Abstract:
PURPOSE:To optimize detection and diagnosis of breast lesions with contrast-enhanced magnetic resonance (MR) imaging. MATERIALS AND METHODS:A three-dimensional fast low-angle shot pulse sequence was used for a group comparison consisting of 76 high-dose (0.16 mmol gadopentetate dimeglumine per kilogram of body weight) and 76 low-dose (0.1 mmol/kg) examinations. Intraindividual comparisons were possible in a subgroup of 20 patients. RESULTS:Enhancement with the high dose was about 1.5 times higher for benign and malignant tissues. With the lower dose, no false-positive findings could be avoided and definition of a threshold that excluded false-negative findings was problematic. Conspicuity of malignant lesions was much improved with the higher dose (a good to excellent rating in 81% vs 26% with the lower dose). Three small foci were visible only with the higher dose. CONCLUSION:The higher dose of contrast material allowed much better results. Dose comparison studies are also recommended for other techniques.
journal_name
Radiologyjournal_title
Radiologyauthors
Heywang-Köbrunner SH,Haustein J,Pohl C,Beck R,Lommatzsch B,Untch M,Nathrath WBdoi
10.1148/radiology.191.3.8184040subject
Has Abstractpub_date
1994-06-01 00:00:00pages
639-46issue
3eissn
0033-8419issn
1527-1315journal_volume
191pub_type
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