Alzheimer disease: improved visual interpretation of PET images by using three-dimensional stereotaxic surface projections.

Abstract:

PURPOSE:To compare the diagnostic usefulness of three-dimensional (3D) stereotaxic surface projection (SSP) with that of standard transaxial display in brain positron emission tomography (PET) in Alzheimer disease (AD). MATERIALS AND METHODS:Standard transaxial section display and 3D-SSP PET image sets obtained after administration of 2-deoxy-2-[fluorine-18]fluoro-D-glucose in 39 patients with probable AD (aged 53-82 years; 15 men, 24 women) and 40 subjects without AD (aged 21-78 years; 14 men, 26 women) were randomly interpreted. Receiver operating characteristic (ROC) analysis was performed. RESULTS:Diagnostic performance was superior with 3D SSP (Az[section]=0.94,Az[3D SSP]=0.99[Az=area under the ROC curve];P=.043). With 3D SSP, diagnosis of AD was equally good in beginners and experts. The sensitivity and specificity in questionable or mild dementia were 94% and 99% with 3D SSP and 79% and 88% with standard transaxial display. CONCLUSION:Accuracy of detecting AD was improved in PET with 3D SSP.

journal_name

Radiology

journal_title

Radiology

authors

Burdette JH,Minoshima S,Vander Borght T,Tran DD,Kuhl DE

doi

10.1148/radiology.198.3.8628880

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

837-43

issue

3

eissn

0033-8419

issn

1527-1315

journal_volume

198

pub_type

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