Does the Clearance of Inhaled (99m)Tc-Sestamibi Correlate with Multidrug Resistance Protein 1 Expression in the Human Lung?

Abstract:

:Purpose To examine the relation between the lung elimination rate of inhaled technetium 99m ((99m)Tc)-sestamibi and immunohistochemical expression of bronchopulmonary multidrug resistance protein 1 (MRP1) and permeability glycoprotein (P-gp) and assess the repeatability of the inhaled (99m)Tc-sestamibi clearance technique. Materials and Methods (99m)Tc-sestamibi is a known substrate for P-gp and MRP1, which are established cellular drug efflux transporters. The elimination rate of (99m)Tc-sestamibi from the lungs after inhalation as an aerosol has been hypothesized to be regulated by expression of these transporters. Institutional ethics committee approval was received for this prospective study. Written informed consent was obtained from all participants. The clearance of inhaled (99m)Tc-sestamibi from the lungs of 13 patients due to undergo surgery for primary lung cancer (five of 13) or spontaneous pneumothorax (eight of 13) was estimated after dynamic imaging of the lungs during a period of 40 minutes. The time taken to clear 50% of inhaled sestamibi (T1/2) was compared with a semiquantitative immunohistochemical assessment (grade 0-3) of MRP1 and P-gp expression in the lung by using parametric and nonparametric tests. The study was repeated in five participants to assess the repeatability of the technique by using a Bland Altman analysis method. Results MRP1 expression was seen in 12 of 13 patients, while P-gp expression was seen in only two. The mean (99m)Tc-sestamibi elimination rate was faster in patients (n = 6) with low levels of MRP1 expression (grade 0-1) and mean T1/2 of 105 minutes ± 20 (standard deviation), compared with those with higher levels of MRP1 expression (grade 2-3, n = 7) and mean T1/2 of 149 minutes ± 28 (P = .008). Bland-Altman analysis revealed excellent agreement between test and retest values. Conclusion Inhaled (99m)Tc-sestamibi clearance study is a repeatable technique demonstrating significant correlation with MRP1 expression in the lungs. (©) RSNA, 2016.

journal_name

Radiology

journal_title

Radiology

authors

Mohan HK,Routledge T,Cane P,Livieratos L,Ballinger JR,Peters AM

doi

10.1148/radiol.16151389

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

924-30

issue

3

eissn

0033-8419

issn

1527-1315

journal_volume

280

pub_type

杂志文章
  • Urethral stones: US for identification in boys with hematuria and dysuria.

    abstract::There are multiple causes for hematuria in infants and children. When hematuria is accompanied by dysuria, however, one should focus attention on the lower urinary tract. Although ultrasound (US) is a well-established method for assessing the kidneys and bladder, little attention has been focused on its use for evalua...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.185.3.1438760

    authors: Kessler A,Rosenberg HK,Smoyer WE,Blyth B

    更新日期:1992-12-01 00:00:00

  • Screening for occlusive vascular disease with intraarterial DSA: preliminary experience with a high flow 4-F catheter.

    abstract::Forty-two patients underwent intraarterial digital subtraction angiography (DSA) of the carotid or renal arteries, utilizing a new 4-F aortic flush catheter; 37 procedures were percutaneous transbrachial, five were percutaneous transfemoral. Image quality was consistently good or excellent. The safety of nonselective ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.153.3.6387800

    authors: Becker GJ,Hicks ME,Holden RW,Edwards MK,Jackson VP,Bendick PJ

    更新日期:1984-12-01 00:00:00

  • Living donor liver transplantation: complications in donors and interventional management.

    abstract:PURPOSE:To evaluate the incidence of postoperative complications in liver donors and the efficacy of interventional management for treating these complications. MATERIALS AND METHODS:The study included 386 consecutive donors: 219 donors underwent right lobectomy or segmentectomy and 167 donors underwent left lobectomy...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2302021318

    authors: Lee SY,Ko GY,Gwon DI,Song HY,Lee SG,Yoon HK,Sung KB

    更新日期:2004-02-01 00:00:00

  • Hepatic artery stenosis and thrombosis in transplant recipients: Doppler diagnosis with resistive index and systolic acceleration time.

    abstract:PURPOSE:To assess the value of resistive index (RI) and systolic acceleration time (SAT) for diagnosis of stenoses and thromboses of the hepatic artery in liver transplant recipients. MATERIALS AND METHODS:Doppler sonograms and angiograms in 125 liver transplant recipients were correlated and analyzed for any statisti...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.192.3.8058930

    authors: Dodd GD 3rd,Memel DS,Zajko AB,Baron RL,Santaguida LA

    更新日期:1994-09-01 00:00:00

  • Peripheral arterial disease: meta-analysis of the diagnostic performance of MR angiography.

    abstract:PURPOSE:To summarize the overall diagnostic performance of magnetic resonance (MR) angiography in the evaluation of peripheral arteriosclerotic occlusive disease and to identify the most important sources of variation in diagnostic accuracy between studies. MATERIALS AND METHODS:A search strategy in MEDLINE and citati...

    journal_title:Radiology

    pub_type: 杂志文章,meta分析

    doi:10.1148/radiology.217.1.r00oc11105

    authors: Nelemans PJ,Leiner T,de Vet HC,van Engelshoven JM

    更新日期:2000-10-01 00:00:00

  • A Simplified Whole-Organ CT Perfusion Technique with Biphasic Acquisition: Preliminary Investigation of Accuracy and Protocol Feasibility in Kidneys.

    abstract:PURPOSE:To determine the feasibility and accuracy of a protocol for calculating whole-organ renal perfusion (renal blood flow [RBF]) and regional perfusion on the basis of biphasic computed tomography (CT), with concurrent dynamic contrast material-enhanced (DCE) CT perfusion serving as the reference standard. MATERIA...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2015142757

    authors: Yuan X,Zhang J,Quan C,Tian Y,Li H,Ao G

    更新日期:2016-04-01 00:00:00

  • Neural network analysis of ventilation-perfusion lung scans.

    abstract::A neural network model was constructed to interpret ventilation-perfusion (V/Q) lung scans. This model was trained with data from 100 consecutive V/Q scans with pulmonary angiographic correlation. The network was constructed from 28 input parameters that described various standard V/Q findings, which were fed into a s...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.186.3.8430170

    authors: Scott JA,Palmer EL

    更新日期:1993-03-01 00:00:00

  • Varicosity of the left renal ascending lumbar communicant vein: a pitfall in CT diagnosis.

    abstract::An anastomosis between the left renal and left ascending lumbar veins may appear as a mass on CT scans due to a varicosity where the veins separate. Intravenous injection of contrast material reveals the vascular nature of the mass. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.152.2.6739820

    authors: Lien HH,von Krogh J

    更新日期:1984-08-01 00:00:00

  • Mammographically detected breast cancer: location in women under 50 years old.

    abstract::The mammograms of 86 women under the age of 50 years with mammographically detected cancers were reviewed. Sixty-three of these cancers (73%) were found at the periphery of the breast as defined by a zone 1 cm wide beneath the subcutaneous fat or anterior to the retromammary fat. This finding is likely due to the geom...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.186.3.8381550

    authors: Stacey-Clear A,McCarthy KA,Hall DA,Pile-Spellman E,White G,Hulka CA,Whitman GJ,Halpern EF,Kopans DB

    更新日期:1993-03-01 00:00:00

  • Feasibility of absolute activity measurements using the Cleon emission tomography system.

    abstract::Large volume and small discrete sources of Tc-99m were used to study the spatial resolution, sensitivity, linearity and reproducibility of the radionuclide brain images. The spatial resolution is constant both within and perpendicular to the section. For uniform distributions of activity the response is uniform over t...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/133.2.497

    authors: Flower MA,Parker RP,Coles IP,Fox RA,Trott NG

    更新日期:1979-11-01 00:00:00

  • Sleep apnea syndrome: comparison of MR imaging of the oropharynx with physiologic indexes.

    abstract:PURPOSE:To compare magnetic resonance (MR) imaging of the oropharynx in patients with sleep apnea syndrome with fiberoptic nasopharyngoscopy, and oropharyngeal pressure and apnea index values. MATERIALS AND METHODS:After sleep induction, 24 patients with sleep apnea syndrome and nine patients with non-sleep-apnea snor...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.201.2.8888230

    authors: Suto Y,Matsuda E,Inoue Y,Suzuki T,Ohta Y

    更新日期:1996-11-01 00:00:00

  • Pulmonary embolism: segmental appearance of perfusion lung scan defects correlates with successful response to thrombolytic therapy.

    abstract::Lung scan data from a series of 45 patients receiving thrombolytic therapy were reviewed to determine if any pattern on the pretherapy perfusion lung scans could be identified that predicted response to therapy. A segmental appearance on the pretherapy scans (complete or nearly complete absence of perfusion in a whole...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.174.2.2104990

    authors: Parker JA,Nagel JS,Drum DE,Tumeh SS,Goldhaber SZ

    更新日期:1990-02-01 00:00:00

  • Radiological detection of aneurysms involving the aortic root.

    abstract::Dilatation of the aortic root, outlined by a periaortic fat layer, was observed in 19 of 25 successive cases of aneurysm of the ascending aorta. In one of these cases the aneurysm was entirely confined to the aortic root. In two other cases the aneurysms could not be detected on standard chest radiographs judged in th...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.138.3.7465830

    authors: Szamosi A

    更新日期:1981-03-01 00:00:00

  • Tomography of hydrogen with nuclear magnetic resonance.

    abstract::A nuclear magnetic resonance (NMR) imager with a 6.5-cm aperture is described. Spatial resolution is 0.47 X 2.0 mm with a slice thickness of 8.4 mm. Contrast resolution is 3% for a 4-minute image. Because of the excellent spatial resolution and high contrast between soft tissues, the images provide a great deal of det...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.136.3.7403550

    authors: Crooks L,Hoenninger J,Arakawa M,Kaufman L,McRee R,Watts J,Singer JH

    更新日期:1980-09-01 00:00:00

  • Ioglucomide: a new nonionic myelographic agent. Preclinical studies.

    abstract::Ioglucomide, a new iodinated nonionic contrast medium directed primarily toward myelographic use, was subjected to an extensive toxicological examination in animals. In the majority of studies, ioglucomide was compared directly with metrizamide. In some respects, including freedom from production of arachnoiditis, iog...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.140.3.7280240

    authors: Hopkins RM,Adams MD,Lau DH,Creighton JM,Hoey GB

    更新日期:1981-09-01 00:00:00

  • Carotid-cavernous fistula associated with intracranial fibromuscular dysplasia.

    abstract::Fibromuscular dysplasia (FMD) of the intracranial internal carotid and vertebro-basilar system is extremely rare. A case with diffuse intracranial involvement and an associated carotid-cavernous fistula is presented. The literature is reviewed and the pathogenesis of this complication of FMD is discussed. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/122.3.725

    authors: Zimmerman R,Leeds NE,Naidich TP

    更新日期:1977-03-01 00:00:00

  • Barium studies in small-bowel infarction. Radiological-pathological correlation.

    abstract::Seven patients with proved small-bowel infarction were studied to determine whether the radiographic appearance of an ischemic segment is helpful in predicting the severity of the process, in particular the potential viability or nonviability of the affected bowel. It was found that the barium examination is useful in...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/123.2.303

    authors: Joffe N,Goldman H,Antonioli DA

    更新日期:1977-05-01 00:00:00

  • Recurrent colorectal carcinoma: evaluation with barium enema examination and CT.

    abstract::The efficacy of the barium enema examination and abdominal computed tomography (CT) was investigated in 81 patients who had undergone operation for colorectal carcinoma. Recurrent disease was found in 52 patients and was divided into local (anastomotic and perianastomotic) and remote (distant and hepatic metastases) t...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.163.2.3562810

    authors: Chen YM,Ott DJ,Wolfman NT,Gelfand DW,Karsteadt N,Bechtold RE

    更新日期:1987-05-01 00:00:00

  • Carcinoma of the prostate gland: MR imaging with pelvic phased-array coils versus integrated endorectal--pelvic phased-array coils.

    abstract:PURPOSE:To compare the performance of pelvic phased-array (PPA) coils and integrated endorectal PPA coils in evaluation of local extent of prostate cancer. MATERIALS AND METHODS:Seventy-one men underwent magnetic resonance (MR) imaging within 3 weeks of radical prostatectomy. MR findings of tumor, extracapsular extens...

    journal_title:Radiology

    pub_type: 临床试验,杂志文章

    doi:10.1148/radiology.193.3.7972810

    authors: Hricak H,White S,Vigneron D,Kurhanewicz J,Kosco A,Levin D,Weiss J,Narayan P,Carroll PR

    更新日期:1994-12-01 00:00:00

  • Participation of the external and internal carotid arteries in the blood supply of acoustic neurinomas.

    abstract::Six cases of acoustic neurinoma are presented in which the tumor is supplied by branches of the external carotid artery, with or without supply from the internal carotid artery. A new angiographic protocol for the investigation of masses in the cerebellopontine angle is suggested. According to early results of the CT ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/118.1.83

    authors: Théron J,Lasjaunias P

    更新日期:1976-01-01 00:00:00

  • MR imaging and outcome of term neonates with perinatal asphyxia: value of diffusion-weighted MR imaging and ¹H MR spectroscopy.

    abstract:PURPOSE:To compare the association between neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy following perinatal asphyxia and (a) apparent diffusion coefficients (ADCs) in the thalamus and basal ganglia at diffusion-weighted (DW) magnetic resonance (MR) imaging and (b) hydrogen 1 (¹H) MR spect...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.11110213

    authors: Alderliesten T,de Vries LS,Benders MJ,Koopman C,Groenendaal F

    更新日期:2011-10-01 00:00:00

  • Three-dimensional Deep Convolutional Neural Networks for Automated Myocardial Scar Quantification in Hypertrophic Cardiomyopathy: A Multicenter Multivendor Study.

    abstract::Background Cardiac MRI late gadolinium enhancement (LGE) scar volume is an important marker for outcome prediction in patients with hypertrophic cardiomyopathy (HCM); however, its clinical application is hindered by a lack of measurement standardization. Purpose To develop and evaluate a three-dimensional (3D) convolu...

    journal_title:Radiology

    pub_type: 杂志文章,多中心研究

    doi:10.1148/radiol.2019190737

    authors: Fahmy AS,Neisius U,Chan RH,Rowin EJ,Manning WJ,Maron MS,Nezafat R

    更新日期:2020-01-01 00:00:00

  • Dobutamine response and myocardial infarct transmurality: functional improvement after coronary artery bypass grafting--initial experience.

    abstract::The Investigational Review Board approved the protocol, and all patients provided signed informed consent. The protocol was compliant with HIPAA. The purpose of the study was to prospectively test the hypothesis that addition of low-dose dobutamine and quantification of inotropic reserve in segments with 1%-50% infarc...

    journal_title:Radiology

    pub_type: 临床试验,杂志文章

    doi:10.1148/radiol.2403051150

    authors: Bove CM,DiMaria JM,Voros S,Conaway MR,Kramer CM

    更新日期:2006-09-01 00:00:00

  • The revised Atlanta classification of acute pancreatitis: its importance for the radiologist and its effect on treatment.

    abstract::An international working group has modified the Atlanta classification for acute pancreatitis to update the terminology and provide simple functional clinical and morphologic classifications. The modifications (a) address the clinical course and severity of disease, (b) divide acute pancreatitis into interstitial edem...

    journal_title:Radiology

    pub_type: 杂志文章,评审

    doi:10.1148/radiol.11110947

    authors: Thoeni RF

    更新日期:2012-03-01 00:00:00

  • Characterization of prostate lesions as benign or malignant at multiparametric MR imaging: comparison of three scoring systems in patients treated with radical prostatectomy.

    abstract:PURPOSE:To compare the subjective Likert score to the Prostate Imaging Reporting and Data System (PIRADS) and morphology-location-signal intensity (MLS) scores for categorization of prostate lesions as benign or malignant at multiparametric magnetic resonance (MR) imaging. MATERIALS AND METHODS:Two hundred fifteen pat...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.14131584

    authors: Vaché T,Bratan F,Mège-Lechevallier F,Roche S,Rabilloud M,Rouvière O

    更新日期:2014-08-01 00:00:00

  • Acute rat lung injury: feasibility of assessment with micro-CT.

    abstract:PURPOSE:To evaluate the feasibility of micro-computed tomography (CT) for analysis of the lung fine structure and its alterations during endotoxin-induced lung injury. MATERIALS AND METHODS:Intravital perfusion-fixed rat lungs with (n = 5) and without (n = 5) endotoxin perfusion were scanned with micro-CT. Three imagi...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2331031340

    authors: Langheinrich AC,Leithäuser B,Greschus S,Von Gerlach S,Breithecker A,Matthias FR,Rau WS,Bohle RM

    更新日期:2004-10-01 00:00:00

  • Common bile duct calculi: updated experience with dissolution with methyl tertiary butyl ether.

    abstract::The authors describe their experience with methyl tertiary butyl ether (MTBE) in a larger series of patients than previously reported in order to acquaint physicians with both its effectiveness for dissolution of common bile duct calculi and the limitations of its use. Ten patients with 13 biliary calculi underwent pe...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.166.3.3340760

    authors: Brandon JC,Teplick SK,Haskin PH,Sammon JK,Muhr WF,Hofmann AF,Gambescia RA,Zitomer N

    更新日期:1988-03-01 00:00:00

  • Ghost infantile vertebrae and hemipelves within adult skeleton from thorotrast administration in childhood.

    abstract::In 2 adults who had received thorotrast intravenously at ages 2 and 3 years, respectively, radiopaque outlines of their infantile vertebrae were seen in the adult vertebrae. Similar "ghosts" of the hemipelves were present in the pelvis of 1 patient. Autopsy findings and autoradiographs in 1 patient strongly suggest th...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/129.3.657

    authors: Teplick JG,Head GL,Kricun ME,Haskin ME

    更新日期:1978-12-01 00:00:00

  • Survival outcomes of breast cancer patients who receive neoadjuvant chemotherapy: association with dynamic contrast-enhanced MR imaging with computer-aided evaluation.

    abstract:PURPOSE:To retrospectively evaluate whether dynamic contrast agent-enhanced (DCE) magnetic resonance (MR) imaging parameters assessed by a computer-aided evaluation program are associated with recurrence-free and overall survival in breast cancer patients who received neoadjuvant chemotherapy (NAC). MATERIALS AND METH...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.13121801

    authors: Yi A,Cho N,Im SA,Chang JM,Kim SJ,Moon HG,Han W,Park IA,Noh DY,Moon WK

    更新日期:2013-09-01 00:00:00

  • Major geometric variations between multiple high-dose-rate applications of brachytherapy in cancer of the cervix: frequency and types of variation.

    abstract:PURPOSE:To evaluate major geometric variations in multiple intracavitary applications for carcinoma of the cervix. MATERIALS AND METHODS:Orthogonal radiographs were reviewed of 17 consecutive patients with carcinoma of the cervix treated with 70 applications of high-dose-rate brachytherapy. In seven patients, consciou...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.195.2.7724760

    authors: Kim RY,Meyer JT,Plott WE,Spencer SA,Meredith RF,Jennelle RL,Salter MM

    更新日期:1995-05-01 00:00:00