Abstract:
:Ioglucomide, a new iodinated nonionic contrast medium directed primarily toward myelographic use, was subjected to an extensive toxicological examination in animals. In the majority of studies, ioglucomide was compared directly with metrizamide. In some respects, including freedom from production of arachnoiditis, ioglucomide and metrizamide were comparable. However, acute toxicity after intravenous injection or instillation into cerebrospinal fluid was significantly less for ioglucomide. Also, in contrast to metrizamide, ioglucomide produced no evidence of any type of convulsive activity after subarachnoid administration. The improved safety of ioglucomide could not be related to osmolality; therefore, the importance of osmolality for nonionic myelographic agent safety is questioned.
journal_name
Radiologyjournal_title
Radiologyauthors
Hopkins RM,Adams MD,Lau DH,Creighton JM,Hoey GBdoi
10.1148/radiology.140.3.7280240subject
Has Abstractpub_date
1981-09-01 00:00:00pages
713-7issue
3eissn
0033-8419issn
1527-1315journal_volume
140pub_type
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