Renal hyperconcentration of 99mTc-HEDP in experimental acute tubular necrosis.

Abstract:

:The effect of transient renal ischemia on renal concentration and distribution of 99mTc-HEDP, 99mTc-DMSA, and 99mTc-DTPA was compared in rabbits with acute tubular necrosis. Scintigrams were obtained after injection in normal rabbits or ones with unilateral or bilateral ischemia. 99mTc-HEDP concentration in ischemic tissue was 8 to 18 times normal 1--4 hours after injection, and the resulting images delineated the morphological changes in the ischemic kidneys more accurately than those obtained with DMSA or DTPA. Calcium concentration in the ischemic kidneys increased sixfold. 99mTc-HEDP may be useful in evaluation of renal failure secondary to tubular injury.

journal_name

Radiology

journal_title

Radiology

authors

Lavelle KJ,Park HM,Moseman AM,Lewis S

doi

10.1148/131.2.491

subject

Has Abstract

pub_date

1979-05-01 00:00:00

pages

491-5

issue

2

eissn

0033-8419

issn

1527-1315

journal_volume

131

pub_type

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