Abstract:
PURPOSE:To validate three previously identified quantitative image features across multiparametric magnetic resonance (MR) images acquired with imagers made by two different manufacturers to differentiate prostate cancer (PC) from normal prostatic tissue and to assess cancer aggressiveness. MATERIALS AND METHODS:This study was HIPAA-compliant and approved by the institutional review board. Preoperative 1.5-T multiparametric endorectal MR images of 119 PC patients (dataset A, 71 patients; dataset B, 48 patients) were analyzed, and 265 PC and normal peripheral zone regions of interests (ROIs) were identified through histologic and MR consensus review. The 10th percentile average apparent diffusion coefficient (ADC) value, average ADC value, and skewness of T2-weighted signal-intensity histogram were evaluated with area under the receiver operating characteristic curve (AUC). The image features were combined with a linear discriminant analysis classifier and evaluated both on the image dataset of each type of imager alone (leave-one-patient-out evaluation) and across the datasets (training on one dataset, testing on the other). Spearman correlation coefficient was calculated between the image features and ROI-specific Gleason scores. RESULTS:AUC values of the image features combined were 0.95 ± 0.02 (standard error) and 0.88 ± 0.03 on dataset B and dataset A alone, respectively, and 0.96 ± 0.02 and 0.89 ± 0.03 when training on dataset A and testing on dataset B and vice versa, respectively. Spearman correlation coefficients between Gleason scores and the ADC features were between -0.27 and -0.34. CONCLUSION:Consistently across images from datasets A and B, the 10th percentile ADC value, average ADC value, and T2-weighted skewness can distinguish PC from normal-tissue ROIs, and ADC features correlate moderately with ROI-specific Gleason scores.
journal_name
Radiologyjournal_title
Radiologyauthors
Peng Y,Jiang Y,Antic T,Giger ML,Eggener SE,Oto Adoi
10.1148/radiol.14131320subject
Has Abstractpub_date
2014-05-01 00:00:00pages
461-71issue
2eissn
0033-8419issn
1527-1315journal_volume
271pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract::This study evaluates the mammographic findings in 352 patients, aged 30-85 years, who underwent spot localization and biopsy for evaluation of nonpalpable breast abnormalities. Malignancy was found at biopsy in 114 cases. The mammographic appearance (specifically, whether grouped microcalcifications, mass, or both wer...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.169.2.2845470
更新日期:1988-11-01 00:00:00
abstract:PURPOSE:To evaluate the elasticity of the coracohumeral ligament (CHL) in healthy individuals and patients with clinical findings suggestive of unilaterally involved adhesive capsulitis of the shoulder (ACS). MATERIALS AND METHODS:The institutional review board approved this single-institution prospective study, which...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2015150888
更新日期:2016-02-01 00:00:00
abstract::Primary and secondary lung malignancies are often treated with surgery. Many patients are poor surgical candidates owing to advanced age or medical comorbidities. Alternatives to surgery for localized disease include radiation therapy and the newer treatments known as image-guided thermal ablation. Image-guided therma...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.11091126
更新日期:2011-09-01 00:00:00
abstract::Computed tomography of the brain was used in evaluating demented and nondemented elderly people. The incidence of convulutional atrophy and ventricular enlargement correlated well with pathologic and pneumoencephalographic examination of a similar population. Computed tomography also showed certain instances of dement...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/116.1.85
更新日期:1975-07-01 00:00:00
abstract:PURPOSE:To prospectively correlate single- and multisection magnetic resonance (MR) imaging measurements with clinical measurements for assessment of abdominal adipose tissue volumes in healthy (control subjects), overweight, and diabetic overweight preadolescents and adolescents. MATERIALS AND METHODS:The study was a...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2423060111
更新日期:2007-03-01 00:00:00
abstract::The ultrasonographic features of gastric wall lesions were studied in 40 patients and correlated with the CT findings in 14. Features diagnostic of tumor included (a) an infiltrative lesion causing thickening of the gastric wall, which can be localized or diffuse and smooth or irregular; (b) a globular mass, nodular o...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.141.1.7291520
更新日期:1981-10-01 00:00:00
abstract:PURPOSE:To retrospectively determine the frequency and severity of various abnormal laboratory test values following percutaneous cryoablation of liver tumors and to estimate the correlation between laboratory test values and tumor and ablation volumes. MATERIALS AND METHODS:This HIPAA-compliant study had institutiona...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2481061874
更新日期:2008-07-01 00:00:00
abstract:PURPOSE:To determine whether contrast material-enhanced helical computed tomography (CT) of the thorax and upper abdomen changes the tumor stage and management compared with nonenhanced helical CT in patients with newly diagnosed lung cancer. MATERIALS AND METHODS:During 15 months, any patient in whom lung cancer was ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.212.1.r99jl1956
更新日期:1999-07-01 00:00:00
abstract:PURPOSE:To evaluate with sonography the normal development of the fetal cerebellum in the second trimester. MATERIALS AND METHODS:The study included all patients undergoing second trimester genetic amniocentesis who had structurally normal fetuses, in whom the posterior fossa was adequately seen and in whom the karyot...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.193.3.7972820
更新日期:1994-12-01 00:00:00
abstract:PURPOSE:To assess the outcome of interventional radiologic placement of tunneled hemodialysis catheters via the right internal jugular vein. MATERIALS AND METHODS:In 194 patients, the catheter was placed via the right internal jugular vein unless thrombosis was present. Real-time ultrasound-guided puncture and fluoros...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.203.2.9114110
更新日期:1997-05-01 00:00:00
abstract::To ascertain the sensitivity of physical examination with respect to significant arterial injury, the angiographic findings of 61 stab wounds to the extremities were correlated with specific physical findings. In 25 injuries there were physical findings of major injury, including one or more of the following: pulse de...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.162.2.3797660
更新日期:1987-02-01 00:00:00
abstract:PURPOSE:To study the frequency, timing, and associations of thoracic metastases in advanced (stage III and IV) high-grade serous ovarian cancer (HGSC) to help optimize the use of cross-sectional chest imaging. MATERIALS AND METHODS:This institutional review board-approved retrospective study with waived informed conse...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2015142467
更新日期:2015-12-01 00:00:00
abstract::Purpose To evaluate the performance of three imaging methods (radiography, dual-energy x-ray absorptiometry [DXA], and quantitative computed tomography [CT]) and that of a numerical analysis with finite element modeling (FEM) in the prediction of failure load of the proximal femur and to identify the best densitometri...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2016142796
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:To evaluate the frequency, location, and appearance of transient increased attenuation in the liver during arterial-phase helical or incremental computed tomography (CT) in patients with gallbladder disease without hepatic extension. MATERIALS AND METHODS:Findings in dynamic CT examinations in 31 patients with...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.204.3.9280250
更新日期:1997-09-01 00:00:00
abstract::Purpose To evaluate the association between Breast Imaging Reporting and Data System (BI-RADS) mammographic and magnetic resonance (MR) imaging features and breast cancer recurrence risk in patients with estrogen receptor-positive breast cancer who underwent the Oncotype DX assay. Materials and Methods In this institu...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2017162333
更新日期:2018-01-01 00:00:00
abstract::Purpose To evaluate the diagnostic accuracy of the quantitative parameter standardized uptake value (SUV) at single photon emission computed tomography (SPECT)/computed tomography (CT) for the evaluation of temporomandibular joint (TMJ) disorder (TMD). Materials and Methods This study was approved by the institutional...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2016152294
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:To prospectively evaluate the accuracy of contrast material-enhanced magnetic resonance (MR) angiography in the evaluation of vascular invasion by bone and soft-tissue tumors, with surgery serving as the reference standard. MATERIALS AND METHODS:This study was approved by the regional ethics committee, and all...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2382041725
更新日期:2006-02-01 00:00:00
abstract::A new sign for the diagnosis of lipohemarthrosis on vertical beam lateral knee radiographs depends upon visualization of the joint capsule due to the presence of fat lying both within and outside of the joint. Recognition of lipohemarthrosis on routine knee radiographs may aid in the diagnosis of subtle tibial plateau...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/122.1.31
更新日期:1977-01-01 00:00:00
abstract:PURPOSE:To determine the value of magnetic resonance (MR) imaging in predicting resectability of head and neck neoplasms around the carotid arteries. MATERIALS AND METHODS:Forty-nine patients (28 male patients and 21 female patients aged 17-79 years; mean, 57.3 years) with head and neck masses and clinical evidence of...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.195.3.7754000
更新日期:1995-06-01 00:00:00
abstract::Purpose To determine if the change in tumor apparent diffusion coefficient (ADC) at diffusion-weighted (DW) MRI is predictive of pathologic complete response (pCR) to neoadjuvant chemotherapy for breast cancer. Materials and Methods In this prospective multicenter study, 272 consecutive women with breast cancer were e...
journal_title:Radiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1148/radiol.2018180273
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:To determine if the addition of three-dimensional (3D) proton magnetic resonance (MR) spectroscopic imaging to endorectal MR imaging helps diagnose extracapsular extension (ECE) of prostate cancer. MATERIALS AND METHODS:Endorectal MR imaging and 3D MR spectroscopic imaging were performed in 53 patients with pr...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.213.2.r99nv26481
更新日期:1999-11-01 00:00:00
abstract:PURPOSE:To prospectively evaluate the effectiveness and safety of selective embolization of the uterine arteries in the management of symptomatic uterine leiomyoma. MATERIALS AND METHODS:Eighty consecutive women (mean age, 44.7 years) with symptomatic uterine leiomyoma, none of whom desired future pregnancy, underwent...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.215.2.r00ma11428
更新日期:2000-05-01 00:00:00
abstract::Purpose To examine the relation between the lung elimination rate of inhaled technetium 99m ((99m)Tc)-sestamibi and immunohistochemical expression of bronchopulmonary multidrug resistance protein 1 (MRP1) and permeability glycoprotein (P-gp) and assess the repeatability of the inhaled (99m)Tc-sestamibi clearance techn...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.16151389
更新日期:2016-09-01 00:00:00
abstract::Gated radionuclide imaging with 99mTc-labeled red blood cells was employed to assess changes in right atrial (RA) volume in 17 subjects. Studies were repeated within two hours in five of 12 normal subjects and at two and ten days after infarction in five patients. Time-activity curves were generated for the RA and rig...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.139.3.7232740
更新日期:1981-06-01 00:00:00
abstract:PURPOSE:To test an optimized functional magnetic resonance (MR) imaging procedure to depict the motor hand representation area (HRA) in patients with epilepsy lesions near the central sulcus. MATERIALS AND METHODS:Fast low-angle shot MR imaging was performed with an oblique single-section imaging technique in eight co...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.210.2.r99ja31529
更新日期:1999-02-01 00:00:00
abstract:PURPOSE:To assess the feasibility of automatic needle-guide tracking by using a real-time phase-only cross correlation ( POCC phase-only cross correlation ) algorithm-based sequence for transrectal 3-T in-bore magnetic resonance (MR)-guided prostate biopsies. MATERIALS AND METHODS:This study was approved by the ethics...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.14132067
更新日期:2014-12-01 00:00:00
abstract::Body computed tomographic (CT) scans were reviewed in 73 patients with hematomas of recent onset. The incidence, extent, and morphologic variation of regions of hyperdensity on precontrast scans were assessed. Hyperdensity was also sought in the scans of 80 control subjects with a mass due to neoplasm or abscess demon...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.148.3.6878700
更新日期:1983-09-01 00:00:00
abstract::Gold, silver and lead thioglucose were evaluated in rodents to determine the value of organo-metallic compounds in the study of metabolic abnormalities. Increased radioactivity concentration was noted in the hypothalamus with all compounds. Gold thioglucose concentrated in the kidneys and thymus, and 203Pb-thioglucose...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/15.3.723
更新日期:1975-06-01 00:00:00
abstract::The purpose of this study was to demonstrate the feasibility of computing three-dimensional relaxation maps of spin-lattice relaxation time in the rotating frame (T1rho) from in vivo magnetic resonance (MR) images of the human patellofemoral joint. T1rho was measured by applying a three-dimensional gradient-echo pulse...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2291021041
更新日期:2003-10-01 00:00:00
abstract::Scattered radiation and veiling glare in digital subtraction angiography degrade contrast signals in a nonlinear and nonuniform way. This effect prohibits direct use of image data for accurate iodine measurement or energy subtraction imaging. Two techniques based on the use of scanning lead bars were proposed to measu...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.157.1.3898220
更新日期:1985-10-01 00:00:00