALS AND METHODS:This study was approved by the local inst...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.14132809
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:To validate three previously identified quantitative image features across multiparametric magnetic resonance (MR) images acquired with imagers made by two different manufacturers to differentiate prostate cancer (PC) from normal prostatic tissue and to assess cancer aggressiveness. MATERIALS AND METHODS:This ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.14131320
更新日期:2014-05-01 00:00:00
abstract::Fifty-one patients underwent both radionuclide and ultrasound studies of the hepatobiliary system. Eleven patients had large bile duct obstruction, six had intrahepatic diffuse small duct obstruction, and 37 had no obstruction. In all 11 patients with large duct obstruction, the radionuclide images were abnormal, but ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.138.1.7455080
更新日期:1981-01-01 00:00:00
abstract::The computed tomographic findings in a patient with lead encephalopathy are described. The predominantly unilateral abnormalities and the clinical history were suggestive of a cerebral tumor. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/123.1.91
更新日期:1977-04-01 00:00:00
abstract::The diagnostic accuracy of both planar and single-photon emission computed tomography (SPECT) bone scintigraphy, radionuclide angiography, arthrography, and conventional radiography was evaluated in 36 patients with temporomandibular joint (TMJ) dysfunction undergoing preoperative testing. The sensitivity of SPECT bon...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.149.2.6226060
更新日期:1983-11-01 00:00:00
abstract::An overview of current air-contrast stomach examination techniques is offered: (a) Hampton's technique which does not use distension; (b) the Japanese method which utilizes the relaxant drug Buscopan, good distension, and much patient rotation; (c) a third method in which no drugs are used but more distension is obtai...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/117.3.743
更新日期:1975-12-01 00:00:00
abstract::Radiological abnormalities of the ribs are reported in 5 newborn infants with myotonic dystrophy. In all 5, the ribs appeared very thin, in contrast to the normal appearance of the rest of the skeleton. This slenderness, which is important for diagnosis and prognosis, seems to be caused by hypotonia of the intercostal...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/127.3.747
更新日期:1978-06-01 00:00:00
abstract:PURPOSE:To prospectively determine in swine the effects of cardiac-specific and hypoxia-inducible vascular endothelial growth factor (VEGF) expression gene on angiogenesis and arteriogenesis by using cardiovascular magnetic resonance (MR) imaging for evaluation of infarct resorption and left ventricular (LV) function. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2432060928
更新日期:2007-05-01 00:00:00
abstract:PURPOSE:To prospectively evaluate the safety and efficacy of undersized stents used in patients with high-grade intracranial stenosis and recurrent ischemic symptoms who are undergoing medical treatment. MATERIALS AND METHODS:In 18 patients (13 men, five women; age range, 51-82 years), 20 high-grade (>70%) intracrania...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2311030183
更新日期:2004-04-01 00:00:00
abstract:PURPOSE:Quantification of regional cerebral blood flow (rCBF) and volume (rCBV) with dynamic magnetic resonance (MR) imaging. MATERIALS AND METHODS:After bolus administration of a paramagnetic contrast medium, rapid T2*-weighted gradient-echo images of two sections were acquired for the simultaneous creation of concen...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.193.3.7972800
更新日期:1994-12-01 00:00:00
abstract::Four patients with proved osteopetrosis (three with the infantile malignant form and one with the benign form) were examined with magnetic resonance imaging at 1.5 T. All patients were studied in the coronal and sagittal planes using both short and long repetition time/echo time sequences. The infantile malignant form...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.161.1.3763870
更新日期:1986-10-01 00:00:00
abstract:PURPOSE:To prospectively evaluate to what extent image quality in 16-detector row computed tomographic (CT) coronary angiography is a function of the heart rate and the image reconstruction technique used. MATERIALS AND METHODS:A total of 70 patients (49 men, 21 women; mean age, 59.1 years +/- 5.8 [standard deviation]...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2381041595
更新日期:2006-01-01 00:00:00
abstract::A system for computerized processing of video image series was utilized for the real-time digitization of arteriograms. There were 256 x 256 picture elements (pixels) per image with a resolution of 256 gray levels. Temporal changes in x-ray absorption at each pixel as induced by contrast media were computed for the ex...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.141.1.7291540
更新日期:1981-10-01 00:00:00
abstract::We describe a patient who had cryptosporidiosis and cytomegalovirus infection of the gastric antrum that was initially detected on computed tomography (CT) scans. CT may be useful in the evaluation of immunocompromised patients with diarrheal illness, as well as in the assessment of the gastrointestinal tract. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.159.3.3704150
更新日期:1986-06-01 00:00:00
abstract::Hippurate function scintiscans were obtained in prone and standing positions in a group of 76 patients with concurrent hypertension and nephroptosis. TWelve of these patients had massive, bilateral disturbance of intrarenal hippurate transport in the standing position; hippurate transport was normal in the prone posit...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.140.1.7244230
更新日期:1981-07-01 00:00:00
abstract::The rationale for prebiopsy and preoperative irradiation in a multimodal approach to treatment of osteosarcoma is presented. Six patients with osteosarcoma underwent preoperative irradiation, amputation, and elective chemotherapy. Five of these also received prebiopsy irradiation: three survive without metastases at 2...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/125.2.497
更新日期:1977-11-01 00:00:00
abstract::The purpose of this study was to prospectively use a whole-heart three-dimensional (3D) coronary magnetic resonance (MR) angiography technique specifically adapted for use at 3 T and a parallel imaging technique (sensitivity encoding) to evaluate coronary arterial anomalies and variants (CAAV). This HIPAA-compliant st...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2471070274
更新日期:2008-04-01 00:00:00
abstract::Perfusion lung scans are occasionally characterized by focal zones of apparent hyperperfusion ("hot spots"). To investigate the frequency and significance of this phenomenon, ventilation-perfusion lung scans and pulmonary arteriograms were reviewed in 72 patients who underwent both procedures for the evaluation of sus...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.173.1.2781030
更新日期:1989-10-01 00:00:00
abstract:PURPOSE:To determine, with arterial spin labeling (ASL) perfusion magnetic resonance (MR) imaging and physostigmine challenge, if abnormal hippocampal blood flow in ill Gulf War veterans persists 11 years after initial testing with single photon emission computed tomography and nearly 20 years after the 1991 Gulf War. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.11101715
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:To retrospectively evaluate computed tomographic (CT) findings of immunoglobulin G4 (IgG4)-related disease involving the vascular system. MATERIALS AND METHODS:This study was approved by the institutional review board, and all patients included had consented to the use of their medical records for the purpose ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.11102250
更新日期:2011-11-01 00:00:00
abstract::Uroradiological examinations on 33 patients subjected to abdomino-perineal resection were analyzed. The most common finding was medial displacement of both ureters, with the right one frequently crossing the midline. Bladder deformity, sometimes severe, was present in all patients. Localized ureteral narrowing due to ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/128.2.345
更新日期:1978-08-01 00:00:00
abstract::This description of procedures in two patients illustrates successful thoracic needle biopsy, despite the fact that the lesion was obscured by overlapping bones in each instance. The technique of screwing a 20-gauge needle through the overlapping bone is suggested as an innovative method when more traditional approach...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.177.1.2399330
更新日期:1990-10-01 00:00:00