Ioglucomide: a new nonionic myelographic agent. Preclinical studies.

Abstract:

:Ioglucomide, a new iodinated nonionic contrast medium directed primarily toward myelographic use, was subjected to an extensive toxicological examination in animals. In the majority of studies, ioglucomide was compared directly with metrizamide. In some respects, including freedom from production of arachnoiditis, ioglucomide and metrizamide were comparable. However, acute toxicity after intravenous injection or instillation into cerebrospinal fluid was significantly less for ioglucomide. Also, in contrast to metrizamide, ioglucomide produced no evidence of any type of convulsive activity after subarachnoid administration. The improved safety of ioglucomide could not be related to osmolality; therefore, the importance of osmolality for nonionic myelographic agent safety is questioned.

journal_name

Radiology

journal_title

Radiology

authors

Hopkins RM,Adams MD,Lau DH,Creighton JM,Hoey GB

doi

10.1148/radiology.140.3.7280240

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

713-7

issue

3

eissn

0033-8419

issn

1527-1315

journal_volume

140

pub_type

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