Abstract:
:The rationale for prebiopsy and preoperative irradiation in a multimodal approach to treatment of osteosarcoma is presented. Six patients with osteosarcoma underwent preoperative irradiation, amputation, and elective chemotherapy. Five of these also received prebiopsy irradiation: three survive without metastases at 29, 36, and 56 months, with no therapy for 10, 16, and 37 months, respectively; two patients died at 6 and 19 months of pulmonary metastases which appeared at 2 and 10 months, respectively. The latter two did not receive prebiopsy irradiation. Another patient, whose pulmonary metastasis regressed at 6 months with adriamycin and was later resected, died of cardiac failure at 59 months without evident metastasis. Immunologic aspects of the disease are also discussed.
journal_name
Radiologyjournal_title
Radiologyauthors
Munzenrider JE,Emami B,Tchakarova I,Necheles TF,Banks HH,Paradelo JC,Oh WHdoi
10.1148/125.2.497subject
Has Abstractpub_date
1977-11-01 00:00:00pages
497-502issue
2eissn
0033-8419issn
1527-1315journal_volume
125pub_type
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