Abstract:
PURPOSE:Quantification of regional cerebral blood flow (rCBF) and volume (rCBV) with dynamic magnetic resonance (MR) imaging. MATERIALS AND METHODS:After bolus administration of a paramagnetic contrast medium, rapid T2*-weighted gradient-echo images of two sections were acquired for the simultaneous creation of concentration-time curves in the brain-feeding arteries and in brain tissue. Absolute rCBF and rCBV values were determined for gray and white brain matter in 12 subjects with use of principles of the indicator dilution theory. RESULTS:The mean rCBF value in gray matter was 69.7 mL/min +/- 29.7 per 100 g tissue and in white matter, 33.6 mL/min +/- 11.5 per 100 g tissue; the average rCBV was 8.0 mL +/- 3.1 per 100 g tissue and 4.2 mL +/- 1.0 per 100 g tissue, respectively. An age-related decrease in rCBF and rCBV for gray and white matter was observed. CONCLUSION:Preliminary data demonstrate that the proposed technique allows the quantification of rCBF and rCBV. Although the results are in good agreement with data from positron emission tomography studies, further evaluation is needed to establish the validity of method.
journal_name
Radiologyjournal_title
Radiologyauthors
Rempp KA,Brix G,Wenz F,Becker CR,Gückel F,Lorenz WJdoi
10.1148/radiology.193.3.7972800subject
Has Abstractpub_date
1994-12-01 00:00:00pages
637-41issue
3eissn
0033-8419issn
1527-1315journal_volume
193pub_type
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