Abstract:
PURPOSE:To compare the diagnostic usefulness of three-dimensional (3D) stereotaxic surface projection (SSP) with that of standard transaxial display in brain positron emission tomography (PET) in Alzheimer disease (AD). MATERIALS AND METHODS:Standard transaxial section display and 3D-SSP PET image sets obtained after administration of 2-deoxy-2-[fluorine-18]fluoro-D-glucose in 39 patients with probable AD (aged 53-82 years; 15 men, 24 women) and 40 subjects without AD (aged 21-78 years; 14 men, 26 women) were randomly interpreted. Receiver operating characteristic (ROC) analysis was performed. RESULTS:Diagnostic performance was superior with 3D SSP (Az[section]=0.94,Az[3D SSP]=0.99[Az=area under the ROC curve];P=.043). With 3D SSP, diagnosis of AD was equally good in beginners and experts. The sensitivity and specificity in questionable or mild dementia were 94% and 99% with 3D SSP and 79% and 88% with standard transaxial display. CONCLUSION:Accuracy of detecting AD was improved in PET with 3D SSP.
journal_name
Radiologyjournal_title
Radiologyauthors
Burdette JH,Minoshima S,Vander Borght T,Tran DD,Kuhl DEdoi
10.1148/radiology.198.3.8628880subject
Has Abstractpub_date
1996-03-01 00:00:00pages
837-43issue
3eissn
0033-8419issn
1527-1315journal_volume
198pub_type
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